{"id":"https://openalex.org/W2808775342","doi":"https://doi.org/10.2210/pdb5m6u/pdb","title":"Discovery of a Potent, Selective, and Orally Available PI3K delta Inhibitor for the Treatment of Inflammatory Diseases.","display_name":"Discovery of a Potent, Selective, and Orally Available PI3K delta Inhibitor for the Treatment of Inflammatory Diseases.","publication_year":2017,"publication_date":"2017-01-31","ids":{"openalex":"https://openalex.org/W2808775342","doi":"https://doi.org/10.2210/pdb5m6u/pdb","mag":"2808775342"},"language":"en","primary_location":{"id":"mag:2808775342","doi":"https://doi.org/10.2210/pdb5m6u/pdb","is_oa":false,"landing_page_url":"https://www.rcsb.org/structure/5M6U","pdf_url":null,"source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":null},"volume":null,"type":"dataset","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043121710","display_name":"Montse Erra","orcid":"https://orcid.org/0000-0002-8753-8692","observed_orcids":["https://orcid.org/0000-0002-8753-8692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Montse Erra","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8753-8692","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083380380","display_name":"Joan Taltavull","orcid":"https://orcid.org/0000-0002-5199-5349","observed_orcids":["https://orcid.org/0000-0002-5199-5349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joan Taltavull","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5199-5349","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022272257","display_name":"Angelique Gr\u00e9co","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angelique Gr\u00e9co","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Francisco Javier Valera Bernal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francisco Javier Valera Bernal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078870010","display_name":"Juan Francisco Caturla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Francisco Caturla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090600841","display_name":"Jordi Gr\u00e0cia","orcid":"https://orcid.org/0000-0002-7470-6933","observed_orcids":["https://orcid.org/0000-0002-7470-6933"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordi Gr\u00e0cia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7470-6933","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113212830","display_name":"M.-A. Dominguez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.-A. Dominguez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064529065","display_name":"Mar Sabat\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar Sabat\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036394320","display_name":"St\u00e9phane Paris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"St\u00e9phane Paris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077414352","display_name":"Salom\u00e9 Soria","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salom\u00e9 Soria","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113792125","display_name":"Bego\u00f1a Hern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bego\u00f1a Hern\u00e1ndez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091059469","display_name":"Clara Armengol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clara Armengol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062369842","display_name":"Judit Cabedo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judit Cabedo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022243738","display_name":"M\u00f3nica Bravo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M\u00f3nica Bravo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033902407","display_name":"Elena Calama","orcid":"https://orcid.org/0000-0001-5294-6445","observed_orcids":["https://orcid.org/0000-0001-5294-6445"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Calama","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5294-6445","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011244775","display_name":"Montserrat Miralpeix","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Montserrat Miralpeix","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Lehner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lehner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":null,"first_page":"118","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3kdelta-inhibitor","display_name":"PI3K\u03b4 inhibitor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.6539999842643738},{"id":"https://openalex.org/keywords/selective-kinase-inhibitors","display_name":"selective kinase inhibitors","score":0.6650000214576721},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.8880000114440918},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.6190000176429749},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5664717555046082},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48591914772987366},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33596694469451904}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2808775342","doi":"https://doi.org/10.2210/pdb5m6u/pdb","is_oa":false,"landing_page_url":"https://www.rcsb.org/structure/5M6U","pdf_url":null,"source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1694144932","https://openalex.org/W2560024871","https://openalex.org/W6967096410","https://openalex.org/W6941107738","https://openalex.org/W2788159312","https://openalex.org/W2752232786","https://openalex.org/W6888864871","https://openalex.org/W2521225321","https://openalex.org/W2255781431","https://openalex.org/W2410869890"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-29T00:00:00"}