{"id":"https://openalex.org/W2808611417","doi":"https://doi.org/10.4049/jimmunol.200.supp.166.50","title":"Human anti-dopamine receptor 1 monoclonal autoantibody (mAb) identifies potential mechanisms of neuronal signaling in post-infectious autoimmune-mediated neuropsychiatric disease","display_name":"Human anti-dopamine receptor 1 monoclonal autoantibody (mAb) identifies potential mechanisms of neuronal signaling in post-infectious autoimmune-mediated neuropsychiatric disease","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2808611417","doi":"https://doi.org/10.4049/jimmunol.200.supp.166.50","mag":"2808611417"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.200.supp.166.50","doi":"https://doi.org/10.4049/jimmunol.200.supp.166.50","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.200.supp.166.50","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048986977","display_name":"Chandra M. Menendez","orcid":"https://orcid.org/0000-0002-2535-8848","observed_orcids":["https://orcid.org/0000-0002-2535-8848"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandra M Menendez","raw_affiliation_strings":["University of Oklahoma Health Sciences Center","1University of Oklahoma Health Sciences Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma Health Sciences Center","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"1University of Oklahoma Health Sciences Center","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036661480","display_name":"Jonathan Zuccolo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Zuccolo","raw_affiliation_strings":["Delivra Inc ,","2Delivra Inc, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delivra Inc ,","institution_ids":[]},{"raw_affiliation_string":"2Delivra Inc, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076546666","display_name":"Amir Zuccolo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amir Zuccolo","raw_affiliation_strings":["University of Oklahoma Health Sciences Center","1University of Oklahoma Health Sciences Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma Health Sciences Center","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"1University of Oklahoma Health Sciences Center","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053371670","display_name":"Hilla Ben\u2010Pazi","orcid":"https://orcid.org/0000-0002-8039-4761","observed_orcids":["https://orcid.org/0000-0002-8039-4761"]},"institutions":[{"id":"https://openalex.org/I2801962034","display_name":"Shaare Zedek Medical Center","ror":"https://ror.org/04d0szq68","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801962034"]},{"id":"https://openalex.org/I2802879425","display_name":"Bikur Cholim Hospital","ror":"https://ror.org/03zpnb459","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2802879425"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hilla Ben-Pazi","raw_affiliation_strings":["Neuropediatric Unit Shaare Zedek Medical Center ,","3Neuropediatric Unit Shaare Zedek Medical Center, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropediatric Unit Shaare Zedek Medical Center ,","institution_ids":["https://openalex.org/I2801962034","https://openalex.org/I2802879425"]},{"raw_affiliation_string":"3Neuropediatric Unit Shaare Zedek Medical Center, Israel","institution_ids":["https://openalex.org/I2801962034","https://openalex.org/I2802879425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026595384","display_name":"Carol J. Cox","orcid":"https://orcid.org/0000-0002-1394-3978","observed_orcids":["https://orcid.org/0000-0002-1394-3978"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Cox","raw_affiliation_strings":["University of Oklahoma Health Sciences Center","1University of Oklahoma Health Sciences Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma Health Sciences Center","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"1University of Oklahoma Health Sciences Center","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019437038","display_name":"Susan E. Swedo","orcid":"https://orcid.org/0000-0003-0586-2235","observed_orcids":["https://orcid.org/0000-0003-0586-2235"]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Swedo","raw_affiliation_strings":["NIMH","4NIMH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIMH","institution_ids":["https://openalex.org/I4210158500"]},{"raw_affiliation_string":"4NIMH","institution_ids":["https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024828248","display_name":"Madeleine White Cunningham","orcid":"https://orcid.org/0000-0001-8122-728X","observed_orcids":["https://orcid.org/0000-0001-8122-728X"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madeleine W Cunningham","raw_affiliation_strings":["University of Oklahoma Health Sciences Center","1University of Oklahoma Health Sciences Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma Health Sciences Center","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"1University of Oklahoma Health Sciences