{"id":"https://openalex.org/W2808812349","doi":"https://doi.org/10.2337/db18-1752-p","title":"Phosphoregulation Profiles of Transcription Factors during Early Stage of Thermogenesis in Brown Fat","display_name":"Phosphoregulation Profiles of Transcription Factors during Early Stage of Thermogenesis in Brown Fat","publication_year":2018,"publication_date":"2018-06-22","ids":{"openalex":"https://openalex.org/W2808812349","doi":"https://doi.org/10.2337/db18-1752-p","mag":"2808812349"},"language":"en","primary_location":{"id":"doi:10.2337/db18-1752-p","doi":"https://doi.org/10.2337/db18-1752-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db18-1752-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"XIAOJING GAO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"XIAOJING GAO","raw_affiliation_strings":["Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09622217,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.9750000238418579},{"id":"https://openalex.org/keywords/non-shivering-thermogenesis","display_name":"non-shivering thermogenesis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/transcription-factor-phosphorylation","display_name":"transcription factor phosphorylation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/phosphoproteome","display_name":"phosphoproteome","score":0.9380000233650208},{"id":"https://openalex.org/keywords/norepinephrine-stimulation","display_name":"norepinephrine stimulation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/prdm16","display_name":"PRDM16","score":0.9900000095367432},{"id":"https://openalex.org/keywords/rip140","display_name":"RIP140","score":0.9980000257492065},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.5260000228881836},{"id":"https://openalex.org/keywords/atf2","display_name":"ATF2","score":0.996999979019165},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.6460000276565552},{"id":"https://openalex.org/keywords/obesity-treatment","display_name":"obesity treatment","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.776310920715332},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.685375988483429},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5663113594055176},{"id":"https://openalex.org/C81979416","wikidata":"https://www.wikidata.org/wiki/Q419493","display_name":"Thermogenin","level":4,"score":0.5517958998680115},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5446126461029053},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42441457509994507},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42261821031570435},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.41598737239837646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36514580249786377},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20184674859046936},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.19287538528442383},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1876707673072815},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db18-1752-p","doi":"https://doi.org/10.2337/db18-1752-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db18-1752-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1988534457","https://openalex.org/W2162186867","https://openalex.org/W7138826124","https://openalex.org/W2955880526","https://openalex.org/W2313332065","https://openalex.org/W4284889292","https://openalex.org/W7053177696","https://openalex.org/W2586730869","https://openalex.org/W7220919366","https://openalex.org/W4210522665"],"abstract_inverted_index":{"Brown":[0],"adipose":[1],"receives":[2],"extensive":[3],"attention":[4],"for":[5,60,64,76,233,248,265],"dissipating":[6],"stored":[7],"chemical":[8],"energy":[9,263],"in":[10,215,253],"heat":[11],"via":[12],"nonshivering":[13],"thermogenesis.":[14,231],"However,":[15],"whether":[16],"and":[17,49,73,87,147,155,181,192,197,228,269],"how":[18],"the":[19,38,47,61,109,124,157,234],"dynamics":[20],"of":[21,31,53,171,187,241,251,267],"key":[22],"transcription":[23,94,148],"factors":[24],"(TFs)":[25],"phosphorylation":[26,51,185],"contributes":[27],"to":[28,45,56,123,133,175,261],"initial":[29,249],"activation":[30,63,250],"thermogenesis":[32,65,252],"remains":[33],"unknown.":[34],"Here,":[35],"we":[36,207],"employed":[37],"stat-of-the-art":[39],"data-independent":[40],"acquisition":[41],"(DIA)":[42],"mass":[43],"spectrometry":[44],"explore":[46],"global":[48,127],"temporal":[50,238],"profiles":[52,240],"signaling":[54],"networks":[55],"elucidate":[57],"mechanism":[58],"responsible":[59],"TF":[62],"gene":[66],"transcription.":[67,205],"The":[68,126,150],"nucleus":[69],"was":[70,113,259],"isolated":[71],"before":[72,163],"after":[74],"stimulation":[75],"5,":[77],"10,":[78],"20,":[79],"30,":[80],"40,":[81],"45,":[82],"50,":[83],"55,":[84],"60,":[85],"70":[86],"80":[88],"min":[89],"with":[90,101,203],"NE.":[91],"Consequently,":[92],"401":[93],"regulators":[95,170],"bearing":[96],"1007":[97],"phosphosites":[98,212],"were":[99,173],"identified":[100],"high":[102],"reproducibility":[103],"across":[104],"12":[105],"time":[106],"points.":[107],"Firstly,":[108],"UCP1":[110,144,164,172,204],"transcriptional":[111,169,226],"level":[112],"measured,":[114],"which":[115,135,161,243],"began":[116,194],"at":[117,159],"30min,":[118,196],"then":[119],"rose":[120],"until":[121,199],"70min":[122],"peakedness.":[125],"phosphoproteome":[128],"displayed":[129],"dramatic":[130],"changes":[131],"early":[132],"20-30min,":[134],"could":[136],"be":[137,176,245],"classified":[138],"into":[139],"two":[140],"dynamic":[141],"clusters,":[142],"namely":[143],"pre-transcription":[145],"phase":[146],"phase.":[149],"former":[151],"changed":[152],"from":[153,195],"5min,":[154],"reached":[156],"extremum":[158],"20-40min,":[160],"functioned":[162],"action.":[165],"Some":[166],"well-":[167],"characterized":[168],"founded":[174],"phosphorylated,":[177],"such":[178,189],"as":[179,190],"PRDM16":[180],"RIP140.":[182],"Alternatively,":[183],"other":[184,270],"events":[186],"TFs":[188],"Jun":[191],"ATF2":[193],"maintained":[198],"70min,":[200],"almost":[201],"synchronizing":[202],"Intriguingly,":[206],"found":[208],"THRAP3":[209,223],"posed":[210],"multiple":[211],"but":[213],"involving":[214],"different":[216],"regulation":[217,227],"patterns.":[218],"This":[219],"might":[220,244],"indicate":[221],"that":[222],"had":[224],"distinct":[225],"functions":[229],"upon":[230],"We,":[232],"first":[235],"time,":[236],"uncovered":[237],"phosphoregulation":[239],"TFs,":[242],"potentially":[246],"required":[247],"brown":[254],"fat.":[255],"A":[256],"new":[257],"sight":[258],"provided":[260],"increase":[262],"expenditure":[264],"treatment":[266],"obesity":[268],"metabolic":[271],"syndrome.":[272],"Disclosure":[273],"X.":[274],"Gao:":[275],"None.":[276]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-29T00:00:00"}
