{"id":"https://openalex.org/W2808843365","doi":"https://doi.org/10.1016/j.smim.2018.06.001","title":"The potential of imaging tools as correlates of infection and disease for new TB vaccine development","display_name":"The potential of imaging tools as correlates of infection and disease for new TB vaccine development","publication_year":2018,"publication_date":"2018-06-18","ids":{"openalex":"https://openalex.org/W2808843365","doi":"https://doi.org/10.1016/j.smim.2018.06.001","mag":"2808843365","pmid":"https://pubmed.ncbi.nlm.nih.gov/29914653"},"language":"en","primary_location":{"id":"doi:10.1016/j.smim.2018.06.001","doi":"https://doi.org/10.1016/j.smim.2018.06.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.smim.2018.06.001","pdf_url":null,"source":{"id":"https://openalex.org/S161731549","display_name":"Seminars in Immunology","issn_l":"1044-5323","issn":["1044-5323","1096-3618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003619189","display_name":"Stephanus Theron Malherbe","orcid":"https://orcid.org/0000-0002-7563-8231","observed_orcids":["https://orcid.org/0000-0002-7563-8231"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Stephanus T. Malherbe","raw_affiliation_strings":["DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075472009","display_name":"L\u00e9anie Kleynhans","orcid":"https://orcid.org/0000-0003-1635-253X","observed_orcids":["https://orcid.org/0000-0003-1635-253X"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"L\u00e9anie Kleynhans","raw_affiliation_strings":["DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I26092322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022897595","display_name":"Gerhard Walzl","orcid":"https://orcid.org/0000-0003-2487-125X","observed_orcids":["https://orcid.org/0000-0003-2487-125X"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Gerhard Walzl","raw_affiliation_strings":["DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: gwalzl@sun.ac.za","DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"],"raw_orcid":"https://orcid.org/0000-0003-2487-125X","affiliations":[{"raw_affiliation_string":"DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: gwalzl@sun.ac.za","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I26092322"]},{"raw_affiliation_string":"DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I26092322"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022897595"],"corresponding_institution_ids":["https://openalex.org/I10947320","https://openalex.org/I26092322"],"apc_list":{"value":4370,"currency":"USD","value_usd":4370},"apc_paid":null,"fwci":0.2557,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.29656863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"39","issue":null,"first_page":"73","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis-vaccine-development","display_name":"tuberculosis vaccine development","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/imaging-tools","display_name":"imaging tools","score":0.6079999804496765},{"id":"https://openalex.org/keywords/latent-tuberculosis-infection","display_name":"latent tuberculosis infection","score":0.5740000009536743},{"id":"https://openalex.org/keywords/subclinical-tuberculosis","display_name":"subclinical tuberculosis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/tuberculosis-relapse","display_name":"tuberculosis relapse","score":0.7540000081062317},{"id":"https://openalex.org/keywords/early-infection","display_name":"early infection","score":0.5329999923706055},{"id":"https://openalex.org/keywords/bacterial-load","display_name":"bacterial load","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.7505091428756714},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.687830924987793},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6608827710151672},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.655315101146698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6433034539222717},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4930092990398407},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3481329083442688},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.31908223032951355},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15687251091003418}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013183","descriptor_name":"Sputum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D032581","descriptor_name":"Tuberculosis Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055985","descriptor_name":"Latent Tuberculosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D055985","descriptor_name":"Latent Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055985","descriptor_name":"Latent Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D055985","descriptor_name":"Latent Tuberculosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.smim.2018.06.001","doi":"https://doi.org/10.1016/j.smim.2018.06.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.smim.2018.06.001","pdf_url":null,"source":{"id":"https://openalex.org/S161731549","display_name":"Seminars in Immunology","issn_l":"1044-5323","issn":["1044-5323","1096-3618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Immunology","raw_type":"journal-article"},{"id":"pmid:29914653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29914653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W198142007","https://openalex.org/W890916005","https://openalex.org/W1496499242","https://openalex.org/W1540889530","https://openalex.org/W1826311018","https://openalex.org/W1840825137","https://openalex.org/W1871263388","https://openalex.org/W1967362871","https://openalex.org/W1967594644","https://openalex.org/W1971792821","https://openalex.org/W1971805575","https://openalex.org/W1973789730","https://openalex.org/W1977033353","https://openalex.org/W1977639829","https://openalex.org/W1989232379","https://openalex.org/W1989826112","https://openalex.org/W1992097684","https://openalex.org/W1992214887","https://openalex.org/W1992279490","https://openalex.org/W2000241568","https://openalex.org/W2002991152","https://openalex.org/W2005620571","https://openalex.org/W2008411978","https://openalex.org/W2014732976","https://openalex.org/W2017238103","https://openalex.org/W2028868357","https://openalex.org/W2031450179","https://openalex.org/W2036597270","https://openalex.org/W2036637841","https://openalex.org/W2043193112","https://openalex.org/W2052957181","https://openalex.org/W2055262996","https://openalex.org/W2065049812","https://openalex.org/W2065504863","https://openalex.org/W2071388966","https://openalex.org/W2075344979","https://openalex.org/W2092448486","https://openalex.org/W2096913570","https://openalex.org/W2097225219","https://openalex.org/W2099871245","https://openalex.org/W2101006059","https://openalex.org/W2111744777","https://openalex.org/W2112088257","https://openalex.org/W2124508731","https://openalex.org/W2127794387","https://openalex.org/W2128600803","https://openalex.org/W2128693605","https://openalex.org/W2132555469","https://openalex.org/W2135868268","https://openalex.org/W2136173889","https://openalex.org/W2136190705","https://openalex.org/W2138041013","https://openalex.org/W2138222315","https://openalex.org/W2140708650","https://openalex.org/W2140969120","https://openalex.org/W2142044793","https://openalex.org/W2142893183","https://openalex.org/W2145938281","https://openalex.org/W2149389548","https://openalex.org/W2153416012","https://openalex.org/W2157354429","https://openalex.org/W2161458072","https://openalex.org/W2164008726","https://openalex.org/W2165885466","https://openalex.org/W2168066272","https://openalex.org/W2169602677","https://openalex.org/W2169831776","https://openalex.org/W2181646849","https://openalex.org/W2276230520","https://openalex.org/W2321738133","https://openalex.org/W2411865353","https://openalex.org/W2413430220","https://openalex.org/W2489518495","https://openalex.org/W2510407367","https://openalex.org/W2514983845","https://openalex.org/W2525562806","https://openalex.org/W2555703133","https://openalex.org/W2583907366","https://openalex.org/W2590105546","https://openalex.org/W2605040531","https://openalex.org/W2613567896","https://openalex.org/W2621785961","https://openalex.org/W2742907526","https://openalex.org/W2752315601","https://openalex.org/W2770157003","https://openalex.org/W2784242447","https://openalex.org/W2786068252","https://openalex.org/W6629720731","https://openalex.org/W6638792221","https://openalex.org/W6726090027","https://openalex.org/W6732575555","https://openalex.org/W6743869771"],"related_works":["https://openalex.org/W3135494135","https://openalex.org/W2326410252","https://openalex.org/W2379825952","https://openalex.org/W2972554714","https://openalex.org/W2945315710","https://openalex.org/W2096913570","https://openalex.org/W2078921741","https://openalex.org/W2146225837","https://openalex.org/W4410827365","https://openalex.org/W4411690840"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-29T00:00:00"}