{"id":"https://openalex.org/W2808288208","doi":"https://doi.org/10.1158/0008-5472.can-17-3993","title":"Licofelone Enhances the Efficacy of Paclitaxel in Ovarian Cancer by Reversing Drug Resistance and Tumor Stem-like Properties","display_name":"Licofelone Enhances the Efficacy of Paclitaxel in Ovarian Cancer by Reversing Drug Resistance and Tumor Stem-like Properties","publication_year":2018,"publication_date":"2018-06-11","ids":{"openalex":"https://openalex.org/W2808288208","doi":"https://doi.org/10.1158/0008-5472.can-17-3993","mag":"2808288208","pmid":"https://pubmed.ncbi.nlm.nih.gov/29891506","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6072598"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-17-3993","doi":"https://doi.org/10.1158/0008-5472.can-17-3993","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-17-3993","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6072598","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003443127","display_name":"Jeff J. Hirst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Hirst","raw_affiliation_strings":["1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015247627","display_name":"Harsh B. Pathak","orcid":"https://orcid.org/0000-0003-4034-0520","observed_orcids":["https://orcid.org/0000-0003-4034-0520"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harsh B. Pathak","raw_affiliation_strings":["1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058265159","display_name":"Stephen D. Hyter","orcid":"https://orcid.org/0000-0001-8176-9644","observed_orcids":["https://orcid.org/0000-0001-8176-9644"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Hyter","raw_affiliation_strings":["1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020195433","display_name":"Ziyan Yuan Pessetto","orcid":"https://orcid.org/0000-0003-4847-657X","observed_orcids":["https://orcid.org/0000-0003-4847-657X"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ziyan Y. Pessetto","raw_affiliation_strings":["1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049956550","display_name":"Thuc Ly","orcid":"https://orcid.org/0000-0002-3971-5404","observed_orcids":["https://orcid.org/0000-0002-3971-5404"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thuc Ly","raw_affiliation_strings":["1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078983295","display_name":"Stefan Graw","orcid":"https://orcid.org/0000-0002-6386-8267","observed_orcids":["https://orcid.org/0000-0002-6386-8267"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Graw","raw_affiliation_strings":["2Department of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046887908","display_name":"Devin C. Koestler","orcid":"https://orcid.org/0000-0002-0598-0146","observed_orcids":["https://orcid.org/0000-0002-0598-0146"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devin C. Koestler","raw_affiliation_strings":["2Department of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas","3University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"3University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210097601","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027579250","display_name":"Adam J. Krieg","orcid":"https://orcid.org/0000-0002-3069-0378","observed_orcids":["https://orcid.org/0000-0002-3069-0378"]},"institutions":[{"id":"https://openalex.org/I102507086","display_name":"Oregon National Primate Research Center","ror":"https://ror.org/05fcfqq67","country_code":"US","type":"facility","lineage":["https://openalex.org/I102507086"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam J. Krieg","raw_affiliation_strings":["4Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon","5Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon"],"raw_orcid":"https://orcid.org/0000-0002-3069-0378","affiliations":[{"raw_affiliation_string":"4Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"5Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon","institution_ids":["https://openalex.org/I102507086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071439052","display_name":"Katherine F. Roby","orcid":"https://orcid.org/0000-0001-6667-9464","observed_orcids":["https://orcid.org/0000-0001-6667-9464"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine F. Roby","raw_affiliation_strings":["3University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas","6Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas","7Department of Anatomy & Cell Biology, University of Kansas Medical Center, Kansas City, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210097601","https://openalex.org/I4210128618"]},{"raw_affiliation_string":"6Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"7Department of Anatomy & Cell