{"id":"https://openalex.org/W2808564687","doi":"https://doi.org/10.1186/s12964-018-0242-1","title":"Emerging roles and regulation of MiT/TFE transcriptional factors","display_name":"Emerging roles and regulation of MiT/TFE transcriptional factors","publication_year":2018,"publication_date":"2018-06-15","ids":{"openalex":"https://openalex.org/W2808564687","doi":"https://doi.org/10.1186/s12964-018-0242-1","mag":"2808564687","pmid":"https://pubmed.ncbi.nlm.nih.gov/29903018"},"language":"en","primary_location":{"id":"doi:10.1186/s12964-018-0242-1","doi":"https://doi.org/10.1186/s12964-018-0242-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-018-0242-1","pdf_url":"https://biosignaling.biomedcentral.com/track/pdf/10.1186/s12964-018-0242-1.pdf","source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biosignaling.biomedcentral.com/track/pdf/10.1186/s12964-018-0242-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100725247","display_name":"Min Yang","orcid":"https://orcid.org/0000-0003-4781-2615","observed_orcids":["https://orcid.org/0000-0003-4781-2615"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Yang","raw_affiliation_strings":["Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085273906","display_name":"En Liu","orcid":"https://orcid.org/0000-0002-2437-5910","observed_orcids":["https://orcid.org/0000-0002-2437-5910"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"En Liu","raw_affiliation_strings":["Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029727052","display_name":"Li Tang","orcid":"https://orcid.org/0000-0001-5929-6975","observed_orcids":["https://orcid.org/0000-0001-5929-6975"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Tang","raw_affiliation_strings":["Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103131873","display_name":"Yuanyuan Lei","orcid":"https://orcid.org/0000-0001-9900-2150","observed_orcids":["https://orcid.org/0000-0001-9900-2150"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Lei","raw_affiliation_strings":["Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044962091","display_name":"Xuemei Sun","orcid":"https://orcid.org/0000-0002-4501-7098","observed_orcids":["https://orcid.org/0000-0002-4501-7098","https://orcid.org/0000-0002-7860-0669","https://orcid.org/0000-0003-3281-3914"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuemei Sun","raw_affiliation_strings":["Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015892707","display_name":"Jiaxi Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxi Hu","raw_affiliation_strings":["Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053257075","display_name":"Hui Dong","orcid":"https://orcid.org/0000-0001-5500-7099","observed_orcids":["https://orcid.org/0000-0001-5500-7099"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Hui Dong","raw_affiliation_strings":["Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China","Department of Medicine, University of California San Diego, San Diego, CA, 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]},{"raw_affiliation_string":"Department of Medicine, University of California San Diego, San Diego, CA, 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100700841","display_name":"Shiming Yang","orcid":"https://orcid.org/0000-0002-0000-4795","observed_orcids":["https://orcid.org/0000-0002-0000-4795"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi-Ming Yang","raw_affiliation_strings":["Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053509540","display_name":"Mingfa Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingfa Gao","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 40037, China. 839722706@qq.com","Department of Hepatobiliary Surgery, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 40037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 40037, China. 839722706@qq.com","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]},{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 40037, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052226142","display_name":"Bo Tang","orcid":"https://orcid.org/0000-0003-4089-5155","observed_orcids":["https://orcid.org/0000-0003-4089-5155"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bo Tang","raw_affiliation_strings":["Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China. atreebobo@163.com","Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China"],"raw_orcid":"https://orcid.org/0000-0003-4089-5155","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China. atreebobo@163.com","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]},{"raw_affiliation_string":"Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052226142","https://openalex.org/A5053509540"],"corresponding_institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":9.375,"has_fulltext":true,"cited_by_count":93,"citation_normalized_percentile":{"value":0.98668787,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"16","issue":"1","first_page":"31","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.921999990940094},{"id":"https://openalex.org/keywords/lysosomal-biogenesis","display_name":"lysosomal