{"id":"https://openalex.org/W2808720403","doi":null,"title":"Study of Autonomic Nervous System Dysfunction in Parkinson\u2019s Patients.","display_name":"Study of Autonomic Nervous System Dysfunction in Parkinson\u2019s Patients.","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W2808720403","mag":"2808720403"},"language":"en","primary_location":{"id":"mag:2808720403","doi":null,"is_oa":false,"landing_page_url":"http://repository-tnmgrmu.ac.in/586/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067115639","display_name":"E Arunraj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"E Arunraj","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067115639"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/autonomic-dysfunction","display_name":"autonomic dysfunction","score":0.968999981880188},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.6190000176429749},{"id":"https://openalex.org/keywords/hoehn-and-yahr-stage","display_name":"Hoehn and Yahr stage","score":0.8700000047683716},{"id":"https://openalex.org/keywords/sexual-dysfunction","display_name":"sexual dysfunction","score":0.675000011920929},{"id":"https://openalex.org/keywords/gastrointestinal-dysfunction","display_name":"gastrointestinal dysfunction","score":0.8799999952316284},{"id":"https://openalex.org/keywords/urinary-dysfunction","display_name":"urinary dysfunction","score":0.5989999771118164},{"id":"https://openalex.org/keywords/non-motor-symptoms","display_name":"non-motor symptoms","score":0.7139999866485596},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6480000019073486},{"id":"https://openalex.org/keywords/autonomic-function-tests","display_name":"autonomic function testing","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.68495774269104},{"id":"https://openalex.org/C2779543035","wikidata":"https://www.wikidata.org/wiki/Q620639","display_name":"Dysautonomia","level":3,"score":0.677268922328949},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.5820398330688477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5796871781349182},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5429834723472595},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.5111799836158752},{"id":"https://openalex.org/C2779097696","wikidata":"https://www.wikidata.org/wiki/Q1822234","display_name":"Lewy body","level":4,"score":0.46641290187835693},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4305295944213867},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.41680267453193665},{"id":"https://openalex.org/C2778261627","wikidata":"https://www.wikidata.org/wiki/Q2608695","display_name":"Movement disorders","level":3,"score":0.41430214047431946},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3858785331249237},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2935211658477783},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.10720333456993103},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2808720403","doi":null,"is_oa":false,"landing_page_url":"http://repository-tnmgrmu.ac.in/586/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W34103945","https://openalex.org/W304529363","https://openalex.org/W1977314903","https://openalex.org/W1983653142","https://openalex.org/W1990036897","https://openalex.org/W2004536497","https://openalex.org/W2006490924","https://openalex.org/W2008560062","https://openalex.org/W2011046855","https://openalex.org/W2020335763","https://openalex.org/W2039458933","https://openalex.org/W2043906288","https://openalex.org/W2045470394","https://openalex.org/W2052799886","https://openalex.org/W2053969387","https://openalex.org/W2054065049","https://openalex.org/W2062981527","https://openalex.org/W2074560876","https://openalex.org/W2074836948","https://openalex.org/W2078589023","https://openalex.org/W2080902873","https://openalex.org/W2084441631","https://openalex.org/W2087937241","https://openalex.org/W2090187118","https://openalex.org/W2093674229","https://openalex.org/W2106113586","https://openalex.org/W2126518215","https://openalex.org/W2127155643","https://openalex.org/W2142700313","https://openalex.org/W2155175950","https://openalex.org/W2312577998","https://openalex.org/W2413070816","https://openalex.org/W2569094787","https://openalex.org/W3109116512"],"related_works":["https://openalex.org/W2101697102","https://openalex.org/W2493026967","https://openalex.org/W4312129943","https://openalex.org/W3155538500","https://openalex.org/W2005043001","https://openalex.org/W4293267248","https://openalex.org/W2789181969","https://openalex.org/W2991891929","https://openalex.org/W2959802936","https://openalex.org/W1987740763"],"abstract_inverted_index":{"Parkinson\u2019s":[0,114,227],"disease":[1,8,115,228,415,430,447],"(PD)1":[2],"is":[3,20,42,229,255,266,345,362,376,395,402,424],"a":[4,21,68,181,230,377,464],"chronic":[5],"neurodegenerative":[6,32],"progressive\r\nneurological":[7],"with":[9,444,446],"clinical":[10],"features":[11],"viz":[12],"rigidity,":[13],"bradykinesia,":[14],"rest\r\ntremor":[15],"and":[16,48,73,100,106,131,133,139,151,199,213,233,270,284,296,303,319,331,338,356,383,409,469,472,493],"postural":[17],"instability.":[18],"Assymetry":[19],"prominent":[22],"feature":[23],"of":[24,40,50,80,86,98,129,135,154,170,173,189,204,215,220,252,261,275,292,298,310,327,333,388,420,474],"this\r\ndisease.":[25],"PD":[26,41,58,72,165,194,259],"ranks":[27],"second":[28],"among":[29],"the":[30,74,108,136,171,202,245,282,317,346,363,381,392,407,414,418],"common":[31,231,348,365],"disease\r\nnext":[33],"only":[34,439,485],"to":[35,77,180,208,236,240,455],"Alzheimer\u2019s":[36],"dementia.