{"id":"https://openalex.org/W2808700523","doi":"https://doi.org/10.1177/1744806918783535","title":"Participation of pro-inflammatory cytokines in neuropathic pain evoked by chemotherapeutic oxaliplatin via central GABAergic pathway","display_name":"Participation of pro-inflammatory cytokines in neuropathic pain evoked by chemotherapeutic oxaliplatin via central GABAergic pathway","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2808700523","doi":"https://doi.org/10.1177/1744806918783535","mag":"2808700523","pmid":"https://pubmed.ncbi.nlm.nih.gov/29900804","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6047101"},"language":"en","primary_location":{"id":"doi:10.1177/1744806918783535","doi":"https://doi.org/10.1177/1744806918783535","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1744806918783535","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1744806918783535","source":{"id":"https://openalex.org/S49886757","display_name":"Molecular Pain","issn_l":"1744-8069","issn":["1744-8069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/1744806918783535","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055908165","display_name":"Dongsheng Xu","orcid":"https://orcid.org/0000-0002-8477-5377","observed_orcids":["https://orcid.org/0000-0002-8477-5377"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongsheng Xu","raw_affiliation_strings":["Tumor Center, The First Hospital of Jilin University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Center, The First Hospital of Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034465643","display_name":"Hui Zhao","orcid":"https://orcid.org/0000-0003-4742-1139","observed_orcids":["https://orcid.org/0000-0003-4742-1139"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Zhao","raw_affiliation_strings":["Tumor Center, The First Hospital of Jilin University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Center, The First Hospital of Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056483814","display_name":"Han Tony Gao","orcid":"https://orcid.org/0000-0002-6752-906X","observed_orcids":["https://orcid.org/0000-0002-6752-906X"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Gao","raw_affiliation_strings":["Tumor Center, The First Hospital of Jilin University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Center, The First Hospital of Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024133324","display_name":"Huiling Zhao","orcid":"https://orcid.org/0000-0003-2971-3576","observed_orcids":["https://orcid.org/0000-0003-2971-3576"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiling Zhao","raw_affiliation_strings":["Tumor Center, The First Hospital of Jilin University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Center, The First Hospital of Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100327119","display_name":"Dandan Liu","orcid":"https://orcid.org/0000-0003-2558-6127","observed_orcids":["https://orcid.org/0000-0003-2558-6127","https://orcid.org/0009-0007-1829-4069","https://orcid.org/0009-0003-7869-1382"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Liu","raw_affiliation_strings":["Center of Physical Examination, The First Hospital of Jilin University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physical Examination, The First Hospital of Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101646975","display_name":"Jing Li","orcid":"https://orcid.org/0000-0003-2476-9968","observed_orcids":["https://orcid.org/0000-0003-2476-9968"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Li","raw_affiliation_strings":["Department of Radiology, The First Hospital (Eastern Division) of Jilin University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Hospital (Eastern Division) of Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210125137"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101646975"],"corresponding_institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210125137"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":3.5289,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.92910415,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":null,"first_page":"1744806918783535","last_page":"1744806918783535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.8500000238418579},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/chemotherapy-induced-pain","display_name":"chemotherapy-induced pain","score":0.7300000190734863},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9200000166893005},{"id":"https://openalex.org/keywords/periaqueductal-gray","display_name":"periaqueductal gray","score":0.9039999842643738},{"id":"https://openalex.org/keywords/gabaergic-pathway","display_name":"GABAergic pathway","score":0.8730000257492065},{"id":"https://openalex.org/keywords/descending-inhibitory-pathways","display_name":"descending inhibitory pathways","score":0.7670000195503235},{"id":"https://openalex.org/keywords/mechanical-hyperalgesia","display_name":"mechanical hyperalgesia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cold-hypersensitivity","display_name":"cold hypersensitivity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9350000023841858},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/cytokine-receptors","display_name":"cytokine receptors","score":0.921999990940094},{"id":"https://openalex.org/keywords/gaba-receptors","display_name":"GABA receptors","score":0.5860000252723694},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.742839515209198},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.7106525897979736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6622979640960693},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.6235277652740479},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5097262263298035},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.44308075308799744},{"id":"https://openalex.org/C2910863469","wikidata":"https://www.wikidata.org/wiki/Q5062137","display_name":"Central pain","level":2,"score":0.43660563230514526},{"id":"https://openalex.org/C2776608144","wikidata":"https://www.wikidata.org/wiki/Q410352","display_name":"Gabapentin","level":3,"score":0.42666566371917725},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.41935232281684875},{"id":"https://openalex.org/C39920043","wikidata":"https://www.wikidata.org/wiki/Q786278","display_name":"Neurochemistry","level":3,"score":0.410758376121521},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.40493229031562805},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37833550572395325},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2637495696544647},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16722238063812256},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.14902079105377197},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13425341248512268},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.13189110159873962},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10463473200798035},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.08989614248275757},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010487","descriptor_name":"Periaqueductal