{"id":"https://openalex.org/W2809268783","doi":"https://doi.org/10.1002/1873-3468.13171","title":"Protein kinase D displays intrinsic Tyr autophosphorylation activity: insights into mechanism and regulation","display_name":"Protein kinase D displays intrinsic Tyr autophosphorylation activity: insights into mechanism and regulation","publication_year":2018,"publication_date":"2018-06-22","ids":{"openalex":"https://openalex.org/W2809268783","doi":"https://doi.org/10.1002/1873-3468.13171","mag":"2809268783","pmid":"https://pubmed.ncbi.nlm.nih.gov/29933512","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6099456"},"language":"en","primary_location":{"id":"doi:10.1002/1873-3468.13171","doi":"https://doi.org/10.1002/1873-3468.13171","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1873-3468.13171","pdf_url":"https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.13171","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.13171","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007258571","display_name":"Mathias Cobbaut","orcid":"https://orcid.org/0000-0003-0279-0336","observed_orcids":["https://orcid.org/0000-0003-0279-0336"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Mathias Cobbaut","raw_affiliation_strings":["Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium","Leuven Cancer Institute (LKI), KU Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-0279-0336","affiliations":[{"raw_affiliation_string":"Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Leuven Cancer Institute (LKI), KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025303265","display_name":"Rita Derua","orcid":"https://orcid.org/0000-0002-1784-0677","observed_orcids":["https://orcid.org/0000-0002-1784-0677"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rita Derua","raw_affiliation_strings":["Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000996602","display_name":"Peter J. Parker","orcid":"https://orcid.org/0000-0002-6218-2933","observed_orcids":["https://orcid.org/0000-0002-6218-2933"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter J. Parker","raw_affiliation_strings":["Protein Phosphorylation Lab, The Francis Crick Institute, London, UK","School of Cancer and Pharmaceutical Sciences, King's College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Phosphorylation Lab, The Francis Crick Institute, London, UK","institution_ids":["https://openalex.org/I2801081054"]},{"raw_affiliation_string":"School of Cancer and Pharmaceutical Sciences, King's College London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062031834","display_name":"Etienne Waelkens","orcid":"https://orcid.org/0000-0001-5756-0605","observed_orcids":["https://orcid.org/0000-0001-5756-0605"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Etienne Waelkens","raw_affiliation_strings":["Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052092471","display_name":"Veerle Janssens","orcid":"https://orcid.org/0000-0002-6772-8448","observed_orcids":["https://orcid.org/0000-0002-6772-8448"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Veerle Janssens","raw_affiliation_strings":["Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium","Leuven Cancer Institute (LKI), KU Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-6772-8448","affiliations":[{"raw_affiliation_string":"Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Leuven Cancer Institute (LKI), KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073273206","display_name":"Johan Van Lint","orcid":"https://orcid.org/0000-0002-0275-571X","observed_orcids":["https://orcid.org/0000-0002-0275-571X"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Johan Van Lint","raw_affiliation_strings":["Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium","Leuven Cancer Institute (LKI), KU Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-0275-571X","affiliations":[{"raw_affiliation_string":"Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Leuven Cancer Institute (LKI), KU Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073273206"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":{"value":3980,"currency":"USD","value_usd":3980},"fwci":0.2341,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.46300669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"592","issue":"14","first_page":"2432","last_page":"2443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-d","display_name":"protein kinase D","score":0.9980000257492065},{"id":"https://openalex.org/keywords/activation-loop","display_name":"activation loop","score":0.6150000095367432},{"id":"https://openalex.org/keywords/catalytic-cysteine","display_name":"catalytic cysteine","score":0.6890000104904175},{"id":"https://openalex.org/keywords/pkd1","display_name":"PKD1","score":0.5860000252723694},{"id":"https://openalex.org/keywords/kinase-regulation","display_name":"kinase regulation","score":0.515999972820282},{"id":"https://openalex.org/keywords/inhibiting-factors","display_name":"inhibiting factors","score":0.6919999718666077},{"id":"https://openalex.org/keywords/multisite-phosphorylation","display_name":"multisite phosphorylation","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.9479520320892334},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7430207133293152},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5484323501586914},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5065935850143433},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4437016546726227},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43778735399246216},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4078388512134552},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32668519020080566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24369129538536072},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09387916326522827},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1002/1873-3468.13171","doi":"https://doi.org/10.1002/1873-3468.13171","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1873-3468.13171","pdf_url":"https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.13171","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5050411","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6099456","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6099456","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6099456","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Lett","raw_type":"Text"},{"id":"pmid:29933512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29933512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/415d09f1-9d4d-4a3e-ba0d-f662f9d583bb","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/415d09f1-9d4d-4a3e-ba0d-f662f9d583bb","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cobbaut, M, Derua, R, Parker, P