{"id":"https://openalex.org/W2808420239","doi":"https://doi.org/10.1186/s13287-018-0913-2","title":"Neural stem cell therapy for subacute and chronic ischemic stroke","display_name":"Neural stem cell therapy for subacute and chronic ischemic stroke","publication_year":2018,"publication_date":"2018-06-13","ids":{"openalex":"https://openalex.org/W2808420239","doi":"https://doi.org/10.1186/s13287-018-0913-2","mag":"2808420239","pmid":"https://pubmed.ncbi.nlm.nih.gov/29895321","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5998588"},"language":"en","primary_location":{"id":"doi:10.1186/s13287-018-0913-2","doi":"https://doi.org/10.1186/s13287-018-0913-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-018-0913-2","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-018-0913-2.pdf","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-018-0913-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088585172","display_name":"Austin C. Boese","orcid":"https://orcid.org/0000-0002-2261-3436","observed_orcids":["https://orcid.org/0000-0002-2261-3436"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Austin C. Boese","raw_affiliation_strings":["Department of Physiology, Tulane University School of Medicine, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Tulane University School of Medicine, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072357389","display_name":"Quan-Son Eric Le","orcid":"https://orcid.org/0000-0003-1409-7790","observed_orcids":["https://orcid.org/0000-0003-1409-7790"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quan-Son Eric Le","raw_affiliation_strings":["Department of Physiology, Tulane University School of Medicine, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Tulane University School of Medicine, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077359896","display_name":"Dylan L. Pham","orcid":"https://orcid.org/0000-0002-3470-4618","observed_orcids":["https://orcid.org/0000-0002-3470-4618"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dylan Pham","raw_affiliation_strings":["Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103921330","display_name":"Milton H. Hamblin","orcid":"https://orcid.org/0009-0006-8538-4841","observed_orcids":["https://orcid.org/0009-0006-8538-4841"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milton H. Hamblin","raw_affiliation_strings":["Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009793238","display_name":"Jean\u2010Pyo Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jean-Pyo Lee","raw_affiliation_strings":["Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA. JEANPYOL@tulane.edu","Department of Physiology, Tulane University School of Medicine, New Orleans, LA, 70112, USA. JEANPYOL@tulane.edu","Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA. JEANPYOL@tulane.edu","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Physiology, Tulane University School of Medicine, New Orleans, LA, 70112, USA. JEANPYOL@tulane.edu","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009793238"],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":2.1387,"has_fulltext":true,"cited_by_count":203,"citation_normalized_percentile":{"value":0.89423077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"154","last_page":"154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.7207000255584717,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.7207000255584717,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.08179999887943268,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.062199998646974564,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-stem-cell-transplantation","display_name":"neural stem cell transplantation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9359999895095825},{"id":"https://openalex.org/keywords/subacute-stroke","display_name":"subacute stroke","score":0.7940000295639038},{"id":"https://openalex.org/keywords/chronic-stroke","display_name":"chronic stroke","score":0.996999979019165},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.8949999809265137},{"id":"https://openalex.org/keywords/blood-brain-barrier-disruption","display_name":"blood-brain barrier disruption","score":0.8109999895095825},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neurovascular-injury","display_name":"neurovascular injury","score":0.7459999918937683},{"id":"https://openalex.org/keywords/stroke-treatment","display_name":"stroke treatment","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.723979115486145},{"id":"https://openalex.org/C2779389132","wikidata":"https://www.wikidata.org/wiki/Q1533033","display_name":"Stem-cell