{"id":"https://openalex.org/W2808931399","doi":"https://doi.org/10.2337/db18-324-or","title":"Foxo1-Expressing Cells in the Gut as a Source of Insulin for Diabetes Treatment","display_name":"Foxo1-Expressing Cells in the Gut as a Source of Insulin for Diabetes Treatment","publication_year":2018,"publication_date":"2018-06-22","ids":{"openalex":"https://openalex.org/W2808931399","doi":"https://doi.org/10.2337/db18-324-or","mag":"2808931399"},"language":"en","primary_location":{"id":"doi:10.2337/db18-324-or","doi":"https://doi.org/10.2337/db18-324-or","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db18-324-or","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011919288","display_name":"Wendy M. McKimpson","orcid":"https://orcid.org/0000-0002-2262-5998","observed_orcids":["https://orcid.org/0000-0002-2262-5998"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"WENDY MCKIMPSON","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034964059","display_name":"Taiyi Kuo","orcid":"https://orcid.org/0000-0001-6167-0284","observed_orcids":["https://orcid.org/0000-0001-6167-0284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"TAIYI KUO","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017924277","display_name":"Domenico Accili","orcid":"https://orcid.org/0000-0002-6874-3949","observed_orcids":["https://orcid.org/0000-0002-6874-3949"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DOMENICO ACCILI","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2617,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58328765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"67","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxo1","display_name":"FOXO1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9470000267028809},{"id":"https://openalex.org/keywords/insulin-producing-cells","display_name":"insulin-producing cells","score":0.6520000100135803},{"id":"https://openalex.org/keywords/parietal-cells","display_name":"parietal cells","score":0.7429999709129333},{"id":"https://openalex.org/keywords/h-k-atpase","display_name":"H+/K+-ATPase","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cell-fate-conversion","display_name":"cell fate conversion","score":0.4749999940395355},{"id":"https://openalex.org/keywords/beta-cell-regeneration","display_name":"beta cell regeneration","score":0.722000002861023},{"id":"https://openalex.org/keywords/neurogenin-3","display_name":"neurogenin 3","score":0.7409999966621399},{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6708163619041443},{"id":"https://openalex.org/C140149449","wikidata":"https://www.wikidata.org/wiki/Q17928793","display_name":"FOXO1","level":4,"score":0.6152698397636414},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.5428872108459473},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5193568468093872},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4755932092666626},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4117595851421356},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37542176246643066},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35023820400238037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.334589421749115},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.28384479880332947},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1265053153038025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12415054440498352},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.08429238200187683},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06658440828323364}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db18-324-or","doi":"https://doi.org/10.2337/db18-324-or","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db18-324-or","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3023979573","https://openalex.org/W2036682769","https://openalex.org/W7095701090","https://openalex.org/W1990349720","https://openalex.org/W7096480527","https://openalex.org/W4280633855","https://openalex.org/W4307210298","https://openalex.org/W4307139395","https://openalex.org/W1977882790","https://openalex.org/W4221090090"],"abstract_inverted_index":{"The":[0,53],"hallmark":[1],"of":[2,10,26,40,88,95,125,146,156,167,187,223,256],"type":[3],"1":[4],"diabetes":[5],"is":[6,21,267],"the":[7,14,24,51,92,96,113,123,143,168,221,260],"irreversible":[8],"destruction":[9],"insulin-secreting":[11,48],"\u03b2-cells":[12,28],"in":[13,42,91,107,112,200,206,220,233,259],"pancreas.":[15],"Consequently,":[16],"an":[17],"attractive":[18],"therapeutic":[19,67],"approach":[20],"to":[22,193,269,273],"trigger":[23],"regeneration":[25],"functional":[27,47],"elsewhere":[29],"within":[30,50],"a":[31,62,70,77,85,253],"diseased":[32],"individual.":[33],"We":[34,174],"have":[35,83,163,251],"previously":[36],"demonstrated":[37,263],"that":[38,75,264],"removal":[39],"Foxo1":[41,188,199,226,232,265],"Neurogenin3":[43],"(Ngn3)-expressing":[44],"cells":[45,49,60,90,99,106,111,117,133,151,192,205,214,258,272],"creates":[46],"intestine.":[52],"cells,":[54,128,161,195],"however,":[55],"only":[56],"convert":[57,190,270],"into":[58],"insulin+":[59],"at":[61],"low":[63],"frequency,":[64],"limiting":[65],"their":[66],"potential.":[68],"Using":[69],"novel":[71,86],"knock-in":[72],"reporter":[73],"mouse":[74],"encodes":[76],"Foxo1-Venus":[78],"fusion":[79],"protein":[80],"(FoxV),":[81],"we":[82,129,196,212,230,237,250],"identified":[84,252],"population":[87,255],"Foxo1-expressing":[89,257],"glandular":[93],"epithelium":[94],"stomach.":[97],"These":[98],"are":[100],"distinct":[101],"from":[102,134],"other":[103],"gut":[104],"FoxV+":[105,116,147],"that,":[108],"unlike":[109],"Foxo1+":[110,126],"intestine,":[114],"stomach":[115,127,135,191,222,235,261],"rarely":[118],"express":[119,154],"serotonin.":[120],"To":[121,183],"identify":[122],"nature":[124],"next":[130,197],"isolated":[131],"single":[132],"and,":[136],"using":[137,208],"flow":[138],"cytometry":[139],"and":[140,181,218,244,262],"qPCR,":[141],"analyzed":[142],"gene":[144,242],"expression":[145,243],"cells.":[148,247,275],"Although":[149],"Foxo1-positive":[150],"do":[152],"not":[153],"markers":[155],"chief,":[157],"pit,":[158],"or":[159,203],"neck":[160],"they":[162],"increased":[164,240],"transcript":[165],"levels":[166],"parietal":[169,204],"cell":[170],"marker":[171],"H+/K+":[172],"ATPase.":[173],"further":[175],"validated":[176],"these":[177,271],"results":[178],"by":[179],"immunofluorescence":[180],"FACS.":[182],"determine":[184],"if":[185],"elimination":[186],"can":[189],"insulin-producing":[194,274],"ablated":[198],"either":[201],"Ngn3+":[202],"mice":[207,224],"cre-mediated":[209],"recombination.":[210],"Strikingly,":[211],"detected":[213,238],"positive":[215],"for":[216],"insulin":[217],"C-peptide":[219],"harboring":[225],"deletion.":[227],"Similarly,":[228],"when":[229],"inactivated":[231],"primary":[234],"cultures,":[236],"markedly":[239],"\u201c\u03b2-like\u201d":[241],"insulin+,":[245],"C-peptide+":[246],"Taken":[248],"together":[249],"new":[254],"ablation":[266],"sufficient":[268],"Disclosure":[276],"W.":[277],"McKimpson:":[278],"None.":[279,282,285],"T.":[280],"Kuo:":[281],"D.":[283],"Accili:":[284]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2018-06-29T00:00:00"}