{"id":"https://openalex.org/W2808735182","doi":"https://doi.org/10.3389/fneur.2018.00549","title":"Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-\u03b2 and Tau Pathologies","display_name":"Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-\u03b2 and Tau Pathologies","publication_year":2018,"publication_date":"2018-08-14","ids":{"openalex":"https://openalex.org/W2808735182","doi":"https://doi.org/10.3389/fneur.2018.00549","mag":"2808735182","pmid":"https://pubmed.ncbi.nlm.nih.gov/30158892","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6104478"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2018.00549","doi":"https://doi.org/10.3389/fneur.2018.00549","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2018.00549","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2018.00549/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fneur.2018.00549/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001995198","display_name":"Joana Ribeiro Guedes","orcid":"https://orcid.org/0000-0001-9054-1887","observed_orcids":["https://orcid.org/0000-0001-9054-1887"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT","US"],"is_corresponding":false,"raw_author_name":"Joana R. Guedes","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States","Doctoral Programme in Experimental Biology and Biomedicine, CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Doctoral Programme in Experimental Biology and Biomedicine, CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"raw_affiliation_string":"Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042861374","display_name":"Taotao Lao","orcid":"https://orcid.org/0000-0001-9207-4071","observed_orcids":["https://orcid.org/0000-0001-9207-4071"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taotao Lao","raw_affiliation_strings":["Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069397403","display_name":"Ana Lu\u00edsa Cardoso","orcid":"https://orcid.org/0000-0001-5145-4561","observed_orcids":["https://orcid.org/0000-0001-5145-4561"]},"institutions":[{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana L. Cardoso","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101598934","display_name":"Joseph B. El Khoury","orcid":"https://orcid.org/0000-0003-1498-1703","observed_orcids":["https://orcid.org/0000-0003-1498-1703"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph El Khoury","raw_affiliation_strings":["Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States","Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101598934"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.983,"has_fulltext":true,"cited_by_count":113,"citation_normalized_percentile":{"value":0.72543742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"9","issue":null,"first_page":"549","last_page":"549"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.22419999539852142,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9549999833106995},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9520000219345093},{"id":"https://openalex.org/keywords/chemokine-receptors","display_name":"chemokine receptors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tau-pathology","display_name":"tau pathology","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/microglial-migration","display_name":"microglial migration","score":0.6669999957084656},{"id":"https://openalex.org/keywords/monocyte-recruitment","display_name":"monocyte recruitment","score":0.9449999928474426},{"id":"https://openalex.org/keywords/amyloid-beta-phagocytosis","display_name":"amyloid-beta phagocytosis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ccl2-ccr2","display_name":"CCL2/CCR2","score":0.984000027179718},{"id":"https://openalex.org/keywords/cx3cl1-cx3cr1","display_name":"CX3CL1/CX3CR1","score":0.996999979019165},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.726718544960022},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6303874254226685},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.6029843091964722},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5683535933494568},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.49932384490966797},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48650163412094116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4559193253517151},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4416861832141876},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.42671677470207214},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.319733202457428},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2881013751029968},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25894296169281006},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.21968457102775574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10471093654632568}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fneur.2018.00549","doi":"https://doi.org/10.3389/fneur.2018.00549","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2018.00549","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2018.00549/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5062037","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6104478","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6104478","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6104478","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurol","raw_type":"Text"},{"id":"pmid:30158892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30158892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neurology","raw_type":"Journal Article"},{"id":"pmh:oai:estudogeral.uc.pt:10316/107626","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10316/107626","pdf_url":"https://estudogeral.uc.pt/bitstream/10316/107626/1/Roles%20of%20microglial%20and%20monocyte%20chemokines%20and%20their%20receptors%20in%20regulating%20Alzheimer%27s%20disease-associated%20amyloid-%ce%b2%20and%20tau%20pathologies.pdf","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:44f74b68b36446d582a2f83759eb6274","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/44f74b68b36446d582a2f83759eb6274","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, Vol 9 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2018.00549","doi":"https://doi.org/10.3389/fneur.2018.00549","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2018.00549","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2018.00549/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2209288276","display_name":"MIRNA