{"id":"https://openalex.org/W2808631097","doi":"https://doi.org/10.7150/ijbs.25711","title":"Aberrant Levels of Cystatin C in Amyotrophic Lateral Sclerosis: a Systematic Review and Meta Analysis","display_name":"Aberrant Levels of Cystatin C in Amyotrophic Lateral Sclerosis: a Systematic Review and Meta Analysis","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2808631097","doi":"https://doi.org/10.7150/ijbs.25711","mag":"2808631097","pmid":"https://pubmed.ncbi.nlm.nih.gov/29989057","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6036727"},"language":"en","primary_location":{"id":"doi:10.7150/ijbs.25711","doi":"https://doi.org/10.7150/ijbs.25711","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.25711","pdf_url":"http://www.ijbs.com/v14p1041.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.ijbs.com/v14p1041.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101865631","display_name":"Yu Zhu","orcid":"https://orcid.org/0000-0002-4904-9628","observed_orcids":["https://orcid.org/0000-0002-4904-9628"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zhu","raw_affiliation_strings":["Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101582205","display_name":"Mi Yang","orcid":"https://orcid.org/0000-0002-1975-3075","observed_orcids":["https://orcid.org/0000-0002-1975-3075","https://orcid.org/0000-0001-7280-1497","https://orcid.org/0000-0002-8209-1000","https://orcid.org/0000-0002-1875-1692","https://orcid.org/0009-0003-9666-4986"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mi Yang","raw_affiliation_strings":["Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074263632","display_name":"Fangjun Li","orcid":"https://orcid.org/0000-0002-9593-3289","observed_orcids":["https://orcid.org/0000-0002-9593-3289"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangjun Li","raw_affiliation_strings":["Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045859953","display_name":"Meng-Hua Li","orcid":"https://orcid.org/0000-0001-5194-2506","observed_orcids":["https://orcid.org/0000-0001-5194-2506"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menghua Li","raw_affiliation_strings":["Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024694225","display_name":"Zhenzhen Xu","orcid":"https://orcid.org/0000-0003-4111-3530","observed_orcids":["https://orcid.org/0000-0003-4111-3530","https://orcid.org/0009-0008-4678-1996"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenzhen Xu","raw_affiliation_strings":["Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112429770","display_name":"Fang Yang","orcid":"https://orcid.org/0000-0001-6795-099X","observed_orcids":["https://orcid.org/0000-0001-6795-099X"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Yang","raw_affiliation_strings":["Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111475699","display_name":"Yue Liu","orcid":"https://orcid.org/0000-0002-6025-5326","observed_orcids":["https://orcid.org/0000-0002-6025-5326"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Liu","raw_affiliation_strings":["Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112958844","display_name":"Wenzhi Chen","orcid":"https://orcid.org/0000-0003-0720-5888","observed_orcids":["https://orcid.org/0000-0003-0720-5888"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenzhi Chen","raw_affiliation_strings":["Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yougen Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yougen Zhang","raw_affiliation_strings":["Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100298869","display_name":"Renshi Xu","orcid":"https://orcid.org/0000-0003-0313-3434","observed_orcids":["https://orcid.org/0000-0003-0313-3434","https://orcid.org/0000-0002-1672-7322"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Renshi Xu","raw_affiliation_strings":["Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The first affiliated hospital of Nanchang university, Nanchang 330006, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100298869"],"corresponding_institution_ids":["https://openalex.org/I4210164024"],"apc_list":{"value":2000,"currency":"AUD","value_usd":1337},"apc_paid":{"value":2000,"currency":"AUD","value_usd":1337},"fwci":0.1159,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.08475034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"9","first_page":"1041","last_page":"1053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":0.921999990940094},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.8830000162124634},{"id":"https://openalex.org/keywords/serum-cystatin-c","display_name":"serum cystatin C","score":0.8339999914169312},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.8149999976158142},{"id":"https://openalex.org/keywords/motor-neuron-disease","display_name":"motor neuron