Gray","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056587","descriptor_name":"Cryopyrin-Associated Periodic Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056587","descriptor_name":"Cryopyrin-Associated Periodic Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1177/1744806918783535","doi":"https://doi.org/10.1177/1744806918783535","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1744806918783535","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1744806918783535","source":{"id":"https://openalex.org/S49886757","display_name":"Molecular Pain","issn_l":"1744-8069","issn":["1744-8069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pain","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5002654","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6047101","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:29900804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29900804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pain","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6047101","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6047101/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Pain","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ec526a92535a4e31b469eddf8dbe3515","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ec526a92535a4e31b469eddf8dbe3515","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Pain, Vol 14 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/1744806918783535","doi":"https://doi.org/10.1177/1744806918783535","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1744806918783535","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1744806918783535","source":{"id":"https://openalex.org/S49886757","display_name":"Molecular Pain","issn_l":"1744-8069","issn":["1744-8069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pain","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2808700523.pdf"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W641588968","https://openalex.org/W823098362","https://openalex.org/W1516995431","https://openalex.org/W1776476655","https://openalex.org/W1965453486","https://openalex.org/W1970433486","https://openalex.org/W1977265431","https://openalex.org/W1991782692","https://openalex.org/W1996548067","https://openalex.org/W2012811416","https://openalex.org/W2013885507","https://openalex.org/W2020077263","https://openalex.org/W2021043915","https://openalex.org/W2021163482","https://openalex.org/W2021194790","https://openalex.org/W2030204659","https://openalex.org/W2030857678","https://openalex.org/W2035185002","https://openalex.org/W2037043198","https://openalex.org/W2040898679","https://openalex.org/W2047817815","https://openalex.org/W2052030111","https://openalex.org/W2062657498","https://openalex.org/W2062700118","https://openalex.org/W2065347834","https://openalex.org/W2066106589","https://openalex.org/W2069681479","https://openalex.org/W2073051214","https://openalex.org/W2081090537","https://openalex.org/W2087356150","https://openalex.org/W2089100446","https://openalex.org/W2090894311","https://openalex.org/W2121109193","https://openalex.org/W2161934021","https://openalex.org/W2172201406","https://openalex.org/W2279354379","https://openalex.org/W2573195065","https://openalex.org/W2579456645","https://openalex.org/W2580584788","https://openalex.org/W2677996574","https://openalex.org/W2753361193","https://openalex.org/W3021212401","https://openalex.org/W4237642202","https://openalex.org/W4255704462"],"related_works":["https://openalex.org/W2804995042","https://openalex.org/W2087838893","https://openalex.org/W4313199019","https://openalex.org/W2924429053","https://openalex.org/W2795107224","https://openalex.org/W2752963019","https://openalex.org/W2598458960","https://openalex.org/W2473225285","https://openalex.org/W3189728982","https://openalex.org/W1988823943"],"abstract_inverted_index":{"Background":[0],"Neuropathic":[1,81],"pain":[2,56,82,236,272,282],"is":[3,10,29,44,262],"observed":[4],"in":[5,70,90,137,174,207,229,237,255,270],"patients":[6],"as":[7],"chemotherapeutic":[8,286],"oxaliplatin":[9,89,120,144,160,211,221,238,260],"used":[11,98],"to":[12,99,177,264,277],"treat":[13],"metastatic":[14],"digestive":[15],"tumors;":[16],"however,":[17],"the":[18,32,40,49,60,67,116,138,149,167,185,193,230,245,256,266,278],"mechanisms":[19],"responsible":[20],"for":[21,62],"hyperalgesia":[22,73,215],"are":[23],"not":[24,157],"well":[25],"understood.":[26],"Chronic":[27],"neuroinflammation":[28],"one":[30],"of":[31,34,36,48,66,88,119,124,143,152,195,210,225,247,259,280,285],"hallmarks":[33],"pathophysiology":[35],"neuropathic":[37,235,281],"pain.":[38],"Since":[39],"midbrain":[41],"periaqueductal":[42,68,117,141,168,208,231,257],"gray":[43,69,118,142,169,209,232,258],"an":[45],"important":[46],"component":[47],"descending":[50,267],"inhibitory":[51,163,268],"pathway":[52],"controlling":[53],"on":[54,184],"central":[55],"transmission,":[57],"we":[58],"examined":[59],"role":[61],"pro-inflammatory":[63,101,153,204,248,252],"cytokines":[64,249],"system":[65],"regulating":[71,271],"mechanical":[72,178,214],"and":[74,93,104,111,127,133,180,213,216,250,274],"cold":[75,186,217],"hypersensitivity":[76,218],"evoked":[77,219],"by":[78,85,201,220],"oxaliplatin.":[79,287],"Methods":[80],"was":[83,146,156,170],"induced":[84],"intraperitoneal":[86],"injection":[87],"rats.":[91,121,239],"ELISA":[92],"western":[94],"blot":[95],"analysis":[96],"were":[97,113,198,222],"examine":[100],"cytokine":[102,154,205,253],"levels":[103],"their":[105],"receptors":[106,129,155,206,228],"expression.":[107],"Results":[108],"IL-1\u03b2,":[109,125],"IL-6,":[110,126],"TNF-\u03b1":[112,128],"elevated":[114],"within":[115,166],"Protein":[122],"expression":[123,151],"(namely,":[130],"IL-1R,":[131],"IL-6R,":[132],"TNFR":[134],"subtype":[135],"TNFR1)":[136],"plasma":[139],"membrane":[140,251],"rats":[145,261],"upregulated,":[147],"whereas":[148],"total":[150],"altered.":[158],"In":[159],"rats,":[161],"impaired":[162],"gamma-aminobutyric":[164,196,226],"acid":[165,197,227],"accompanied":[171],"with":[172],"decreases":[173],"withdrawal":[175],"thresholds":[176],"stimulus":[179],"%":[181],"time":[182],"spent":[183],"plate.":[187],"Our":[188,241],"data":[189,242],"further":[190],"showed":[191],"that":[192,244],"concentrations":[194],"largely":[199],"restored":[200],"blocking":[202],"those":[203],"rats;":[212],"attenuated.":[223],"Stimulation":[224],"also":[233],"blunted":[234],"Conclusions":[240],"suggest":[243],"upregulation":[246],"receptor":[254],"likely":[263],"impair":[265],"pathways":[269],"transmission":[273],"thereby":[275],"contributes":[276],"development":[279],"after":[283],"application":[284]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-21T00:00:00"}
