{"id":"https://openalex.org/W2809106943","doi":"https://doi.org/10.1093/ibd/izy201","title":"The Mesentery, Systemic Inflammation, and Crohn\u2019s Disease","display_name":"The Mesentery, Systemic Inflammation, and Crohn\u2019s Disease","publication_year":2018,"publication_date":"2018-06-06","ids":{"openalex":"https://openalex.org/W2809106943","doi":"https://doi.org/10.1093/ibd/izy201","mag":"2809106943","pmid":"https://pubmed.ncbi.nlm.nih.gov/29920595"},"language":"en","primary_location":{"id":"doi:10.1093/ibd/izy201","doi":"https://doi.org/10.1093/ibd/izy201","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ibd/izy201","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108622660","display_name":"Edgardo D. Rivera Rivera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edgardo D Rivera","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, University of Miami Miller School of Medicine, Mailman Center for Child Development, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, University of Miami Miller School of Medicine, Mailman Center for Child Development, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048691800","display_name":"John Calvin Coffey","orcid":"https://orcid.org/0000-0003-0007-8206","observed_orcids":["https://orcid.org/0000-0003-0007-8206"]},"institutions":[{"id":"https://openalex.org/I230495080","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72","country_code":"IE","type":"education","lineage":["https://openalex.org/I230495080"]},{"id":"https://openalex.org/I2802992464","display_name":"University Hospital Limerick","ror":"https://ror.org/04y3ze847","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2800263200","https://openalex.org/I2802992464","https://openalex.org/I37076085","https://openalex.org/I4210136517"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"John Calvin Coffey","raw_affiliation_strings":["Department of Surgery, University Hospital Limerick Group, Limerick, Ireland","FRCSI Surgery, Graduate Entry Medical School, University of Limerick, Limerick, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University Hospital Limerick Group, Limerick, Ireland","institution_ids":["https://openalex.org/I2802992464"]},{"raw_affiliation_string":"FRCSI Surgery, Graduate Entry Medical School, University of Limerick, Limerick, Ireland","institution_ids":["https://openalex.org/I230495080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013518847","display_name":"Dara Walsh","orcid":"https://orcid.org/0000-0002-4962-9809","observed_orcids":["https://orcid.org/0000-0002-4962-9809"]},"institutions":[{"id":"https://openalex.org/I2802992464","display_name":"University Hospital Limerick","ror":"https://ror.org/04y3ze847","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2800263200","https://openalex.org/I2802992464","https://openalex.org/I37076085","https://openalex.org/I4210136517"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Dara Walsh","raw_affiliation_strings":["Department of Surgery, University Hospital Limerick Group, Limerick, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University Hospital Limerick Group, Limerick, Ireland","institution_ids":["https://openalex.org/I2802992464"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069136704","display_name":"Eli D. Ehrenpreis","orcid":"https://orcid.org/0000-0002-7209-729X","observed_orcids":["https://orcid.org/0000-0002-7209-729X"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I189273616","display_name":"Rosalind Franklin University of Medicine and Science","ror":"https://ror.org/04fegvg32","country_code":"US","type":"education","lineage":["https://openalex.org/I189273616"]},{"id":"https://openalex.org/I2801579017","display_name":"Advocate Lutheran General Hospital","ror":"https://ror.org/04c8vnp90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801579017","https://openalex.org/I4210088488"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eli D Ehrenpreis","raw_affiliation_strings":["Advocate Lutheran General Hospital, Park Ridge, Illinois","Division of Gastroenterology, Hepatology and Nutrition, University of Miami Miller School of Medicine, Miami, Florida","Rosalind Franklin University Medical School, North Chicago, Illinois"],"raw_orcid":"https://orcid.org/0000-0002-7209-729X","affiliations":[{"raw_affiliation_string":"Advocate Lutheran General Hospital, Park Ridge, Illinois","institution_ids":["https://openalex.org/I2801579017"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, University of Miami Miller School of Medicine, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Rosalind Franklin University Medical School, North Chicago, Illinois","institution_ids":["https://openalex.org/I189273616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5069136704"],"corresponding_institution_ids":["https://openalex.org/I145608581","https://openalex.org/I189273616","https://openalex.org/I2801579017"],"apc_list":{"value":3862,"currency":"USD","value_usd":3862},"apc_paid":null,"fwci":1.3764,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.79549967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"25","issue":"2","first_page":"226","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13962","display_name":"Omental and Epiploic Conditions","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12089","display_name":"Intestinal and Peritoneal