Center","institution_ids":["https://openalex.org/I49332381"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"200","issue":"Supplement_1","first_page":"166.50","last_page":"166.50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pandas","display_name":"PANDAS","score":0.7549999952316284},{"id":"https://openalex.org/keywords/sydenham-chorea","display_name":"Sydenham's chorea","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dopaminergic-neurotransmission","display_name":"dopamine signaling","score":0.6499999761581421},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7850000262260437},{"id":"https://openalex.org/keywords/receptor-sensitization","display_name":"receptor sensitization","score":0.7250000238418579},{"id":"https://openalex.org/keywords/dopamine-release","display_name":"dopamine release","score":0.6100000143051147},{"id":"https://openalex.org/keywords/streptococcal-infection","display_name":"streptococcal infection","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C2776338565","wikidata":"https://www.wikidata.org/wiki/Q2043695","display_name":"PANDAS","level":2,"score":0.929834246635437},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.8079854249954224},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7347689867019653},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.6964160203933716},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.582363486289978},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5400830507278442},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.45872920751571655},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45546895265579224},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4476161599159241},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3633359968662262},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3279948830604553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32680100202560425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3095477223396301}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.200.supp.166.50","doi":"https://doi.org/10.4049/jimmunol.200.supp.166.50","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.200.supp.166.50","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2161140251","https://openalex.org/W4320061525","https://openalex.org/W2156107325","https://openalex.org/W4402939054","https://openalex.org/W4387504083","https://openalex.org/W2159628080","https://openalex.org/W4313343456","https://openalex.org/W7204154347","https://openalex.org/W3037599676","https://openalex.org/W2808362799"],"abstract_inverted_index":{"Abstract":[0],"Neuropsychiatric":[1],"and":[2,9,16,56,109,130,150,160,200,229],"movement":[3],"disorders":[4,22],"are":[5],"associated":[6,45],"with":[7,46,54,156,180],"infections":[8],"anti-neuronal":[10],"autoantibodies":[11,36,51,202,208],"against":[12,123],"dopamine":[13,86,174,218,226],"receptors":[14],"D1R":[15,55,113,124,139,147,185,211],"D2R.":[17,57],"Most":[18],"characterized":[19],"of":[20,31,79,94,116,142,146],"these":[21],"is":[23],"Sydenham":[24],"chorea":[25],"(SC),":[26],"an":[27,80,96],"autoimmune":[28,42],"neurologic":[29],"manifestation":[30],"streptococcal-induced":[32],"rheumatic":[33],"fever":[34],"where":[35,197],"target":[37],"the":[38,138,143],"basal":[39],"ganglia.":[40],"Pediatric":[41],"neuropsychiatric":[43,195,230],"disorder":[44],"streptococci":[47],"(PANDAS)":[48],"have":[49,100],"similar":[50],"that":[52],"react":[53],"SC-derived":[58],"human":[59,89,157],"mAb":[60,158,166,182],"24.3.1":[61,84],"or":[62],"SC":[63,129],"derived":[64],"IgG":[65,121,136],"signal":[66],"D2R":[67],"in":[68,118,128,175,205],"transfected":[69,119],"cells":[70],"by":[71,114,220],"decreasing":[72],"cyclic":[73],"AMP-dependent":[74],"kinase":[75],"(cAMP)":[76],"activity,":[77],"reflective":[78],"inhibitory":[81],"receptor.":[82],"Anti-D2R":[83],"increases":[85],"release":[87],"from":[88],"neuronal":[90],"cells.":[91,120],"However,":[92],"signaling":[93,227],"D1R,":[95],"activating":[97],"receptor,":[98,140],"can":[99],"different":[101],"biological":[102],"effects.":[103],"Our":[104],"PANDAS-derived":[105],"anti-D1R":[106,165,199,207],"mAb,":[107],"B4C,":[108],"PANDAS":[110,131,161],"sera":[111],"signaled":[112],"activation":[115],"cAMP":[117,169],"titers":[122],"were":[125,148],"significantly":[126,155],"elevated":[127],"sera.":[132],"To":[133],"further":[134],"show":[135],"recognized":[137],"peptides":[141],"extracellular":[144],"loop":[145],"constructed":[149],"a":[151,176],"defined":[152],"sequence":[153],"reacted":[154],"B4C":[159,167,183],"serum":[162],"IgG.":[163],"Human":[164],"induced":[168,219],"activity":[170],"levels":[171],"comparable":[172],"to":[173,186,192,216,225],"dose-dependent":[177],"manner.":[178],"Combined":[179],"dopamine,":[181],"sensitized":[184],"at":[187],"least":[188],"50X":[189],"more":[190,214],"responsive":[191],"dopamine.":[193],"In":[194],"diseases":[196],"both":[198],"anti-D2R":[201,221],"may":[203],"be":[204],"combination,":[206],"could":[209],"sensitize":[210],"making":[212],"it":[213],"sensitive":[215],"excess":[217],"autoantibodies;":[222],"thus,":[223],"contributing":[224],"abnormalities":[228],"pathogenesis.":[231]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-06-21T00:00:00"}