{"id":"https://openalex.org/W2808779054","doi":"https://doi.org/10.1002/chem.201801734","title":"Rational Design of a 310\u2010Helical PIP\u2010Box Mimetic Targeting PCNA, the Human Sliding Clamp","display_name":"Rational Design of a 310\u2010Helical PIP\u2010Box Mimetic Targeting PCNA, the Human Sliding Clamp","publication_year":2018,"publication_date":"2018-06-19","ids":{"openalex":"https://openalex.org/W2808779054","doi":"https://doi.org/10.1002/chem.201801734","mag":"2808779054","pmid":"https://pubmed.ncbi.nlm.nih.gov/29917264"},"language":"en","primary_location":{"id":"doi:10.1002/chem.201801734","doi":"https://doi.org/10.1002/chem.201801734","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chem.201801734","pdf_url":null,"source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035215848","display_name":"Kate L. Wegener","orcid":"https://orcid.org/0000-0002-1562-6060","observed_orcids":["https://orcid.org/0000-0002-1562-6060"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kate L. Wegener","raw_affiliation_strings":["Institute for Photonics and Advanced Sensing (IPAS), School of Biological Sciences, The University of Adelaide, South Australia, 5005 Australia"],"raw_orcid":"https://orcid.org/0000-0002-1562-6060","affiliations":[{"raw_affiliation_string":"Institute for Photonics and Advanced Sensing (IPAS), School of Biological Sciences, The University of Adelaide, South Australia, 5005 Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045661568","display_name":"Amy E. McGrath","orcid":"https://orcid.org/0000-0001-9408-4521","observed_orcids":["https://orcid.org/0000-0001-9408-4521"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Amy E. McGrath","raw_affiliation_strings":["Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, NSW, 2522 Australia"],"raw_orcid":"https://orcid.org/0000-0001-9408-4521","affiliations":[{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, NSW, 2522 Australia","institution_ids":["https://openalex.org/I204824540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011359890","display_name":"Nicholas E. Dixon","orcid":"https://orcid.org/0000-0002-5958-6945","observed_orcids":["https://orcid.org/0000-0002-5958-6945"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicholas E. Dixon","raw_affiliation_strings":["Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, NSW, 2522 Australia"],"raw_orcid":"https://orcid.org/0000-0002-5958-6945","affiliations":[{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, NSW, 2522 Australia","institution_ids":["https://openalex.org/I204824540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067844458","display_name":"Aaron J. Oakley","orcid":"https://orcid.org/0000-0002-4764-014X","observed_orcids":["https://orcid.org/0000-0002-4764-014X"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Aaron J. Oakley","raw_affiliation_strings":["Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, NSW, 2522 Australia"],"raw_orcid":"https://orcid.org/0000-0002-4764-014X","affiliations":[{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, NSW, 2522 Australia","institution_ids":["https://openalex.org/I204824540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014978932","display_name":"Denis B. Scanlon","orcid":"https://orcid.org/0000-0003-0960-8197","observed_orcids":["https://orcid.org/0000-0003-0960-8197"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Denis B. Scanlon","raw_affiliation_strings":["Department of Chemistry, The University of Adelaide, South Australia, 5005 Australia"],"raw_orcid":"https://orcid.org/0000-0003-0960-8197","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Adelaide, South Australia, 5005 Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033537928","display_name":"Andrew David Abell","orcid":"https://orcid.org/0000-0002-0604-2629","observed_orcids":["https://orcid.org/0000-0002-0604-2629"]},"institutions":[{"id":"https://openalex.org/I4391768102","display_name":"ARC Centre for Nanoscale BioPhotonics","ror":"https://ror.org/00g76w893","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4391768102"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew D. Abell","raw_affiliation_strings":["Institute for Photonics and Advanced Sensing (IPAS), Department of Chemistry, and the Centre for Nanoscale BioPhotonics, The University of Adelaide, South Australia, 5005 Australia"],"raw_orcid":"https://orcid.org/0000-0002-0604-2629","affiliations":[{"raw_affiliation_string":"Institute for Photonics and Advanced Sensing (IPAS), Department of Chemistry, and the Centre for Nanoscale BioPhotonics, The University of Adelaide, South Australia, 5005 