Biology, University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033625395","display_name":"Andrew K. Godwin","orcid":"https://orcid.org/0000-0002-3987-9580","observed_orcids":["https://orcid.org/0000-0002-3987-9580"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew K. Godwin","raw_affiliation_strings":["1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas","3University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"3University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210097601","https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5033625395"],"corresponding_institution_ids":["https://openalex.org/I4210097601","https://openalex.org/I4210128618"],"apc_list":null,"apc_paid":null,"fwci":7.4815,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.97705265,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"78","issue":"15","first_page":"4370","last_page":"4385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.1527000069618225,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/licofelone","display_name":"licofelone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9919999837875366},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7689999938011169},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.9259999990463257},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7170000076293945},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7379999756813049},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.9055206775665283},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7922420501708984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5572943091392517},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5434477925300598},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5233449339866638},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.511840283870697},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4847218990325928},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4811921715736389},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48003044724464417},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45915713906288147},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4591308534145355},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.45617222785949707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3065560460090637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2866296172142029},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071916","descriptor_name":"AC133 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-17-3993","doi":"https://doi.org/10.1158/0008-5472.can-17-3993","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-17-3993","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:29891506","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29891506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6072598","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6072598","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6072598","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6072598","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2737981367","display_name":"Exploiting Biological Networks to Improve Clinical Treatment of Ovarian Cancer","funder_award_id":"R01CA140323","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000869322","display_name":"Kansas IDeA Network of Biomedical Research Excellence 5","funder_award_id":"P20GM103418","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000911857","display_name":"The University of Kansas Cancer Center","funder_award_id":"P30CA168524","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G920922199","display_name":"Kansas BIRCWH Career Develo[pment Program in Women's Health","funder_award_id":"K12HD052027","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1480984787","https://openalex.org/W1573780709","https://openalex.org/W1596453879","https://openalex.org/W1904009550","https://openalex.org/W1967761437","https://openalex.org/W1982365736","https://openalex.org/W1983770566","https://openalex.org/W1989175172","https://openalex.org/W1989541787","https://openalex.org/W1994659121","https://openalex.org/W1995206147","https://openalex.org/W1997254130","https://openalex.org/W2009015730","https://openalex.org/W2017975901","https://openalex.org/W2020216997","https://openalex.org/W2025516968","https://openalex.org/W2025847801","https://openalex.org/W2026862874","https://openalex.org/W2031456603","https://openalex.org/W2032520688","https://openalex.org/W2042278655","https://openalex.org/W2056950140","https://openalex.org/W2067067209","https://openalex.org/W2071006154","https://openalex.org/W2071756286","https://openalex.org/W2074082353","https://openalex.org/W2074982201","https://openalex.org/W2077945404","https://openalex.org/W2078160295","https://openalex