therapy","level":3,"score":0.7138165235519409},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.6899245381355286},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.5791144967079163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5633978843688965},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5035378336906433},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4097551107406616},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3334731459617615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29811131954193115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22336116433143616},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.15135875344276428},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s13287-018-0913-2","doi":"https://doi.org/10.1186/s13287-018-0913-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-018-0913-2","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-018-0913-2.pdf","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4965247","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5998588","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5998588","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5998588","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Res Ther","raw_type":"Text"},{"id":"pmid:29895321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29895321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:736dff92e02741a68fa36e746c92b230","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/736dff92e02741a68fa36e746c92b230","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-17 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13287-018-0913-2","doi":"https://doi.org/10.1186/s13287-018-0913-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-018-0913-2","pdf_url":"https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-018-0913-2.pdf","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317903","display_name":"Louisiana Clinical and Translational Science Center","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2808420239.pdf","grobid_xml":"https://content.openalex.org/works/W2808420239.grobid-xml"},"referenced_works_count":246,"referenced_works":["https://openalex.org/W133124857","https://openalex.org/W204521712","https://openalex.org/W292067595","https://openalex.org/W1016386445","https://openalex.org/W1437882706","https://openalex.org/W1487852103","https://openalex.org/W1494319831","https://openalex.org/W1495237503","https://openalex.org/W1512235237","https://openalex.org/W1515821766","https://openalex.org/W1523932090","https://openalex.org/W1525032009","https://openalex.org/W1545606956","https://openalex.org/W1558038422","https://openalex.org/W1575233743","https://openalex.org/W1668720646","https://openalex.org/W1674673636","https://openalex.org/W1729621315","https://openalex.org/W1884487830","https://openalex.org/W1889700241","https://openalex.org/W1936342032","https://openalex.org/W1963128268","https://openalex.org/W1963765937","https://openalex.org/W1965681567","https://openalex.org/W1967114216","https://openalex.org/W1967675581","https://openalex.org/W1970341486","https://openalex.org/W1971218073","https://openalex.org/W1973342484","https://openalex.org/W1973647216","https://openalex.org/W1975164266","https://openalex.org/W1977267175","https://openalex.org/W1978311064","https://openalex.org/W1980499453","https://openalex.org/W1980969801","https://openalex.org/W1981836314","https://openalex.org/W1982780398","https://openalex.org/W1983089266","https://openalex.org/W1983763042","https://openalex.org/W1984974003","https://openalex.org/W1987278634","https://openalex.org/W1987774343","https://openalex.org/W1987899329","https://openalex.org/W1988312440","https://openalex.org/W1988896202","https://openalex.org/W1989560466","https://openalex.org/W1989696297","https://openalex.org/W1990136719","https://openalex.org/W1990378473","https://openalex.org/W1992365602","https://openalex.org/W1992891651","https://openalex.org/W1993638375","https://openalex.org/W1993646910","https://openalex.org/W1993965974","https://openalex.org/W1994334993","https://openalex.org/W1994687979","https://openalex.org/W1995037165","https://openalex.org/W1995628673","https://openalex.org/W1996070098","https://openalex.org/W1997801266","https://openalex.org/W1998080268","https://openalex.org/W1998463679","https://openalex.org/W1999783884","https://openalex.org/W2000825873","https://openalex.org/W2001500938","https://openalex.org/W2002820374","https://openalex.org/W2002864022","https://openalex.org/W2004927868","https://openalex.org/W2005290678","https://openalex.org/W2007883