\r\nThe":[37],"pathological":[38],"characteristic":[39],"intraneuronal":[43],"alpha":[44],"synuclein\r\npositive":[45],"Lewy":[46],"bodies":[47],"loss":[49],"neuronal":[51],"cell.":[52],"Apart":[53],"from":[54,247],"classical":[55],"motor":[56,63,91],"symptoms":[57,92,112,145],"patients":[59,260,445,489],"also":[60],"develop":[61],"non":[62,90],"symptoms.":[64],"Non":[65],"motor\r\nsymptoms":[66],"cause":[67],"major":[69,89],"disability":[70],"in":[71,83,113,120,149,161,164,176,184,226,258,268,278,300,313,335,351,368,459,478,490],"prominently":[75],"contribute":[76],"decreasing":[78],"quality":[79],"life":[81],"especially":[82],"advanced":[84],"stages":[85],"disease.":[87],"\r\nThe":[88],"are":[93],"olfactory":[94],"loss,":[95],"psychiatric":[96],"disturbances":[97],"depression":[99],"anxiety,":[101],"sleep":[102],"disorders,":[103],"cognitive":[104],"dysfunction,":[105,442],"\r\nchiefly":[107],"Autonomic":[109,111],"Dysfunction.":[110],"(PD)":[116],"were":[117],"first":[118],"reported":[119],"1817":[121],"by":[122,290,325,354,371],"James":[123],"Parkinson":[124],"himself.":[125],"\r\nHe":[126],"described":[127],"abnormalities":[128],"salivation":[130],"sweating,":[132],"dysfunction":[134,163,225,254,277,312,350,367,389,421,458],"alimentary":[137],"tract":[138],"urinary":[140],"bladder.":[141],"Patients":[142],"rarely":[143],"volunteer":[144],"\r\nof":[146],"autonomic":[147,162,221,358],"disturbance":[148],"clinic,":[150],"perhaps":[152],"because":[153],"this,":[155],"there":[156],"has":[157,195,235],"been":[158],"little":[159],"interest":[160],"until":[166],"recent":[167,182],"years.":[168],"\r\nDemonstration":[169],"importance":[172],"dysautonomia":[175],"Parkinsonism":[177],"patients,":[178],"led":[179],"resurgence":[183],"this":[185],"area.":[186],"The":[187,250,264,273,308,386],"introduction":[188,203],"standardised":[190],"\r\ndiagnostic":[191],"criteria":[192],"for":[193],"improved":[196],"diagnostic":[197],"accuracy,":[198],"reports":[200],"since":[201],"these":[205],"guidelines":[206],"continue":[207],"suggest":[209],"that":[210],"between":[211,380,406,467],"\r\n50%":[212],"80%":[214],"subjects":[216],"have":[217,305,340,495],"objective":[218],"evidence":[219],"involvement.\r\nAutonomic":[222],"nervous":[223],"system":[224],"problem":[232],"it":[234],"be":[237],"identified":[238],"early":[239],"initiate":[241],"proper\r\ntreatment.":[242],"We":[243],"conclude":[244],"following":[246],"our":[248],"study.\r\n1.":[249],"prevalence":[251,265,274,309],"ANS":[253,276,306,311,341,349,366,384,441,457,475,497],"significantly":[256],"high":[257],"83.7%":[262],".":[263],"82.75%":[267],"males":[269,293,299,352],"85.2%":[271],"in\r\nfemales.\r\n2.":[272],"Males":[279],"increases":[280,287,315,322,422],"as":[281,288,316,323,391],"Hoehn":[283,318,468],"Yahr":[285,320,470],"stage":[286,301,321,329,336,479,491],"evidenced":[289,324],"68.7%":[291],"in\r\nstage":[294],"I":[295,330,480],"100%":[297,332],"IV":[302,337,492],"V":[304,339,494],"dysfunction.\r\n3.":[307],"Females":[314,334],"80.9%":[326],"females\r\nin":[328],"dysfunction.\r\n4.":[342],"Sexual":[343],"dysfunction(84.7%)":[344],"most":[347,364],"followed":[353,370],"gastrointestinal(56.9%),":[355],"thermoregulatory\r\n(51.3%)":[357],"disturbances.\r\n5.":[359],"Urinary":[360],"disturbances(78.3%),":[361],"females":[369],"thermoregulatory(65.2%),,":[372],"and\r\ncardiovascular":[373],"disturbances(56.5%).\r\n6.":[374],"There":[375,401,462],"significant":[378,397,404,426,465],"correlation":[379,405,466],"age":[382],"dysfunction.":[385,476],"severity":[387,410,419,473],"worsens":[390],"age\r\nadvances,":[393],"which":[394,423],"statistically":[396,425],"(p":[398,427],"value<0.0001)":[399],"7.":[400],"no":[403,437],"sex":[408],"of\r\nANS":[411],"dysfunction.\r\n8.":[412],"As":[413],"duration":[416,431,448],"advances":[417],"value<0.0001).":[428],"Patient\r\nwith":[429],"less":[432],"than":[433],"5":[434],"years":[435,451],"had":[436,452,481],"or":[438,484],"mild":[440,486],"whereas":[443,488],"more":[449],"than\r\n10":[450],"predominantly":[453],"moderate":[454],"severe":[456,496],"all":[460],"patients.\r\n9.":[461],"exists":[463],"staging":[471],"Patient":[477],"no\r\nANS":[482],"dysfunction(26.4%)":[483],"dysfunction(62.3%)":[487],"dysfunction\r\n(100%).":[498]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-29T00:00:00"}