disease","score":0.7870000004768372},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9359999895095825},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.9050104022026062},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.8177005052566528},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7591099739074707},{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.7582131624221802},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7175292372703552},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6591763496398926},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.590168297290802},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5247609615325928},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35859695076942444},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3294292092323303},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.16842588782310486},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.15563958883285522},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08764860033988953},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055316","descriptor_name":"Cystatin C","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D055316","descriptor_name":"Cystatin C","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.7150/ijbs.25711","doi":"https://doi.org/10.7150/ijbs.25711","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.25711","pdf_url":"http://www.ijbs.com/v14p1041.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4990460","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6036727","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:29989057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29989057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6036727","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6036727/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Biol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7150/ijbs.25711","doi":"https://doi.org/10.7150/ijbs.25711","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.25711","pdf_url":"http://www.ijbs.com/v14p1041.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[{"id":"https://openalex.org/G2028825861","display_name":"Tau\u57fa\u56e0\u542f\u52a8\u533a\u30013\u2032\u4e0d\u7ffb\u8bd1\u533a\u3001\u5185\u542b\u5b50\u57fa\u56e0\u591a\u6001\u6027\u4e0e\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u53d1\u75c5\u7684\u7814\u7a76","funder_award_id":"30560042","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3820117514","display_name":null,"funder_award_id":"GJJ13198","funder_id":"https://openalex.org/F4320325626","funder_display_name":"Education Department of Jiangxi Province"},{"id":"https://openalex.org/G4294610707","display_name":null,"funder_award_id":"20171BAB- 215022","funder_id":"https://openalex.org/F4320326696","funder_display_name":"Jiangxi Provincial Department of Science and Technology"},{"id":"https://openalex.org/G5067157456","display_name":null,"funder_award_id":"20142BBG70062","funder_id":"https://openalex.org/F4320326696","funder_display_name":"Jiangxi Provincial Department of Science and Technology"},{"id":"https://openalex.org/G5736497047","display_name":"\u795e\u7ecf\u5143\u81f4\u75c5\u86cb\u767d\u3001\u795e\u7ecf\u5143-\u80f6\u8d28\u7ec6\u80de\u7f51\u7edc\u529f\u80fd\u4e0e\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u8fd0\u52a8\u795e\u7ecf\u5143\u9009\u62e9\u6027\u3001\u8fdb\u884c\u6027\u6b7b\u4ea1\u673a\u5236\u7684\u7814\u7a76","funder_award_id":"81360198","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5793014364","display_name":null,"funder_award_id":"GJJ170021","funder_id":"https://openalex.org/F4320325626","funder_display_name":"Education Department of Jiangxi Province"},{"id":"https://openalex.org/G6658798513","display_name":null,"funder_award_id":"20181019","funder_id":"https://openalex.org/F4320326689","funder_display_name":"Health and Family Planning Commission of Jiangxi Province"},{"id":"https://openalex.org/G824145227","display_name":null,"funder_award_id":"GJJ13198, GJJ170021","funder_id":"https://openalex.org/F4320325626","funder_display_name":"Education Department of Jiangxi Province"},{"id":"https://openalex.org/G8810127729","display_name":"\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u8111\u548c\u810a\u9ad3\u5185\u6e90\u6027\u795e\u7ecf\u524d\u4f53\u7ec6\u80de\u589e\u6b96\u3001\u5206\u5316\u3001\u5b9a\u5411\u8fc1\u79fb\u53ca\u5176\u8c03\u63a7\u56e0\u5b50HoxB\u5bb6\u65cf\u8868\u8fbe\u6539\u53d8\u7684\u5b9e\u9a8c\u7814\u7a76","funder_award_id":"81160161","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325626","display_name":"Education Department of Jiangxi Province","ror":"https://ror.org/04d8xwh61"},{"id":"https://openalex.org/F4320326689","display_name":"Health and Family Planning Commission of Jiangxi Province","ror":null},{"id":"https://openalex.org/F4320326696","display_name":"Jiangxi Provincial Department of Science and Technology","ror":"https://ror.org/00t30yz20"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2808631097.pdf","grobid_xml":"https://content.openalex.org/works/W2808631097.