{"id":"https://openalex.org/W2809255568","doi":"https://doi.org/10.7939/r3r101","title":"Chromatin regulation by histone chaperone Asf1","display_name":"Chromatin regulation by histone chaperone Asf1","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2809255568","doi":"https://doi.org/10.7939/r3r101","mag":"2809255568"},"language":"en","primary_location":{"id":"doi:10.7939/r3r101","doi":"https://doi.org/10.7939/r3r101","is_oa":true,"landing_page_url":"https://doi.org/10.7939/r3r101","pdf_url":null,"source":{"id":"https://openalex.org/S7407053046","display_name":"ERA: Education and Research Archive (University of Alberta)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154425047","host_organization_name":"University of Alberta","host_organization_lineage":["https://openalex.org/I154425047"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.7939/r3r101","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020539167","display_name":"Laura V. Minard","orcid":"https://orcid.org/0000-0002-1545-3470","observed_orcids":["https://orcid.org/0000-0002-1545-3470"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Minard, Laura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5020539167"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asf1","display_name":"Asf1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/histone-chaperone","display_name":"histone chaperone","score":0.9409999847412109},{"id":"https://openalex.org/keywords/chromatin-regulation","display_name":"chromatin regulation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/h3k36-trimethylation","display_name":"H3K36 trimethylation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/set2","display_name":"Set2","score":0.9179999828338623},{"id":"https://openalex.org/keywords/h3k56-acetylation","display_name":"H3K56 acetylation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/rtt109","display_name":"Rtt109","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9020000100135803},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.8579999804496765},{"id":"https://openalex.org/keywords/transcriptional-derepression","display_name":"transcriptional derepression","score":0.9330000281333923},{"id":"https://openalex.org/keywords/snf2","display_name":"SnF2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.871999979019165},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.646392822265625},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.6070734262466431},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5958490371704102},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.495767205953598},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3689382076263428},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3480268716812134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3406244218349457},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32346609234809875},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.20972579717636108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12976643443107605},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.7939/r3r101","doi":"https://doi.org/10.7939/r3r101","is_oa":true,"landing_page_url":"https://doi.org/10.7939/r3r101","pdf_url":null,"source":{"id":"https://openalex.org/S7407053046","display_name":"ERA: Education and Research Archive (University of Alberta)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154425047","host_organization_name":"University of Alberta","host_organization_lineage":["https://openalex.org/I154425047"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2809255568","doi":null,"is_oa":false,"landing_page_url":"https://era.library.ualberta.ca/items/75d47d8e-3456-4882-956f-583fd30bf771/view/1c064ea0-9e8d-4b5c-a05f-6d79ea91b0d8/Minard_Laura_Fall-202010.