{"id":"https://openalex.org/W2808553609","doi":null,"title":"Terapeutski potencijal anti-tetanus toksoid monoklonskih antitela: primena zasnovana na vezivnim karakteristikama","display_name":"Terapeutski potencijal anti-tetanus toksoid monoklonskih antitela: primena zasnovana na vezivnim karakteristikama","publication_year":2018,"publication_date":"2018-06-11","ids":{"openalex":"https://openalex.org/W2808553609","mag":"2808553609"},"language":"sr","primary_location":{"id":"pmh:oai:cherry.chem.bg.ac.rs:123456789/3163","doi":null,"is_oa":true,"landing_page_url":"http://nardus.mpn.gov.rs/123456789/10479","pdf_url":"http://nardus.mpn.gov.rs/123456789/10479","source":{"id":"https://openalex.org/S4306402516","display_name":"Cherry (Univesrity of Belgrade, Faculty of Chemistry)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210101313","host_organization_name":"University Hospital Center Dr Dragi\u0161a Mi\u0161ovi\u0107","host_organization_lineage":["https://openalex.org/I4210101313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0423\u043d\u0438\u0432\u0435\u0440\u0437\u0438\u0442\u0435\u0442 \u0443 \u0411\u0435\u043e\u0433\u0440\u0430\u0434\u0443","raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nardus.mpn.gov.rs/123456789/10479","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036067292","display_name":"Ivana Luki\u0107","orcid":"https://orcid.org/0000-0002-6330-471X","observed_orcids":["https://orcid.org/0000-0002-6330-471X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ivana Luki\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5036067292"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12499","display_name":"Diphtheria, Corynebacterium, and Tetanus","score":0.6439999938011169,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12499","display_name":"Diphtheria, Corynebacterium, and Tetanus","score":0.6439999938011169,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.25929999351501465,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetanus-toxin","display_name":"tetanus toxin","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tetanus-toxoid","display_name":"tetanus toxoid","score":0.7450000047683716},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9649999737739563},{"id":"https://openalex.org/keywords/clostridium-tetani","display_name":"Clostridium tetani","score":0.7839999794960022},{"id":"https://openalex.org/keywords/heterologous-immunity","display_name":"heterologous immunity","score":0.5789999961853027},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.48500001430511475},{"id":"https://openalex.org/keywords/antibody-neutralization","display_name":"antibody neutralization","score":0.34599998593330383},{"id":"https://openalex.org/keywords/tetanus-toxoid-vaccine","display_name":"tetanus toxoid vaccine","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C2779841045","wikidata":"https://www.wikidata.org/wiki/Q47790","display_name":"Tetanus","level":3,"score":0.48803678154945374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25592127442359924},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.14445018768310547},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:cherry.chem.bg.ac.rs:123456789/3163","doi":null,"is_oa":true,"landing_page_url":"http://nardus.mpn.gov.rs/123456789/10479","pdf_url":"http://nardus.mpn.gov.rs/123456789/10479","source":{"id":"https://openalex.org/S4306402516","display_name":"Cherry (Univesrity of Belgrade, Faculty of