{"id":"https://openalex.org/W2808326792","doi":"https://doi.org/10.7150/ijbs.25026","title":"The role of FGF21 in type 1 diabetes and its complications","display_name":"The role of FGF21 in type 1 diabetes and its complications","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2808326792","doi":"https://doi.org/10.7150/ijbs.25026","mag":"2808326792","pmid":"https://pubmed.ncbi.nlm.nih.gov/29989062","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6036735"},"language":"en","primary_location":{"id":"doi:10.7150/ijbs.25026","doi":"https://doi.org/10.7150/ijbs.25026","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.25026","pdf_url":"http://www.ijbs.com/v14p1000.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.ijbs.com/v14p1000.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100409892","display_name":"Jian Zhang","orcid":"https://orcid.org/0000-0001-8338-9426","observed_orcids":["https://orcid.org/0000-0001-8338-9426"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jian Zhang","raw_affiliation_strings":["Pediatrics Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA","The Center of Cardiovascular Disorders, the First Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"The Center of Cardiovascular Disorders, the First Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018898406","display_name":"Wenya Weng","orcid":"https://orcid.org/0000-0002-9368-0556","observed_orcids":["https://orcid.org/0000-0002-9368-0556"]},"institutions":[{"id":"https://openalex.org/I4210099263","display_name":"Ruian People's Hospital","ror":"https://ror.org/011b9vp56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099263"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenya Weng","raw_affiliation_strings":["The Third Affiliated Hospital of Wenzhou Medical University, Ruian Center of Chinese-American Research Institute for Diabetic Complications, Ruian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Affiliated Hospital of Wenzhou Medical University, Ruian Center of Chinese-American Research Institute for Diabetic Complications, Ruian, China","institution_ids":["https://openalex.org/I4210099263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437010","display_name":"Kai Wang","orcid":"https://orcid.org/0000-0002-3615-0663","observed_orcids":["https://orcid.org/0000-0002-3615-0663"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Kai Wang","raw_affiliation_strings":["Pediatrics Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA","The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016987565","display_name":"Xuemian Lu","orcid":"https://orcid.org/0000-0002-2277-0052","observed_orcids":["https://orcid.org/0000-0002-2277-0052","https://orcid.org/0009-0004-7525-5689","https://orcid.org/0000-0003-0882-4816"]},"institutions":[{"id":"https://openalex.org/I4210099263","display_name":"Ruian People's Hospital","ror":"https://ror.org/011b9vp56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099263"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuemian Lu","raw_affiliation_strings":["The Third Affiliated Hospital of Wenzhou Medical University, Ruian Center of Chinese-American Research Institute for Diabetic Complications, Ruian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Affiliated Hospital of Wenzhou Medical University, Ruian Center of Chinese-American Research Institute for Diabetic Complications, Ruian, China","institution_ids":["https://openalex.org/I4210099263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017873319","display_name":"Lu Cai","orcid":"https://orcid.org/0000-0003-3048-1135","observed_orcids":["https://orcid.org/0000-0003-3048-1135"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lu Cai","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA","Pediatrics Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Pediatrics Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017744165","display_name":"Jian Sun","orcid":"https://orcid.org/0000-0002-1772-6786","observed_orcids":["https://orcid.org/0000-0002-1772-6786"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Sun","raw_affiliation_strings":["The Center of Cardiovascular Disorders, the First Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center of Cardiovascular Disorders, the First Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210125137"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017744165","https://openalex.org/A5017873319"],"corresponding_institution_ids":["https://openalex.org/I142740786","https://openalex.org/I4210125137"],"apc_list":{"value":2000,"currency":"AUD","value_usd":1337},"apc_paid":{"value":2000,"currency":"AUD","value_usd":1337},"fwci":0.2449,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.2097571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"14","issue":"9","first_page":"1000","last_page":"1011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf21","display_name":"FGF21","score":0.9909999966621399},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":1.0},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.7609999775886536},{"id":"https://openalex.org/keywords/hypoglycemic-effect","display_name":"hypoglycemic