{"id":"https://openalex.org/W2808462178","doi":"https://doi.org/10.1016/j.dib.2018.06.008","title":"In vitro genotoxicity studies: n-Butyl acrylate L5178Y mouse lymphoma (TK+/\u2212 locus assay), 2-Ethylhexyl acrylate gene mutation assay in Chinese hamster V79 cells, and 2-Ethylhexyl acrylate micronucleus test in human lymphocytes","display_name":"In vitro genotoxicity studies: n-Butyl acrylate L5178Y mouse lymphoma (TK+/\u2212 locus assay), 2-Ethylhexyl acrylate gene mutation assay in Chinese hamster V79 cells, and 2-Ethylhexyl acrylate micronucleus test in human lymphocytes","publication_year":2018,"publication_date":"2018-06-14","ids":{"openalex":"https://openalex.org/W2808462178","doi":"https://doi.org/10.1016/j.dib.2018.06.008","mag":"2808462178","pmid":"https://pubmed.ncbi.nlm.nih.gov/30167439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6111055"},"language":"en","primary_location":{"id":"doi:10.1016/j.dib.2018.06.008","doi":"https://doi.org/10.1016/j.dib.2018.06.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dib.2018.06.008","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2352340918306590/pdf","source":{"id":"https://openalex.org/S2481029507","display_name":"Data in Brief","issn_l":"2352-3409","issn":["2352-3409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Data in Brief","raw_type":"journal-article"},"volume":null,"type":"data-paper","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2352340918306590/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009820453","display_name":"Sandra Reiss Murphy","orcid":"https://orcid.org/0000-0003-0437-1960","observed_orcids":["https://orcid.org/0000-0003-0437-1960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Murphy","raw_affiliation_strings":["Kennett Square, PA 19348, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kennett Square, PA 19348, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111879697","display_name":"Robert G. Ellis\u2010Hutchings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Ellis-Hutchings","raw_affiliation_strings":["The Dow Chemical Company, Midland, MI 48674, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dow Chemical Company, Midland, MI 48674, United States","institution_ids":["https://openalex.org/I4210133143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074743005","display_name":"Lavorgie Finch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111444","display_name":"Arkema (United States)","ror":"https://ror.org/01rdex851","country_code":"US","type":"company","lineage":["https://openalex.org/I151809719","https://openalex.org/I4210111444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lavorgie Finch","raw_affiliation_strings":["Arkema Inc., King of Prussia, PA 19406, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkema Inc., King of Prussia, PA 19406, United States","institution_ids":["https://openalex.org/I4210111444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025254915","display_name":"Stefanie Welz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie Welz","raw_affiliation_strings":["BASF SE, Ludwigshafen am Rhein, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF SE, Ludwigshafen am Rhein, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044971989","display_name":"Karin Wiench","orcid":"https://orcid.org/0000-0002-5848-0428","observed_orcids":["https://orcid.org/0000-0002-5848-0428"]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karin Wiench","raw_affiliation_strings":["BASF SE, Ludwigshafen am Rhein, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF SE, Ludwigshafen am Rhein, Germany","institution_ids":["https://openalex.org/I4210107087"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111879697"],"corresponding_institution_ids":["https://openalex.org/I4210133143"],"apc_list":{"value":1220,"currency":"USD","value_usd":1220},"apc_paid":{"value":1220,"currency":"USD","value_usd":1220},"fwci":null,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":null,"first_page":"316","last_page":"325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11493","display_name":"Water Treatment and Disinfection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-butyl-acrylate","display_name":"butyl acrylate","score":0.8989999890327454},{"id":"https://openalex.org/keywords/2-ethylhexyl-acrylate","display_name":"2-ethylhexyl acrylate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/acrylates","display_name":"acrylates","score":0.8539999723434448},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/v79-cells","display_name":"V79 cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/micronucleus-test","display_name":"micronucleus test","score":0.9160000085830688},{"id":"https://openalex.org/keywords/human-lymphocytes","display_name":"human