639","https://openalex.org/W2008554619","https://openalex.org/W2009392486","https://openalex.org/W2009703235","https://openalex.org/W2012253237","https://openalex.org/W2012311363","https://openalex.org/W2015541518","https://openalex.org/W2017584345","https://openalex.org/W2017607932","https://openalex.org/W2018691632","https://openalex.org/W2019475350","https://openalex.org/W2019935461","https://openalex.org/W2020962929","https://openalex.org/W2022368689","https://openalex.org/W2023749167","https://openalex.org/W2025688778","https://openalex.org/W2026171674","https://openalex.org/W2026859633","https://openalex.org/W2027449023","https://openalex.org/W2028196702","https://openalex.org/W2028471633","https://openalex.org/W2028832381","https://openalex.org/W2029784552","https://openalex.org/W2031713947","https://openalex.org/W2033284482","https://openalex.org/W2034028717","https://openalex.org/W2034101077","https://openalex.org/W2034340486","https://openalex.org/W2035221144","https://openalex.org/W2036914347","https://openalex.org/W2037760848","https://openalex.org/W2039824179","https://openalex.org/W2040611959","https://openalex.org/W2041977230","https://openalex.org/W2045314069","https://openalex.org/W2046450144","https://openalex.org/W2047417345","https://openalex.org/W2051655214","https://openalex.org/W2051850871","https://openalex.org/W2052551969","https://openalex.org/W2053198871","https://openalex.org/W2053235800","https://openalex.org/W2054119137","https://openalex.org/W2054438521","https://openalex.org/W2054507508","https://openalex.org/W2055132644","https://openalex.org/W2056328978","https://openalex.org/W2057608998","https://openalex.org/W2057641653","https://openalex.org/W2059460660","https://openalex.org/W2060279158","https://openalex.org/W2061705828","https://openalex.org/W2062595499","https://openalex.org/W2063045558","https://openalex.org/W2066553255","https://openalex.org/W2067161293","https://openalex.org/W2067371327","https://openalex.org/W2067613633","https://openalex.org/W2067707938","https://openalex.org/W2068227312","https://openalex.org/W2069958858","https://openalex.org/W2072895581","https://openalex.org/W2073811034","https://openalex.org/W2074342738","https://openalex.org/W2076511723","https://openalex.org/W2076543085","https://openalex.org/W2076694212","https://openalex.org/W2076993889","https://openalex.org/W2077983790","https://openalex.org/W2079365338","https://openalex.org/W2079424956","https://openalex.org/W2082070537","https://openalex.org/W2083628520","https://openalex.org/W2084865454","https://openalex.org/W2085610321","https://openalex.org/W2086121277","https://openalex.org/W2087155637","https://openalex.org/W2087786585","https://openalex.org/W2089254388","https://openalex.org/W2089263724","https://openalex.org/W2089735370","https://openalex.org/W2090602521","https://openalex.org/W2090998371","https://openalex.org/W2091825559","https://openalex.org/W2091961823","https://openalex.org/W2094505884","https://openalex.org/W2094505927","https://openalex.org/W2097454127","https://openalex.org/W2098833244","https://openalex.org/W2100167607","https://openalex.org/W2101296507","https://openalex.org/W2101873759","https://openalex.org/W2103312085","https://openalex.org/W2103327450","https://openalex.org/W2105619265","https://openalex.org/W2107203945","https://openalex.org/W2110496051","https://openalex.org/W2111372074","https://openalex.org/W2112350141","https://openalex.org/W2113072613","https://openalex.org/W2113396329","https://openalex.org/W2116505148","https://openalex.org/W2117381245","https://openalex.org/W2117691576","https://openalex.org/W2117890069","https://openalex.org/W2117914751","https://openalex.org/W2118200665","https://openalex.org/W2118610309","https://openalex.org/W2122828560","https://openalex.org/W2123298246","https://openalex.org/W2123436182","https://openalex.org/W2128375499","https://openalex.org/W2129282529","https://openalex.org/W2129974396","https://openalex.org/W2130707752","https://openalex.org/W2133966135","https://openalex.org/W2134717451","https://openalex.org/W2135601713","https://openalex.org/W2136686417","https://openalex.org/W2136863044","https://openalex.org/W2137358434","https://openalex.org/W2139565721","https://openalex.org/W2142792453","https://openalex.org/W2144918294","https://openalex.org/W2149844824","https://openalex.org/W2150953486","https://openalex.org/W2152864702","https://openalex.org/W2153168701","https://openalex.org/W2154349779","https://openalex.org/W2154823004","https://openalex.org/W2155477484","https://openalex.org/W2156076525","https://openalex.org/W2157521028","https