{"id":"https://openalex.org/W2809501033","doi":"https://doi.org/10.7888/juoeh.40.173","title":"Immune Checkpoint Inhibitors (ICIs) in Non-Small Cell Lung Cancer (NSCLC)","display_name":"Immune Checkpoint Inhibitors (ICIs) in Non-Small Cell Lung Cancer (NSCLC)","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2809501033","doi":"https://doi.org/10.7888/juoeh.40.173","mag":"2809501033","pmid":"https://pubmed.ncbi.nlm.nih.gov/29925736"},"language":"en","primary_location":{"id":"doi:10.7888/juoeh.40.173","doi":"https://doi.org/10.7888/juoeh.40.173","is_oa":true,"landing_page_url":"https://doi.org/10.7888/juoeh.40.173","pdf_url":"https://www.jstage.jst.go.jp/article/juoeh/40/2/40_173/_pdf","source":{"id":"https://openalex.org/S2754427771","display_name":"Journal of UOEH","issn_l":"0387-821X","issn":["0387-821X","2187-2864"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313152","host_organization_name":"University of Occupational and Environmental Health Japan","host_organization_lineage":["https://openalex.org/P4310313152"],"host_organization_lineage_names":["University of Occupational and Environmental Health Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of UOEH","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/juoeh/40/2/40_173/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052080777","display_name":"Kazue Yoneda","orcid":"https://orcid.org/0000-0001-7142-2743","observed_orcids":["https://orcid.org/0000-0001-7142-2743"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazue YONEDA","raw_affiliation_strings":["Second Department of Surgery (Chest Surgery), School of Medicine, University of Occupational and Environmental Health, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Surgery (Chest Surgery), School of Medicine, University of Occupational and Environmental Health, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112170296","display_name":"Naoko Imanishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoko IMANISHI","raw_affiliation_strings":["Second Department of Surgery (Chest Surgery), School of Medicine, University of Occupational and Environmental Health, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Surgery (Chest Surgery), School of Medicine, University of Occupational and Environmental Health, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013700595","display_name":"Yoshinobu Ichiki","orcid":"https://orcid.org/0000-0002-1293-6952","observed_orcids":["https://orcid.org/0000-0002-1293-6952"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinobu ICHIKI","raw_affiliation_strings":["Second Department of Surgery (Chest Surgery), School of Medicine, University of Occupational and Environmental Health, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Surgery (Chest Surgery), School of Medicine, University of Occupational and Environmental Health, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015471387","display_name":"Fumihiro Tanaka","orcid":"https://orcid.org/0000-0003-4692-6151","observed_orcids":["https://orcid.org/0000-0003-4692-6151"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumihiro TANAKA","raw_affiliation_strings":["Second Department of Surgery (Chest Surgery), School of Medicine, University of Occupational and Environmental Health, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Surgery (Chest Surgery), School of Medicine, University of Occupational and Environmental Health, Japan","institution_ids":["https://openalex.org/I188700360"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I188700360"],"apc_list":null,"apc_paid":null,"fwci":0.9279,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.71642911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"40","issue":"2","first_page":"173","last_page":"189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":1.0},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":1.0},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.968999981880188},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.5929999947547913},{"id":"https://openalex.org/keywords/locally-advanced-nsclc","display_name":"locally advanced non-small cell lung cancer","score":0.7789999842643738},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6859999895095825},{"id":"https://openalex.org/keywords/early-stage-non-small-cell-lung-cancer","display_name":"early-stage non-small cell lung cancer","score":0.7099999785423279},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8211888074874878},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7046096920967102},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6754418611526489},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6477570533752441},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5581592917442322},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5320219993591309},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.503802478313446},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5001587867736816},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.49392348527908325},{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.45381778478622437},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39249441027641296},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.31088539958000183}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.7888/juoeh.40.173","doi":"https://doi.org/10.7888/juoeh.40.173","is_oa":true,"landing_page_url":"https://doi.org/10.7888/juoeh.40.173","pdf_url":"https://www.jstage.jst.go.jp/article/juoeh/40/2/40_173/_pdf","source":{"id":"https://openalex.org/S2754427771","display_name":"Journal of UOEH","issn_l":"0387-821X","issn":["0387-821X","2187-2864"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313152","host_organization_name":"University of Occupational and Environmental Health Japan","host_organization_lineage":["https://openalex.org/P4310313152"],"host_organization_lineage_names":["University of Occupational and Environmental Health Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of UOEH","raw_type":"journal-article"},{"id":"pmid:29925736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29925736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of