{"id":"https://openalex.org/W2808918705","doi":"https://doi.org/10.1186/s12969-018-0258-5","title":"Early use of alendronate as a protective factor against the development of glucocorticoid-induced bone loss in childhood-onset rheumatic diseases: a cross-sectional study","display_name":"Early use of alendronate as a protective factor against the development of glucocorticoid-induced bone loss in childhood-onset rheumatic diseases: a cross-sectional study","publication_year":2018,"publication_date":"2018-06-18","ids":{"openalex":"https://openalex.org/W2808918705","doi":"https://doi.org/10.1186/s12969-018-0258-5","mag":"2808918705","pmid":"https://pubmed.ncbi.nlm.nih.gov/29914510","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6006935"},"language":"en","primary_location":{"id":"doi:10.1186/s12969-018-0258-5","doi":"https://doi.org/10.1186/s12969-018-0258-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12969-018-0258-5","pdf_url":"https://ped-rheum.biomedcentral.com/track/pdf/10.1186/s12969-018-0258-5","source":{"id":"https://openalex.org/S121831025","display_name":"Pediatric Rheumatology","issn_l":"1546-0096","issn":["1546-0096"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ped-rheum.biomedcentral.com/track/pdf/10.1186/s12969-018-0258-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104728161","display_name":"Yuzaburo Inoue","orcid":"https://orcid.org/0000-0001-5904-687X","observed_orcids":["https://orcid.org/0000-0001-5904-687X"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4405286420","display_name":"Eastern Chiba Medical Center","ror":"https://ror.org/023at0y77","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405262105","https://openalex.org/I4405286420"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuzaburo Inoue","raw_affiliation_strings":["Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan. yuzaburo@chiba-u.jp","Department of Pediatrics, Eastern Chiba Medical Center, 3-6-2 Okayamadai, Togane, Chiba, 283-8686, Japan. yuzaburo@chiba-u.jp","Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan","Department of Pediatrics, Eastern Chiba Medical Center, Chiba, Japan"],"raw_orcid":"https://orcid.org/0000-0001-5904-687X","affiliations":[{"raw_affiliation_string":"Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan. yuzaburo@chiba-u.jp","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Pediatrics, Eastern Chiba Medical Center, 3-6-2 Okayamadai, Togane, Chiba, 283-8686, Japan. yuzaburo@chiba-u.jp","institution_ids":["https://openalex.org/I4405286420"]},{"raw_affiliation_string":"Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Pediatrics, Eastern Chiba Medical Center, Chiba, Japan","institution_ids":["https://openalex.org/I4405286420"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035468036","display_name":"Kanako Mitsunaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098222","display_name":"Chiba Kaihin Municipal Hospital","ror":"https://ror.org/0116akb37","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210098222"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kanako Mitsunaga","raw_affiliation_strings":["Department of Pediatrics, Chiba Kaihin Municipal Hospital, Chiba, Chiba, Japan","Department of Pediatrics, Chiba Kaihin Municipal Hospital, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Chiba Kaihin Municipal Hospital, Chiba, Chiba, Japan","institution_ids":["https://openalex.org/I4210098222"]},{"raw_affiliation_string":"Department of Pediatrics, Chiba Kaihin Municipal Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I4210098222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101782660","display_name":"Takeshi Yamamoto","orcid":"https://orcid.org/0009-0007-3817-0557","observed_orcids":["https://orcid.org/0009-0007-3817-0557"]},"institutions":[{"id":"https://openalex.org/I4405253373","display_name":"Chiba Children's Hospital","ror":"https://ror.org/00khjyb83","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405253373"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Yamamoto","raw_affiliation_strings":["Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Chiba, Japan","Department of Allergy and Rheumatology, Chiba Children\u2019s Hospital, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Chiba, Japan","institution_ids":["https://openalex.org/I4405253373"]},{"raw_affiliation_string":"Department of Allergy and Rheumatology, Chiba Children\u2019s Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I4405253373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033779805","display_name":"Koki Chiba","orcid":"https://orcid.org/0000-0003-3580-2321","observed_orcids":["https://orcid.org/0000-0003-3580-2321"]},"institutions":[{"id":"https://openalex.org/I4210095039","display_name":"Toho University Omori Medical Center","ror":"https://ror.org/00qf0yp70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210095039"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koki Chiba","raw_affiliation_strings":["Department of Traditional Medicine, Toho