{"id":"https://openalex.org/W2808964580","doi":"https://doi.org/10.1212/wnl.90.15_supplement.s21.008","title":"Autoregulation-based Blood Pressure Optimization After Large-vessel Ischemic Stroke using Non-invasive Near-infrared Spectroscopy Monitoring (S21.008)","display_name":"Autoregulation-based Blood Pressure Optimization After Large-vessel Ischemic Stroke using Non-invasive Near-infrared Spectroscopy Monitoring (S21.008)","publication_year":2018,"publication_date":"2018-04-10","ids":{"openalex":"https://openalex.org/W2808964580","doi":"https://doi.org/10.1212/wnl.90.15_supplement.s21.008","mag":"2808964580"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.90.15_supplement.s21.008","doi":"https://doi.org/10.1212/wnl.90.15_supplement.s21.008","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.90.15_supplement.s21.008","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103049465","display_name":"Anson Wang","orcid":"https://orcid.org/0000-0002-7212-7057","observed_orcids":["https://orcid.org/0000-0002-7212-7057"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anson Wang","raw_affiliation_strings":["Department of Neurology, Yale School of Medicine New Haven CT United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Yale School of Medicine New Haven CT United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056529805","display_name":"Kevin Navin Sheth","orcid":"https://orcid.org/0000-0003-2003-5473","observed_orcids":["https://orcid.org/0000-0003-2003-5473"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Sheth","raw_affiliation_strings":["Department of Neurology, Yale School of Medicine New Haven CT United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Yale School of Medicine New Haven CT United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088034421","display_name":"Randolph S. Marshall","orcid":"https://orcid.org/0000-0003-3037-0283","observed_orcids":["https://orcid.org/0000-0003-3037-0283"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randolph Marshall","raw_affiliation_strings":["Department of Neurology, Columbia University New York NY United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University New York NY United States","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044568922","display_name":"David Michael Mampre","orcid":"https://orcid.org/0000-0003-2338-8784","observed_orcids":["https://orcid.org/0000-0003-2338-8784"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Mampre","raw_affiliation_strings":["Department of Neurology, Yale School of Medicine New Haven CT United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Yale School of Medicine New Haven CT United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079380306","display_name":"Ryan Matthew Hebert","orcid":"https://orcid.org/0009-0005-5197-6067","observed_orcids":["https://orcid.org/0009-0005-5197-6067"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Hebert","raw_affiliation_strings":["Department of Neurosurgery, Yale School of Medicine New Haven CT United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Yale School of Medicine New Haven CT United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089032910","display_name":"Charles Christian Matouk","orcid":"https://orcid.org/0000-0003-3234-9541","observed_orcids":["https://orcid.org/0000-0003-3234-9541"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Matouk","raw_affiliation_strings":["Department of Neurosurgery, Yale School of Medicine New Haven CT United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Yale School of Medicine New Haven CT United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010454283","display_name":"Nils Petersen","orcid":"https://orcid.org/0000-0001-9711-3340","observed_orcids":["https://orcid.org/0000-0001-9711-3340"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nils Petersen","raw_affiliation_strings":["Department of Neurology, Yale School of Medicine New Haven CT United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Yale School of Medicine New Haven CT United States","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.196,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54785372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"90","issue":"15_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoregulation","display_name":"autoregulation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/blood-pressure-targets","display_name":"blood pressure targets","score":0.9070000052452087},{"id":"https://openalex.org/keywords/near-infrared-spectroscopy","display_name":"near-infrared spectroscopy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/endovascular-treatment","display_name":"endovascular treatment","score":0.8920000195503235},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.781000018119812},{"id":"https://openalex.org/keywords/cerebral-perfusion-monitoring","display_name":"cerebral perfusion