://openalex.org/W2159103481","https://openalex.org/W2159689462","https://openalex.org/W2159744102","https://openalex.org/W2162189519","https://openalex.org/W2164248223","https://openalex.org/W2164905816","https://openalex.org/W2167739272","https://openalex.org/W2167915117","https://openalex.org/W2168272960","https://openalex.org/W2169575313","https://openalex.org/W2210733653","https://openalex.org/W2263957136","https://openalex.org/W2286168122","https://openalex.org/W2299928089","https://openalex.org/W2332599214","https://openalex.org/W2340192487","https://openalex.org/W2346184067","https://openalex.org/W2398307177","https://openalex.org/W2413620435","https://openalex.org/W2413701608","https://openalex.org/W2414102005","https://openalex.org/W2463703654","https://openalex.org/W2465944627","https://openalex.org/W2490585184","https://openalex.org/W2506572744","https://openalex.org/W2520026487","https://openalex.org/W2525248844","https://openalex.org/W2530418442","https://openalex.org/W2580792129","https://openalex.org/W2598700789","https://openalex.org/W2607177626","https://openalex.org/W2619378610","https://openalex.org/W2621060624","https://openalex.org/W2638561866","https://openalex.org/W2741124763","https://openalex.org/W2754629219","https://openalex.org/W2765511636","https://openalex.org/W2766154317","https://openalex.org/W2767690683","https://openalex.org/W2789329186","https://openalex.org/W2796418566","https://openalex.org/W4234098388","https://openalex.org/W4242171500","https://openalex.org/W4252882482"],"related_works":["https://openalex.org/W3186832335","https://openalex.org/W4206404042","https://openalex.org/W2889110736","https://openalex.org/W7151503792","https://openalex.org/W2980951470","https://openalex.org/W3010084808","https://openalex.org/W2597386824","https://openalex.org/W2148991829","https://openalex.org/W2788641685","https://openalex.org/W2917730449"],"abstract_inverted_index":{"Neural":[0],"stem":[1],"cells":[2],"(NSCs)":[3],"play":[4],"vital":[5],"roles":[6],"in":[7,154],"brain":[8,97],"homeostasis":[9],"and":[10,33,57,71,117,143,166,177,199,205],"exhibit":[11],"a":[12,27,92,193],"broad":[13],"repertoire":[14],"of":[15,31,80,89,115,141,189,208],"potentially":[16],"therapeutic":[17],"actions":[18],"following":[19,122,180],"neurovascular":[20,197],"injury.":[21],"One":[22],"such":[23],"injury":[24,37,170,198],"is":[25,46,65,85],"stroke,":[26],"worldwide":[28],"leading":[29],"cause":[30],"death":[32],"disability.":[34],"Clinically,":[35],"extensive":[36,58],"from":[38,42],"ischemic":[39,152,209],"stroke":[40,133,156,159],"results":[41],"ischemia-reperfusion":[43],"(IR),":[44],"which":[45],"accompanied":[47],"by":[48],"inflammation,":[49],"blood-brain":[50],"barrier":[51],"(BBB)":[52],"damage,":[53],"neural":[54],"cell":[55],"death,":[56],"tissue":[59],"loss.":[60],"Tissue":[61],"plasminogen":[62],"activator":[63],"(tPA)":[64],"still":[66],"the":[67,77,83,87,96,111,186,203],"only":[68],"US":[69],"Food":[70],"Drug":[72],"Administration-approved":[73],"clot-lysing":[74],"agent.":[75],"Whereas":[76],"thrombolytic":[78],"role":[79],"tPA":[81,90,116],"within":[82,95],"vasculature":[84],"beneficial,":[86],"effects":[88,114],"(in":[91],"non-thrombolytic":[93],"role)":[94],"parenchyma":[98],"have":[99],"been":[100],"reported":[101],"as":[102,171,173,192],"harmful.":[103],"Thus,":[104,148],"new":[105],"therapies":[106,134,160],"are":[107],"needed":[108],"to":[109,162],"reduce":[110],"deleterious":[112],"side":[113],"quickly":[118],"facilitate":[119],"vascular":[120],"repair":[121],"stroke.":[123,181,210],"The":[124],"Stroke":[125],"Treatment":[126],"Academic":[127],"Industry":[128],"Roundtable":[129],"(STAIR)":[130],"recommends":[131],"that":[132,144],"\"focus":[135],"on":[136,150,164],"drugs/devices/treatments":[137],"with":[138],"multiple":[139,146],"mechanisms":[140,179],"action":[142],"target":[145],"pathways\".":[147],"based":[149],"multifactorial":[151],"cascades":[153],"various":[155],"stages,":[157],"effective":[158],"need":[161],"focus":[163],"targeting":[165],"ameliorating":[167],"early":[168],"IR":[169],"well":[172],"facilitating":[174],"angiogenesis,":[175],"neurogenesis,":[176],"neurorestorative":[178],"This":[182],"review":[183],"will":[184,200],"discuss":[185],"preclinical":[187],"perspectives":[188],"NSC":[190],"transplantation":[191],"promising":[194],"treatment":[195],"for":[196],"emphasize":[201],"both":[202],"subacute":[204],"chronic":[206],"phase":[207]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":45},{"year":2022,"cited_by_count":37},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-06-21T00:00:00"}
