{"id":"https://openalex.org/W2809052744","doi":"https://doi.org/10.11575/prism/31941","title":"Concurrent Assessment of Knee Cartilage Morphology and Bone Microarchitecture using Contrast-Enhanced HR-pQCT Imaging","display_name":"Concurrent Assessment of Knee Cartilage Morphology and Bone Microarchitecture using Contrast-Enhanced HR-pQCT Imaging","publication_year":2018,"publication_date":"2018-05-22","ids":{"openalex":"https://openalex.org/W2809052744","doi":"https://doi.org/10.11575/prism/31941","mag":"2809052744"},"language":"en","primary_location":{"id":"pmh:oai:prism.ucalgary.ca:1880/106674","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1880/106674","pdf_url":"http://hdl.handle.net/1880/106674","source":{"id":"https://openalex.org/S4306402261","display_name":"Libraries and Cultural Resources (University of Calgary)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168635309","host_organization_name":"University of Calgary","host_organization_lineage":["https://openalex.org/I168635309"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1880/106674","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057119949","display_name":"Geoffrey J. Michalak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michalak, Geoffrey Jan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057119949"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.42500001192092896,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.42500001192092896,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.3158999979496002,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.09700000286102295,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/knee-cartilage","display_name":"knee cartilage","score":0.8009999990463257},{"id":"https://openalex.org/keywords/articular-cartilage-thickness","display_name":"articular cartilage thickness","score":0.7889999747276306},{"id":"https://openalex.org/keywords/bone-microarchitecture","display_name":"bone microarchitecture","score":0.8820000290870667},{"id":"https://openalex.org/keywords/high-resolution-peripheral-quantitative-computed-tomography","display_name":"high-resolution peripheral quantitative computed tomography","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cortical-bone-mineral-density","display_name":"cortical bone mineral density","score":0.8999999761581421},{"id":"https://openalex.org/keywords/trabecular-bone-mineral-density","display_name":"trabecular bone mineral density","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cadaveric-knee","display_name":"cadaveric knee","score":0.7089999914169312},{"id":"https://openalex.org/keywords/mri-validation","display_name":"MRI validation","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C107598950","wikidata":"https://www.wikidata.org/wiki/Q259864","display_name":"Microarchitecture","level":2,"score":0.5631961226463318},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5565758943557739},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.5186313986778259},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48194336891174316},{"id":"https://openalex.org/C3018143345","wikidata":"https://www.wikidata.org/wiki/Q37425","display_name":"Knee cartilage","level":5,"score":0.4296915531158447},{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.4112355709075928},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3814891278743744},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3772847652435303},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.2836189866065979},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.2574078440666199},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23931410908699036},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23530274629592896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11026817560195923},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.05368807911872864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:prism.ucalgary.ca:1880/106674","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1880/106674","pdf_url":"http://hdl.handle.net/1880/106674","source":{"id":"https://openalex.org/S4306402261","display_name":"Libraries and Cultural Resources (University of Calgary)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168635309","host_organization_name":"University of Calgary","host_organization_lineage":["https://openalex.org/I168635309"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"master thesis"},{"id":"pmh:oai:ucalgary.scholaris.ca:1880/106674","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1880/106674","pdf_url":"https://ucalgary.scholaris.ca/bitstreams/5f396c76-78a5-4058-a2ee-9c4bcd69a66c/download","source":{"id":"https://openalex.org/S4306402261","display_name":"Libraries and Cultural Resources (University of Calgary)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168635309","host_organization_name":"University of