{"id":"https://openalex.org/W2808765249","doi":"https://doi.org/10.25557/2073-7998.2018.05.39-46","title":"\u0413\u0440\u0443\u0437 \u0438 \u0440\u0430\u0437\u043d\u043e\u043e\u0431\u0440\u0430\u0437\u0438\u0435 \u043d\u0430\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u0441\u043a\u0435\u043b\u0435\u0442\u0430 \u0443 \u0434\u0435\u0442\u0441\u043a\u043e\u0433\u043e \u043d\u0430\u0441\u0435\u043b\u0435\u043d\u0438\u044f 12 \u0440\u0430\u0439\u043e\u043d\u043e\u0432 \u0432 \u0420\u043e\u0441\u0442\u043e\u0432\u0441\u043a\u043e\u0439 \u043e\u0431\u043b\u0430\u0441\u0442\u0438","display_name":"\u0413\u0440\u0443\u0437 \u0438 \u0440\u0430\u0437\u043d\u043e\u043e\u0431\u0440\u0430\u0437\u0438\u0435 \u043d\u0430\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u0441\u043a\u0435\u043b\u0435\u0442\u0430 \u0443 \u0434\u0435\u0442\u0441\u043a\u043e\u0433\u043e \u043d\u0430\u0441\u0435\u043b\u0435\u043d\u0438\u044f 12 \u0440\u0430\u0439\u043e\u043d\u043e\u0432 \u0432 \u0420\u043e\u0441\u0442\u043e\u0432\u0441\u043a\u043e\u0439 \u043e\u0431\u043b\u0430\u0441\u0442\u0438","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2808765249","doi":"https://doi.org/10.25557/2073-7998.2018.05.39-46","mag":"2808765249"},"language":"ru","primary_location":{"id":"mag:2808765249","doi":"https://doi.org/10.25557/2073-7998.2018.05.39-46","is_oa":false,"landing_page_url":"https://www.medgen-journal.ru/jour/article/view/439/316","pdf_url":null,"source":{"id":"https://openalex.org/S4210224986","display_name":"Nauchno-prakticheskii zhurnal \u00abMedicinskaia genetika\u00bb","issn_l":"2073-7998","issn":["2073-7998"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430\u044f \u0433\u0435\u043d\u0435\u0442\u0438\u043a\u0430","raw_type":null},"parent_works":[],"lineage":["https://openalex.org/W2808765249"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.medgen-journal.ru/jour/article/view/439","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061402999","display_name":"R. A. Valkov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799351582","display_name":"Russian Railways","ror":"https://ror.org/02zjtq409","country_code":"RU","type":"government","lineage":["https://openalex.org/I2799351582"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"R. A. Valkov","raw_affiliation_strings":["\u041d\u0435\u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0435 \u0443\u0447\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u00ab\u0414\u043e\u0440\u043e\u0436\u043d\u0430\u044f \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0431\u043e\u043b\u044c\u043d\u0438\u0446\u0430 \u043d\u0430 \u0441\u0442\u0430\u043d\u0446\u0438\u0438 \u0420\u043e\u0441\u0442\u043e\u0432-\u0413\u043b\u0430\u0432\u043d\u044b\u0439 \u041e\u0410\u041e \u00ab\u0420\u0416\u0414\u00bb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u041d\u0435\u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0435 \u0443\u0447\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u00ab\u0414\u043e\u0440\u043e\u0436\u043d\u0430\u044f \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0431\u043e\u043b\u044c\u043d\u0438\u0446\u0430 \u043d\u0430 \u0441\u0442\u0430\u043d\u0446\u0438\u0438 \u0420\u043e\u0441\u0442\u043e\u0432-\u0413\u043b\u0430\u0432\u043d\u044b\u0439 \u041e\u0410\u041e \u00ab\u0420\u0416\u0414\u00bb","institution_ids":["https://openalex.org/I2799351582"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038580542","display_name":"Svetlana S. Amelina","orcid":"https://orcid.org/0000-0001-7957-790X","observed_orcids":["https://orcid.org/0000-0001-7957-790X"]},"institutions":[{"id":"https://openalex.org/I16478408","display_name":"Rostov State Medical University","ror":"https://ror.org/046a1ah60","country_code":"RU","type":"education","lineage":["https://openalex.org/I16478408"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"\u0421. \u0421. \u0410\u043c\u0435\u043b\u0438\u043d\u0430","raw_affiliation_strings":["\u0424\u0413\u0411\u041e\u0423 \u0412\u041e \u00ab\u0420\u043e\u0441\u0442\u043e\u0432\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u00bb \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0424\u0413\u0411\u041e\u0423 \u0412\u041e \u00ab\u0420\u043e\u0441\u0442\u043e\u0432\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u00bb \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438","institution_ids":["https://openalex.org/I16478408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109331327","display_name":"\u041b. \u041a. \u041c\u0438\u0445\u0430\u0439\u043b\u043e\u0432\u0430","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109445","display_name":"Central Scientific Research Institute of Traumatology and Orthopedics","ror":"https://ror.org/022d6m891","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210109445"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"\u041b. \u041a. \u041c\u0438\u0445\u0430\u0439\u043b\u043e\u0432\u0430","raw_affiliation_strings":["\u0424\u0413\u0411\u0423 \u00ab\u0426\u0435\u043d\u0442\u0440\u0430\u043b\u044c\u043d\u044b\u0439 \u043d\u0430\u0443\u0447\u043d\u043e-\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u0442\u0440\u0430\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043e\u0440\u0442\u043e\u043f\u0435\u0434\u0438\u0438 \u0438\u043c\u0435\u043d\u0438 \u041d.