Australia","institution_ids":["https://openalex.org/I4391768102","https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059039218","display_name":"John B. Bruning","orcid":"https://orcid.org/0000-0002-6919-1824","observed_orcids":["https://orcid.org/0000-0002-6919-1824"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"John B. Bruning","raw_affiliation_strings":["Institute for Photonics and Advanced Sensing (IPAS), School of Biological Sciences, The University of Adelaide, South Australia, 5005 Australia"],"raw_orcid":"https://orcid.org/0000-0002-6919-1824","affiliations":[{"raw_affiliation_string":"Institute for Photonics and Advanced Sensing (IPAS), School of Biological Sciences, The University of Adelaide, South Australia, 5005 Australia","institution_ids":["https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059039218"],"corresponding_institution_ids":["https://openalex.org/I5681781"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":0.7998,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.69191226,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"24","issue":"44","first_page":"11325","last_page":"11331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pcna","display_name":"PCNA","score":0.9520000219345093},{"id":"https://openalex.org/keywords/sliding-clamp","display_name":"sliding clamp","score":0.7710000276565552},{"id":"https://openalex.org/keywords/pip-box","display_name":"PIP box","score":0.925000011920929},{"id":"https://openalex.org/keywords/peptidomimetics","display_name":"peptidomimetics","score":0.843999981880188},{"id":"https://openalex.org/keywords/310-helix","display_name":"310-helix","score":0.9670000076293945},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.781000018119812},{"id":"https://openalex.org/keywords/protein-protein-interaction-inhibitors","display_name":"protein-protein interaction inhibitors","score":0.8519999980926514},{"id":"https://openalex.org/keywords/dna-replication-inhibitors","display_name":"DNA replication inhibitors","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cancer-therapeutics","display_name":"cancer therapeutics","score":0.6830000281333923},{"id":"https://openalex.org/keywords/co-crystal-structure","display_name":"co-crystal structure","score":0.7450000047683716},{"id":"https://openalex.org/keywords/rational-peptide-design","display_name":"rational peptide design","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2776161997","wikidata":"https://www.wikidata.org/wiki/Q846600","display_name":"Clamp","level":3,"score":0.7365867495536804},{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.624217689037323},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.49732163548469543},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3904631435871124},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3541003465652466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3339330554008484},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33383822441101074},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3314962387084961},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30637380480766296},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2485012412071228},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1676982343196869},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.11785006523132324},{"id":"https://openalex.org/C84111939","wikidata":"https://www.wikidata.org/wiki/Q5125465","display_name":"Clamping","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057786","descriptor_name":"Peptidomimetics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/chem.201801734","doi":"https://doi.org/10.1002/chem.201801734","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chem.201801734","pdf_url":null,"source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},{"id":"pmid:29917264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29917264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry (Weinheim an der Bergstrasse, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:ro.uow.edu.au:smhpapers1-1114","doi":null,"is_oa":false,"landing_page_url":"https://ro.uow.edu.au/smhpapers1/113","pdf_url":null,"source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty of Science, Medicine and Health - Papers: Part B","raw_type":"article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/117190","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2440/117190","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dx.doi.org/10.1002/chem.201801734","raw_type":"Journal article"},{"id":"pmh:oai:figshare.com:article/27780345","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/Rational_Design_of_a_310-Helical_PIP-Box_Mimetic_Targeting_PCNA_the_Human_Sliding_Clamp/27780345","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5603111460","display_name":"ARC