{"id":"https://openalex.org/W2808071872","doi":null,"title":"MECHANISMS OF THYMIC TOXICITY INDUCED BY ENVIRONMENTALLY RELEVANT CONCENTRATIONS OF ARSENIC","display_name":"MECHANISMS OF THYMIC TOXICITY INDUCED BY ENVIRONMENTALLY RELEVANT CONCENTRATIONS OF ARSENIC","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2808071872","mag":"2808071872"},"language":"en","primary_location":{"id":"pmh:oai:digitalrepository.unm.edu:biom_etds-1159","doi":null,"is_oa":false,"landing_page_url":"https://digitalrepository.unm.edu/biom_etds/164","pdf_url":null,"source":{"id":"https://openalex.org/S4377196368","display_name":"UNM\u2019s Digital Repository (University of New Mexico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169521973","host_organization_name":"University of New Mexico","host_organization_lineage":["https://openalex.org/I169521973"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Sciences ETDs","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083302535","display_name":"Huan Xu","orcid":"https://orcid.org/0000-0002-9009-3786","observed_orcids":["https://orcid.org/0000-0002-9009-3786"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Huan Xu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9009-3786","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5083302535"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arsenic","display_name":"arsenic","score":0.9330000281333923},{"id":"https://openalex.org/keywords/immunotoxicity","display_name":"immunotoxicity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/thymus","display_name":"thymus","score":0.9190000295639038},{"id":"https://openalex.org/keywords/arsenite","display_name":"arsenite","score":0.9169999957084656},{"id":"https://openalex.org/keywords/monomethylarsonous-acid","display_name":"monomethylarsonous acid","score":0.9539999961853027},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9269999861717224},{"id":"https://openalex.org/keywords/parp-inhibition","display_name":"PARP inhibition","score":0.8299999833106995},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.972000002861023},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.6679999828338623},{"id":"https://openalex.org/keywords/zinc-supplementation","display_name":"zinc supplementation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/il-7-signaling","display_name":"IL-7 signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.6830000281333923},{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.8330000042915344},{"id":"https://openalex.org/keywords/synergistic-toxicity","display_name":"synergistic toxicity","score":0.6790000200271606},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cyp1b1","display_name":"CYP1B1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/benzo-a-pyrene-diol-epoxide","display_name":"benzo[a]pyrene diol epoxide","score":0.5649999976158142},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7347158789634705},{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.6698797941207886},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.5100675225257874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4451959729194641},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.39063701033592224},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.35013943910598755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23955482244491577},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalrepository.unm.edu:biom_etds-1159","doi":null,"is_oa":false,"landing_page_url":"https://digitalrepository.unm.edu/biom_etds/164","pdf_url":null,"source":{"id":"https://openalex.org/S4377196368","display_name":"UNM\u2019s Digital Repository (University of New Mexico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169521973","host_organization_name":"University of New Mexico","host_organization_lineage":["https://openalex.org/I169521973"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Sciences ETDs","raw_type":"text"},{"id":"mag:2808071872","doi":null,"is_oa":false,"landing_page_url":"https://digitalrepository.unm.edu/biom_etds/164/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W162528498","https://openalex.org/W616713952","https://openalex.org/W1480305532","https://openalex.org/W1491270159","https://openalex.org/W1570986866","https://openalex.org/W1575749274","https://openalex.org/W1710773429","https://openalex.org/W1920118401","https://openalex.org/W1922673470","https://openalex.org/W1939229836","https://openalex.org/W1964848161","https://openalex.org/W1966402929","https://openalex.org/W1966406725","https://openalex.org/W1966434283","https://openalex.org/W1966452132","https://openalex.org/W1970051475","https://openalex.org/W1971636989","https