\u041d. \u041f\u0440\u0438\u043e\u0440\u043e\u0432\u0430\u00bb \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0424\u0413\u0411\u0423 \u00ab\u0426\u0435\u043d\u0442\u0440\u0430\u043b\u044c\u043d\u044b\u0439 \u043d\u0430\u0443\u0447\u043d\u043e-\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u0442\u0440\u0430\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043e\u0440\u0442\u043e\u043f\u0435\u0434\u0438\u0438 \u0438\u043c\u0435\u043d\u0438 \u041d.\u041d. \u041f\u0440\u0438\u043e\u0440\u043e\u0432\u0430\u00bb \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438","institution_ids":["https://openalex.org/I4210109445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013907580","display_name":"\u041d. \u0412. \u0412\u0435\u0442\u0440\u043e\u0432\u0430","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137534880","display_name":"Southern Federal University","ror":"https://ror.org/01tv9ph92","country_code":"RU","type":"education","lineage":["https://openalex.org/I137534880"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"\u041d. \u0412. \u0412\u0435\u0442\u0440\u043e\u0432\u0430","raw_affiliation_strings":["\u0410\u043a\u0430\u0434\u0435\u043c\u0438\u044f \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0438\u043c. \u0414.\u0418. \u0418\u0432\u0430\u043d\u043e\u0432\u0441\u043a\u043e\u0433\u043e \u0424\u0413\u0410\u041e\u0423 \u0412\u041e \u00ab\u042e\u0436\u043d\u044b\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u044b\u0439 \u0423\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u00bb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0410\u043a\u0430\u0434\u0435\u043c\u0438\u044f \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0438\u043c. \u0414.\u0418. \u0418\u0432\u0430\u043d\u043e\u0432\u0441\u043a\u043e\u0433\u043e \u0424\u0413\u0410\u041e\u0423 \u0412\u041e \u00ab\u042e\u0436\u043d\u044b\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u044b\u0439 \u0423\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u00bb","institution_ids":["https://openalex.org/I137534880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080586686","display_name":"Tatiana Ivanovna Ponomareva","orcid":"https://orcid.org/0000-0003-0347-8440","observed_orcids":["https://orcid.org/0000-0003-0347-8440"]},"institutions":[{"id":"https://openalex.org/I16478408","display_name":"Rostov State Medical University","ror":"https://ror.org/046a1ah60","country_code":"RU","type":"education","lineage":["https://openalex.org/I16478408"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"\u0422. \u0418. \u041f\u043e\u043d\u043e\u043c\u0430\u0440\u0435\u0432\u0430","raw_affiliation_strings":["\u0424\u0413\u0411\u041e\u0423 \u0412\u041e \u00ab\u0420\u043e\u0441\u0442\u043e\u0432\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u00bb \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0424\u0413\u0411\u041e\u0423 \u0412\u041e \u00ab\u0420\u043e\u0441\u0442\u043e\u0432\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u00bb \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438","institution_ids":["https://openalex.org/I16478408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015814371","display_name":"Maria Aleksandrovna Amelina","orcid":"https://orcid.org/0000-0003-3545-1365","observed_orcids":["https://orcid.org/0000-0003-3545-1365","https://orcid.org/0000-0002-0972-5118"]},"institutions":[{"id":"https://openalex.org/I137534880","display_name":"Southern Federal University","ror":"https://ror.org/01tv9ph92","country_code":"RU","type":"education","lineage":["https://openalex.org/I137534880"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maria Amelina","raw_affiliation_strings":["\u0410\u043a\u0430\u0434\u0435\u043c\u0438\u044f \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0438\u043c. \u0414.\u0418. \u0418\u0432\u0430\u043d\u043e\u0432\u0441\u043a\u043e\u0433\u043e \u0424\u0413\u0410\u041e\u0423 \u0412\u041e \u00ab\u042e\u0436\u043d\u044b\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u044b\u0439 \u0423\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u00bb"],"raw_orcid":"https://orcid.org/0009-0005-1780-3402","affiliations":[{"raw_affiliation_string":"\u0410\u043a\u0430\u0434\u0435\u043c\u0438\u044f \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u0431\u0438\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0438\u043c. \u0414.