.org/W2089755408","https://openalex.org/W2094454542","https://openalex.org/W2123108235","https://openalex.org/W2126787483","https://openalex.org/W2129213113","https://openalex.org/W2151417473","https://openalex.org/W2154885792","https://openalex.org/W2155156801","https://openalex.org/W2156778593","https://openalex.org/W2184394483","https://openalex.org/W2190767857","https://openalex.org/W2291038537","https://openalex.org/W2304994032","https://openalex.org/W2326557216","https://openalex.org/W2333245858","https://openalex.org/W2396911170","https://openalex.org/W2407388461","https://openalex.org/W2411583021","https://openalex.org/W2418684115","https://openalex.org/W2428522048","https://openalex.org/W2529083907","https://openalex.org/W2549705216","https://openalex.org/W2562144787","https://openalex.org/W2570618306","https://openalex.org/W2746789875","https://openalex.org/W2788735115","https://openalex.org/W4250162239","https://openalex.org/W6713916749","https://openalex.org/W6715127292"],"related_works":["https://openalex.org/W2898414304","https://openalex.org/W4412392845","https://openalex.org/W3018869716","https://openalex.org/W3034020069","https://openalex.org/W1599115647","https://openalex.org/W2317066648","https://openalex.org/W2015223324","https://openalex.org/W2153602227","https://openalex.org/W3168372462","https://openalex.org/W3083699822"],"abstract_inverted_index":{"Abstract":[0],"Drug":[1],"development":[2],"for":[3,14,22,60,215],"first-line":[4,241],"treatment":[5],"of":[6,41,65,95,103,118,135,148,170,178,254],"epithelial":[7],"ovarian":[8,149,157,229,273],"cancer":[9],"(EOC)":[10],"has":[11],"been":[12],"stagnant":[13],"almost":[15],"three":[16],"decades.":[17],"Traditional":[18],"cell":[19,43,48,78],"culture":[20,79],"methods":[21],"primary":[23,244],"drug":[24,222,260],"screening":[25,261],"do":[26],"not":[27],"always":[28],"accurately":[29],"reflect":[30],"clinical":[31],"disease.":[32],"To":[33],"overcome":[34],"this":[35],"barrier,":[36],"we":[37,122],"grew":[38],"a":[39,69,101,116,162],"panel":[40],"EOC":[42,66],"lines":[44],"in":[45,128,156,161,228,238,243,256,272],"three-dimensional":[46],"(3D)":[47],"cultures":[49],"to":[50,80,90,183,234,263,268],"form":[51],"multicellular":[52],"tumor":[53,164],"spheroids":[54],"(MCTS).":[55],"We":[56],"characterized":[57],"these":[58],"MCTS":[59,86,129,158],"molecular":[61],"and":[62,67,97,99,109,160,207,245],"cellular":[63],"features":[64],"performed":[68],"comparative":[70],"screen":[71],"with":[72,125,154,172,202,240],"cells":[73],"grown":[74],"using":[75],"two-dimensional":[76],"(2D)":[77],"identify":[81,214,264],"previously":[82],"unappreciated":[83],"anticancer":[84],"drugs.":[85],"exhibited":[87],"greater":[88],"resistance":[89,227,271],"chemotherapeutic":[91,226],"agents,":[92],"showed":[93],"signs":[94],"senescence":[96],"hypoxia,":[98],"expressed":[100],"number":[102],"stem":[104],"cell\u2013associated":[105],"transcripts":[106],"including":[107],"ALDH1A":[108],"CD133,":[110],"also":[111,152],"known":[112],"as":[113],"PROM1.":[114],"Using":[115],"library":[117],"clinically":[119,235],"repurposed":[120],"drugs,":[121],"identified":[123],"candidates":[124],"preferential":[126],"activity":[127],"over":[130],"2D":[131],"cultured":[132],"cells.":[133],"One":[134],"the":[136,139,145,168,175,216,232,252],"lead":[137],"compounds,":[138],"dual":[140],"COX/LOX":[141],"inhibitor":[142],"licofelone,":[143],"reversed":[144],"stem-like":[146],"properties":[147],"MCTS.":[150],"Licofelone":[151],"synergized":[153],"paclitaxel":[155,173,184,208],"models":[159],"patient-derived":[163],"xenograft":[165],"model.":[166],"Importantly,":[167],"combination":[169,239],"licofelone":[171,187,237],"prolonged":[174],"median":[176],"survival":[177],"mice":[179],"(>141":[180],"days)":[181],"relative":[182],"(115":[185],"days),":[186,189],"(37":[188],"or":[190],"vehicle":[191,203],"(30":[192],"days).":[193],"Increased":[194],"efficacy":[195],"was":[196],"confirmed":[197],"by":[198],"Mantel\u2013Haenszel":[199],"HR":[200],"compared":[201],"(HR":[204,209],"=":[205,210],"0.037)":[206],"0.017).":[211],"These":[212],"results":[213],"first":[217],"time":[218],"an":[219,255],"unappreciated,":[220],"anti-inflammatory":[221],"that":[223],"can":[224],"reverse":[225,269],"cancer,":[230],"highlighting":[231],"need":[233],"evaluate":[236],"chemotherapy":[242,270],"chemotherapy-refractory":[246],"EOC.":[247],"Significance:":[248],"This":[249],"study":[250],"highlights":[251],"use":[253],"vitro":[257],"spheroid":[258],"3D":[259],"model":[262],"new":[265],"therapeutic":[266],"approaches":[267],"cancer.":[274],"Cancer":[275],"Res;":[276],"78(15);":[277],"4370\u201385.":[278],"\u00a92018":[279],"AACR.":[280]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-21T00:00:00"}