Centre of Excellence for Nanoscale BioPhotonics","funder_award_id":"CE140100003","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G8855319142","display_name":"Molecular Interactions with an antibiotic target in DNA replication","funder_award_id":"DP180100805","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"}],"funders":[{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W137428939","https://openalex.org/W198782672","https://openalex.org/W1535608802","https://openalex.org/W1551855406","https://openalex.org/W1576533924","https://openalex.org/W1967671116","https://openalex.org/W1971495173","https://openalex.org/W1978176012","https://openalex.org/W1980116731","https://openalex.org/W1987177096","https://openalex.org/W2007141443","https://openalex.org/W2016706363","https://openalex.org/W2025572038","https://openalex.org/W2029309152","https://openalex.org/W2054731547","https://openalex.org/W2055260065","https://openalex.org/W2056283033","https://openalex.org/W2059214032","https://openalex.org/W2061731390","https://openalex.org/W2062143483","https://openalex.org/W2067517099","https://openalex.org/W2086372997","https://openalex.org/W2088955873","https://openalex.org/W2090050796","https://openalex.org/W2103638753","https://openalex.org/W2110927313","https://openalex.org/W2116537286","https://openalex.org/W2124026197","https://openalex.org/W2132629607","https://openalex.org/W2133179696","https://openalex.org/W2135338948","https://openalex.org/W2147949826","https://openalex.org/W2154197653","https://openalex.org/W2154714625","https://openalex.org/W2169707043","https://openalex.org/W2262861430","https://openalex.org/W2320758425","https://openalex.org/W2334400090","https://openalex.org/W2412882054","https://openalex.org/W2526993267"],"related_works":["https://openalex.org/W2953504204","https://openalex.org/W6991978959","https://openalex.org/W3160642445","https://openalex.org/W2344921244","https://openalex.org/W1971406651","https://openalex.org/W2062143483","https://openalex.org/W4225117690","https://openalex.org/W2946957646","https://openalex.org/W2262861430","https://openalex.org/W2346160190"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"human":[2],"sliding":[3],"clamp":[4],"(PCNA)":[5],"controls":[6],"access":[7],"to":[8,22,75,118,152,182],"DNA":[9,15,55],"for":[10,127,191,195],"many":[11],"proteins":[12],"involved":[13],"in":[14,59,143,175],"replication":[16,56],"and":[17,57,85,166],"repair.":[18],"Proteins":[19],"are":[20],"recruited":[21],"the":[23,36,82,88,95,101,120,123,135,168,176],"PCNA":[24,77,90,103,128,170,192],"surface":[25],"by":[26,53],"means":[27],"of":[28,42,87,114,179],"a":[29,71,187],"short,":[30],"conserved":[31],"peptide":[32,65,138],"motif":[33],"known":[34,163],"as":[35,50,70,173,197],"PCNA\u2010interacting":[37],"protein":[38],"box":[39],"(PIP\u2010box).":[40],"Inhibitors":[41],"these":[43,60],"essential":[44],"protein\u2010protein":[45],"interactions":[46],"may":[47],"be":[48],"useful":[49],"cancer":[51],"therapeutics":[52],"disrupting":[54],"repair":[58],"highly":[61],"proliferative":[62],"cells.":[63],"PIP\u2010box":[64,98,164],"mimetics":[66,107],"have":[67],"been":[68],"identified":[69],"potentially":[72],"rapid":[73],"route":[74],"potent":[76],"inhibitors.":[78],"Here":[79],"we":[80],"describe":[81],"rational":[83],"design":[84,194],"synthesis":[86],"first":[89],"peptidomimetic":[91],"ligands,":[92],"based":[93],"on":[94],"high":[96],"affinity":[97,159],"sequence":[99],"from":[100],"natural":[102],"inhibitor":[104,193],"p21.":[105],"These":[106],"incorporate":[108],"covalent":[109],"i,i+4":[110],"side\u2010chain/side\u2010chain":[111],"lactam":[112],"linkages":[113],"different":[115],"lengths,":[116],"designed":[117],"constrain":[119],"peptides":[121],"into":[122,148],"310\u2010helical":[124,149],"structure":[125,142,150,178],"required":[126],"binding.":[129],"NMR":[130],"studies":[131],"confirmed":[132],"that":[133],"while":[134],"unmodified":[136],"p21":[137],"had":[139],"little":[140],"defined":[141],"solution,":[144],"mimetic":[145],"ACR2":[146,156,180],"pre\u2010organized":[147],"prior":[151],"interaction":[153],"with":[154],"PCNA.":[155,183],"displayed":[157],"higher":[158],"binding":[160,171],"than":[161],"most":[162],"peptides,":[165],"retains":[167],"native":[169],"mode,":[172],"observed":[174],"co\u2010crystal":[177],"bound":[181],"This":[184],"study":[185],"offers":[186],"promising":[188],"new":[189],"strategy":[190],"use":[196],"anti\u2010cancer":[198],"therapeutics.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-29T00:00:00"}