Chemistry)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210101313","host_organization_name":"University Hospital Center Dr Dragi\u0161a Mi\u0161ovi\u0107","host_organization_lineage":["https://openalex.org/I4210101313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0423\u043d\u0438\u0432\u0435\u0440\u0437\u0438\u0442\u0435\u0442 \u0443 \u0411\u0435\u043e\u0433\u0440\u0430\u0434\u0443","raw_type":"doctoralThesis"},{"id":"pmh:oai:nardus.mpn.gov.rs:123456789/10479","doi":null,"is_oa":true,"landing_page_url":"https://nardus.mpn.gov.rs/handle/123456789/10479","pdf_url":null,"source":{"id":"https://openalex.org/S4377196110","display_name":"National Repository of Dissertations in Serbia","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0423\u043d\u0438\u0432\u0435\u0440\u0437\u0438\u0442\u0435\u0442 \u0443 \u0411\u0435\u043e\u0433\u0440\u0430\u0434\u0443","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2808553609","doi":null,"is_oa":false,"landing_page_url":"https://nardus.mpn.gov.rs/handle/123456789/10479","pdf_url":null,"source":{"id":"https://openalex.org/S4306540430","display_name":"\u0423\u043d\u0438\u0432\u0435\u0440\u0437\u0438\u0442\u0435\u0442 \u0443 \u0411\u0435\u043e\u0433\u0440\u0430\u0434\u0443","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u0423\u043d\u0438\u0432\u0435\u0440\u0437\u0438\u0442\u0435\u0442 \u0443 \u0411\u0435\u043e\u0433\u0440\u0430\u0434\u0443","raw_type":null}],"best_oa_location":{"id":"pmh:oai:cherry.chem.bg.ac.rs:123456789/3163","doi":null,"is_oa":true,"landing_page_url":"http://nardus.mpn.gov.rs/123456789/10479","pdf_url":"http://nardus.mpn.gov.rs/123456789/10479","source":{"id":"https://openalex.org/S4306402516","display_name":"Cherry (Univesrity of Belgrade, Faculty of Chemistry)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210101313","host_organization_name":"University Hospital Center Dr Dragi\u0161a Mi\u0161ovi\u0107","host_organization_lineage":["https://openalex.org/I4210101313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0423\u043d\u0438\u0432\u0435\u0440\u0437\u0438\u0442\u0435\u0442 \u0443 \u0411\u0435\u043e\u0433\u0440\u0430\u0434\u0443","raw_type":"doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2207192594","display_name":null,"funder_award_id":"172049","funder_id":"https://openalex.org/F4320322729","funder_display_name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja"}],"funders":[{"id":"https://openalex.org/F4320322729","display_name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","ror":"https://ror.org/01znas443"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2808553609.pdf","grobid_xml":"https://content.openalex.org/works/W2808553609.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2138460061","https://openalex.org/W2157171051","https://openalex.org/W4210571587"],"related_works":["https://openalex.org/W4252760041","https://openalex.org/W6991135909","https://openalex.org/W3124533228","https://openalex.org/W4311808424","https://openalex.org/W4316259315","https://openalex.org/W819668402","https://openalex.org/W4288047018","https://openalex.org/W4413450851","https://openalex.org/W4392344498","https://openalex.org/W4230293273"],"abstract_inverted_index":{"Tetanus":[0],"toksin":[1],"(TT),":[2],"produkt":[3],"anaerobne":[4],"bakterije":[5],"Clostridium":[6],"tetani,":[7],"je":[8,123,222,240],"izuzetno\\npotentan":[9],"neurotoksin":[10],"koji":[11],"mo\u017ee":[12,179],"izazvati":[13],"tetanus,":[14],"te\u