{"id":"https://openalex.org/W2808082304","doi":"https://doi.org/10.3390/metabo9010007","title":"Palbociclib and Fulvestrant Act in Synergy to Modulate Central Carbon Metabolism in Breast Cancer Cells","display_name":"Palbociclib and Fulvestrant Act in Synergy to Modulate Central Carbon Metabolism in Breast Cancer Cells","publication_year":2019,"publication_date":"2019-01-02","ids":{"openalex":"https://openalex.org/W2808082304","doi":"https://doi.org/10.3390/metabo9010007","mag":"2808082304","pmid":"https://pubmed.ncbi.nlm.nih.gov/30609717","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6359333"},"language":"en","primary_location":{"id":"doi:10.3390/metabo9010007","doi":"https://doi.org/10.3390/metabo9010007","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/metabo9010007","pdf_url":"https://www.mdpi.com/2218-1989/9/1/7/pdf?version=1546416957","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-1989/9/1/7/pdf?version=1546416957","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041929818","display_name":"Benedikt Warth","orcid":"https://orcid.org/0000-0002-6104-0706","observed_orcids":["https://orcid.org/0000-0002-6104-0706"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT","US"],"is_corresponding":false,"raw_author_name":"Benedikt Warth","raw_affiliation_strings":["Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, W\u00e4hringerstra\u00dfe 38, 1090 Vienna, Austria","The Scripps Research Institute, Scripps Center for Metabolomics and Mass Spectrometry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","Vienna Metabolomics Center (VIME), University of Vienna, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, W\u00e4hringerstra\u00dfe 38, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"The Scripps Research Institute, Scripps Center for Metabolomics and Mass Spectrometry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Vienna Metabolomics Center (VIME), University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059966935","display_name":"Amelia Palermo","orcid":"https://orcid.org/0000-0001-5705-6521","observed_orcids":["https://orcid.org/0000-0001-5705-6521"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amelia Palermo","raw_affiliation_strings":["The Scripps Research Institute, Scripps Center for Metabolomics and Mass Spectrometry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, Scripps Center for Metabolomics and Mass Spectrometry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060542334","display_name":"Nicholas J. W. Rattray","orcid":"https://orcid.org/0000-0002-3528-6905","observed_orcids":["https://orcid.org/0000-0002-3528-6905"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J.W. Rattray","raw_affiliation_strings":["Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT 06511, USA"],"raw_orcid":"https://orcid.org/0000-0002-3528-6905","affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072732582","display_name":"Nathan V. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan V. Lee","raw_affiliation_strings":["Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077097017","display_name":"Zhou Zhu","orcid":"https://orcid.org/0000-0002-0642-8919","observed_orcids":["https://orcid.org/0000-0002-0642-8919","https://orcid.org/0009-0006-6003-9996"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhou Zhu","raw_affiliation_strings":["Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005094851","display_name":"Linh Truc Hoang","orcid":"https://orcid.org/0000-0002-0077-8213","observed_orcids":["https://orcid.org/0000-0002-0077-8213"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linh T. Hoang","raw_affiliation_strings":["The Scripps Research Institute, Scripps Center for Metabolomics and Mass Spectrometry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, Scripps Center for Metabolomics and Mass Spectrometry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050024114","display_name":"Yuping A. Cai","orcid":"https://orcid.org/0000-0002-5701-3609","observed_orcids":["https://orcid.org/0000-0002-5701-3609"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuping Cai","raw_affiliation_strings":["Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110868","display_name":"Anthony Mazurek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Mazurek","raw_affiliation_strings":["Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020368586","display_name":"Stephen G. Dann","orcid":"https://orcid.org/0009-0009-4372-4344","observed_orcids":["https://orcid.org/0009-0009-4372-4344"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Dann","raw_affiliation_strings":["Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060336842","display_name":"Todd L. VanArsdale","orcid":"https://orcid.org/0009-0003-7692-623X","observed_orcids":["https://orcid.org/0009-0003-7692-623X"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd VanArsdale","raw_affiliation_strings":["Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059897477","display_name":"Valeria R. Fantin","orcid":"https://orcid.org/0009-0005-8328-0152","observed_orcids":["https://orcid.org/0009-0005-8328-0152"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valeria R. Fantin","raw_affiliation_strings":["Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011377778","display_name":"David