{"id":"https://openalex.org/W2809268384","doi":"https://doi.org/10.1515/znc-2017-0172","title":"Cyanidin-3-rutinoside protects INS-1 pancreatic \u03b2 cells against high glucose-induced glucotoxicity by apoptosis","display_name":"Cyanidin-3-rutinoside protects INS-1 pancreatic \u03b2 cells against high glucose-induced glucotoxicity by apoptosis","publication_year":2018,"publication_date":"2018-06-20","ids":{"openalex":"https://openalex.org/W2809268384","doi":"https://doi.org/10.1515/znc-2017-0172","mag":"2809268384","pmid":"https://pubmed.ncbi.nlm.nih.gov/29924740"},"language":"en","primary_location":{"id":"doi:10.1515/znc-2017-0172","doi":"https://doi.org/10.1515/znc-2017-0172","is_oa":false,"landing_page_url":"https://doi.org/10.1515/znc-2017-0172","pdf_url":null,"source":{"id":"https://openalex.org/S67401564","display_name":"Zeitschrift f\u00fcr Naturforschung C","issn_l":"0341-0471","issn":["0341-0471","0939-5075","1865-7125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Naturforschung C","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020818535","display_name":"Kung-Ha Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123920","display_name":"Silla University","ror":"https://ror.org/02w3gk008","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210123920"]},{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kung-Ha Choi","raw_affiliation_strings":["Department of Food Science and Nutrition , Pusan National University , Busan 46241 , Republic of Korea","Department of Food and Nutrition , College of Medical and Life Science , Silla University , Busan 46958 , Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition , Pusan National University , Busan 46241 , Republic of Korea","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"Department of Food and Nutrition , College of Medical and Life Science , Silla University , Busan 46958 , Republic of Korea","institution_ids":["https://openalex.org/I4210123920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068964888","display_name":"Mi Hwa Park","orcid":"https://orcid.org/0000-0002-3123-2870","observed_orcids":["https://orcid.org/0000-0002-3123-2870"]},"institutions":[{"id":"https://openalex.org/I4210123920","display_name":"Silla University","ror":"https://ror.org/02w3gk008","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210123920"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mi Hwa Park","raw_affiliation_strings":["Department of Food and Nutrition , College of Medical and Life Science , Silla University , Busan 46958 , Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition , College of Medical and Life Science , Silla University , Busan 46958 , Republic of Korea","institution_ids":["https://openalex.org/I4210123920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054306682","display_name":"Hyun Ah Lee","orcid":"https://orcid.org/0000-0002-3352-1908","observed_orcids":["https://orcid.org/0000-0002-3352-1908"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Ah Lee","raw_affiliation_strings":["Department of Food Science and Nutrition , Pusan National University , Busan 46241 , Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition , Pusan National University , Busan 46241 , Republic of Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030512706","display_name":"Ji-Sook Han","orcid":"https://orcid.org/0000-0002-6282-6815","observed_orcids":["https://orcid.org/0000-0002-6282-6815"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Ji-Sook Han","raw_affiliation_strings":["Department of Food Science and Nutrition , Pusan National University , Busan 609-735 , Republic of South Korea , Phone: +82-51-510-2836, Fax: +82-51-583-3648"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition , Pusan National University , Busan 609-735 , Republic of South Korea , Phone: +82-51-510-2836, Fax: +82-51-583-3648","institution_ids":["https://openalex.org/I4921948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030512706"],"corresponding_institution_ids":["https://openalex.org/I4921948"],"apc_list":{"value":2400,"currency":"EUR","value_usd":2712},"apc_paid":null,"fwci":0.909,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.73444606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"73","issue":"7-8","first_page":"281","last_page":"289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.6596999764442444,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.6596999764442444,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.3310999870300293,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyanidin-3-o-rutinoside","display_name":"cyanidin-3-rutinoside","score":1.0},{"id":"https://openalex.org/keywords/anthocyanins","display_name":"anthocyanins","score":0.8690000176429749},{"id":"https://openalex.org/keywords/glucotoxicity","display_name":"glucotoxicity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.6589999794960022},{"id":"https://openalex.org/keywords/ins-1-cells","display_name":"INS-1 cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8059999942779541},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9100000262260437},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8980000019073486},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.9330000281333923},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6960924863815308},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47194045782089233},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4509356915950775},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3929206430912018},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37337613105773926},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3367801606655121},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23958852887153625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22443968057632446},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22062569856643677}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000872","descriptor_name":"Anthocyanins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1515/znc-2017-0172","doi":"https://doi.org/10.1515/znc-2017-0172","is_oa":false,"landing_page_url":"https://doi.org/10.1515/znc-2017-0172","pdf_url":null,"source":{"id":"https://openalex.org/S67401564","display_name":"Zeitschrift f\u00fcr Naturforschung C","issn_l":"0341-0471","issn":["0341-0471","0939-5075","1865-7125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Naturforschung C","raw_type":"journal-article"},{"id":"pmid:29924740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29924740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W191793640","https://openalex.org/W1865758164","https://openalex.org/W1965891907","https://openalex.org/W1975980695","https://openalex.org/W1977371315","https://openalex.org/W1980859020","https://openalex.org/W2006728188","https://openalex.org/W2017645793","https://openalex.org/W2022803736","https://openalex.org/W2042566241","https://openalex.org/W2055267258","https://openalex.org/W2074800090","https://openalex.org/W2076518384","https://openalex.org/W2077067297","https://openalex.org/W2088866343","https://openalex.org/W2092346917","https://openalex.org/W2101861123","https://openalex.org/W2104622496","https://openalex.org/W2113544353","https://openalex.org/W2133451731","https://openalex.org/W2152656461","https://openalex.org/W2165265330","https://openalex.org/W2172084084","https://openalex.org/W2187683320","https://openalex.org/W3086807137"],"related_works":["https://openalex.org/W2037154802","https://openalex.org/W3166250798","https://openalex.org/W2024592447","https://openalex.org/W7162086940","https://openalex.org/W4386057054","https://openalex.org/W4200053833","https://openalex.org/W2138822452","https://openalex.org/W4400040068","https://openalex.org/W1532285634","https://openalex.org/W7126174480"],"abstract_inverted_index":{"Exposure":[0],"to":[1,10,29,72],"high":[2,157],"levels":[3],"of":[4,25,33,38,109,116,133],"glucose":[5],"may":[6,163],"cause":[7],"glucotoxicity,":[8],"leading":[9],"pancreatic":[11,45,54],"\u03b2":[12,46,55,169],"cell":[13,16,56,142,170],"dysfunction,":[14],"including":[15],"apoptosis":[17,42,61],"and":[18,60,90,126,129],"impaired":[19],"glucose-stimulated":[20],"insulin":[21],"secretion.":[22],"The":[23],"aim":[24],"this":[26],"study":[27],"was":[28,144],"explore":[30],"the":[31,107,114,131,134],"effect":[32],"cyanidin-3-rutinoside":[34],"(C3R),":[35],"a":[36,101],"derivative":[37],"anthocyanin,":[39],"on":[40],"glucotoxicity-induced":[41],"in":[43,64,75,100,138,172],"INS-1":[44,53],"cells.":[47,79,140],"Glucose":[48],"(30":[49],"mM)":[50],"treatment":[51,97],"induced":[52],"death,":[57],"but":[58],"glucotoxicity":[59],"significantly":[62,155],"decreased":[63],"cells":[65],"treated":[66],"with":[67],"50":[68],"\u03bcM":[69],"C3R":[70,96,104,154,162],"compared":[71],"that":[73,153],"observed":[74],"30":[76],"mM":[77],"glucose-treated":[78],"Furthermore,":[80],"hyperglycemia":[81],"increased":[82,106,130],"intracellular":[83],"reactive":[84],"oxygen":[85],"species":[86],"(ROS),":[87],"lipid":[88],"peroxidation,":[89],"nitric":[91],"oxide":[92],"(NO)":[93],"levels,":[94],"while":[95],"reduced":[98,113,156],"these":[99],"dose-dependent":[102],"manner.":[103],"also":[105],"activity":[108],"antioxidant":[110],"enzymes,":[111],"markedly":[112],"expression":[115,132],"pro-apoptotic":[117],"proteins":[118],"(such":[119],"as":[120],"Bax,":[121],"cytochrome":[122],"c,":[123],"caspase":[124,127],"9":[125],"3),":[128],"anti-apoptotic":[135],"protein,":[136],"Bcl-2,":[137],"hyperglycemia-exposed":[139],"Finally,":[141],"death":[143],"examined":[145],"using":[146],"annexin":[147],"V/propidium":[148],"iodide":[149],"staining,":[150],"which":[151],"revealed":[152],"glucose-induced":[158],"apoptosis.":[159],"In":[160],"conclusion,":[161],"have":[164],"therapeutic":[165],"effects":[166],"against":[167],"hyperglycemia-induced":[168],"damage":[171],"diabetes.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-29T00:00:00"}