Calgary","host_organization_lineage":["https://openalex.org/I168635309"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"doi:10.11575/prism/31941","doi":"https://doi.org/10.11575/prism/31941","is_oa":true,"landing_page_url":"https://doi.org/10.11575/prism/31941","pdf_url":null,"source":{"id":"https://openalex.org/S4306402261","display_name":"Libraries and Cultural Resources (University of Calgary)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168635309","host_organization_name":"University of Calgary","host_organization_lineage":["https://openalex.org/I168635309"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"},{"id":"mag:2809052744","doi":null,"is_oa":false,"landing_page_url":"https://prism.ucalgary.ca/handle/1880/106674","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:prism.ucalgary.ca:1880/106674","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1880/106674","pdf_url":"http://hdl.handle.net/1880/106674","source":{"id":"https://openalex.org/S4306402261","display_name":"Libraries and Cultural Resources (University of Calgary)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168635309","host_organization_name":"University of Calgary","host_organization_lineage":["https://openalex.org/I168635309"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2809052744.pdf","grobid_xml":"https://content.openalex.org/works/W2809052744.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1964983194","https://openalex.org/W1972727376","https://openalex.org/W1978795762","https://openalex.org/W1979023284","https://openalex.org/W1992926057","https://openalex.org/W1996090319","https://openalex.org/W2002824528","https://openalex.org/W2011038175","https://openalex.org/W2014250775","https://openalex.org/W2019122688","https://openalex.org/W2023538813","https://openalex.org/W2034251536","https://openalex.org/W2039986348","https://openalex.org/W2042811650","https://openalex.org/W2047178252","https://openalex.org/W2048138776","https://openalex.org/W2051898119","https://openalex.org/W2055406925","https://openalex.org/W2058147305","https://openalex.org/W2058229406","https://openalex.org/W2060764537","https://openalex.org/W2078025505","https://openalex.org/W2081714290","https://openalex.org/W2104307326","https://openalex.org/W2115007414","https://openalex.org/W2118963985","https://openalex.org/W2130005339","https://openalex.org/W2131907878","https://openalex.org/W2146548807","https://openalex.org/W2148508563","https://openalex.org/W2159783272","https://openalex.org/W2204551059","https://openalex.org/W2432892462","https://openalex.org/W2566517905","https://openalex.org/W2605270397","https://openalex.org/W2625705642","https://openalex.org/W2736214243"],"related_works":["https://openalex.org/W2884715880","https://openalex.org/W4385276133","https://openalex.org/W2605384796","https://openalex.org/W2790685681","https://openalex.org/W2904042246","https://openalex.org/W2605693896","https://openalex.org/W2987075882","https://openalex.org/W2047766488","https://openalex.org/W7166198579","https://openalex.org/W2798049097"],"abstract_inverted_index":{"Osteoarthritis":[0],"(OA)":[1],"is":[2],"a":[3,31],"prevalent":[4],"articular":[5,11,83],"disease":[6],"characterized":[7],"by":[8,87],"degradation":[9],"of":[10,74,91,135,148],"cartilage":[12,51,84,92,150],"and":[13,29,50,58,68,81,104,125,151],"bone.":[14,152],"Presently,":[15],"no":[16],"single":[17],"imaging":[18,34,63,138],"modality":[19],"concurrently":[20,46],"captures":[21],"these":[22],"changes.":[23],"This":[24,129],"study":[25,130],"sought":[26],"to":[27,45,96,111,143],"develop":[28],"validate":[30],"novel":[32],"joint":[33,137],"technique,":[35],"contrast":[36,76],"enhanced":[37],"high":[38],"resolution":[39],"peripheral":[40],"quantitative":[41],"computed":[42],"tomography":[43],"(CEHR-pQCT),":[44],"assess":[47],"bone":[48,119],"microarchitecture":[49,108],"morphology.":[52],"Cadaveric":[53],"knees":[54],"were":[55,79,94],"harvested":[56],"(n=10)":[57],"scanned":[59],"using":[60],"magnetic":[61],"resonance":[62],"(MRI),":[64],"HR-pQCT":[65],"without":[66],"contrast,":[67],"HR-":[69],"pQCT":[70],"following":[71],"intra-articular":[72],"injection":[73],"non-ionic":[75],"media.":[77],"Joints":[78],"disarticulated,":[80],"the":[82,133,141],"thickness":[85],"measured":[86],"needle":[88,102],"probe.":[89],"Measures":[90],"morphology":[93],"found":[95,110],"be":[97,112],"significantly":[98,113],"different":[99,114],"between":[100],"MRI,":[101],"probing":[103],"CEHR-":[105],"pQCT.":[106],"Bone":[107],"was":[109,123],"in":[115,145],"CEHR-pQCT,":[116],"where":[117],"cortical":[118],"mineral":[120],"density":[121],"(BMD)":[122],"depressed,":[124],"trabecular":[126],"BMD":[127],"increased.":[128],"contributes":[131],"toward":[132],"advancement":[134],"whole":[136],"techniques,":[139],"laying":[140],"foundation":[142],"perform":[144],"vivo":[146],"scanning":[147],"knee":[149]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2018-06-29T00:00:00"}