biogenesis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.6330000162124634},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/mtorc1-signaling","display_name":"mTORC1 signaling","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pkc-signaling","display_name":"PKC signaling","score":0.9700000286102295},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.996999979019165},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.902999997138977},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C132647116","wikidata":"https://www.wikidata.org/wiki/Q18032677","display_name":"TFEB","level":4,"score":0.8234437704086304},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7159202098846436},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7068833112716675},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6128365397453308},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.5880565047264099},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.5762296915054321},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.52779620885849},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47123369574546814},{"id":"https://openalex.org/C155432671","wikidata":"https://www.wikidata.org/wiki/Q17073362","display_name":"Organelle biogenesis","level":4,"score":0.4596729874610901},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.45963698625564575},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.45336514711380005},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.44277438521385193},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4360272288322449},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37242984771728516},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.3607942759990692},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23423075675964355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14257711172103882},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12605977058410645},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.07020330429077148},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071182","descriptor_name":"Autophagosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071182","descriptor_name":"Autophagosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071182","descriptor_name":"Autophagosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051739","descriptor_name":"Microphthalmia-Associated Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051739","descriptor_name":"Microphthalmia-Associated Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051739","descriptor_name":"Microphthalmia-Associated Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12964-018-0242-1","doi":"https://doi.org/10.1186/s12964-018-0242-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-018-0242-1","pdf_url":"https://biosignaling.biomedcentral.com/track/pdf/10.1186/s12964-018-0242-1.pdf","source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},{"id":"pmid:29903018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29903018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell communication and signaling : CCS","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4984505","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6003119","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6003119","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6003119","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Commun Signal","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c703a096f2ac4327a9d0d680cfc6cacd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c703a096f2ac4327a9d0d680cfc6cacd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-11 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12964-018-0242-1","doi":"https://doi.org/10.1186/s12964-018-0242-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-018-0242-1","pdf_url":"https://biosignaling.biomedcentral.com/track/pdf/10.1186/s12964-018-0242-1.pdf","source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1158610748","display_name":null,"funder_award_id":"81661148050","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4057276191","display_name":null,"funder_award_id":"81602577","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8509021995","display_name":null,"funder_award_id":"NO.81602577","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2808564687.pdf","grobid_xml":"https://content.openalex.org/works/W2808564687.