{"id":"https://openalex.org/W2808095003","doi":"https://doi.org/10.1111/1346-8138.14503","title":"Mortality in bullous pemphigoid: A systematic review and meta\u2010analysis of standardized mortality ratios","display_name":"Mortality in bullous pemphigoid: A systematic review and meta\u2010analysis of standardized mortality ratios","publication_year":2018,"publication_date":"2018-06-15","ids":{"openalex":"https://openalex.org/W2808095003","doi":"https://doi.org/10.1111/1346-8138.14503","mag":"2808095003","pmid":"https://pubmed.ncbi.nlm.nih.gov/29905389"},"language":"en","primary_location":{"id":"doi:10.1111/1346-8138.14503","doi":"https://doi.org/10.1111/1346-8138.14503","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1346-8138.14503","pdf_url":null,"source":{"id":"https://openalex.org/S143887118","display_name":"The Journal of Dermatology","issn_l":"0385-2407","issn":["0385-2407","1346-8138"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070588042","display_name":"Khalaf Kridin","orcid":"https://orcid.org/0000-0001-9971-9151","observed_orcids":["https://orcid.org/0000-0001-9971-9151"]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Khalaf Kridin","raw_affiliation_strings":["Department of Dermatology, Rambam Health Care Campus, Haifa, Israel"],"raw_orcid":"https://orcid.org/0000-0001-9971-9151","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Rambam Health Care Campus, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045241659","display_name":"Naama Schwartz","orcid":"https://orcid.org/0000-0002-5238-4080","observed_orcids":["https://orcid.org/0000-0002-5238-4080"]},"institutions":[{"id":"https://openalex.org/I91203450","display_name":"University of Haifa","ror":"https://ror.org/02f009v59","country_code":"IL","type":"education","lineage":["https://openalex.org/I91203450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Naama Schwartz","raw_affiliation_strings":["School of Public Health, University of Haifa, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, University of Haifa, Haifa, Israel","institution_ids":["https://openalex.org/I91203450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008417497","display_name":"Arnon Dov Cohen","orcid":"https://orcid.org/0000-0002-8377-9982","observed_orcids":["https://orcid.org/0000-0002-8377-9982"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]},{"id":"https://openalex.org/I64767286","display_name":"Clalit Health Services","ror":"https://ror.org/04zjvnp94","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Arnon D. Cohen","raw_affiliation_strings":["Department of Quality Measurements and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel","Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheeva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quality Measurements and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel","institution_ids":["https://openalex.org/I64767286"]},{"raw_affiliation_string":"Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheeva, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028555246","display_name":"Shira Zelber\u2010Sagi","orcid":"https://orcid.org/0000-0002-1324-7497","observed_orcids":["https://orcid.org/0000-0002-1324-7497"]},"institutions":[{"id":"https://openalex.org/I91203450","display_name":"University of Haifa","ror":"https://ror.org/02f009v59","country_code":"IL","type":"education","lineage":["https://openalex.org/I91203450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Shira Zelber\u2010Sagi","raw_affiliation_strings":["School of Public Health, University of Haifa, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, University of Haifa, Haifa, Israel","institution_ids":["https://openalex.org/I91203450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070588042"],"corresponding_institution_ids":["https://openalex.org/I2801301638"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":null,"fwci":0.7195,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.54759568,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"45","issue":"9","first_page":"1094","last_page":"1100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11730","display_name":"Autoimmune Bullous Skin Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11730","display_name":"Autoimmune Bullous Skin Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bullous-pemphigoid","display_name":"bullous pemphigoid","score":1.0},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.9919999837875366},{"id":"https://openalex.org/keywords/standardized-mortality-ratio","display_name":"standardized mortality ratio","score":0.9940000176429749},{"id":"https://openalex.org/keywords/excess-mortality","display_name":"excess mortality","score":0.796999990940094},{"id":"https://openalex.org/keywords/secular-trends","display_name":"secular trends","score":0.9340000152587891},{"id":"https://openalex.org/keywords/autoimmune-blistering-disease","display_name":"autoimmune blistering