University Omori Medical Center, Ota-ku, Tokyo, Japan","Department of Traditional Medicine, Toho University Omori Medical Center, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional Medicine, Toho University Omori Medical Center, Ota-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I4210095039"]},{"raw_affiliation_string":"Department of Traditional Medicine, Toho University Omori Medical Center, Tokyo, Japan","institution_ids":["https://openalex.org/I4210095039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069225878","display_name":"Fumiya Yamaide","orcid":"https://orcid.org/0000-0002-2916-9710","observed_orcids":["https://orcid.org/0000-0002-2916-9710"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumiya Yamaide","raw_affiliation_strings":["Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan","Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079943912","display_name":"Taiji Nakano","orcid":"https://orcid.org/0000-0001-7499-1204","observed_orcids":["https://orcid.org/0000-0001-7499-1204"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taiji Nakano","raw_affiliation_strings":["Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan","Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101543136","display_name":"Yoshinori Morita","orcid":"https://orcid.org/0000-0003-0532-9326","observed_orcids":["https://orcid.org/0000-0003-0532-9326"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshinori Morita","raw_affiliation_strings":["Department of Pediatrics, IMS Memorial Hospital, Itabashi-ku, Tokyo, Japan","Department of Pediatrics, IMS Memorial Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, IMS Memorial Hospital, Itabashi-ku, Tokyo, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, IMS Memorial Hospital, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005354494","display_name":"Akiko Yamaide","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405253373","display_name":"Chiba Children's Hospital","ror":"https://ror.org/00khjyb83","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405253373"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Yamaide","raw_affiliation_strings":["Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Chiba, Japan","Department of Allergy and Rheumatology, Chiba Children\u2019s Hospital, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Chiba, Japan","institution_ids":["https://openalex.org/I4405253373"]},{"raw_affiliation_string":"Department of Allergy and Rheumatology, Chiba Children\u2019s Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I4405253373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084991542","display_name":"Shuichi Suzuki","orcid":"https://orcid.org/0000-0003-4295-4630","observed_orcids":["https://orcid.org/0000-0003-4295-4630"]},"institutions":[{"id":"https://openalex.org/I4405284263","display_name":"National Hospital Organization Shimoshizu Hospital","ror":"https://ror.org/0380vfr03","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405284263"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi Suzuki","raw_affiliation_strings":["Department of Pediatrics, Shimoshizu National Hospital, Yotsukaido, Chiba, Japan","Department of Pediatrics, Shimoshizu National Hospital, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Shimoshizu National Hospital, Yotsukaido, Chiba, Japan","institution_ids":["https://openalex.org/I4405284263"]},{"raw_affiliation_string":"Department of Pediatrics, Shimoshizu National Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I4405284263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008512966","display_name":"Takayasu Arima","orcid":"https://orcid.org/0000-0001-9968-5692","observed_orcids":["https://orcid.org/0000-0001-9968-5692"]},"institutions":[{"id":"https://openalex.org/I4405253710","display_name":"Kimitsu Chuo Hospital","ror":"https://ror.org/0104w5s79","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405253710"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayasu Arima","raw_affiliation_strings":["Department of Pediatrics, Kimitsu Chuo Hospital, Kisarazu, Chiba, Japan","Department of Pediatrics, Kimitsu Chuo Hospital, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kimitsu Chuo Hospital, Kisarazu, Chiba, Japan","institution_ids":["https://openalex.org/I4405253710"]},{"raw_affiliation_string":"Department of Pediatrics, Kimitsu Chuo Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I4405253710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104041015","display_name":"Kenichi Yamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087594","display_name":"St. Luke's International Hospital","ror":"https://ror.org/002wydw38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087594"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-ichi Yamaguchi","raw_affiliation_strings":["Immuno-Rheumatology Center, St.Luke's Internationl Hospital, Chuou-ku, Tokyo, Japan","Immuno-Rheumatology Center, St.Luke\u2019s Internationl Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immuno-Rheumatology