J. Shields","orcid":"https://orcid.org/0009-0003-5238-3912","observed_orcids":["https://orcid.org/0009-0003-5238-3912"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Shields","raw_affiliation_strings":["Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067311581","display_name":"Gary E. Siuzdak","orcid":"https://orcid.org/0000-0002-4749-0014","observed_orcids":["https://orcid.org/0000-0002-4749-0014"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Siuzdak","raw_affiliation_strings":["The Scripps Research Institute, Scripps Center for Metabolomics and Mass Spectrometry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":"https://orcid.org/0000-0002-4749-0014","affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, Scripps Center for Metabolomics and Mass Spectrometry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006765542","display_name":"Caroline Helen Johnson","orcid":"https://orcid.org/0000-0002-5298-1299","observed_orcids":["https://orcid.org/0000-0002-5298-1299"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Caroline H. Johnson","raw_affiliation_strings":["Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT 06511, USA","The Scripps Research Institute, Scripps Center for Metabolomics and Mass Spectrometry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":"https://orcid.org/0000-0002-5298-1299","affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT 06511, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"The Scripps Research Institute, Scripps Center for Metabolomics and Mass Spectrometry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006765542"],"corresponding_institution_ids":["https://openalex.org/I123431417","https://openalex.org/I32971472"],"apc_list":{"value":1400,"currency":"CHF","value_usd":1418},"apc_paid":{"value":1400,"currency":"CHF","value_usd":1418},"fwci":1.2869,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79593105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":"1","first_page":"7","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.1737000048160553,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.03420000150799751,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.996999979019165},{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.5839999914169312},{"id":"https://openalex.org/keywords/central-carbon-metabolism","display_name":"central carbon metabolism","score":0.7250000238418579},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6809999942779541},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6669999957084656},{"id":"https://openalex.org/keywords/antiestrogens","display_name":"antiestrogens","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"pentose phosphate pathway","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.7080000042915344},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2780482068","wikidata":"https://www.wikidata.org/wiki/Q5508491","display_name":"Fulvestrant","level":5,"score":0.9586451053619385},{"id":"https://openalex.org/C2779744173","wikidata":"https://www.wikidata.org/wiki/Q15269707","display_name":"Palbociclib","level":5,"score":0.8354682922363281},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6473620533943176},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4968145191669464},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43867695331573486},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3870975971221924},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3594319820404053},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3406171202659607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33365416526794434},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33041083812713623},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.18493103981018066},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.1410040557384491}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3390/metabo9010007","doi":"https://doi.org/10.3390/metabo9010007","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/metabo9010007","pdf_url":"https://www.mdpi.com/2218-1989/9/1/7/pdf?version=1546416957","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},{"id":"doi:10.1101/348722","doi":"https://doi.org/10.1101/348722","is_oa":true,"landing_page_url":"https://doi.org/10.1101/348722","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/06/16/348722.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:5358165","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6359333","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6359333","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6359333","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"Text"},{"id":"pmid:30609717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30609717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"Journal Article"},{"id":"pmh:oai:strathprints.strath.ac.uk:70069","doi":null,"is_oa":true,"landing_page_url":"https://strathprints.strath.ac.uk/view/author/1184089.html>","pdf_url":"https://strathprints.strath.ac.uk/70069/1/Warth_etal_Metabolites_2019_Palbociclib_and_fulvestrant_act_in_synergy_to_modulate_central_carbon.pdf","source":{"id":"https://openalex.org/S4306402226","display_name":"Strathprints: The University of Strathclyde institutional repository (University of Strathclyde)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181647926","host_organization_name":"University of