J, Waelkens, E, Janssens, V & Van Lint, J 2018, 'Protein kinase D displays intrinsic Tyr autophosphorylation activity : insights into mechanism and regulation', FEBS Letters, vol. 592, no. 14, pp. 2432-2443. https://doi.org/10.1002/1873-3468.13171","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/625565","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/625565","pdf_url":"https://lirias.kuleuven.be/retrieve/2709a223-36ef-4cf9-9758-0a4906ec50f7","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Febs Letters, vol. 592 (14), (2432-2443)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:figshare.com:article/12619253","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Protein_kinase_D_displays_intrinsic_Tyr_autophosphorylation_activity_insights_into_mechanism_and_regulation/12619253","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/1873-3468.13171","doi":"https://doi.org/10.1002/1873-3468.13171","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1873-3468.13171","pdf_url":"https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1873-3468.13171","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1295066907","display_name":null,"funder_award_id":"259770","funder_id":"https://openalex.org/F4320338377","funder_display_name":"FP7 Health"},{"id":"https://openalex.org/G1674919717","display_name":null,"funder_award_id":"FC001130","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G1734864329","display_name":null,"funder_award_id":"15683","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3724108107","display_name":null,"funder_award_id":"FC001130","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G5176842869","display_name":null,"funder_award_id":"FC001130","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5428613875","display_name":null,"funder_award_id":"G.0816.11","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5538095322","display_name":null,"funder_award_id":"FWO G.0816.11","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G7101917450","display_name":null,"funder_award_id":"111101","funder_id":"https://openalex.org/F4320321732","funder_display_name":"Agentschap voor Innovatie door Wetenschap en Technologie"},{"id":"https://openalex.org/G7327640966","display_name":null,"funder_award_id":"FC001130","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"},{"id":"https://openalex.org/G8182769102","display_name":null,"funder_award_id":"10130","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312060","display_name":"Francis Crick Institute","ror":"https://ror.org/04tnbqb63"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320321732","display_name":"Agentschap voor Innovatie door Wetenschap en Technologie","ror":"https://ror.org/01antkr91"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320338377","display_name":"FP7 Health","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2809268783.pdf","grobid_xml":"https://content.openalex.org/works/W2809268783.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1494495256","https://openalex.org/W1972492345","https://openalex.org/W1974672059","https://openalex.org/W1982728028","https://openalex.org/W2000271974","https://openalex.org/W2003049417","https://openalex.org/W2003381961","https://openalex.org/W2004717166","https://openalex.org/W2006986579","https://openalex.org/W2016729411","https://openalex.org/W2017289994","https://openalex.org/W2019075830","https://openalex.org/W2021526208","https://openalex.org/W2028415754","https://openalex.org/W2030205108","https://openalex.org/W2031757749","https://openalex.org/W2045053669","https://openalex.org/W2045187262","https://openalex.org/W2046795066","https://openalex.org/W2047530218","https://openalex.org/W2051928958","https://openalex.org/W2060797544","https://openalex.org/W2064725210","https://openalex.org/W2065289702","https://openalex.org/W2065685023","https://openalex.org/W2065823396","https://openalex.org/W2070896368","https://openalex.org/W2071184880","https://openalex.org/W2072784374","https://openalex.org/W2076730997","https://openalex.org/W2079867322","https://openalex.org/W2083021738","https://openalex.org/W2093390493","https://openalex.org/W2100894616","https://openalex.org/W2105090849","https://openalex.org/W2105388112","https://openalex.org/W2116992704","https://openalex.org/W2118460316","https://openalex.org/W2133883957","https://openalex.org/W2144888494","https://openalex.org/W2147563065","https://openalex.org/W2157058776","https://openalex.org/W2515862768","https://openalex.org/W2522277158","https://openalex.org/W2563178391","https://openalex.org/W2604733154"],"related_works":["https://openalex.org/W4319302777","https://openalex.org/W2070896368","https://openalex.org/W2017289994","https://openalex.org/W2333056020","https://openalex.org/W2069761907","https://openalex.org/W2083927760","https://openalex.org/W2009240129","https://openalex.org/W2045187262","https://openalex.org/W2168483798","https://openalex.org/W2038809002"],"abstract_inverted_index":{"The":[0],"protein":[1],"kinase":[2],"D":[3],"(PKD)":[4],"family":[5],"is":[6,97],"regulated":[7],"through":[8,99],"multi-site":[9],"phosphorylation,":[10],"including":[11],"autophosphorylation.":[12],"For":[13],"example,":[14],"PKD":[15,46,94,113],"displays":[16,48],"in":[17,24,26,32,49,57,82,84],"vivo":[18],"autophosphorylation":[19,96],"on":[20],"Ser-742":[21],"(and":[22],"Ser-738":[23],"vitro)":[25],"the":[27,33,42,58,64,69,85,100],"activation":[28,65],"loop":[29,62,87],"and":[30,76],"Ser-910":[31],"C-tail":[34],"(hPKD1":[35],"numbering).":[36],"In":[37,92],"this":[38,73],"paper,":[39],"we":[40],"describe":[41],"surprising":[43],"observation":[44],"that":[45],"also":[47],"vitro":[50],"autocatalytic":[51],"activity":[52,75],"towards":[53],"a":[54,78],"Tyr":[55,95],"residue":[56,80],"P":[59],"+":[60],"1":[61],"of":[63,89,102],"segment.":[66],"We":[67],"define":[68],"molecular":[70],"determinants":[71],"for":[72],"unusual":[74],"identify":[77],"Cys":[79],"(C705":[81],"PKD1)":[83],"catalytic":[86],"as":[88],"utmost":[90],"importance.":[91],"cells,":[93],"suppressed":[98],"association":[101],"an":[103],"inhibitory":[104],"factor.":[105],"Our":[106],"findings":[107],"provide":[108],"important":[109],"novel":[110],"insights":[111],"into":[112],"(auto)regulation.":[114]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-06-29T00:00:00"}