disease","score":0.824999988079071},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8278464078903198},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7691943645477295},{"id":"https://openalex.org/C102803821","wikidata":"https://www.wikidata.org/wiki/Q7598403","display_name":"Standardized mortality ratio","level":3,"score":0.7592058777809143},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6419349908828735},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.559123158454895},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.5520635843276978},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.5162327289581299},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.49488919973373413},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3816642165184021},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.11990901827812195},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D010391","descriptor_name":"Pemphigoid, Bullous","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D064887","descriptor_name":"Observational Studies as Topic","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/1346-8138.14503","doi":"https://doi.org/10.1111/1346-8138.14503","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1346-8138.14503","pdf_url":null,"source":{"id":"https://openalex.org/S143887118","display_name":"The Journal of Dermatology","issn_l":"0385-2407","issn":["0385-2407","1346-8138"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:29905389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29905389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of dermatology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1525088973","https://openalex.org/W1836292197","https://openalex.org/W1969145745","https://openalex.org/W1973651706","https://openalex.org/W1976227150","https://openalex.org/W1981248553","https://openalex.org/W2014849086","https://openalex.org/W2018445941","https://openalex.org/W2028329527","https://openalex.org/W2042225959","https://openalex.org/W2052165797","https://openalex.org/W2054414140","https://openalex.org/W2062202059","https://openalex.org/W2085109894","https://openalex.org/W2111620283","https://openalex.org/W2116475791","https://openalex.org/W2135033359","https://openalex.org/W2156588802","https://openalex.org/W2158998701","https://openalex.org/W2162560453","https://openalex.org/W2397754804","https://openalex.org/W2473735880","https://openalex.org/W2613446307"],"related_works":["https://openalex.org/W6948362076","https://openalex.org/W2811056062","https://openalex.org/W3137470997","https://openalex.org/W2397754804","https://openalex.org/W2052165797","https://openalex.org/W1525088973","https://openalex.org/W2062202059","https://openalex.org/W4225374442","https://openalex.org/W3200835943","https://openalex.org/W2750713770"],"abstract_inverted_index":{"There":[0,144],"are":[1,21],"inconsistent":[2],"data":[3],"on":[4],"mortality":[5,15,36,51,105,175,189],"rates":[6],"in":[7,14,16,37,49,67,122,148,160,190],"patients":[8,39,177],"with":[9,108,178,182],"bullous":[10],"pemphigoid":[11],"(BP).":[12],"Trends":[13],"BP":[17,38,179,191],"throughout":[18],"the":[19,29,35,42,53,90,119,129,152,183,197],"years":[20],"yet":[22],"to":[23,33,41,46,101,117],"be":[24],"established.":[25],"The":[26,187],"aim":[27],"of":[28,64,75,85],"present":[30],"study":[31,34],"was":[32,87,96,139,145],"relative":[40],"general":[43,185],"population":[44],"and":[45,62,70],"estimate":[47,102],"trends":[48,121],"standardized":[50,104],"over":[52,196],"past":[54,198],"30":[55,199],"years.":[56,200],"We":[57],"performed":[58,97],"a":[59,172],"systematic":[60],"review":[61],"meta-analysis":[63,95],"observational":[65],"studies":[66,77,125],"Medline,":[68],"Embase":[69],"Scopus":[71],"(1823-2017).":[72],"Reference":[73],"lists":[74],"included":[76,127],"were":[78,115,126],"also":[79],"searched":[80],"for":[81],"eligible":[82],"studies.":[83],"Quality":[84],"evidence":[86],"assessed":[88],"using":[89,98],"Newcastle-Ottawa":[91],"Scale":[92],"(NOS).":[93],"A":[94],"random-effects":[99],"models":[100,114],"pooled":[103],"ratios":[106],"(SMR)":[107],"95%":[109,162],"confidence":[110],"intervals":[111],"(CI).":[112],"Meta-regression":[113],"used":[116],"investigate":[118],"secular":[120],"SMR.":[123],"Ten":[124],"covering":[128],"period":[130],"1960-2015":[131],"(1736":[132],"patients,":[133],"746":[134],"deaths).":[135],"Pooled":[136],"all-cause":[137,149],"SMR":[138,150],"3.6":[140],"(95%":[141],"CI,":[142,163],"2.6-5.0).":[143],"no":[146],"trend":[147],"across":[151],"last":[153],"three":[154],"decades":[155],"(regression":[156],"coefficient":[157],"0.02":[158],"[change":[159],"logSMR/year];":[161],"0.04-0.08;":[164],"P":[165],"=":[166],"0.545).":[167],"In":[168],"conclusion,":[169],"there":[170],"is":[171],"3.6-fold":[173],"increased":[174],"among":[176],"as":[180],"compared":[181],"age-matched":[184],"population.":[186],"excess":[188],"has":[192],"not":[193],"changed":[194],"significantly":[195]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-21T00:00:00"}