Strathclyde","host_organization_lineage":["https://openalex.org/I181647926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:409a9d9653694b459a26901fb5d5eee1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/409a9d9653694b459a26901fb5d5eee1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Metabolites, Vol 9, Iss 1, p 7 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/metabo9010007","doi":"https://doi.org/10.3390/metabo9010007","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/metabo9010007","pdf_url":"https://www.mdpi.com/2218-1989/9/1/7/pdf?version=1546416957","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G226624722","display_name":"Metabolomics to investigate combined cancer therapy","funder_award_id":"J3808","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G5974997648","display_name":null,"funder_award_id":"Erwin Schr\u00f6dinger Fellowship J-3808","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"}],"funders":[{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2808082304.pdf","grobid_xml":"https://content.openalex.org/works/W2808082304.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1464936406","https://openalex.org/W1984250518","https://openalex.org/W1995543670","https://openalex.org/W1998767819","https://openalex.org/W1999574084","https://openalex.org/W2014522149","https://openalex.org/W2024857001","https://openalex.org/W2025944550","https://openalex.org/W2035205419","https://openalex.org/W2051522090","https://openalex.org/W2061818721","https://openalex.org/W2065392523","https://openalex.org/W2080046774","https://openalex.org/W2097259163","https://openalex.org/W2114104545","https://openalex.org/W2128601422","https://openalex.org/W2130410032","https://openalex.org/W2131719921","https://openalex.org/W2144790402","https://openalex.org/W2148345265","https://openalex.org/W2158264375","https://openalex.org/W2159482845","https://openalex.org/W2170551349","https://openalex.org/W2290950904","https://openalex.org/W2291124025","https://openalex.org/W2324021033","https://openalex.org/W2502845086","https://openalex.org/W2608815200","https://openalex.org/W2613574304","https://openalex.org/W2760254940","https://openalex.org/W2794334542","https://openalex.org/W4230770774"],"related_works":["https://openalex.org/W4232409591","https://openalex.org/W2998004356","https://openalex.org/W3013314701","https://openalex.org/W2981121574","https://openalex.org/W2090287690","https://openalex.org/W7135060320","https://openalex.org/W2307957811","https://openalex.org/W4390445161","https://openalex.org/W2774152578","https://openalex.org/W2780824399"],"abstract_inverted_index":{"Summary":[0],"Palbociclib,":[1],"is":[2],"a":[3,15],"selective":[4,78],"inhibitor":[5],"of":[6,112,140,179,214],"cyclin-dependent":[7],"kinases":[8],"4":[9],"and":[10,12,61,72,109,151,174,181,216,226,233],"6":[11],"used":[13],"as":[14],"first-line":[16],"treatment":[17],"for":[18,49],"patients":[19,31],"with":[20,40],"estrogen":[21,43,219],"receptor":[22,44,220],"positive":[23,221],"breast":[24,67,164,222],"cancer.":[25,223],"It":[26],"has":[27],"been":[28,192],"shown":[29,234],"that":[30,89],"have":[32,191],"improved":[33],"progression-free":[34],"survival":[35,51],"when":[36,120],"treated":[37],"in":[38,64,131,148,185,218,238],"combination":[39,84,212],"fulvestrant,":[41],"an":[42,200],"antagonist.":[45],"However,":[46],"the":[47,91,97,105,110,121,127,132,138,170,239],"mechanisms":[48,146],"this":[50],"advantage":[52],"are":[53,81],"not":[54],"known.":[55],"We":[56],"sought":[57],"to":[58,75,96,144,159,204,235],"analyze":[59],"metabolic":[60,79,94,99,206,231],"transcriptomic":[62],"changes":[63],"MCF-7":[65],"adenocarcinoma":[66],"cancer":[68,149,165],"cells":[69,166],"following":[70],"single":[71,210],"combined":[73,161],"treatments":[74],"determine":[76],"if":[77],"pathways":[80,190,207,232],"targeted":[82],"during":[83],"therapy.":[85,152],"Our":[86],"results":[87],"showed":[88],"individually,":[90],"drugs":[92,122],"caused":[93],"disruption":[95],"same":[98],"pathways,":[100],"however":[101],"fulvestrant":[102,182,217],"additionally":[103],"attenuated":[104],"pentose":[106,171],"phosphate":[107,172],"pathway":[108,173],"production":[111,176],"important":[113],"coenzymes.":[114],"A":[115],"comprehensive":[116],"effect":[117],"was":[118,183],"observed":[119],"were":[123,228],"applied":[124,199],"together,":[125],"confirming":[126],"combinatory":[128],"therapy\u2032s":[129],"synergism":[130],"cell":[133],"model.":[134],"This":[135],"study":[136,156],"highlights":[137],"power":[139],"merging":[141],"high-dimensional":[142],"datasets":[143],"unravel":[145],"involved":[147,237],"metabolism":[150],"Highlights":[153],"\u25cb":[154,167,177,187],"First":[155],"employing":[157],"multi-omics":[158,202],"investigate":[160],"therapy":[162],"on":[163],"Fulvestrant":[168],"attenuates":[169],"coenzyme":[175],"Synergism":[178],"palbociclib":[180,215],"confirmed":[184],"vitro":[186],"Altered":[188],"key":[189],"identified":[193],"eTOC":[194],"Blurb":[195],"Johnson":[196],"et":[197],"al.":[198],"innovative":[201],"approach":[203],"decipher":[205],"affected":[208],"by":[209],"versus":[211],"dosing":[213],"Key":[224],"metabolites":[225],"genes":[227],"correlated":[229],"within":[230],"be":[236],"drugs\u2032":[240],"synergism.":[241]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2018-06-21T00:00:00"}