{"id":"https://openalex.org/W2809324486","doi":"https://doi.org/10.3390/genes9070316","title":"Gene Therapy for Recurrent Laryngeal Nerve Injury","display_name":"Gene Therapy for Recurrent Laryngeal Nerve Injury","publication_year":2018,"publication_date":"2018-06-25","ids":{"openalex":"https://openalex.org/W2809324486","doi":"https://doi.org/10.3390/genes9070316","mag":"2809324486","pmid":"https://pubmed.ncbi.nlm.nih.gov/29941853","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6071248"},"language":"en","primary_location":{"id":"doi:10.3390/genes9070316","doi":"https://doi.org/10.3390/genes9070316","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/genes9070316","pdf_url":"https://www.mdpi.com/2073-4425/9/7/316/pdf?version=1529935756","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4425/9/7/316/pdf?version=1529935756","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058867062","display_name":"Koji Araki","orcid":"https://orcid.org/0000-0001-6326-3244","observed_orcids":["https://orcid.org/0000-0001-6326-3244"]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Koji Araki","raw_affiliation_strings":["Department of Otolaryngology-Head & Neck Surgery, National Defense Medical College, Saitama 3598513, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6326-3244","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head & Neck Surgery, National Defense Medical College, Saitama 3598513, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101534519","display_name":"Hiroshi Suzuki","orcid":"https://orcid.org/0000-0003-1555-157X","observed_orcids":["https://orcid.org/0000-0003-1555-157X"]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Suzuki","raw_affiliation_strings":["Department of Otolaryngology-Head & Neck Surgery, National Defense Medical College, Saitama 3598513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head & Neck Surgery, National Defense Medical College, Saitama 3598513, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061102488","display_name":"Kosuke Uno","orcid":"https://orcid.org/0000-0002-4795-1407","observed_orcids":["https://orcid.org/0000-0002-4795-1407"]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kosuke Uno","raw_affiliation_strings":["Department of Otolaryngology-Head & Neck Surgery, National Defense Medical College, Saitama 3598513, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4795-1407","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head & Neck Surgery, National Defense Medical College, Saitama 3598513, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021031031","display_name":"Masayuki Tomifuji","orcid":"https://orcid.org/0000-0003-1256-0403","observed_orcids":["https://orcid.org/0000-0003-1256-0403"]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Tomifuji","raw_affiliation_strings":["Department of Otolaryngology-Head & Neck Surgery, National Defense Medical College, Saitama 3598513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head & Neck Surgery, National Defense Medical College, Saitama 3598513, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112818996","display_name":"Akihiro Shiotani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Shiotani","raw_affiliation_strings":["Department of Otolaryngology-Head & Neck Surgery, National Defense Medical College, Saitama 3598513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head & Neck Surgery, National Defense Medical College, Saitama 3598513, Japan","institution_ids":["https://openalex.org/I53888640"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058867062"],"corresponding_institution_ids":["https://openalex.org/I53888640"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.1732,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.10556995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"7","first_page":"316","last_page":"316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.7480000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.7480000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.08510000258684158,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.07440000027418137,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-laryngeal-nerve-injury","display_name":"recurrent laryngeal nerve injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.7350000143051147},{"id":"https://openalex.org/keywords/nerve-regeneration","display_name":"nerve regeneration","score":0.8220000267028809},{"id":"https://openalex.org/keywords/viral-vectors","display_name":"viral vectors","score":0.4659999907016754},{"id":"https://openalex.org/keywords/nonviral-gene-delivery","display_name":"non-viral gene delivery","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2776109941","wikidata":"https://www.wikidata.org/wiki/Q740541","display_name":"Recurrent laryngeal nerve","level":3,"score":0.7315542101860046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6387346982955933},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5982488989830017},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5671138167381287},{"id":"https://openalex.org/C2780866171","wikidata":"https://www.wikidata.org/wiki/Q1003805","display_name":"Nucleus ambiguus","level":4,"score":0.5511120557785034},{"id":"https://openalex.org/C112497637","wikidata":"https://www.wikidata.org/wiki/Q211669","display_name":"Swallowing","level":2,"score":0.5200088620185852},{"id":"https://openalex.org/C2775912687","wikidata":"https://www.wikidata.org/wiki/Q2422765","display_name":"Motor nerve","level":2,"score":0.4860101640224457},{"id":"https://openalex.org/C2775991916","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Nerve injury","level":2,"score":0.41826385259628296},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.41817012429237366},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.4169459342956543},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.37973594665527344},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.37754806876182556},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3240720331668854},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28217339515686035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23027881979942322},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19704189896583557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1789848804473877},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1772163212299347},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.0},{"id":"https://openalex.org/C2778110749","wikidata":"https://www.wikidata.org/wiki/Q189033","display_name":"Medulla oblongata","level":3,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/genes9070316","doi":"https://doi.org/10.3390/genes9070316","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/genes9070316","pdf_url":"https://www.mdpi.com/2073-4425/9/7/316/pdf?version=1529935756","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5032155","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6071248","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29941853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29941853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6071248","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6071248/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b3e497770b5d4aeca018fc4ecf885981","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b3e497770b5d4aeca018fc4ecf885981","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genes, Vol 9, Iss 7, p 316 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/genes9070316","doi":"https://doi.org/10.3390/genes9070316","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/genes9070316","pdf_url":"https://www.mdpi.com/2073-4425/9/7/316/pdf?version=1529935756","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3086745726","display_name":"Development of oncolytic sendai virus therapy for head and neck cancer for clinical application","funder_award_id":"17K11415","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4821767926","display_name":"The development of a novel minimally invasive strategy targeting sentinel lymph node for head and neck cancer.","funder_award_id":"26462627","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5037785967","display_name":"Development toward clinical application of functional preservation therapy for control of cervical lymph node metastasis in head and neck cancer.","funder_award_id":"18K09390","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G664195916","display_name":null,"funder_award_id":"KAKENHI No. 16K11252","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7974965222","display_name":null,"funder_award_id":"25462699 and 23592545","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8010154104","display_name":"New treatment strategy to prevent misdirection in recurrent laryngeal nerve regeneration.","funder_award_id":"16K11252","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8194414422","display_name":"The therapeutic efffect of Oncolytic recombinant Sendai Virus against refractory head and neck cancer.","funder_award_id":"26462626","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8279490518","display_name":"The development of new treatments for peripheral nerve misderected regeneration","funder_award_id":"25670723","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8589572369","display_name":null,"funder_award_id":"KAKENHI No. 16K11252, 26462627, 26462626, 25670723, 25462699 and 23592545","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2809324486.pdf","grobid_xml":"https://content.openalex.org/works/W2809324486.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W108899676","https://openalex.org/W119311588","https://openalex.org/W1527641279","https://openalex.org/W1553961669","https://openalex.org/W1572205809","https://openalex.org/W1903012420","https://openalex.org/W1935224629","https://openalex.org/W1966343604","https://openalex.org/W1967344018","https://openalex.org/W1968625045","https://openalex.org/W1971824270","https://openalex.org/W1974440942","https://openalex.org/W1977340797","https://openalex.org/W1977598303","https://openalex.org/W1978635493","https://openalex.org/W1987154673","https://openalex.org/W1989386072","https://openalex.org/W1994332869","https://openalex.org/W1996417846","https://openalex.org/W1998588332","https://openalex.org/W2001469906","https://openalex.org/W2001607183","https://openalex.org/W2001819832","https://openalex.org/W2002746060","https://openalex.org/W2003338528","https://openalex.org/W2008332694","https://openalex.org/W2023141180","https://openalex.org/W2034657507","https://openalex.org/W2038629005","https://openalex.org/W2049489808","https://openalex.org/W2060882276","https://openalex.org/W2061991700","https://openalex.org/W2073487126","https://openalex.org/W2080262436","https://openalex.org/W2083068373","https://openalex.org/W2096737304","https://openalex.org/W2110208429","https://openalex.org/W2126334442","https://openalex.org/W2126511939","https://openalex.org/W2158756657","https://openalex.org/W2323607732","https://openalex.org/W2324043536","https://openalex.org/W2325918358","https://openalex.org/W2339937547","https://openalex.org/W3091948719"],"related_works":["https://openalex.org/W2000256899","https://openalex.org/W2083068373","https://openalex.org/W2325918358","https://openalex.org/W2080262436","https://openalex.org/W1977598303","https://openalex.org/W3038108457","https://openalex.org/W2220673577","https://openalex.org/W4205720064","https://openalex.org/W2966860092","https://openalex.org/W4407202256"],"abstract_inverted_index":{"Recurrent":[0],"laryngeal":[1,63,109,151],"nerve":[2,61,102],"(RLN)":[3],"injury":[4,88],"has":[5,71,117,128],"considerable":[6],"clinical":[7],"implications,":[8],"including":[9],"voice":[10],"and":[11,65,98,104,108,125,176],"swallowing":[12],"dysfunction,":[13],"which":[14,144],"may":[15,148],"considerably":[16],"impair":[17],"the":[18,57,94,145],"patient\u2019s":[19],"quality":[20],"of":[21,24,39,91,101,122],"life.":[22],"Recovery":[23],"vocal":[25,66,136],"fold":[26,137],"movement":[27,138],"is":[28,46,140,157,162],"an":[29],"essential":[30],"novel":[31],"treatment":[32],"option":[33],"for":[34,42,52,120,134,172],"RLN":[35,53,87],"injury.":[36],"The":[37,49,82],"potential":[38],"gene":[40,54,168],"therapy":[41,55,113,169],"addressing":[43],"this":[44,174],"issue":[45,175],"highly":[47],"promising.":[48],"target":[50],"sites":[51],"are":[56,89,179],"central":[58],"nervous":[59],"system,":[60],"fibers,":[62],"muscles,":[64,152],"cord":[67],"mucosa.":[68],"Gene":[69,112],"transduction":[70],"been":[72,118,129],"reported":[73],"in":[74,93,143],"each":[75],"site":[76],"using":[77,114],"viral":[78],"or":[79],"non-viral":[80],"methods.":[81],"major":[83],"issues":[84],"ensuing":[85],"after":[86],"loss":[90],"motoneurons":[92],"nucleus":[95],"ambiguus,":[96],"degeneration":[97],"poor":[99],"regeneration":[100],"fibers":[103],"motor":[105,160],"end":[106],"plates,":[107],"muscle":[110],"atrophy.":[111],"neurotrophic":[115],"factors":[116],"assessed":[119],"most":[121],"these":[123],"issues,":[124],"its":[126],"efficacy":[127],"reported.":[130],"Another":[131],"important":[132],"matter":[133],"functional":[135],"recovery":[139],"misdirected":[141],"regeneration,":[142],"wrong":[146],"neurons":[147],"innervate":[149],"other":[150],"where":[153],"even":[154],"if":[155],"innervation":[156],"reestablished,":[158],"proper":[159],"function":[161],"not":[163],"restored.":[164],"Novel":[165],"strategies":[166],"involving":[167],"bear":[170],"promise":[171],"overcoming":[173],"further":[177],"investigations":[178],"underway.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-29T00:00:00"}