Adhesions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesentery","display_name":"mesentery","score":0.984000027179718},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C2778948390","wikidata":"https://www.wikidata.org/wiki/Q1135563","display_name":"Mesentery","level":2,"score":0.9387991428375244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6939136981964111},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6918514370918274},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.6762524843215942},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4990863800048828},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.42353394627571106},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33877813816070557},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32566922903060913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24418076872825623}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008643","descriptor_name":"Mesentery","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ibd/izy201","doi":"https://doi.org/10.1093/ibd/izy201","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ibd/izy201","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},{"id":"pmid:29920595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29920595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory bowel diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W71681599","https://openalex.org/W165065086","https://openalex.org/W1487373628","https://openalex.org/W1488560084","https://openalex.org/W1540575638","https://openalex.org/W1546880496","https://openalex.org/W1567541371","https://openalex.org/W1590709474","https://openalex.org/W1965727945","https://openalex.org/W1974410448","https://openalex.org/W1975290789","https://openalex.org/W1976248362","https://openalex.org/W1982252191","https://openalex.org/W1985807442","https://openalex.org/W1987539592","https://openalex.org/W1989235512","https://openalex.org/W1992292929","https://openalex.org/W2007146069","https://openalex.org/W2010352517","https://openalex.org/W2011597057","https://openalex.org/W2019083097","https://openalex.org/W2028800747","https://openalex.org/W2028898179","https://openalex.org/W2035955102","https://openalex.org/W2037836033","https://openalex.org/W2046591942","https://openalex.org/W2054088318","https://openalex.org/W2059067946","https://openalex.org/W2063661991","https://openalex.org/W2067400526","https://openalex.org/W2069782315","https://openalex.org/W2071748269","https://openalex.org/W2073744836","https://openalex.org/W2077086033","https://openalex.org/W2080814925","https://openalex.org/W2083299222","https://openalex.org/W2084961602","https://openalex.org/W2097270587","https://openalex.org/W2098201180","https://openalex.org/W2105954474","https://openalex.org/W2110871895","https://openalex.org/W2115613435","https://openalex.org/W2118547872","https://openalex.org/W2129342823","https://openalex.org/W2133741311","https://openalex.org/W2137168534","https://openalex.org/W2149740262","https://openalex.org/W2152024122","https://openalex.org/W2166626624","https://openalex.org/W2170322795","https://openalex.org/W2272547414","https://openalex.org/W2325177149","https://openalex.org/W2343116742","https://openalex.org/W2345409695","https://openalex.org/W2364755651","https://openalex.org/W2398265845","https://openalex.org/W2419428049","https://openalex.org/W2461901323","https://openalex.org/W2525538814","https://openalex.org/W2530453317","https://openalex.org/W2531692255","https://openalex.org/W2543275214","https://openalex.org/W2554647500","https://openalex.org/W2567143702","https://openalex.org/W2588043933","https://openalex.org/W2611387458","https://openalex.org/W2613397238","https://openalex.org/W2783973560","https://openalex.org/W2792766573","https://openalex.org/W2888121871","https://openalex.org/W2909239369","https://openalex.org/W2909462212","https://openalex.org/W2911193155","https://openalex.org/W4245489245"],"related_works":["https://openalex.org/W2593229575","https://openalex.org/W7024450939","https://openalex.org/W3197199512","https://openalex.org/W3021796280","https://openalex.org/W2343116742","https://openalex.org/W4224129972","https://openalex.org/W4410032184","https://openalex.org/W2364755651","https://openalex.org/W3198571726","https://openalex.org/W7076375514"],"abstract_inverted_index":{"Initially":[0],"thought":[1],"to":[2,10],"be":[3,132],"a":[4],"structure":[5],"that":[6,158,167],"only":[7],"provided":[8],"support":[9],"the":[11,14,22,30,41,60,63,75,81,88,98,101,104,125,144,170],"abdominal":[12],"contents,":[13],"mesentery":[15,31,82,102,126],"has":[16,36],"now":[17],"gained":[18],"special":[19],"attention":[20],"in":[21,40,53,62,87,117,127],"scientific":[23],"community.":[24],"The":[25,122],"new":[26],"approach":[27],"of":[28,43,65,74,90,100,124,139,143],"studying":[29],"as":[32,83],"an":[33,84,137],"individual":[34],"organ":[35],"highlighted":[37],"its":[38,50],"importance":[39,99],"development":[42],"local":[44],"and":[45,49,68,106,134,175],"systemic":[46,128],"inflammatory":[47,129,141],"diseases":[48],"potential":[51,171],"role":[52],"Crohn's":[54,91,120,156],"disease.":[55,92,121],"Its":[56],"topographical":[57],"relationship":[58],"with":[59,119],"intestine":[61],"setting":[64],"active":[66],"inflammation":[67,116],"\"creeping":[69],"fat\"":[70],"is":[71],"possibly":[72],"one":[73],"most":[76],"important":[77,85],"arguments":[78],"for":[79,151,155,172],"including":[80],"factor":[86],"pathogenesis":[89],"In":[93],"this":[94],"review,":[95],"we":[96,135,147],"discuss":[97,148],"from":[103],"anatomical":[105],"embryological":[107],"standpoints.":[108],"We":[109],"also":[110],"will":[111,131],"summarize":[112],"data":[113,165],"on":[114],"mesenteric":[115,160],"patients":[118,152],"significance":[123],"syndromes":[130],"discussed,":[133],"provide":[136],"overview":[138],"primary":[140],"disorders":[142],"mesentery.":[145],"Finally,":[146],"surgical":[149],"approaches":[150],"requiring":[153],"resection":[154],"disease":[157,177],"incorporate":[159],"factors,":[161],"pointing":[162],"out":[163],"recent":[164],"suggesting":[166],"these":[168],"have":[169],"improving":[173],"outcomes":[174],"reducing":[176],"recurrence.":[178],"10.1093/ibd/izy201_video1izy201.video15794169491001.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-29T00:00:00"}