\u0418. \u0418\u0432\u0430\u043d\u043e\u0432\u0441\u043a\u043e\u0433\u043e \u0424\u0413\u0410\u041e\u0423 \u0412\u041e \u00ab\u042e\u0436\u043d\u044b\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u044b\u0439 \u0423\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u00bb","institution_ids":["https://openalex.org/I137534880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038436430","display_name":"Rena A. Zinchenko","orcid":"https://orcid.org/0000-0003-3586-3458","observed_orcids":["https://orcid.org/0000-0003-3586-3458"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"\u0420. \u0410. \u0417\u0438\u043d\u0447\u0435\u043d\u043a\u043e","raw_affiliation_strings":["\u0424\u0413\u0411\u041d\u0423 \u00ab\u041c\u0435\u0434\u0438\u043a\u043e-\u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u043d\u0430\u0443\u0447\u043d\u044b\u0439 \u0446\u0435\u043d\u0442\u0440\u00bb; \u0424\u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u00ab\u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0439 \u043d\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0439 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0438\u043c\u0435\u043d\u0438 \u041d.\u0418. \u041f\u0438\u0440\u043e\u0433\u043e\u0432\u0430\u00bb \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438"],"raw_orcid":"https://orcid.org/0000-0003-3586-3458","affiliations":[{"raw_affiliation_string":"\u0424\u0413\u0411\u041d\u0423 \u00ab\u041c\u0435\u0434\u0438\u043a\u043e-\u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u043d\u0430\u0443\u0447\u043d\u044b\u0439 \u0446\u0435\u043d\u0442\u0440\u00bb; \u0424\u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u00ab\u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0439 \u043d\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0439 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0438\u043c\u0435\u043d\u0438 \u041d.\u0418. \u041f\u0438\u0440\u043e\u0433\u043e\u0432\u0430\u00bb \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438","institution_ids":["https://openalex.org/I337778094"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"5","first_page":"39","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.3970000147819519,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.3970000147819519,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.16429999470710754,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.12020000070333481,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetic-load","display_name":"genetic load","score":0.9480000138282776},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.49000000953674316},{"id":"https://openalex.org/keywords/rostov-oblast","display_name":"Rostov region","score":0.7319999933242798},{"id":"https://openalex.org/keywords/population-structure","display_name":"population structure","score":0.765999972820282},{"id":"https://openalex.org/keywords/inbreeding","display_name":"inbreeding","score":0.6940000057220459},{"id":"https://openalex.org/keywords/autosomal-dominant-disorder","display_name":"autosomal dominant disorder","score":0.8050000071525574},{"id":"https://openalex.org/keywords/autosomal-recessive-disorder","display_name":"autosomal recessive disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/x-linked-disorders","display_name":"X-linked disorders","score":0.9959999918937683},{"id":"https://openalex.org/keywords/urban-rural-differences","display_name":"urban-rural differences","score":0.9240000247955322},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C2777782036","wikidata":"https://www.wikidata.org/wiki/Q38978","display_name":"Inbreeding","level":3,"score":0.6612229347229004},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6503885388374329},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.5859076976776123},{"id":"https://openalex.org/C24218269","wikidata":"https://www.wikidata.org/wiki/Q1047416","display_name":"Genetic load","level":4,"score":0.5857765078544617},{"id":"https://openalex.org/C2994082534","wikidata":"https://www.wikidata.org/wiki/Q175185","display_name":"Rural population","level":3,"score":0.5617851614952087},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.4825127124786377},{"id":"https://openalex.org/C46576788","wikidata":"https://www.wikidata.org/wiki/Q5532925","display_name":"Genetic structure","level":4,"score":0.4801580309867859},{"id":"https://openalex.org/C177860879","wikidata":"https://www.wikidata.org/wiki/Q5532897","display_name":"Genetic epidemiology","level":3,"score":0.46233293414115906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42962777614593506},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.410469651222229},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.400325745344162},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3595174252986908},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3083053529262543},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1684870421886444},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2808765249","doi":"https://doi.org/10.25557/2073-7998.2018.05.39-46","is_oa":false,"landing_page_url":"https://www.medgen-journal.ru/jour/article/view/439/316","pdf_url":null,"source":{"id":"https://openalex.org/S4210224986","display_name":"Nauchno-prakticheskii