{"id":"https://openalex.org/W2809507578","doi":"https://doi.org/10.1021/acsmedchemlett.8b00145","title":"Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma","display_name":"Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma","publication_year":2018,"publication_date":"2018-06-23","ids":{"openalex":"https://openalex.org/W2809507578","doi":"https://doi.org/10.1021/acsmedchemlett.8b00145","mag":"2809507578","pmid":"https://pubmed.ncbi.nlm.nih.gov/30034600","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6047040"},"language":"en","primary_location":{"id":"doi:10.1021/acsmedchemlett.8b00145","doi":"https://doi.org/10.1021/acsmedchemlett.8b00145","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsmedchemlett.8b00145","pdf_url":null,"source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6047040","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051119122","display_name":"Xianhai Huang","orcid":"https://orcid.org/0000-0003-0757-2047","observed_orcids":["https://orcid.org/0000-0003-0757-2047"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xianhai Huang","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":"https://orcid.org/0000-0003-0757-2047","affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113218015","display_name":"Jason D. Brubaker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Brubaker","raw_affiliation_strings":["Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101764521","display_name":"Wei Zhou","orcid":"https://orcid.org/0000-0003-2787-5045","observed_orcids":["https://orcid.org/0000-0003-2787-5045","https://orcid.org/0009-0009-6047-4201"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhou","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111873340","display_name":"Purakkattle Biju","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Purakkattle J. Biju","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100375305","display_name":"Xiao Li","orcid":"https://orcid.org/0009-0006-1755-1839","observed_orcids":["https://orcid.org/0009-0006-1755-1839","https://orcid.org/0000-0002-7708-2193","https://orcid.org/0009-0008-4544-5130"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Xiao","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034988362","display_name":"Ning Shao","orcid":"https://orcid.org/0000-0003-0573-3636","observed_orcids":["https://orcid.org/0000-0003-0573-3636","https://orcid.org/0000-0001-5116-2446"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ning Shao","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036877016","display_name":"Ying R. Huang","orcid":"https://orcid.org/0000-0001-5265-3984","observed_orcids":["https://orcid.org/0000-0001-5265-3984"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Huang","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100630616","display_name":"Li Dong","orcid":"https://orcid.org/0000-0002-2894-4957","observed_orcids":["https://orcid.org/0000-0002-2894-4957"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Dong","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhidan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhidan Liu","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086764563","display_name":"Rema Bitar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rema Bitar","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077327197","display_name":"Alexei V. Buevich","orcid":"https://orcid.org/0000-0002-5968-9151","observed_orcids":["https://orcid.org/0000-0002-5968-9151"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexei Buevich","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":"https://orcid.org/0000-0002-5968-9151","affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052591725","display_name":"Joon O. Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joon Jung","raw_affiliation_strings":["Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089634441","display_name":"Scott L. Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott L. Peterson","raw_affiliation_strings":["Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062600898","display_name":"John W. Butcher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Butcher","raw_affiliation_strings":["Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050403715","display_name":"Joshua Close","orcid":"https://orcid.org/0000-0003-0696-3759","observed_orcids":["https://orcid.org/0000-0003-0696-3759"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Close","raw_affiliation_strings":["Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michelle Martinez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Martinez","raw_affiliation_strings":["Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012866232","display_name":"Rachel N. MacCoss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel N. MacCoss","raw_affiliation_strings":["Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100330895","display_name":"Hongjun Zhang","orcid":"https://orcid.org/0000-0002-1136-6142","observed_orcids":["https://orcid.org/0000-0002-1136-6142"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongjun Zhang","raw_affiliation_strings":["Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Scott Crawford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Crawford","raw_affiliation_strings":["Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023389020","display_name":"Kevin D. McCormick","orcid":"https://orcid.org/0000-0001-5035-7583","observed_orcids":["https://orcid.org/0000-0001-5035-7583"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin D. McCormick","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091491172","display_name":"Robert G. Aslanian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Aslanian","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018001321","display_name":"Ravi P. Nargund","orcid":"https://orcid.org/0000-0003-1040-022X","observed_orcids":["https://orcid.org/0000-0003-1040-022X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Nargund","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044903569","display_name":"Craig C. Correll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig Correll","raw_affiliation_strings":["Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078120615","display_name":"Fran\u00e7ois G. Gervais","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francois Gervais","raw_affiliation_strings":["Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109232320","display_name":"Hongchen Qiu","orcid":"https://orcid.org/0009-0006-0187-1088","observed_orcids":["https://orcid.org/0009-0006-0187-1088"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongchen Qiu","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","In Vitro Pharmacology, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"In Vitro Pharmacology, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033874532","display_name":"Xiaoxin Yang","orcid":"https://orcid.org/0000-0001-5645-697X","observed_orcids":["https://orcid.org/0000-0001-5645-697X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxin Yang","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","In Vitro