{"id":"https://openalex.org/W2808844529","doi":null,"title":"Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit?","display_name":"Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit?","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2808844529","mag":"2808844529","pmid":"https://pubmed.ncbi.nlm.nih.gov/28786260"},"language":"en","primary_location":{"id":"pmid:28786260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28786260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Israel Medical Association journal : IMAJ","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015972577","display_name":"Giorgia Bizzaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Giorgia Bizzaro","raw_affiliation_strings":["Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103937026","display_name":"Antonio Antico","orcid":"https://orcid.org/0000-0003-0912-9751","observed_orcids":["https://orcid.org/0000-0003-0912-9751"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio Antico","raw_affiliation_strings":["Laboratorio Analisi, Ospedale Civile, Santorso, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Analisi, Ospedale Civile, Santorso, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103118934","display_name":"Antonio Fortunato","orcid":"https://orcid.org/0000-0003-3064-2998","observed_orcids":["https://orcid.org/0000-0003-3064-2998"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio Fortunato","raw_affiliation_strings":["Patologia Clinica, Area Vasta 5 ASUR Marche, Ascoli-Piceno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patologia Clinica, Area Vasta 5 ASUR Marche, Ascoli-Piceno, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041425461","display_name":"Nicola Bizzaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105384","display_name":"Ospedale Sant Antonio","ror":"https://ror.org/01eb9tc45","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210105384"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Bizzaro","raw_affiliation_strings":["Laboratorio di Patologia Clinica, Ospedale S. Antonio, Tolmezzo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio di Patologia Clinica, Ospedale S. Antonio, Tolmezzo, Italy","institution_ids":["https://openalex.org/I4210105384"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.5779,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.98236225,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"19","issue":"7","first_page":"438","last_page":"443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.8220000267028809},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.8259999752044678},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.8050000071525574},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/vdr-polymorphisms","display_name":"VDR polymorphisms","score":0.9509999752044678},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d","display_name":"1,25-dihydroxyvitamin D","score":0.9810000061988831},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.503000020980835},{"id":"https://openalex.org/keywords/confounding-factors","display_name":"confounding factors","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.8480582237243652},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8318842053413391},{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.8159353733062744},{"id":"https://openalex.org/C2779740938","wikidata":"https://www.wikidata.org/wiki/Q4138762","display_name":"vitamin D deficiency","level":3,"score":0.7589306831359863},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6438838243484497},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.6195067763328552},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4733999967575073},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4680701494216919},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.46519720554351807},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.46296194195747375},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.4540945887565613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3898615837097168},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35871079564094543}],"mesh":[{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004872","descriptor_name":"Ergocalciferols","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014808","descriptor_name":"Vitamin D Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D018167","descriptor_name":"Receptors, Calcitriol","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:28786260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28786260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Israel Medical Association journal : IMAJ","raw_type":"Journal Article"},{"id":"mag:2808844529","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28786260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992901493","https://openalex.org/W4233764092","https://openalex.org/W2756822689","https://openalex.org/W4412060670","https://openalex.org/W4366772761","https://openalex.org/W2183874697","https://openalex.org/W3013312647","https://openalex.org/W1964550787","https://openalex.org/W1977821158","https://openalex.org/W7128910504"],"abstract_inverted_index":{"BACKGROUND:":[0],"Vitamin":[1],"D":[2,23,43,63,97,122,156,177],"deficiency":[3,24,98,123],"is":[4,47,116,124],"becoming":[5],"an":[6],"increasing":[7],"problem":[8],"worldwide.":[9],"It":[10],"should":[11],"not":[12,15,117,164],"be":[13,80],"underestimated,":[14],"only":[16],"due":[17],"to":[18,79,91,153,166,169,187],"the":[19,37,58,125,132,136,140],"well-known":[20],"consequences":[21],"vitamin":[22,42,62,96,112,121,155,176],"has":[25],"on":[26],"bone":[27],"health,":[28],"but":[29],"primarily":[30],"because":[31],"recent":[32],"studies":[33],"have":[34],"shown":[35],"how":[36],"biologically":[38],"active":[39],"form":[40],"of":[41,60,74,85,111,131,135,143,146],"-":[44,46],"1,25(OH)2D":[45],"involved":[48],"in":[49,67],"many":[50],"biological":[51],"processes,":[52],"including":[53],"immune":[54,70],"system":[55],"modulation.":[56],"Moreover,":[57],"presence":[59],"a":[61,92,129,171],"receptor":[64],"was":[65],"discovered":[66],"almost":[68],"all":[69],"cells":[71],"and":[72,99,159,179],"some":[73],"its":[75],"polymorphisms":[76],"were":[77],"found":[78],"associated":[81],"with":[82],"increased":[83],"incidence":[84],"autoimmune":[86,100,106,180],"diseases.":[87,101],"This":[88],"finding":[89],"led":[90],"proposed":[93],"link":[94,173],"between":[95,174],"Patients":[102],"affected":[103],"by":[104],"various":[105],"diseases":[107],"showed":[108],"low":[109,175],"levels":[110,178],"D.":[113],"However,":[114],"it":[115],"always":[118],"clear":[119],"whether":[120],"cause":[126],"or":[127],"rather":[128],"consequence":[130],"disease.":[133,181],"Limitations":[134],"studies,":[137],"such":[138],"as":[139],"small":[141],"number":[142],"patients,":[144],"heterogeneity":[145],"selected":[147],"groups,":[148],"environmental":[149],"conditions,":[150],"methods":[151],"used":[152],"measure":[154],"serum":[157],"concentration":[158],"other":[160],"confounding":[161],"factors":[162],"do":[163],"lead":[165],"unequivocal":[167],"results":[168],"demonstrate":[170],"direct":[172],"Therefore,":[182],"randomized":[183],"trials":[184],"are":[185],"needed":[186],"clarify":[188],"conflicting":[189],"results.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-29T00:00:00"}