zhurnal \u00abMedicinskaia genetika\u00bb","issn_l":"2073-7998","issn":["2073-7998"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430\u044f \u0433\u0435\u043d\u0435\u0442\u0438\u043a\u0430","raw_type":null},{"id":"pmh:oai:oai.medgen.elpub.ru:article/439","doi":"https://doi.org/10.25557/2073-7998.2018.05.39-46","is_oa":true,"landing_page_url":"http://www.medgen-journal.ru/jour/article/view/439","pdf_url":null,"source":{"id":"https://openalex.org/S4306400808","display_name":"Medical genetics (Research Centre of Medical Genetics of the Russian Academy of Medical Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210126689","host_organization_name":"Research Centre for Medical Genetics","host_organization_lineage":["https://openalex.org/I4210126689"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medical Genetics; \u0422\u043e\u043c 17, \u2116 5 (2018); 39-46","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:oai.medgen.elpub.ru:article/439","doi":"https://doi.org/10.25557/2073-7998.2018.05.39-46","is_oa":true,"landing_page_url":"http://www.medgen-journal.ru/jour/article/view/439","pdf_url":null,"source":{"id":"https://openalex.org/S4306400808","display_name":"Medical genetics (Research Centre of Medical Genetics of the Russian Academy of Medical Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210126689","host_organization_name":"Research Centre for Medical Genetics","host_organization_lineage":["https://openalex.org/I4210126689"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medical Genetics; \u0422\u043e\u043c 17, \u2116 5 (2018); 39-46","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2808765249.pdf","grobid_xml":"https://content.openalex.org/works/W2808765249.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2915107991"],"related_works":["https://openalex.org/W2794928959","https://openalex.org/W2329268391","https://openalex.org/W3106355940","https://openalex.org/W2094057757","https://openalex.org/W2410417316","https://openalex.org/W3116976573","https://openalex.org/W2896632494","https://openalex.org/W2911687921","https://openalex.org/W3111047430"],"abstract_inverted_index":{"The":[0,30,89,143,194],"study":[1,12,34],"presents":[2],"the":[3,19,26,33,50,60,63,69,72,77,84,93,125,135,146,149,162,168,188,191,198,205,209,214,217,221,232,235,259,262,268,272],"results":[4],"of":[5,13,22,25,32,42,47,53,62,66,71,83,92,96,99,111,129,134,148,176,181,197,202,208,216,220,226,234,238,244,248,261,265],"a":[6,245],"complex":[7],"medical":[8],"and":[9,39,45,87,106,118,152,160,170,179,228,252],"population":[10,21,52,79,95,133,207,270,274],"genetic":[11,38,43,64,127,177,218,236],"hereditary":[14,263],"skeletal":[15],"disorders":[16],"(HSD)":[17],"in":[18,49,68,76,80,145,204,250,255,267,275],"child":[20,51,78,132,206,251,269],"12":[23,81,97],"districts":[24,82,98,159,257],"Rostov":[27],"Region":[28],"(RR).":[29],"aim":[31],"was":[35,137,155,184],"to":[36,58,186],"perform":[37],"epidemiological":[40],"analysis":[41,175,243],"load":[44,74,110,128,150,178,237,247,264],"diversity":[46],"HSD":[48,73,121,130,203,239,249,266],"RR;":[54],"as":[55,57,164,166],"well":[56,165],"evaluate":[59],"role":[61],"structure":[65,219],"RR":[67,100,136,210],"differentiation":[70,144],"values":[75,147,180,233],"RR.":[85],"Materials":[86],"methods:":[88],"total":[90,126,246],"size":[91],"investigated":[94],"is":[101,122,211,240],"101845":[102],"children":[103],"(46356":[104],"urban":[105,169],"55489":[107],"rural).":[108],"A":[109,173],"autosomal":[112,115],"dominant":[113],"(AD),":[114],"recessive":[116],"(AR)":[117],"X-linked":[119],"(XL)":[120],"calculated.":[123],"Results:":[124],"among":[131],"2.47":[138],"\u00b1":[139],"0.16/1,000":[140],"(1:404":[141],"children).":[142],"(AD":[151],"AR":[153],"pathology)":[154],"identified":[156],"both":[157],"between":[158,167],"within":[161],"districts,":[163],"rural":[171],"populations.":[172],"correlation":[174],"random":[182],"inbreeding":[183],"conducted":[185],"determine":[187],"reasons":[189],"for":[190],"differences":[192],"found.":[193],"nosological":[195],"spectrum":[196],"most":[199],"frequent":[200],"forms":[201],"described.":[212],"Conclusion:":[213],"influence":[215],"studied":[222],"populations":[223,254],"(in":[224],"terms":[225],"subdivision":[227],"migration":[229],"characteristics)":[230],"on":[231],"shown.":[241],"Comparative":[242],"adult":[253,273],"different":[256],"showed":[258],"prevalence":[260],"over":[271],"0.5-3.5":[276],"times.":[277]},"counts_by_year":[],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2018-06-29T00:00:00"}