lymphocytes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/weight-of-evidence","display_name":"weight of evidence","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.8655571937561035},{"id":"https://openalex.org/C2777755551","wikidata":"https://www.wikidata.org/wiki/Q2539773","display_name":"Chinese hamster","level":3,"score":0.7647491693496704},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.6677403450012207},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6248684525489807},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6170480251312256},{"id":"https://openalex.org/C36681516","wikidata":"https://www.wikidata.org/wiki/Q1700733","display_name":"Micronucleus","level":4,"score":0.5433477163314819},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.48260653018951416},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.42905765771865845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4248637855052948},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3937762975692749},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3643421232700348},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27480635046958923},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.272458016872406},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1676640510559082},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.dib.2018.06.008","doi":"https://doi.org/10.1016/j.dib.2018.06.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dib.2018.06.008","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2352340918306590/pdf","source":{"id":"https://openalex.org/S2481029507","display_name":"Data in Brief","issn_l":"2352-3409","issn":["2352-3409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Data in Brief","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5064701","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6111055","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6111055","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6111055","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Data Brief","raw_type":"Text"},{"id":"pmid:30167439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30167439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Data in brief","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c9c97b9439b44c678de851291883a961","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c9c97b9439b44c678de851291883a961","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Data in Brief, Vol 20, Iss , Pp 316-325 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.dib.2018.06.008","doi":"https://doi.org/10.1016/j.dib.2018.06.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dib.2018.06.008","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2352340918306590/pdf","source":{"id":"https://openalex.org/S2481029507","display_name":"Data in Brief","issn_l":"2352-3409","issn":["2352-3409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Data in Brief","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2808462178.pdf","grobid_xml":"https://content.openalex.org/works/W2808462178.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2804083941"],"related_works":["https://openalex.org/W2065361607","https://openalex.org/W2068196007","https://openalex.org/W1980503088","https://openalex.org/W2040231787","https://openalex.org/W2008237915","https://openalex.org/W2056307608","https://openalex.org/W2065582710","https://openalex.org/W2087971438","https://openalex.org/W1985678861","https://openalex.org/W2025009262"],"abstract_inverted_index":{"Available":[0],"point":[1],"mutation":[2,62],"tests":[3,14],"have":[4],"shown":[5],"inconsistent":[6],"results":[7],"with":[8],"various":[9],"acrylates.":[10],"Most":[11],"of":[12,66,100,105],"those":[13],"were":[15,89],"performed":[16],"prior":[17],"to":[18,97],"OECD":[19,33],"guidelines":[20],"and":[21,74],"appropriate":[22],"data":[23],"regarding":[24],"cytotoxicity":[25],"are":[26,40],"not":[27,90],"given.":[28],"Data":[29],"from":[30],"three":[31],"current":[32],"guideline":[34],"compliant":[35],"experiments":[36],"conducted":[37],"under":[38,92],"GLP":[39],"provided.":[41],"They":[42],"include":[43],"(a)":[44],"an":[45,56,76],"in":[46,57,77,81],"vitro":[47,58,78],"mouse":[48],"lymphoma":[49],"(TK+/-)":[50],"assay":[51,63],"(OECD":[52,71,84],"490)":[53],"[3],":[54],"(b)":[55],"HPRT":[59],"locus":[60],"gene":[61],"utilizing":[64],"cultures":[65],"Chinese":[67],"hamster":[68],"V79":[69],"cells":[70],"476)":[72],"[1],":[73],"(c)":[75],"micronucleus":[79],"test":[80],"human":[82],"lymphocytes":[83],"487)":[85],"[2].":[86],"Test":[87],"materials":[88],"mutagenic":[91],"these":[93],"experimental":[94],"conditions,":[95],"adding":[96],"the":[98],"weight-of-evidence":[99],"non-genotoxicity":[101],"for":[102],"this":[103],"group":[104],"chemicals.":[106]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2018-06-21T00:00:00"}