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.7939/r3r101","doi":"https://doi.org/10.7939/r3r101","is_oa":true,"landing_page_url":"https://doi.org/10.7939/r3r101","pdf_url":null,"source":{"id":"https://openalex.org/S7407053046","display_name":"ERA: Education and Research Archive (University of Alberta)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154425047","host_organization_name":"University of Alberta","host_organization_lineage":["https://openalex.org/I154425047"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2088924735","https://openalex.org/W2168346118","https://openalex.org/W2048393084","https://openalex.org/W4309436592","https://openalex.org/W2325261083","https://openalex.org/W2023932824","https://openalex.org/W7096943708","https://openalex.org/W2048908822","https://openalex.org/W2070321379","https://openalex.org/W2080617078"],"abstract_inverted_index":{"Asf1":[0,24,67,82,112,127,143,253,266,303],"is":[1,97,132,144,168,176,297],"a":[2,17,60,70,98],"conserved":[3],"H3/H4":[4],"histone":[5,61],"chaperone":[6],"with":[7,114,233,267,299],"multiple":[8],"functions":[9,250],"in":[10,69,101,162,294,312],"chromatin":[11,48,115,288,316],"modulation.":[12],"Using":[13],"budding":[14],"yeast":[15],"as":[16],"model,":[18,226],"we":[19,37,78,121,247,270],"identify":[20,248,271],"new":[21,249,272],"pathways":[22,314],"of":[23,34,86,126,142,152,166,200,214,230,265,285,315],"function,":[25],"and":[26,44,56,64,94,175,195,255,262,275,280],"expand":[27],"current":[28],"knowledge":[29],"regarding":[30],"the":[31,102,140,155,163,196,227,260,282,286,291,300],"known":[32,228,252],"roles":[33],"Asf1.":[35],"First,":[36],"uncover":[38],"novel":[39],"genetic":[40],"interactions":[41],"between":[42,54,278],"ASF1":[43,55,279],"genes":[45,92,221],"encoding":[46],"other":[47],"regulators.":[49],"We":[50,209],"describe":[51],"an":[52],"interaction":[53],"SET2,":[57],"which":[58,96],"encodes":[59],"lysine":[62,157],"methyltransferase,":[63],"show":[65],"that":[66,81,123,211,239,302],"exists":[68],"pathway":[71],"to":[72,105,128,149,310],"promote":[73],"Set2-catalyzed":[74],"H3K36":[75],"trimethylation.":[76],"Second,":[77],"present":[79,169],"evidence":[80],"promotes":[83,304],"transcriptional":[84,137,231],"derepression":[85],"two":[87],"DNA":[88,109],"damage":[89],"response":[90,104],"(DDR)":[91],"(RNR3":[93],"HUG1),":[95],"hallmark":[99],"event":[100],"cellular":[103],"replication":[106,119],"stress":[107],"or":[108],"damage.":[110],"While":[111],"association":[113,229,264],"increases":[116],"globally":[117],"during":[118],"stress,":[120],"find":[122],"direct":[124],"binding":[125],"DDR":[129,184,220,234],"gene":[130,185,235],"promoters":[131,186,236],"not":[133,205],"needed":[134],"for":[135,222,251,259],"their":[136],"derepression.":[138,208,223],"Rather,":[139],"contribution":[141],"dependent":[145],"on":[146,170],"its":[147,308],"ability":[148,309],"stimulate":[150],"acetylation":[151,203],"H3K56":[153,201],"by":[154,189],"Rtt109":[156],"acetyltransferase.":[158],"This":[159],"modification":[160],"occurs":[161],"globular":[164],"domain":[165],"H3,":[167],"all":[171],"newly":[172,218],"synthesized":[173,219],"histones":[174],"lost":[177],"after":[178],"H3":[179,216],"incorporation":[180],"into":[181],"chromatin.":[182,268],"Importantly,":[183],"are":[187],"occupied":[188],"H3K56-acetylated":[190],"nucleosomes":[191],"under":[192,243],"repressing":[193],"conditions,":[194],"steady":[197],"state":[198],"level":[199],"promoter":[202],"does":[204],"change":[206],"upon":[207],"propose":[210],"replication-coupled":[212],"deposition":[213],"K56-acetylated":[215],"poises":[217],"In":[224],"this":[225,295],"repressors":[232],"would":[237],"ensure":[238],"transcription":[240],"remains":[241],"minimal":[242],"normal":[244],"conditions.":[245],"Thirdly,":[246],"motifs":[254],"characterize":[256],"key":[257],"determinants":[258],"constitutive":[261],"inducible":[263],"Finally,":[269],"genetic,":[273],"physical,":[274],"functional":[276],"links":[277],"SNF2,":[281],"catalytic":[283],"subunit":[284],"SWI/SNF":[287],"remodeller.":[289],"Altogether,":[290],"research":[292],"described":[293],"report":[296],"consistent":[298],"idea":[301],"genome":[305],"stability":[306],"through":[307],"function":[311],"diverse":[313],"regulation.":[317]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2018-06-29T00:00:00"}