UOEH","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7888/juoeh.40.173","doi":"https://doi.org/10.7888/juoeh.40.173","is_oa":true,"landing_page_url":"https://doi.org/10.7888/juoeh.40.173","pdf_url":"https://www.jstage.jst.go.jp/article/juoeh/40/2/40_173/_pdf","source":{"id":"https://openalex.org/S2754427771","display_name":"Journal of UOEH","issn_l":"0387-821X","issn":["0387-821X","2187-2864"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313152","host_organization_name":"University of Occupational and Environmental Health Japan","host_organization_lineage":["https://openalex.org/P4310313152"],"host_organization_lineage_names":["University of Occupational and Environmental Health Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of UOEH","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5848512367","display_name":"Early-stage Identification of CTC (Circulating Tumor Cells) by Employing Softcomputing and Dielectrophoretic Phenomenon","funder_award_id":"16H01747","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320316454","display_name":"University of Occupational and Environmental Health","ror":"https://ror.org/020p3h829"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2809501033.pdf","grobid_xml":"https://content.openalex.org/works/W2809501033.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1839238860","https://openalex.org/W1889335134","https://openalex.org/W1915205009","https://openalex.org/W1940241680","https://openalex.org/W1978139448","https://openalex.org/W1982488143","https://openalex.org/W1994993231","https://openalex.org/W2037139573","https://openalex.org/W2049553585","https://openalex.org/W2057893793","https://openalex.org/W2104347254","https://openalex.org/W2107403628","https://openalex.org/W2109485845","https://openalex.org/W2126759268","https://openalex.org/W2130652363","https://openalex.org/W2134693386","https://openalex.org/W2140980839","https://openalex.org/W2151090489","https://openalex.org/W2156353875","https://openalex.org/W2160834915","https://openalex.org/W2170030318","https://openalex.org/W2198093519","https://openalex.org/W2251438188","https://openalex.org/W2260067559","https://openalex.org/W2291298003","https://openalex.org/W2293531514","https://openalex.org/W2337507927","https://openalex.org/W2340636398","https://openalex.org/W2400514548","https://openalex.org/W2464620827","https://openalex.org/W2468576628","https://openalex.org/W2508069933","https://openalex.org/W2527905628","https://openalex.org/W2528861955","https://openalex.org/W2529904548","https://openalex.org/W2538232731","https://openalex.org/W2557730509","https://openalex.org/W2560704457","https://openalex.org/W2567564314","https://openalex.org/W2578528809","https://openalex.org/W2595109242","https://openalex.org/W2620097568","https://openalex.org/W2622499649","https://openalex.org/W2635951006","https://openalex.org/W2725398806","https://openalex.org/W2738406814","https://openalex.org/W2739644750","https://openalex.org/W2753065806","https://openalex.org/W2762592752","https://openalex.org/W2762777471","https://openalex.org/W2763816349","https://openalex.org/W2764212839","https://openalex.org/W2806431043","https://openalex.org/W2807434325"],"related_works":["https://openalex.org/W2919091706","https://openalex.org/W2969594132","https://openalex.org/W3004475955","https://openalex.org/W4386359866","https://openalex.org/W3202724302","https://openalex.org/W2914232380","https://openalex.org/W1983050041","https://openalex.org/W3133053596","https://openalex.org/W7215097157","https://openalex.org/W2918948206"],"abstract_inverted_index":{"Cancer":[0],"immunotherapy":[1,209],"with":[2,44,75,88,105,113,210],"immune":[3],"checkpoint":[4,61],"inhibitors":[5,62],"(ICIs)":[6,63],"has":[7,83],"become":[8],"a":[9,92,124,181],"\"game":[10],"changer\"":[11],"in":[12,73,123,193],"the":[13,154,202],"treatment":[14,87,112,169],"of":[15,94,127,158,174,183,208],"advanced":[16,40,107],"non-small":[17],"cell":[18,49],"lung":[19],"cancer":[20],"(NSCLC).":[21],"Its":[22],"most":[23],"clinically":[24],"important":[25],"advantage":[26],"over":[27],"traditional":[28],"chemotherapy":[29],"using":[30],"cytotoxic":[31],"agents":[32],"are":[33,64,190],"its":[34],"long-term":[35],"survival":[36,102,120],"benefits,":[37],"and":[38,180,200,205],"some":[39],"NSCLC":[41,70],"patients":[42,104],"treated":[43],"an":[45,89,114,136],"antibody":[46,90,116],"against":[47,91],"programmed":[48],"death":[50],"1":[51],"(PD-1)":[52],"have":[53],"survived":[54],"for":[55,68,103,148],"5":[56],"years":[57],"or":[58,77],"longer.":[59],"Immune":[60],"also":[65,177],"potentially":[66],"useful":[67],"earlier-stage":[69],"when":[71],"used":[72],"combination":[74],"surgery":[76],"radiotherapy.":[78],"A":[79],"recent":[80],"clinical":[81,195],"trial":[82],"shown":[84],"that":[85],"consolidation":[86],"ligand":[93],"PD-1":[95],"(PD-L1)":[96],"following":[97],"chemo-radiotherapy":[98],"significantly":[99],"improves":[100],"progression-free":[101],"locally":[106],"NSCLC.":[108],"However,":[109],"current":[110,203],"single-agent":[111],"anti-PD-1/PD-L1":[115],"may":[117,176],"provide":[118],"significant":[119],"benefits":[121],"only":[122],"small":[125],"subset":[126],"patients.":[128],"PD-L1":[129,163],"expression":[130,164],"status":[131,165,204],"on":[132,172],"tumor":[133],"cells":[134],"is":[135,145,166],"approved":[137],"biomarker":[138],"to":[139,142],"predict":[140],"response":[141],"ICIs,":[143],"but":[144],"not":[146],"enough":[147],"optimal":[149],"patient":[150],"selection.":[151],"To":[152],"improve":[153],"therapeutic":[155],"outcomes,":[156],"development":[157],"novel":[159],"biomarkers":[160],"other":[161],"than":[162],"essential.":[167],"Combination":[168],"strategies":[170],"based":[171],"blockade":[173],"PD-1/PD-L1":[175],"be":[178],"promising,":[179],"variety":[182],"combinations,":[184],"such":[185],"as":[186],"ICIs":[187],"plus":[188],"chemotherapy,":[189],"being":[191],"examined":[192],"ongoing":[194],"trials.":[196],"Here":[197],"we":[198],"review":[199],"discuss":[201],"future":[206],"perspectives":[207],"ICIs.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-29T00:00:00"}
