{"id":"https://openalex.org/W2808360658","doi":"https://doi.org/10.1080/10286020.2018.1465413","title":"Sesquiterpenoids from the roots of Croton crassifolius","display_name":"Sesquiterpenoids from the roots of Croton crassifolius","publication_year":2018,"publication_date":"2018-06-10","ids":{"openalex":"https://openalex.org/W2808360658","doi":"https://doi.org/10.1080/10286020.2018.1465413","mag":"2808360658","pmid":"https://pubmed.ncbi.nlm.nih.gov/29888617"},"language":"en","primary_location":{"id":"doi:10.1080/10286020.2018.1465413","doi":"https://doi.org/10.1080/10286020.2018.1465413","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10286020.2018.1465413","pdf_url":null,"source":{"id":"https://openalex.org/S201142877","display_name":"Journal of Asian Natural Products Research","issn_l":"1028-6020","issn":["1028-6020","1477-2213"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Asian Natural Products Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069086097","display_name":"Jinlong Tian","orcid":"https://orcid.org/0000-0001-7149-9441","observed_orcids":["https://orcid.org/0000-0001-7149-9441"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Long Tian","raw_affiliation_strings":["Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441360","display_name":"Chenxi Li","orcid":"https://orcid.org/0000-0003-1903-8685","observed_orcids":["https://orcid.org/0000-0003-1903-8685"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen-Xi Li","raw_affiliation_strings":["Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110631557","display_name":"Xin\u2010Yue Shang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin-Yue Shang","raw_affiliation_strings":["Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085529427","display_name":"Xuewen Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue-Wen Hou","raw_affiliation_strings":["Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100777320","display_name":"Yan Zhang","orcid":"https://orcid.org/0000-0002-7983-8396","observed_orcids":["https://orcid.org/0000-0002-7983-8396","https://orcid.org/0000-0001-8903-7966"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100718437","display_name":"Lingzhi Li","orcid":"https://orcid.org/0000-0001-9119-7133","observed_orcids":["https://orcid.org/0000-0001-9119-7133"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling-Zhi Li","raw_affiliation_strings":["Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032797705","display_name":"Xiao\u2010Xiao Huang","orcid":"https://orcid.org/0000-0003-0099-1118","observed_orcids":["https://orcid.org/0000-0003-0099-1118","https://orcid.org/0000-0002-2008-8949"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]},{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-Xiao Huang","raw_affiliation_strings":["Chinese People\u2019s Liberation Army 210 Hospital, Dalian, China","Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese People\u2019s Liberation Army 210 Hospital, Dalian, China","institution_ids":["https://openalex.org/I4210160531"]},{"raw_affiliation_string":"Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062668196","display_name":"Shao\u2010Jiang Song","orcid":"https://orcid.org/0000-0002-9074-2467","observed_orcids":["https://orcid.org/0000-0002-9074-2467"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shao-Jiang Song","raw_affiliation_strings":["Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China","institution_ids":["https://openalex.org/I103890011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032797705","https://openalex.org/A5062668196"],"corresponding_institution_ids":["https://openalex.org/I103890011","https://openalex.org/I4210160531"],"apc_list":null,"apc_paid":null,"fwci":0.0754,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.34574813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"21","issue":"7","first_page":"666","last_page":"672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/croton-crassifolius","display_name":"Croton crassifolius","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sesquiterpenes","display_name":"sesquiterpenes","score":0.9549999833106995},{"id":"https://openalex.org/keywords/roots","display_name":"roots","score":0.5640000104904175},{"id":"https://openalex.org/keywords/new-natural-products","display_name":"new natural products","score":0.7149999737739563},{"id":"https://openalex.org/keywords/absolute-configuration","display_name":"absolute configuration","score":0.8930000066757202},{"id":"https://openalex.org/keywords/ecd-calculations","display_name":"ECD calculations","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.972000002861023},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hep3b-cells","display_name":"Hep3B cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C2778261524","wikidata":"https://www.wikidata.org/wiki/Q519802","display_name":"Croton","level":2,"score":0.7508056163787842},{"id":"https://openalex.org/C2776211264","wikidata":"https://www.wikidata.org/wiki/Q80218","display_name":"Sesquiterpene","level":2,"score":0.7054336071014404},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.6973903775215149},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6034837365150452},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5888258814811707},{"id":"https://openalex.org/C2994380890","wikidata":"https://www.wikidata.org/wiki/Q11173","display_name":"Chemical constituents","level":2,"score":0.5405503511428833},{"id":"https://openalex.org/C2991951333","wikidata":"https://www.wikidata.org/wiki/Q188403","display_name":"Quantum chemical","level":3,"score":0.49271419644355774},{"id":"https://openalex.org/C2778942509","wikidata":"https://www.wikidata.org/wiki/Q456053","display_name":"Croton oil","level":3,"score":0.47587504982948303},{"id":"https://openalex.org/C2992560755","wikidata":"https://www.wikidata.org/wiki/Q41500","display_name":"Plant roots","level":2,"score":0.4364311099052429},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.36582058668136597},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2898659408092499},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20340126752853394},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.20319348573684692},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.15637090802192688},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.15112003684043884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11876943707466125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.04347574710845947},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076723","descriptor_name":"Negative Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D029802","descriptor_name":"Croton","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/10286020.2018.1465413","doi":"https://doi.org/10.1080/10286020.2018.1465413","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10286020.2018.1465413","pdf_url":null,"source":{"id":"https://openalex.org/S201142877","display_name":"Journal of Asian Natural Products Research","issn_l":"1028-6020","issn":["1028-6020","1477-2213"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Asian Natural Products Research","raw_type":"journal-article"},{"id":"pmid:29888617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29888617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Asian natural products research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1963666476","https://openalex.org/W1999188758","https://openalex.org/W2038014513","https://openalex.org/W2046795305","https://openalex.org/W2084855120","https://openalex.org/W2220629970","https://openalex.org/W2416836202","https://openalex.org/W2573182870","https://openalex.org/W2583344991","https://openalex.org/W2591511724","https://openalex.org/W2681365983","https://openalex.org/W2766418727","https://openalex.org/W2766989000"],"related_works":["https://openalex.org/W2523531936","https://openalex.org/W2046795305","https://openalex.org/W2583344991","https://openalex.org/W2035839088","https://openalex.org/W4221002121","https://openalex.org/W4318829566","https://openalex.org/W2950415355","https://openalex.org/W4409269777","https://openalex.org/W2358708371","https://openalex.org/W2573182870"],"abstract_inverted_index":{"Phytochemical":[0],"investigation":[1],"of":[2,29,66,76],"Croton":[3,70],"crassifolius":[4],"roots":[5],"afforded":[6],"five":[7],"sesquiterpenes":[8,13],"(1\u20135),":[9],"including":[10],"two":[11],"new":[12,31],"6S-hydroxy-cyperenoic":[14],"acid":[15],"(1)":[16],"and":[17,39,85],"crassifterpenoid":[18],"A":[19,51],"(5),":[20],"together":[21],"with":[22],"three":[23],"known":[24],"compounds":[25,32,78],"(2\u20134).":[26],"The":[27],"structures":[28],"the":[30,54,64,74],"were":[33,43,87],"determined":[34,44],"by":[35,45],"comprehensive":[36],"spectroscopic":[37],"methods,":[38],"their":[40],"absolute":[41],"configurations":[42],"quantum":[46],"chemical":[47,67],"ECD":[48],"calculation.":[49],"Crassifterpenoid":[50],"(5)":[52],"is":[53],"first":[55],"germacrane-type":[56],"sesquiterpene":[57],"isolated":[58],"from":[59],"C.":[60],"crassifolius,":[61],"which":[62],"enriched":[63],"diversity":[65],"constituents":[68],"in":[69],"crassifolius.":[71],"In":[72],"addition,":[73],"cytotoxicities":[75],"all":[77],"against":[79],"human":[80],"liver":[81],"cancer":[82],"lines":[83],"HepG2":[84],"Hep3B":[86],"determined,":[88],"but":[89],"none":[90],"showed":[91],"significant":[92],"activity.":[93]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-21T00:00:00"}