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W209484349","https://openalex.org/W1408841334","https://openalex.org/W1481026039","https://openalex.org/W1493861444","https://openalex.org/W1499820592","https://openalex.org/W1565351177","https://openalex.org/W1595732636","https://openalex.org/W1678795445","https://openalex.org/W1824115720","https://openalex.org/W1853148353","https://openalex.org/W1884934928","https://openalex.org/W1945821141","https://openalex.org/W1970661950","https://openalex.org/W1975200363","https://openalex.org/W1982635732","https://openalex.org/W1984621921","https://openalex.org/W1990263777","https://openalex.org/W2005298277","https://openalex.org/W2005678965","https://openalex.org/W2005964981","https://openalex.org/W2015009944","https://openalex.org/W2022206899","https://openalex.org/W2027785297","https://openalex.org/W2033708806","https://openalex.org/W2036709151","https://openalex.org/W2038612187","https://openalex.org/W2046447620","https://openalex.org/W2049298036","https://openalex.org/W2053127333","https://openalex.org/W2063920469","https://openalex.org/W2070658923","https://openalex.org/W2071624194","https://openalex.org/W2077499130","https://openalex.org/W2078184757","https://openalex.org/W2080486488","https://openalex.org/W2090422348","https://openalex.org/W2101499880","https://openalex.org/W2106771547","https://openalex.org/W2106946808","https://openalex.org/W2111607026","https://openalex.org/W2112736050","https://openalex.org/W2112956181","https://openalex.org/W2113379770","https://openalex.org/W2116505693","https://openalex.org/W2117112828","https://openalex.org/W2118031242","https://openalex.org/W2123508600","https://openalex.org/W2124028721","https://openalex.org/W2125408763","https://openalex.org/W2125842849","https://openalex.org/W2127845119","https://openalex.org/W2137546031","https://openalex.org/W2139948451","https://openalex.org/W2141133346","https://openalex.org/W2146355396","https://openalex.org/W2148659064","https://openalex.org/W2150470627","https://openalex.org/W2150824725","https://openalex.org/W2153188271","https://openalex.org/W2153824991","https://openalex.org/W2154970776","https://openalex.org/W2156351032","https://openalex.org/W2268528663","https://openalex.org/W2300170141","https://openalex.org/W2301313697","https://openalex.org/W2301685087","https://openalex.org/W2419601133","https://openalex.org/W2464503524","https://openalex.org/W2475246463","https://openalex.org/W2520973513","https://openalex.org/W2525423931","https://openalex.org/W2525996450","https://openalex.org/W2556506792","https://openalex.org/W2562152674","https://openalex.org/W2565299087","https://openalex.org/W2565398910","https://openalex.org/W2569600607","https://openalex.org/W2587142564","https://openalex.org/W2588818369","https://openalex.org/W2600710454","https://openalex.org/W2601565410","https://openalex.org/W2606513998","https://openalex.org/W2626522201","https://openalex.org/W2672980727","https://openalex.org/W2731448183","https://openalex.org/W2740618823","https://openalex.org/W2751666483","https://openalex.org/W2752017840","https://openalex.org/W2757961295","https://openalex.org/W2759645669","https://openalex.org/W2762001618","https://openalex.org/W2762211973","https://openalex.org/W2762273017","https://openalex.org/W2770643652","https://openalex.org/W2791660672","https://openalex.org/W2801715743","https://openalex.org/W3006462722"],"related_works":["https://openalex.org/W2809738004","https://openalex.org/W4306971719","https://openalex.org/W3192029614","https://openalex.org/W4385191034","https://openalex.org/W4243180838","https://openalex.org/W2488751783","https://openalex.org/W2084229141","https://openalex.org/W4323967820","https://openalex.org/W2464438946","https://openalex.org/W2290496554"],"abstract_inverted_index":{"The":[0,16,62],"MiT/TFE":[1,22,83,108,142,156],"transcription":[2,63],"factors":[3,97,158],"play":[4],"a":[5,125],"pivotal":[6],"role":[7,127],"in":[8,35,76,98,128,163],"the":[9,30,36,42,49,77,107,139,152],"regulation":[10],"of":[11,21,51,53,95,113,141,151],"autophagy":[12,60],"and":[13,19,38,59,80,120,123,159],"lysosomal":[14,57,121],"biogenesis.":[15],"subcellular":[17],"localization":[18],"activity":[20],"proteins":[23,109],"are":[24],"primarily":[25],"regulated":[26],"through":[27],"phosphorylation.":[28],"And":[29],"phosphorylated":[31],"protein":[32],"is":[33],"retained":[34],"cytoplasm":[37],"subsequently":[39],"translocates":[40],"to":[41,56,91],"nucleus":[43],"upon":[44],"dephosphorylation,":[45],"where":[46],"it":[47],"stimulates":[48],"expression":[50],"hundreds":[52],"genes,":[54],"leading":[55],"biogenesis":[58],"induction.":[61],"factor-mediated":[64],"lysosome-to-nucleus":[65],"signaling":[66,73],"can":[67],"be":[68,136],"directly":[69],"controlled":[70],"by":[71],"several":[72],"molecules":[74],"involved":[75],"mTORC1,":[78],"PKC,":[79],"AKT":[81],"pathways.":[82],"family":[84,143],"members":[85],"have":[86,104],"attracted":[87],"much":[88],"attention":[89],"owing":[90],"their":[92,160],"intracellular":[93],"clearance":[94],"pathogenic":[96],"numerous":[99],"diseases.":[100],"Recently,":[101],"multiple":[102],"studies":[103],"also":[105],"revealed":[106],"as":[110],"master":[111],"regulators":[112],"cellular":[114],"metabolic":[115],"reprogramming,":[116],"converging":[117],"on":[118,138,155],"autophagic":[119],"function":[122],"playing":[124],"critical":[126],"cancer,":[129],"suggesting":[130],"that":[131],"novel":[132],"therapeutic":[133],"strategies":[134],"could":[135],"based":[137],"modulation":[140],"member":[144],"activity.":[145],"Here,":[146],"we":[147],"present":[148],"an":[149],"overview":[150],"latest":[153],"research":[154],"transcriptional":[157],"potential":[161],"mechanisms":[162],"cancer.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}