{"id":"https://openalex.org/W2808888644","doi":"https://doi.org/10.2337/db18-1748-p","title":"Impaired Insulin Resistance in IF1-Deficient Mice Subjected to a High-Fat Diet with Reduced-Fat Mass and Skeletal Muscle Lipid Accumulation","display_name":"Impaired Insulin Resistance in IF1-Deficient Mice Subjected to a High-Fat Diet with Reduced-Fat Mass and Skeletal Muscle Lipid Accumulation","publication_year":2018,"publication_date":"2018-06-22","ids":{"openalex":"https://openalex.org/W2808888644","doi":"https://doi.org/10.2337/db18-1748-p","mag":"2808888644"},"language":"en","primary_location":{"id":"doi:10.2337/db18-1748-p","doi":"https://doi.org/10.2337/db18-1748-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db18-1748-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060307962","display_name":"Fengyuan Huang","orcid":"https://orcid.org/0000-0002-6696-9290","observed_orcids":["https://orcid.org/0000-0002-6696-9290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FENGYUAN HUANG","raw_affiliation_strings":["Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068110198","display_name":"Kevin Yang","orcid":"https://orcid.org/0009-0005-6370-4931","observed_orcids":["https://orcid.org/0009-0005-6370-4931"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KEVIN YANG","raw_affiliation_strings":["Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048436021","display_name":"K. Saja","orcid":"https://orcid.org/0000-0002-2902-4984","observed_orcids":["https://orcid.org/0000-0002-2902-4984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KAMALAMMA SAJA","raw_affiliation_strings":["Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101340494","display_name":"Yicheng Huang","orcid":"https://orcid.org/0009-0000-2457-9481","observed_orcids":["https://orcid.org/0009-0000-2457-9481"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YICHENG HUANG","raw_affiliation_strings":["Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084850554","display_name":"QINGQIANG LONG","orcid":"https://orcid.org/0000-0001-9036-8535","observed_orcids":["https://orcid.org/0000-0001-9036-8535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"QINGQIANG LONG","raw_affiliation_strings":["Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105688209","display_name":"Masasuke Yoshida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MASASUKE YOSHIDA","raw_affiliation_strings":["Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101884781","display_name":"Qinglin Yang","orcid":"https://orcid.org/0000-0002-6024-2517","observed_orcids":["https://orcid.org/0000-0002-6024-2517"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"QINGLIN YANG","raw_affiliation_strings":["Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL, Thiruvananthapuram, India, Wuhan, China, Kyoto, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0793,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.36927372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"67","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.4553000032901764,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.4553000032901764,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.2345999926328659,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.08839999884366989,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atpase-inhibitory-factor-1","display_name":"ATPase inhibitory factor 1","score":0.9440000057220459},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8510000109672546},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9290000200271606},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9369999766349792},{"id":"https://openalex.org/keywords/skeletal-muscle-lipid-accumulation","display_name":"skeletal muscle lipid accumulation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.7990000247955322},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.8690000176429749},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/mitochondrial-atp-synthase","display_name":"mitochondrial ATP synthase","score":0.8190000057220459},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.6600000262260437},{"id":"https://openalex.org/keywords/insulin-tolerance","display_name":"insulin