monitoring","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6289666295051575},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.585303008556366},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.5653873085975647},{"id":"https://openalex.org/C111774379","wikidata":"https://www.wikidata.org/wiki/Q1364253","display_name":"Autoregulation","level":3,"score":0.5281296372413635},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4919860064983368},{"id":"https://openalex.org/C43571822","wikidata":"https://www.wikidata.org/wiki/Q599037","display_name":"Near-infrared spectroscopy","level":2,"score":0.4478524327278137},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3394697904586792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2724111080169678},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.20945149660110474},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.14775514602661133},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09561187028884888},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.90.15_supplement.s21.008","doi":"https://doi.org/10.1212/wnl.90.15_supplement.s21.008","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.90.15_supplement.s21.008","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389440863","https://openalex.org/W3032341669","https://openalex.org/W7119667093","https://openalex.org/W2914079613","https://openalex.org/W4319018106","https://openalex.org/W3005661879","https://openalex.org/W4389465377","https://openalex.org/W4409227126","https://openalex.org/W4393224498","https://openalex.org/W3082780638"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"determine":[2],"the":[3,27,36,66,85,90,104,120,144,157,173,225,264,298],"effect":[4],"of":[5,30,38,69,129,196,216,257,301],"individualized,":[6],"autoregulation-based":[7,286],"blood":[8,131],"pressure":[9],"(BP)":[10],"targets":[11,275],"on":[12,263],"functional":[13,280],"outcome":[14,169,188,262],"among":[15],"stroke":[16,34,71,101,303],"patients":[17,98,203],"undergoing":[18],"endovascular":[19],"therapy.":[20],"Background:":[21],"Abnormalities":[22],"in":[23,26,119,165,201],"cerebrovascular":[24],"autoregulation":[25,147],"acute":[28],"phase":[29],"large-vessel":[31],"occlusion":[32],"(LVO)":[33],"increase":[35],"risk":[37],"secondary":[39],"brain":[40],"injury":[41],"from":[42,249,272],"relative":[43],"cerebral":[44,58,130],"hypo-":[45],"or":[46,151],"hyperperfusion.":[47],"While":[48],"BP":[49,64,76,136,145,287],"is":[50,78,276,293],"an":[51,212],"important":[52],"modifiable":[53],"target":[54],"to":[55,61,103,304,313,319,325,331,337,343,349],"ensure":[56],"proper":[57],"perfusion,":[59],"how":[60],"best":[62,149],"manage":[63],"during":[65],"early":[67],"stages":[68],"LVO":[70,100,302],"remains":[72],"uncertain.":[73],"Autoregulation-derived,":[74],"personalized":[75],"management":[77,288],"a":[79,127,254,260],"plausible":[80],"strategy":[81],"that":[82,285],"would":[83],"provide":[84],"optimal":[86,273],"physiologic":[87],"environment":[88],"for":[89],"injured":[91],"brain.":[92],"Design/Methods:":[93],"We":[94],"prospectively":[95],"enrolled":[96],"21":[97],"with":[99,211,235,253,278],"admitted":[102],"Neuro":[105],"ICU":[106],"at":[107,178,237,241,266],"Yale-New":[108],"Haven":[109],"Hospital.":[110],"Autoregulatory":[111],"function":[112],"was":[113,141,148,154,170,199,221,228,232,251],"continuously":[114],"measured":[115],"by":[116],"interrogating":[117],"changes":[118],"near-infrared":[121],"spectroscopy":[122],"(NIRS)-derived":[123],"tissue-oxygenation":[124],"index":[125],"-":[126,133],"surrogate":[128],"flow":[132],"and":[134,163,180,187,224,240,295],"arterial":[135],"using":[137,172,191,289],"time-correlation":[138],"analysis.":[139],"MAPopt":[140,164,197,250],"defined":[142],"as":[143,156],"where":[146],"preserved":[150],"\u201coptimal\u201d.":[152],"\u0394MAPopt":[153,185,227,231],"calculated":[155],"absolute":[158],"difference":[159],"between":[160,184],"mean":[161,208,226],"MAP":[162,220,274],"individual":[166],"patients.":[167],"Functional":[168],"assessed":[171,190],"modified":[174],"Rankin":[175],"Scale":[176],"(mRS)":[177],"discharge":[179,238],"90":[181,242,267],"days.":[182,268],"Associations":[183],"\u2212":[186,198],"were":[189],"ordinal":[192],"regression.":[193],"Results:":[194],"Identification":[195],"possible":[200],"all":[202],"(mean":[204],"age":[205],"70\u00b116,":[206],"6F,":[207],"NIHSS":[209],"16)":[210],"average":[213],"monitoring":[214,292],"time":[215],"19.4\u00b17":[217],"hours.":[218],"Average":[219],"89\u00b111.2":[222],"mmHg":[223,247],"9.3\u00b17.9":[229],"mmHg.":[230],"significantly":[233],"associated":[234,252,277],"mRS":[236,265],"(p=0.0137),":[239],"days":[243],"(p=0.0278).":[244],"Every":[245],"5":[246],"deviation":[248,271],"3.2-fold":[255],"likelihood":[256],"shifting":[258],"towards":[259],"worse":[261,279],"Conclusions:":[269],"Increased":[270],"outcome.":[281],"Our":[282],"study":[283],"suggests":[284],"non-invasive":[290],"NIRS":[291],"feasible":[294],"could":[296],"guide":[297],"therapeutic":[299],"course":[300],"optimize":[305],"clinical":[306],"outcomes.":[307],"Disclosure:":[308],"Dr.":[309,315,321,327,333,339,345],"Wang":[310],"has":[311,317,323,329,335,341,347],"nothing":[312,318,324,330,336,342,348],"disclose.":[314,320,326,332,338,344,350],"Sheth":[316],"Marshall":[322],"Mampre":[328],"Hebert":[334],"Matouk":[340],"Petersen":[346]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2018-06-29T00:00:00"}
