{"id":"https://openalex.org/W2808990598","doi":"https://doi.org/10.1093/annonc/mdy151.034","title":"Hepatic stellate cells (HSCs) activating HSF1-mediated COMP secretion promote liver metastasis of pancreatic cancer through CD36/AKT/FOXM1 signaling","display_name":"Hepatic stellate cells (HSCs) activating HSF1-mediated COMP secretion promote liver metastasis of pancreatic cancer through CD36/AKT/FOXM1 signaling","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2808990598","doi":"https://doi.org/10.1093/annonc/mdy151.034","mag":"2808990598"},"language":"en","primary_location":{"id":"doi:10.1093/annonc/mdy151.034","doi":"https://doi.org/10.1093/annonc/mdy151.034","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdy151.034","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/annonc/mdy151.034","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"L. Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L. Sun","raw_affiliation_strings":["Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089519258","display_name":"Y. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Wang","raw_affiliation_strings":["Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016540348","display_name":"Qineng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q. Li","raw_affiliation_strings":["Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013983117","display_name":"L. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L. Wang","raw_affiliation_strings":["Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006581522","display_name":"C. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"C. Wang","raw_affiliation_strings":["Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091596042","display_name":"Bowen Yao","orcid":"https://orcid.org/0000-0002-8293-0695","observed_orcids":["https://orcid.org/0000-0002-8293-0695"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"B. Yao","raw_affiliation_strings":["Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037511263","display_name":"Z. Liu","orcid":"https://orcid.org/0000-0001-5879-7073","observed_orcids":["https://orcid.org/0000-0001-5879-7073"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Z. Liu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"T. Song","raw_affiliation_strings":["Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065617386","display_name":"Kangsheng Tu","orcid":"https://orcid.org/0000-0002-0032-1459","observed_orcids":["https://orcid.org/0000-0002-0032-1459"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"K. Tu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040484479","display_name":"Qun-Ce Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q. Liu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":{"value":5080,"currency":"USD","value_usd":5080},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":null,"first_page":"v10","last_page":"v10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.16060000658035278,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.05009999871253967,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/heat-shock-factor-1","display_name":"heat shock factor 1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cartilage-oligomeric-matrix-protein","display_name":"cartilage oligomeric matrix protein","score":0.9449999928474426},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":1.0},{"id":"https://openalex.org/keywords/cd36","display_name":"CD36","score":0.9559999704360962},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9350000023841858},{"id":"https://openalex.org/keywords/foxm1","display_name":"FOXM1","score":0.996999979019165},{"id":"https://openalex.org/keywords/pre-metastatic-niche","display_name":"pre-metastatic niche","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7210000157356262},{"id":"https://openalex.org/keywords/myofibroblast-transdifferentiation","display_name":"myofibroblast transdifferentiation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/extracellular-matrix-secretion","display_name":"extracellular matrix secretion","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7447973489761353},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6670750379562378},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6456878185272217},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.5972477793693542},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5585790872573853},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4694627821445465},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46484795212745667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4116789698600769},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3528108298778534},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2595388889312744},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23678359389305115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2344648241996765},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21289736032485962}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/annonc/mdy151.034","doi":"https://doi.org/10.1093/annonc/mdy151.034","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdy151.034","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/annonc/mdy151.034","doi":"https://doi.org/10.1093/annonc/mdy151.034","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdy151.034","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2109187650","https://openalex.org/W1993840794","https://openalex.org/W2104416279","https://openalex.org/W2889919103","https://openalex.org/W2885453810","https://openalex.org/W2384189170","https://openalex.org/W7165161774","https://openalex.org/W3031115936","https://openalex.org/W2035396091","https://openalex.org/W2943967825"],"abstract_inverted_index":{"Introduction:":[0],"Previous":[1],"studies":[2],"demonstrated":[3],"that":[4],"primary":[5],"pancreatic":[6,44],"cancer":[7,45],"cells":[8],"can":[9,31],"release":[10],"circulating":[11],"factors":[12],"or":[13],"exosomes":[14],"into":[15,33],"the":[16,34],"liver":[17],"to":[18],"form":[19],"premetastatic":[20,27],"niches.":[21],"HSCs":[22],"are":[23],"important":[24],"in":[25,58,75],"forming":[26],"niches":[28],"because":[29],"they":[30],"transdifferentiate":[32],"tumor-associated":[35],"myofibroblasts,":[36],"and":[37,41,61],"then":[38],"promote":[39],"metastasis":[40],"growth":[42],"of":[43],"cells.":[46],"The":[47],"transcriptional":[48],"regulator":[49],"heat":[50],"shock":[51],"factor":[52],"1":[53],"(HSF1)":[54],"is":[55,67],"frequently":[56],"activated":[57],"tumor":[59],"stroma,":[60],"Cartilage":[62],"oligomeric":[63],"matrix":[64],"protein":[65],"(COMP)":[66],"a":[68],"524":[69],"kDa":[70],"soluble":[71],"glycoprotein":[72],"particularly":[73],"expressed":[74],"fibrotic":[76],"conditions.":[77]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-06-29T00:00:00"}