0161ko":[15],"i":[16,51,88,104,118,132,141,156],"\u010desto":[17],"fatalno":[18],"oboljenje.":[19],"Uprkos\\nvi\u0161edecenijskom":[20],"sistematskom":[21],"sprovo\u0111enju":[22],"vakcinacije":[23],"protiv":[24],"tetanusa,":[25],"incidenca\\ntetanusa":[26],"jo\u0161":[27],"uvek":[28],"nije":[29],"zanemarljiva.":[30],"TT-specifi\u010dna":[31,89,191],"antitela":[32,75,149,178,192],"su":[33,170],"klju\u010dni":[34],"faktor":[35],"u\\nspre\u010davanju":[36],"intoksikacije":[37],"TT-om.":[38],"Pored":[39],"toga,":[40],"predpostavlja":[41],"se":[42,70,84,93],"da":[43,77,111,124,152,172,187,201,213,232],"bi":[44],"ova":[45],"antitela,":[46,228],"usled\\nukr\u0161tene":[47],"reaktivnosti,":[48],"mogla":[49],"doprinositi":[50],"otpornosti":[52,160],"ka":[53,113,161,184,242],"heterologim":[54],"infekcijama.":[55],"Kod\\nosoba":[56],"koja":[57,72,193],"nemaju":[58],"uspostavljen":[59],"adekvatan":[60],"TT-specifi\u010dan":[61],"imunski":[62],"odgovor,":[63],"a":[64,252],"postoji\\nsumnja":[65],"na":[66,139,181],"intoksikaciju":[67,154,198],"TT-om,":[68],"preporu\u010duje":[69],"imunoterapija":[71],"podrazumeva\\naplikaciju":[73],"TT-specifi\u010dnih":[74,227],"sposobnih":[76],"neutrali\u0161u":[78],"slobodno":[79],"cirkuli\u0161u\u0107i":[80],"TT.":[81],"Du\u017ei\\nniz":[82],"godina":[83],"kao":[85,94],"imunoterapeutici":[86],"razmatraju":[87],"monoklonska":[90],"antitela\\n(MAt)":[91],"gde":[92],"jedan":[95],"od":[96],"problema":[97],"name\u0107e":[98],"pitanje":[99],"kako":[100],"selektovati":[101],"za\u0161titno":[102],"MAt":[103,131],"/":[105,157,176],"ili\\nformulisati":[106],"efikasan":[107],"preparat":[108],"s":[109],"obzirom":[110],"specifi\u010dnost":[112],"TT":[114,177],"ne":[115,253],"zna\u010di":[116],"nu\u017eno":[117],"za\u0161tini\\npotencijal.\\nCilj":[119],"ove":[120,167],"doktorske":[121,168],"disertacije":[122],"se,":[125],"kroz":[126],"ispitivanje":[127],"vezivnih":[128],"karakteristika\\npanela":[129],"TTd/TT-specifi\u010dnih":[130],"njihovog":[133],"za\u0161titnog":[134],"potencijala":[135],"in":[136,196],"vivo,":[137],"utvrdi":[138],"koji\\nna\u010din":[140],"u":[142,164],"kojoj":[143],"meri":[144],"vezivne":[145],"karakteristike":[146],"TTd/TT":[147],"specifi\u010dnih":[148],"odre\u0111uju":[150],"njihovu\\nsposobnost":[151],"spre\u010de":[153],"TT-om":[155,199,203],"ili":[158],"doprinesu":[159],"heterologim\\ninfekcijama.\\nIstra\u017eivanja":[162],"realizovana":[163],"okviru":[165],"izrade":[166],"teze":[169],"pokazala":[171],"se\\nza\u0161titni":[173],"potencijal":[174,237],"anti-TTd":[175],"proceniti":[180],"osnovu":[182],"afiniteta":[183],"TT-u":[185,221,243],"i\\nsposobnosti":[186],"inhibiraju":[188,214],"TT-GD1b":[189,234,250],"interakciju.":[190,235],"mogu":[194],"da\\nspre\u010de":[195],"vivo":[197],"treba":[200],"vezuju":[202],"sa":[204],"afinitetom":[205],"\u2265":[206,244],"1x108":[207,245],"M-1":[208,246],"i\\nda":[209],"istovremeno":[210],"imaju":[211],"sposobnost":[212,231],"vezivanje":[215],"TT-a":[216],"za":[217],"GD1b":[218],"gangliozide.\\nAfinitet":[219],"prema":[220],"prvi":[223],"selekcioni":[224],"kriterijum":[225],"za\u0161titnih":[226],"a\\npotom":[229],"njihova":[230],"preveniraju":[233],"Za\u0161titni":[236],"TTspecifi\u010dnih\\nantitala":[238],"\u010diji":[239],"afinitet":[241],"dominantno":[247],"odre\u0111uje":[248],"sposobnost\\ninhibiranja":[249],"interakcije":[251],"sam":[254],"afinitet...":[255]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-21T00:00:00"}