effect","score":0.9819999933242798},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.574999988079071},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8289999961853027},{"id":"https://openalex.org/keywords/diabetes-treatment","display_name":"diabetes treatment","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.84470534324646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.798019289970398},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7874423265457153},{"id":"https://openalex.org/C106646824","wikidata":"https://www.wikidata.org/wiki/Q5425475","display_name":"FGF21","level":4,"score":0.7803372144699097},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5003175735473633},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.4958671033382416},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4416748881340027},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.43561944365501404},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3338952958583832},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2688400149345398},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22032901644706726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08583495020866394},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.07863619923591614},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.7150/ijbs.25026","doi":"https://doi.org/10.7150/ijbs.25026","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.25026","pdf_url":"http://www.ijbs.com/v14p1000.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4990468","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6036735","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6036735","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6036735","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Biol Sci","raw_type":"Text"},{"id":"pmid:29989062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29989062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7150/ijbs.25026","doi":"https://doi.org/10.7150/ijbs.25026","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.25026","pdf_url":"http://www.ijbs.com/v14p1000.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G140592361","display_name":null,"funder_award_id":"1-18-IBS-082","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4190374832","display_name":null,"funder_award_id":"81770374","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5871638111","display_name":null,"funder_award_id":"1\u201018\u2010IBS\u2010082","funder_id":"https://openalex.org/F4320306089","funder_display_name":"American Diabetes Association"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2808326792.pdf","grobid_xml":"https://content.openalex.org/works/W2808326792.grobid-xml"},"referenced_works_count":125,"referenced_works":["https://openalex.org/W20183598","https://openalex.org/W146001025","https://openalex.org/W565001682","https://openalex.org/W1495551695","https://openalex.org/W1515060166","https://openalex.org/W1515671273","https://openalex.org/W1522113235","https://openalex.org/W1757847430","https://openalex.org/W1966270159","https://openalex.org/W1968091833","https://openalex.org/W1970437421","https://openalex.org/W1973873267","https://openalex.org/W1977214950","https://openalex.org/W1977586395","https://openalex.org/W1984913749","https://openalex.org/W1986199468","https://openalex.org/W1987373627","https://openalex.org/W1988476050","https://openalex.org/W1989043810","https://openalex.org/W1989618690","https://openalex.org/W1990886132","https://openalex.org/W1997884729","https://openalex.org/W1999249055","https://openalex.org/W1999449586","https://openalex.org/W1999974405","https://openalex.org/W2000665430","https://openalex.org/W2001449527","https://openalex.org/W2003177585","https://openalex.org/W2005063766","https://openalex.org/W2006243734","https://openalex.org/W2007215002","https://openalex.org/W2007343435","https://openalex.org/W2011284225","https://openalex.org/W2011712684","https://openalex.org/W2012780205","https://openalex.org/W2016543968","https://openalex.org/W2020495368","https://openalex.org/W2021743307","https://openalex.org/W2028034176","https://openalex.org/W2028617804","https://openalex.org/W2029880965","https://openalex.org/W2039844480","https://openalex.org/W2047726905","https://openalex.org/W2048411348","https://openalex.org/W2050259739","https://openalex.org/W2058380147","https://openalex.org/W2061333499","https://openalex.org/W2061450170","https://openalex.org/W2061512091","https://openalex.org/W2062842771","https://openalex.org/W2064125892","https://openalex.org/W2070126973","https://openalex.org/W2073654379","https://openalex.org/W2075995458","https://openalex.org/W2076037986","https://openalex.org/W2077799214","https://openalex.org/W2078451276","https://openalex.org/W2080199877","https://openalex.org/W2085379045","https://openalex.org/W2086624706","https://openalex.org/W2088845412","https://openalex.org/W2089807028","https://openalex.org/W2089817491","https://openalex.org/W2090060547","https://openalex.org/W2095126843","https://openalex.org/W2095480970","https://openalex.org/W2100232436","https://openalex.org/W2101369634","https://openalex.org/W2101962482","https://openalex.org/W2105014495","https://openalex.org/W2106745402","https://openalex.org/W2110534048","https://openalex.org/W2114650931","https://openalex.org/W2116691565","https://openalex.org/W2119351413","https://openalex.org/W2119432184","https://openalex.org/W2120610691","https://openalex.org/W2121049950","https://openalex.org/W2122813925","https://openalex.org/W2123768117","https://openalex.org/W2126188293","https://openalex.org/W2127359651","https://openalex.org/W2128384554","https://openalex.org/W2129100766","https://openalex.org/W2129631252","https://openalex.org/W2130700195","https://openalex.org/W2131044927","https://openalex.org/W2131622156","https://openalex.org/W2133699997","https://openalex.org/W2133706171","https://openalex.org/W2134810803","https://openalex.org/W2134944069","https://openalex.org/W2141124825","https://openalex.org/W2145142659","https://openalex.org/W2147029239","https://openalex.org/W2147734839","https://openalex.org/W2151175711","https://openalex.org/W2155010729","https://openalex.org/W2157891550","https://openalex.org/W2158061384","https://openalex.org/W2160274347","https://openalex.org/W2162056776","https://openalex.org/W2166878182","https://openalex.org/W2168649725","https://openalex.org/W2171151924","https://openalex.org/W2265613929","https://openalex.org/W2294945370","https://openalex.org/W2327015076","https://openalex.org/W2335155892","https://openalex.org/W2350983772","https://openalex.org/W2397676298","https://openalex.org/W2413062894","https://openalex.org/W2469398832","https://openalex.org/W2471356895","https://openalex.org/W2541714644","https://openalex.org/W2558467589","https://openalex.org/W2613579128","https://openalex.org/W2618222125","https://openalex.org/W2735844318","https://openalex.org/W2740692193","https://openalex.org/W2762919761","https://openalex.org/W4249622111","https://openalex.org/W4406542368","https://openalex.org/W6650525488","https://openalex.org/W6676893752"],"related_works":["https://openalex.org/W2358877724","https://openalex.org/W2105246360","https://openalex.org/W2110708451","https://openalex.org/W4213435996","https://openalex.org/W3157676683","https://openalex.org/W2092804860","https://openalex.org/W1978914376","https://openalex.org/W1966270159","https://openalex.org/W3037257824","https://openalex.org/W1757847430"],"abstract_inverted_index":{"complications,":[0,154],"are":[1,132,156],"yet":[2],"far":[3],"from":[4],"ideal.":[5],"Therefore,":[6],"an":[7],"urgent":[8],"need":[9],"exists":[10],"for":[11,97,171],"the":[12,43,51,58,63,83,87,92,103,115,139,143,180],"development":[13],"of":[14,42,60,67,89,94,117,146,166,184],"more":[15],"effective":[16],"therapies.":[17],"Numerous":[18],"studies":[19,44,140],"have":[20],"been":[21],"conducted":[22,49],"to":[23,135,173],"establish":[24],"and":[25,34,71,91,120,152,161,169,177,182],"confirm":[26],"whether":[27],"FGF21":[28,47,61,90,109,147],"exerts":[29,110],"beneficial":[30,144],"effects":[31],"on":[32,86,102,148],"obesity":[33],"diabetes":[35,70,127,151],"along":[36],"with":[37,46,53],"its":[38,72,153],"complications.":[39],"However,":[40],"most":[41],"associated":[45],"were":[48,74],"in":[50,62,124,138],"patients":[52],"type":[54,68,98,125,149,185],"2":[55,150],"diabetes.":[56,100,187],"Subsequently,":[57],"effect":[59],"prevention":[64,181],"or":[65],"treatment":[66,96,183],"1":[69,99,126,186],"complications":[73,123],"also":[75,157],"increasingly":[76],"reported.":[77],"In":[78],"this":[79],"review,":[80],"we":[81,106],"summarize":[82],"findings":[84,162],"available":[85,104],"function":[88,116],"status":[93],"FGF21's":[95],"Based":[101],"information,":[105],"found":[107],"that":[108,141,163],"a":[111],"hypoglycemic":[112],"effect,":[113],"restores":[114],"brown":[118],"fat,":[119],"inhibits":[121],"various":[122],"patients.":[128],"Although":[129],"these":[130],"features":[131,160],"predominantly":[133],"similar":[134],"those":[136],"observed":[137],"showed":[142],"impact":[145],"there":[155],"certain":[158],"distinct":[159],"may":[164],"be":[165],"provide":[167],"important":[168],"instructive":[170],"us":[172],"understand":[174],"mechanistic":[175],"insights":[176],"further":[178],"promote":[179]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-21T00:00:00"}