Pharmacology, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"In Vitro Pharmacology, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083743261","display_name":"Charles G. Garlisi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Garlisi","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","In Vitro Pharmacology, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"In Vitro Pharmacology, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059324301","display_name":"Diane Rindgen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Rindgen","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Drug Metabolism and Pharmacokinetics, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Drug Metabolism and Pharmacokinetics, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085621143","display_name":"Kevin M. Maloney","orcid":"https://orcid.org/0000-0003-1422-5422","observed_orcids":["https://orcid.org/0000-0003-1422-5422"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin M. Maloney","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032980474","display_name":"Phieng Siliphaivanh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phieng Siliphaivanh","raw_affiliation_strings":["Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry and Immunology, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042502468","display_name":"Anandan Palani","orcid":"https://orcid.org/0000-0001-7803-5631","observed_orcids":["https://orcid.org/0000-0001-7803-5631"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anandan Palani","raw_affiliation_strings":["Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Chemistry, In Vitro Pharmacology, Drug Metabolism and Pharmacokinetics, and Process Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Discovery Chemistry, Merck Research Laboratory, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042502468","https://openalex.org/A5051119122"],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.0821,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77304874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":"7","first_page":"679","last_page":"684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.3499999940395355},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.9419999718666077},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7870000004768372},{"id":"https://openalex.org/keywords/lead-optimization","display_name":"lead optimization","score":0.718999981880188},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2781081902","wikidata":"https://www.wikidata.org/wiki/Q3539074","display_name":"Tricyclic","level":2,"score":0.8479543924331665},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6999462842941284},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6959162950515747},{"id":"https://openalex.org/C2777383412","wikidata":"https://www.wikidata.org/wiki/Q4770891","display_name":"Antagonism","level":3,"score":0.5759036540985107},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5655503869056702},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5063525438308716},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4810217022895813},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4756081700325012},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.45791095495224},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.4500005841255188},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.433353066444397},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3602103292942047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3421028256416321},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3245777487754822},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13581258058547974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12672212719917297}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1021/acsmedchemlett.8b00145","doi":"https://doi.org/10.1021/acsmedchemlett.8b00145","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsmedchemlett.8b00145","pdf_url":null,"source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6047040","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6047040","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Med Chem Lett","raw_type":"Text"},{"id":"pmid:30034600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30034600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6047040","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6047040","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Med Chem Lett","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1519407136","https://openalex.org/W1535429252","https://openalex.org/W1722247753","https://openalex.org/W1930217537","https://openalex.org/W1967036092","https://openalex.org/W1981546405","https://openalex.org/W1983047545","https://openalex.org/W1985242752","https://openalex.org/W1991225939","https://openalex.org/W1994616660","https://openalex.org/W1997181919","https://openalex.org/W2041082200","https://openalex.org/W2076002509","https://openalex.org/W2087196444","https://openalex.org/W2121533007","https://openalex.org/W2128627230","https://openalex.org/W2130579948","https://openalex.org/W2150068375","https://openalex.org/W2154411575","https://openalex.org/W2155672819","https://openalex.org/W2313856416","https://openalex.org/W3102901846","https://openalex.org/W4206612918"],"related_works":["https://openalex.org/W2130579948","https://openalex.org/W1974839577","https://openalex.org/W2912805658","https://openalex.org/W2054197086","https://openalex.org/W1964207966","https://openalex.org/W4323531454","https://openalex.org/W2736365793","https://openalex.org/W1978506981","https://openalex.org/W2050449539","https://openalex.org/W2317155281"],"abstract_inverted_index":{"A":[0],"novel":[1],"series":[2],"of":[3,35,64,106],"tricyclic":[4,56],"tetrahydroquinolines":[5],"were":[6],"identified":[7],"as":[8],"potent":[9,86],"and":[10,17,87,92],"selective":[11,88],"CRTh2":[12,29,89],"receptor":[13,30],"antagonists.":[14],"The":[15,33],"agonism":[16],"antagonism":[18],"switch":[19],"was":[20,42],"achieved":[21],"through":[22,50],"structure-based":[23],"drug":[24],"design":[25],"(SBDD)":[26],"using":[27],"a":[28,74,93],"homologue":[31],"model.":[32],"challenge":[34],"very":[36],"low":[37],"exposures":[38],"in":[39,61],"pharmacokinetic":[40],"studies":[41,53],"overcome":[43],"by":[44],"exhaustive":[45],"medicinal":[46],"chemistry":[47],"lead":[48],"optimization":[49,59],"focused":[51],"SAR":[52],"on":[54],"the":[55,62,65],"core.":[57],"Further":[58],"resulted":[60],"identification":[63],"preclinical":[66],"candidate":[67],"4-(cyclopropyl((3":[68],"aS,9":[69],"R,9":[70],"aR":[71],")-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3":[72],"a,4,9,9":[73],"-hexahydro-1":[75],"H":[76],"-cyclopenta[":[77],"b":[78],"]quinolin-9-yl)amino)-4-oxobutanoic":[79],"acid":[80],"(":[81],"15c,":[82],"MK-8318":[83],")":[84],"with":[85],"antagonist":[90],"activity":[91],"favorable":[94],"PK":[95],"profile":[96],"suitable":[97],"for":[98,103],"once":[99],"daily":[100],"oral":[101],"dosing":[102],"potential":[104],"treatment":[105],"asthma.":[107]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-29T00:00:00"}