tolerance","score":0.7120000123977661},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8330000042915344},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.9390000104904175},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8975346088409424},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.893276572227478},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7249598503112793},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5738533139228821},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5597037076950073},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.5043433904647827},{"id":"https://openalex.org/C2776188179","wikidata":"https://www.wikidata.org/wiki/Q24768727","display_name":"GLUT4","level":4,"score":0.46978986263275146},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.46305155754089355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46264708042144775},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.43090564012527466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38279828429222107},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.28990796208381653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15743038058280945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1531575322151184},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15056690573692322}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db18-1748-p","doi":"https://doi.org/10.2337/db18-1748-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db18-1748-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2739682907","https://openalex.org/W3089042814","https://openalex.org/W7203640973","https://openalex.org/W1977486949","https://openalex.org/W2133800593","https://openalex.org/W7170917351","https://openalex.org/W2982321558","https://openalex.org/W2145148177","https://openalex.org/W2788531301","https://openalex.org/W3003454806"],"abstract_inverted_index":{"Mitochondrial":[0],"ATP":[1,13,16,38,48],"synthase":[2,14,49],"catalyzes":[3],"the":[4,21,24,44,70,89,130,217,223,255,273],"coupling":[5],"step":[6],"of":[7,47,55,74,91,129,144,191],"oxidative":[8],"phosphorylation.":[9],"Under":[10],"pathologic":[11],"conditions,":[12],"hydrolyzes":[15],"to":[17,50,109,137,260,280],"replenish":[18],"protons":[19],"from":[20],"matrix":[22],"into":[23],"intermembrane":[25],"space,":[26],"sustaining":[27],"mitochondrial":[28],"membrane":[29],"potential.":[30],"ATPase":[31],"inhibitory":[32],"factor":[33,270],"1":[34],"(IF1)":[35],"is":[36,120,265],"an":[37,266,281],"synthase-interacting":[39],"protein":[40],"that":[41,116,164,179,200,216,263,271],"selectively":[42],"inhibits":[43],"hydrolysis":[45],"activity":[46],"preserve":[51],"ATP.":[52],"The":[53],"role":[54,73],"IF1":[56,75,87,99,117,133,165,201,224,256,264],"in":[57,71,76,79,88,101,106,122,126,147,222,283],"patients":[58],"with":[59,229],"obesity":[60,80],"and":[61,81,94,103,155,182,195,206,233,248,285],"type":[62],"2":[63],"diabetes(T2D)":[64],"has":[65],"been":[66],"reported":[67],"recently":[68],"but":[69,124],"vivo":[72],"metabolic":[77,268],"regulation":[78],"T2D":[82],"remains":[83],"unclear.":[84],"To":[85],"understand":[86],"development":[90,274],"insulin":[92,196,207,276],"resistance":[93],"T2D,":[95],"we":[96],"first":[97],"assess":[98],"expression":[100,119],"adipose":[102],"skeletal":[104,127,243,286],"tissues":[105],"mice":[107,135,149,167,174,203,226,258],"subjected":[108,136,259],"a":[110,140,151,240],"high-fat":[111],"diet":[112],"(HFD).":[113],"We":[114],"found":[115],"transcript":[118],"upregulated":[121],"adipose,":[123],"reduced":[125],"muscle":[128,287],"HFD-fed":[131],"mice.":[132,193],"knockout":[134],"HFD":[138,210,261],"showed":[139,178,245],"substantially":[141],"slower":[142],"increase":[143],"body":[145,156],"weight":[146],"adult":[148],"despite":[150],"similar":[152],"food":[153],"intake":[154],"composition":[157],"analysis":[158],"using":[159],"Magnetic":[160],"resonance":[161],"imaging(MRI)":[162],"revealed":[163,199,215],"KO":[166,202,225,257],"had":[168],"less":[169],"fat":[170,184,220],"mass":[171,185,221],"than":[172,189],"WT":[173,192],"littermates":[175],".Morphometric":[176],"measurements":[177],"gonadal,":[180],"subcutaneous":[181],"mesenteric":[183],"were":[186],"relatively":[187,218],"lower":[188,219],"those":[190],"Glucose":[194],"tolerance":[197],"assay":[198],"impaired":[204],"glucose":[205],"tolerances":[208],"after":[209],"feeding.":[211],"Biochemical":[212],"assays":[213],"further":[214],"was":[227],"concomitant":[228],"increased":[230,246],"circulating":[231],"triglyceride":[232,247],"free":[234],"fatty":[235],"acids":[236],"(FFA)":[237],"levels.":[238],"As":[239],"result,":[241],"Gastrocnemius":[242],"muscles":[244],"FFA":[249],"contents.":[250],"Taken":[251],"together,":[252],"studies":[253],"on":[254],"uncover":[262],"important":[267],"regulating":[269],"affects":[272],"HFD-induced":[275],"resistance,":[277],"probably":[278],"due":[279],"impairment":[282],"adipogenesis":[284],"lipid":[288],"accumulation.":[289],"Disclosure":[290],"F.":[291],"Huang:":[292,301],"None.":[293,296,299,302,305,308,311],"K.":[294,297],"Yang:":[295,310],"Saja:":[298],"Y.":[300],"Q.":[303,309],"Long:":[304],"M.":[306],"Yoshida:":[307]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-29T00:00:00"}