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W246286872","https://openalex.org/W277625174","https://openalex.org/W1458080684","https://openalex.org/W1563993759","https://openalex.org/W1597629772","https://openalex.org/W1686423757","https://openalex.org/W1699719812","https://openalex.org/W1717426898","https://openalex.org/W1899656823","https://openalex.org/W1974739417","https://openalex.org/W1975000552","https://openalex.org/W1976381342","https://openalex.org/W1982286690","https://openalex.org/W1987066016","https://openalex.org/W1987262253","https://openalex.org/W1996528337","https://openalex.org/W1999109058","https://openalex.org/W2005501262","https://openalex.org/W2008452978","https://openalex.org/W2012739537","https://openalex.org/W2024888626","https://openalex.org/W2027154798","https://openalex.org/W2030094387","https://openalex.org/W2032629617","https://openalex.org/W2035016723","https://openalex.org/W2057374183","https://openalex.org/W2067587881","https://openalex.org/W2075044628","https://openalex.org/W2075416033","https://openalex.org/W2079370736","https://openalex.org/W2082170795","https://openalex.org/W2084563861","https://openalex.org/W2084634452","https://openalex.org/W2085777459","https://openalex.org/W2096432058","https://openalex.org/W2096936673","https://openalex.org/W2104246038","https://openalex.org/W2108381339","https://openalex.org/W2111035539","https://openalex.org/W2126930838","https://openalex.org/W2135292732","https://openalex.org/W2135610921","https://openalex.org/W2135742702","https://openalex.org/W2140445641","https://openalex.org/W2142064395","https://openalex.org/W2152897383","https://openalex.org/W2156098321","https://openalex.org/W2157823046","https://openalex.org/W2161938104","https://openalex.org/W2263595714","https://openalex.org/W2432488913","https://openalex.org/W2515812439","https://openalex.org/W2520147597","https://openalex.org/W2621245281","https://openalex.org/W2776294548","https://openalex.org/W4248830098","https://openalex.org/W4294215472","https://openalex.org/W4297918764"],"related_works":["https://openalex.org/W2091575335","https://openalex.org/W1458080684","https://openalex.org/W2084634452","https://openalex.org/W7213537631","https://openalex.org/W2292680196","https://openalex.org/W2263303459","https://openalex.org/W2856122503","https://openalex.org/W2085777459","https://openalex.org/W2057374183","https://openalex.org/W2903722463"],"abstract_inverted_index":{"Evidences":[0],"suggest":[1],"that":[2],"Cystatin":[3],"C":[4,35,58,117,163,208,220,264,285,296,316],"(Cys":[5],"C)":[6],"levels":[7,36,59,118,164,209,221,265,286,297,317],"might":[8,320],"be":[9,321],"a":[10,27,61,126,158,309],"biomarker":[11,62,311,325],"in":[12,23,37,49,63,76,170,188,210,217,222,227,231,261,268,287,300,318],"amyotrophic":[13],"lateral":[14],"sclerosis":[15],"(ALS)":[16],"diagnosis,":[17],"but":[18,244,306],"the":[19,113,135,145,199,262,269,301],"conclusion":[20],"is":[21,60],"still":[22],"doubts.":[24],"We":[25],"conducted":[26],"systematic":[28,127,190],"review":[29,128],"and":[30,42,94,97,119,129,147,178,212,253,273,289],"meta":[31,130,200,277],"analysis":[32,278],"of":[33,45,80,137,149,151,165,193,266,303,326],"Cys":[34,57,116,162,207,219,263,284,295,315],"cerebrospinal":[38],"cord":[39],"fluid":[40],"(CSF)":[41],"peripheral":[43,168],"blood":[44,169,267],"patients":[46,121,172,229,252],"with":[47,174],"ALS":[48,64,120,171,228,251,272,304],"order":[50],"to":[51,124,197,239],"further":[52],"confirm":[53],"whether":[54],"or":[55,90,100,102,104,106,108,167,291],"not":[56,308],"diagnosis.":[65],"The":[66,83,141,161,275],"English":[67],"relevant":[68,180,255],"studies":[69,111,185,205,214],"without":[70],"year":[71],"limitation":[72],"were":[73,122,155,186,195,224],"systematically":[74],"searched":[75,84],"PubMed,":[77],"EMBASE,":[78],"Web":[79],"Science":[81],"databases.":[82],"term":[85],"contained":[86],"\"Amyotrophic":[87],"Lateral":[88],"Sclerosis\"":[89],"\"Motor":[91],"Neuron":[92],"Diseases\"":[93],"\"Cystatin":[95],"C\"":[96],"\"Cerebrospinal":[98],"fluid\"":[99],"\"CSF\"":[101],"\"Biomarker\"":[103],"\"Serum\"":[105],"\"Plasma\"":[107],"\"Blood\".":[109],"Observational":[110],"reporting":[112],"associations":[114],"between":[115,250,271,283],"selected":[123,152,196],"conduct":[125],"analysis.":[131,201],"Two":[132],"reviewers":[133],"performed":[134],"selection":[136],"this":[138,313],"study":[139],"independently.":[140],"Newcastle-Ottawa":[142],"Scale":[143],"assesses":[144],"quality":[146],"risk":[148],"bias":[150],"studies.":[153],"Estimates":[154],"pooled":[156],"using":[157],"random-effects":[159],"model.":[160],"CSF":[166,211,223,288,302,319],"compared":[173],"health":[175],"controls":[176],"(HCs)":[177],"several":[179,254],"neurodegenerative":[181],"diseases":[182],"(NDDs).":[183],"Sixteen":[184],"included":[187],"our":[189],"review,":[191],"9":[192],"them":[194],"perform":[198],"Of":[202],"these,":[203],"eight":[204],"measured":[206,215],"three":[213],"it":[216],"blood.":[218],"significantly":[225,298],"lower":[226],"than":[230],"HCs":[232],"(Hedge's":[233],"g":[234],"=":[235,242],"-1.398,":[236],"95%CI:":[237],"-2.43":[238],"-0.36;":[240],"p":[241],"0.008),":[243],"there":[245],"was":[246],"no":[247,280],"statistical":[248],"difference":[249,260],"NDDs.":[256],"No":[257],"statistically":[258],"significant":[259,281],"comparison":[270],"HCs.":[274],"correlation":[276,282],"presented":[279],"age":[290],"disease":[292],"duration":[293],"respectively.":[294],"decrease":[299],"patients,":[305],"are":[307],"specific":[310],"for":[312],"disease.":[314],"an":[322],"auxiliary":[323],"diagnostic":[324],"ALS.":[327]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2018-06-21T00:00:00"}