{"id":"https://openalex.org/W2808354716","doi":"https://doi.org/10.1161/circgen.118.002176","title":"Response by Kapplinger et al to Letter Regarding Article, \u201cYield of the RYR2 Genetic Test in Suspected Catecholaminergic Polymorphic Ventricular Tachycardia and Implications for Test Interpretation\u201d","display_name":"Response by Kapplinger et al to Letter Regarding Article, \u201cYield of the RYR2 Genetic Test in Suspected Catecholaminergic Polymorphic Ventricular Tachycardia and Implications for Test Interpretation\u201d","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2808354716","doi":"https://doi.org/10.1161/circgen.118.002176","mag":"2808354716","pmid":"https://pubmed.ncbi.nlm.nih.gov/29752402"},"language":"en","primary_location":{"id":"doi:10.1161/circgen.118.002176","doi":"https://doi.org/10.1161/circgen.118.002176","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circgen.118.002176","pdf_url":null,"source":{"id":"https://openalex.org/S4210202128","display_name":"Circulation Genomic and Precision Medicine","issn_l":"2574-8300","issn":["2574-8300"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation: Genomic and Precision Medicine","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047079067","display_name":"Jamie D. Kapplinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie D. Kapplinger","raw_affiliation_strings":["Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.)","Mayo Clinic School of Medicine (J.D.K., M.J.A.)","Medical Scientist Training Program (J.D.K.)","Jamie D. Kapplinger Mayo Clinic School of Medicine (J.D.K., M.J.A.) Medical Scientist Training Program (J.D.K.) Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.)","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic School of Medicine (J.D.K., M.J.A.)","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Medical Scientist Training Program (J.D.K.)","institution_ids":[]},{"raw_affiliation_string":"Jamie D. Kapplinger Mayo Clinic School of Medicine (J.D.K., M.J.A.) Medical Scientist Training Program (J.D.K.) Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.)","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052564552","display_name":"David J. Tester","orcid":"https://orcid.org/0000-0003-4554-2244","observed_orcids":["https://orcid.org/0000-0003-4554-2244"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Tester","raw_affiliation_strings":["Division of Heart Rhythm Services, Department of Cardiovascular Medicine (D.J.T., M.J.A.)","Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.)","David J. Tester Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.) Division of Heart Rhythm Services, Department of Cardiovascular Medicine (D.J.T., M.J.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Heart Rhythm Services, Department of Cardiovascular Medicine (D.J.T., M.J.A.)","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.)","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"David J. Tester Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.) Division of Heart Rhythm Services, Department of Cardiovascular Medicine (D.J.T., M.J.A.)","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055125250","display_name":"Michael John Ackerman","orcid":"https://orcid.org/0000-0002-8011-3333","observed_orcids":["https://orcid.org/0000-0002-8011-3333"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Ackerman","raw_affiliation_strings":["Division of Heart Rhythm Services, Department of Cardiovascular Medicine (D.J.T., M.J.A.)","Division of Pediatric Cardiology, Department of Pediatrics (M.J.A.), Mayo Clinic, Rochester, MN","Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.)","Mayo Clinic School of Medicine (J.D.K., M.J.A.)","Michael J. Ackerman Mayo Clinic School of Medicine (J.D.K., M.J.A.) Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.) Division of Heart Rhythm Services, Department of Cardiovascular Medicine (D.J.T., M.J.A.) Division of Pediatric Cardiology, Department of Pediatrics (M.J.A.), Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Heart Rhythm Services, Department of Cardiovascular Medicine (D.J.T., M.J.A.)","institution_ids":[]},{"raw_affiliation_string":"Division of Pediatric Cardiology, Department of Pediatrics (M.J.A.), Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.)","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic School of Medicine (J.D.K., M.J.A.)","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Michael J. Ackerman Mayo Clinic School of Medicine (J.D.K., M.J.A.) Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.) Division of Heart Rhythm Services, Department of Cardiovascular Medicine (D.J.T., M.J.A.) Division of Pediatric Cardiology, Department of Pediatrics (M.J.A.), Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"5","first_page":"e002176","last_page":"e002176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ryanodine-receptor-2","display_name":"RyR2","score":0.8259999752044678},{"id":"https://openalex.org/keywords/catecholaminergic-polymorphic-ventricular-tachycardia","display_name":"catecholaminergic polymorphic ventricular tachycardia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/genetic-testing","display_name":"genetic testing","score":0.9520000219345093},{"id":"https://openalex.org/keywords/test-yield","display_name":"test yield","score":0.7649999856948853},{"id":"https://openalex.org/keywords/test-interpretation","display_name":"test interpretation","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2778178275","wikidata":"https://www.wikidata.org/wiki/Q1649897","display_name":"Catecholaminergic polymorphic ventricular tachycardia","level":5,"score":0.9598780870437622},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8759269714355469},{"id":"https://openalex.org/C190712762","wikidata":"https://www.wikidata.org/wiki/Q18031341","display_name":"Ryanodine receptor 2","level":4,"score":0.6204511523246765},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.5144715309143066},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5137120485305786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49064818024635315},{"id":"https://openalex.org/C2776331378","wikidata":"https://www.wikidata.org/wiki/Q56002","display_name":"Ventricular tachycardia","level":2,"score":0.48879286646842957},{"id":"https://openalex.org/C2780283014","wikidata":"https://www.wikidata.org/wiki/Q209583","display_name":"Tachycardia","level":2,"score":0.4167727828025818},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.060951173305511475},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.0},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000098850","descriptor_name":"Polymorphic Catecholaminergic Ventricular Tachycardia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017180","descriptor_name":"Tachycardia, Ventricular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1161/circgen.118.002176","doi":"https://doi.org/10.1161/circgen.118.002176","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circgen.118.002176","pdf_url":null,"source":{"id":"https://openalex.org/S4210202128","display_name":"Circulation Genomic and Precision Medicine","issn_l":"2574-8300","issn":["2574-8300"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation: Genomic and Precision Medicine","raw_type":"journal-article"},{"id":"pmid:29752402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29752402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation. Genomic and precision medicine","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W2051978340","https://openalex.org/W2062584443","https://openalex.org/W2151406645","https://openalex.org/W2398772975","https://openalex.org/W2406249485","https://openalex.org/W2788069694","https://openalex.org/W2802353617"],"related_works":["https://openalex.org/W2802353617","https://openalex.org/W2788069694","https://openalex.org/W2886188320","https://openalex.org/W2034022933","https://openalex.org/W1539101816","https://openalex.org/W2946899195","https://openalex.org/W2092263222","https://openalex.org/W2076193115","https://openalex.org/W2788997332","https://openalex.org/W1696763296"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-21T00:00:00"}