CONTRIBUTION TO THE SYSTEMIC IMMUNE RESPONSE AND MONOCYTE RECRUITMENT / FUNCTION IN ALZHEIMER\u00b4S DISEASE: A COMPARATIVE STUDY IN ALZHEIMER\u00b4S DISEASE PATIENTS AND HEALTHY AGE-MATCHED CONTROLS","funder_award_id":"SFRH/BD/51677/2011","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2315166820","display_name":"Dissecting the role of metabotropic glutamate receptor sorting proteins in autism spectrum disorders","funder_award_id":"SFRH/BPD/120611/2016","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2805299368","display_name":"The Neuroimmune System in Alzheimer's Disease","funder_award_id":"RF1AG051506","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3971940647","display_name":"Role of SCARF1 in apoptotic cell clearance and prevention of autoimmunity","funder_award_id":"R01AI119065","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7928374208","display_name":"Understanding the contribution of miRNAs to neuroinflammation in Alzheimer\u00b4s disease","funder_award_id":"SFRH/BPD/108312/2015","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G9000884655","display_name":"Research Training in Rheumatology at Massachusetts General Hospital","funder_award_id":"T32AR007258","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2808735182.pdf","grobid_xml":"https://content.openalex.org/works/W2808735182.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W1560184319","https://openalex.org/W1589197782","https://openalex.org/W1598703170","https://openalex.org/W1883181368","https://openalex.org/W1967383957","https://openalex.org/W1971390151","https://openalex.org/W1972165428","https://openalex.org/W1972958730","https://openalex.org/W1987703244","https://openalex.org/W1989038107","https://openalex.org/W1989369404","https://openalex.org/W1991457465","https://openalex.org/W1996024251","https://openalex.org/W2000668585","https://openalex.org/W2001314906","https://openalex.org/W2002670780","https://openalex.org/W2005659566","https://openalex.org/W2016575029","https://openalex.org/W2018708829","https://openalex.org/W2031144089","https://openalex.org/W2031251046","https://openalex.org/W2031743210","https://openalex.org/W2033366750","https://openalex.org/W2037172408","https://openalex.org/W2045560271","https://openalex.org/W2053128594","https://openalex.org/W2057249855","https://openalex.org/W2057532860","https://openalex.org/W2057624491","https://openalex.org/W2060964242","https://openalex.org/W2062084653","https://openalex.org/W2064874359","https://openalex.org/W2070847731","https://openalex.org/W2075110274","https://openalex.org/W2079472765","https://openalex.org/W2082429191","https://openalex.org/W2086776463","https://openalex.org/W2087243986","https://openalex.org/W2088685810","https://openalex.org/W2090848516","https://openalex.org/W2091102323","https://openalex.org/W2096063777","https://openalex.org/W2096519700","https://openalex.org/W2097867538","https://openalex.org/W2099005297","https://openalex.org/W2101955048","https://openalex.org/W2102885018","https://openalex.org/W2104372589","https://openalex.org/W2105704879","https://openalex.org/W2106914633","https://openalex.org/W2112526127","https://openalex.org/W2113021228","https://openalex.org/W2113107925","https://openalex.org/W2115855931","https://openalex.org/W2117091440","https://openalex.org/W2117478398","https://openalex.org/W2124490243","https://openalex.org/W2125386008","https://openalex.org/W2127559485","https://openalex.org/W2130975342","https://openalex.org/W2132663452","https://openalex.org/W2135955660","https://openalex.org/W2144479616","https://openalex.org/W2145210308","https://openalex.org/W2148721608","https://openalex.org/W2150318471","https://openalex.org/W2152119060","https://openalex.org/W2152709750","https://openalex.org/W2152808530","https://openalex.org/W2153206087","https://openalex.org/W2155172987","https://openalex.org/W2158143414","https://openalex.org/W2160031422","https://openalex.org/W2163410184","https://openalex.org/W2166833329","https://openalex.org/W2169708427","https://openalex.org/W2190404250","https://openalex.org/W2221703732","https://openalex.org/W2339534121","https://openalex.org/W2599098307","https://openalex.org/W2613148122","https://openalex.org/W2622807556","https://openalex.org/W2735082025","https://openalex.org/W2745518706","https://openalex.org/W2772306958","https://openalex.org/W2777928756","https://openalex.org/W3141682137","https://openalex.org/W3214092816"],"related_works":["https://openalex.org/W4410049792","https://openalex.org/W2794968960","https://openalex.org/W2060964242","https://openalex.org/W4416854826","https://openalex.org/W2075110274","https://openalex.org/W3003296917","https://openalex.org/W7097862058","https://openalex.org/W2016000332","https://openalex.org/W4386019862","https://openalex.org/W1542194895"],"abstract_inverted_index":{"Chemokines":[0],"and":[1,11,24,29,41,45,47,65,75,78,83,100,117],"their":[2,79,118],"receptors":[3,80,119],"have":[4],"been":[5],"shown":[6],"to":[7,81],"affect":[8],"amyloid-\u03b2":[9],"(A\u03b2)":[10],"tau":[12,48,84],"pathologies":[13],"in":[14,37,57,60,106,120],"mouse":[15,61],"models":[16,62],"of":[17,63,73,91,112,115,126],"Alzheimer's":[18],"disease":[19],"(AD)":[20],"by":[21],"regulating":[22],"microglia":[23],"monocyte-associated":[25],"neuroinflammation,":[26],"microglial":[27,74],"movement":[28],"monocyte":[30,76],"recruitment":[31],"into":[32],"the":[33,71,89,92,113,124],"brain.":[34],"These":[35],"cells":[36],"turn":[38],"can":[39],"promote":[40],"mediate":[42],"A\u03b2":[43],"phagocytosis":[44],"degradation":[46],"phosphorylation.":[49],"In":[50],"this":[51,58,107,130],"review":[52,66],"we":[53],"discuss":[54],"published":[55],"work":[56],"field":[59],"AD":[64,121],"what":[67],"is":[68],"known":[69],"about":[70],"contributions":[72],"chemokines":[77,116],"amyloid":[82],"pathologies.":[85],"We":[86],"focus":[87],"on":[88],"roles":[90],"chemokine/chemokine":[93],"receptor":[94],"pairs":[95],"CCL2/CCR2,":[96],"CX3CL1/CX3CR1,":[97],"CCL5/CCR5,":[98],"CXCL10/CXCR3":[99],"CXCL1/CXCR2,":[101],"highlighting":[102],"important":[103],"knowledge":[104],"gaps":[105],"field.":[108],"A":[109],"full":[110],"understanding":[111],"functions":[114],"may":[122],"guide":[123],"development":[125],"novel":[127],"immunotherapies":[128],"for":[129],"devastating":[131],"disease.":[132]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-29T00:00:00"}