Center, St.Luke's Internationl Hospital, Chuou-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I4210087594"]},{"raw_affiliation_string":"Immuno-Rheumatology Center, St.Luke\u2019s Internationl Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4210087594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089406218","display_name":"Minako Tomiita","orcid":"https://orcid.org/0000-0002-5665-915X","observed_orcids":["https://orcid.org/0000-0002-5665-915X"]},"institutions":[{"id":"https://openalex.org/I4405253373","display_name":"Chiba Children's Hospital","ror":"https://ror.org/00khjyb83","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405253373"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minako Tomiita","raw_affiliation_strings":["Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Chiba, Japan","Department of Allergy and Rheumatology, Chiba Children\u2019s Hospital, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Rheumatology, Chiba Children's Hospital, Chiba, Chiba, Japan","institution_ids":["https://openalex.org/I4405253373"]},{"raw_affiliation_string":"Department of Allergy and Rheumatology, Chiba Children\u2019s Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I4405253373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039402819","display_name":"Naoki Shimojo","orcid":"https://orcid.org/0000-0002-8076-0493","observed_orcids":["https://orcid.org/0000-0002-8076-0493"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Shimojo","raw_affiliation_strings":["Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan","Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111761518","display_name":"Yoichi Kohno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153700","display_name":"Chiba Rosai Hospital","ror":"https://ror.org/049v7zy31","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210153700"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichi Kohno","raw_affiliation_strings":["Chiba Rosai Hospital, Ichihara, Chiba, Japan","Chiba Rosai Hospital, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiba Rosai Hospital, Ichihara, Chiba, Japan","institution_ids":["https://openalex.org/I4210153700"]},{"raw_affiliation_string":"Chiba Rosai Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I4210153700"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5104728161"],"corresponding_institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4405286420"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":1.6073,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.79637903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"1","first_page":"36","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alendronate","display_name":"alendronate","score":0.9919999837875366},{"id":"https://openalex.org/keywords/glucocorticoid-induced-osteoporosis","display_name":"glucocorticoid-induced osteoporosis","score":0.925000011920929},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.921999990940094},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.7720000147819519},{"id":"https://openalex.org/keywords/glucocorticoid-therapy","display_name":"glucocorticoid therapy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/early-prevention","display_name":"early prevention","score":0.38100001215934753},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9299335479736328},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.8826034069061279},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.7944098711013794},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.6428461670875549},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6225341558456421},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.45549142360687256},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.44271954894065857},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.42643237113952637},{"id":"https://openalex.org/C2776169692","wikidata":"https://www.wikidata.org/wiki/Q4941552","display_name":"Bone disease","level":3,"score":0.42354416847229004}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012216","descriptor_name":"Rheumatic Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019386","descriptor_name":"Alendronate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12969-018-0258-5","doi":"https://doi.org/10.1186/s12969-018-0258-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12969-018-0258-5","pdf_url":"https://ped-rheum.biomedcentral.com/track/pdf/10.1186/s12969-018-0258-5","source":{"id":"https://openalex.org/S121831025","display_name":"Pediatric Rheumatology","issn_l":"1546-0096","issn":["1546-0096"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Rheumatology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4967989","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6006935","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:29914510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29914510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric rheumatology online journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6006935","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6006935/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatr Rheumatol Online J","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2b5054ef234d4399a5f93928e9b789b1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2b5054ef234d4399a5f93928e9b789b1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pediatric Rheumatology Online Journal, Vol 16, Iss 1, Pp 1-9 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12969-018-0258-5","doi":"https://doi.org/10.1186/s12969-018-0258-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12969-018-0258-5","pdf_url":"https://ped-rheum.biomedcentral.com/track/pdf/10.1186/s12969-018-0258-5","source":{"id":"https://openalex.org/S121831025","display_name":"Pediatric Rheumatology","issn_l":"1546-0096","issn":["1546-0096"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Rheumatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2808918705.pdf","grobid_xml":"https://content.openalex.org/works/W2808918705.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1966051039","https://openalex.org/W1975096117","https://openalex.org/W1991114147","https://openalex.org/W1993232754","https://openalex.org/W1993731489","https://openalex.org/W1998752290","https://openalex.org/W2044178924","https://openalex.org/W2050352060","https://openalex.org/W2059709589","https://openalex.org/W2065388026","https://openalex.org/W2095741166","https://openalex.org/W2110706792","https://openalex.org/W2146591423","https://openalex.org/W2166380219","https://openalex.org/W2622691876"],"related_works":["https://openalex.org/W6939929974","https://openalex.org/W6977446294","https://openalex.org/W6958155037","https://openalex.org/W6902285253","https://openalex.org/W2078156734","https://openalex.org/W2162782837","https://openalex.org/W2073492031","https://openalex.org/W2001924322","https://openalex.org/W2077804411","https://openalex.org/W2115647238"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bisphosphonates":[1],"are":[2],"recommended":[3],"for":[4,9,25],"use":[5,71,306],"as":[6],"first-line":[7],"therapy":[8,247,264],"the":[10,20,26,45,49,66,69,98,106,109,117,121,139,142,149,156,163,171,191,194,210,213,218,224,233,243,254,258,269,280,299,315],"prevention":[11,27],"and":[12,55,63,151,178],"treatment":[13,29],"of":[14,23,30,51,68,72,100,105,111,120,130,141,144,148,158,162,186,196,201,215,220,226,230,245,271,282,301,307,317],"glucocorticoid-induced":[15,31,52],"osteoporosis":[16,32,56,90,115,145],"in":[17,33,57,146,160,184,209,232,253,320],"adults.":[18],"However,":[19],"appropriate":[21],"usage":[22],"bisphosphonates":[24],"or":[28,89,114,190,223],"children":[34],"remains":[35],"unclear.":[36],"METHODS:":[37],"We":[38,74],"performed":[39],"a":[40,275,311],"cross-sectional":[41],"study":[42,107],"to":[43,64,85,94],"clarify":[44],"factors":[46,296],"associated":[47,297],"with":[48,59,78,173,298,323],"development":[50,281,300,316],"bone":[53,87,112,122,174,180,283,318],"loss":[54,88,113,175,181,284,319],"patients":[58,77,231,322],"childhood-onset":[60,79,324],"rheumatic":[61,80,325],"disease":[62,81],"investigate":[65],"impact":[67],"early":[70,305],"alendronate.":[73],"recruited":[75],"39":[76],"who":[82,236],"were":[83,166],"evaluated":[84],"detect":[86],"at":[91,116,126,193,212],"3":[92,128,153,240,266],"months":[93,129,154,241,267],"1.5":[95],"years":[96],"after":[97,125,155,242,268],"initiation":[99],"treatment.":[101],"The":[102,228,290,304],"primary":[103,188,197],"outcome":[104],"was":[108,205,248],"presence":[110],"initial":[118],"evaluation":[119,143],"mineral":[123],"density":[124],"least":[127],"glucocorticoid":[131,159,202,216,221,246,272],"therapy.":[132],"RESULTS:":[133],")":[134],"had":[135,274],"been":[136],"started":[137],"by":[138],"time":[140],"46%":[147],"participants":[150,172],"within":[152,239,265],"start":[157,214,244,270],"31%":[161],"participants.":[164],"There":[165],"no":[167,206],"significant":[168,207,277],"differences":[169],"between":[170],"(wBL":[176],"group)":[177,183],"without":[179],"(w/oBL":[182],"terms":[185,200],"gender,":[187],"disease,":[189],"age":[192,211],"onset":[195],"disease.":[198,326],"In":[199,257],"use,":[203,222],"there":[204],"difference":[208],"therapy,":[217],"length":[219],"dose":[225],"glucocorticoids.":[227],"proportion":[229],"w/oBL":[234],"group":[235],"received":[237],"alendronate":[238,308],"significantly":[249],"greater":[250],"than":[251],"that":[252],"wBL":[255],"group.":[256],"logistic":[259],"regression":[260],"analysis,":[261],"only":[262],"\"alendronate":[263],"therapy\"":[273],"statistically":[276],"effect":[278,313],"on":[279],"(OR,":[285],"0.08;":[286],"95%":[287],"CI,":[288],"0.02-0.43).":[289],"analysis":[291],"did":[292],"not":[293],"reveal":[294],"any":[295],"osteoporosis.":[302],"CONCLUSIONS:":[303],"may":[309],"have":[310],"preventive":[312],"against":[314],"glucocorticoid-treated":[321]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-06-29T00:00:00"}