://openalex.org/W1972882006","https://openalex.org/W1975169642","https://openalex.org/W1976056213","https://openalex.org/W1976872531","https://openalex.org/W1979379182","https://openalex.org/W1982330330","https://openalex.org/W1983194131","https://openalex.org/W1983231450","https://openalex.org/W1983243403","https://openalex.org/W1983426396","https://openalex.org/W1984088902","https://openalex.org/W1984105235","https://openalex.org/W1984294697","https://openalex.org/W1984423376","https://openalex.org/W1985417765","https://openalex.org/W1986093310","https://openalex.org/W1986328645","https://openalex.org/W1987610133","https://openalex.org/W1987873876","https://openalex.org/W1993596487","https://openalex.org/W1998459347","https://openalex.org/W2000308772","https://openalex.org/W2004835835","https://openalex.org/W2004891851","https://openalex.org/W2006489736","https://openalex.org/W2008342220","https://openalex.org/W2010183008","https://openalex.org/W2010639752","https://openalex.org/W2011025973","https://openalex.org/W2013298273","https://openalex.org/W2014717991","https://openalex.org/W2014902619","https://openalex.org/W2015081876","https://openalex.org/W2016036988","https://openalex.org/W2018682497","https://openalex.org/W2019132030","https://openalex.org/W2019622048","https://openalex.org/W2020231258","https://openalex.org/W2021988621","https://openalex.org/W2024748688","https://openalex.org/W2029066564","https://openalex.org/W2029073540","https://openalex.org/W2029700286","https://openalex.org/W2031153505","https://openalex.org/W2032497783","https://openalex.org/W2032791144","https://openalex.org/W2034167398","https://openalex.org/W2034485370","https://openalex.org/W2034716273","https://openalex.org/W2038647017","https://openalex.org/W2040982784","https://openalex.org/W2044156224","https://openalex.org/W2044387885","https://openalex.org/W2046669653","https://openalex.org/W2048576022","https://openalex.org/W2048989626","https://openalex.org/W2050815591","https://openalex.org/W2052430038","https://openalex.org/W2052680957","https://openalex.org/W2055084808","https://openalex.org/W2055090900","https://openalex.org/W2059029592","https://openalex.org/W2060292931","https://openalex.org/W2060611655","https://openalex.org/W2061010976","https://openalex.org/W2062121402","https://openalex.org/W2062142744","https://openalex.org/W2066399730","https://openalex.org/W2067793831","https://openalex.org/W2070968982","https://openalex.org/W2071941582","https://openalex.org/W2072252693","https://openalex.org/W2073562334","https://openalex.org/W2073949474","https://openalex.org/W2074618914","https://openalex.org/W2074644527","https://openalex.org/W2075204064","https://openalex.org/W2076728718","https://openalex.org/W2077407693","https://openalex.org/W2079424442","https://openalex.org/W2079985246","https://openalex.org/W2082732798","https://openalex.org/W2084228983","https://openalex.org/W2084714423","https://openalex.org/W2088048060","https://openalex.org/W2089037794","https://openalex.org/W2089865016","https://openalex.org/W2094078805","https://openalex.org/W2095264331","https://openalex.org/W2098906894","https://openalex.org/W2105405045","https://openalex.org/W2107588151","https://openalex.org/W2108621248","https://openalex.org/W2111039071","https://openalex.org/W2112001893","https://openalex.org/W2112637777","https://openalex.org/W2115186999","https://openalex.org/W2116227602","https://openalex.org/W2119322375","https://openalex.org/W2124345149","https://openalex.org/W2126757193","https://openalex.org/W2127549084","https://openalex.org/W2127923213","https://openalex.org/W2127967852","https://openalex.org/W2128839250","https://openalex.org/W2135389576","https://openalex.org/W2145215314","https://openalex.org/W2147276690","https://openalex.org/W2150293665","https://openalex.org/W2153620225","https://openalex.org/W2153625286","https://openalex.org/W2154865658","https://openalex.org/W2155912049","https://openalex.org/W2157388493","https://openalex.org/W2157466320","https://openalex.org/W2157728722","https://openalex.org/W2159119434","https://openalex.org/W2161332085","https://openalex.org/W2161940948","https://openalex.org/W2162087621","https://openalex.org/W2163666912","https://openalex.org/W2164613158","https://openalex.org/W2164995160","https://openalex.org/W2170427580","https://openalex.org/W2240856903","https://openalex.org/W2262871319","https://openalex.org/W2274495895","https://openalex.org/W2281969699","https://openalex.org/W2320246876","https://openalex.org/W2325378155","https://openalex.org/W2336573375","https://openalex.org/W2418010073","https://openalex.org/W2468092933","https://openalex.org/W2522714512","https://openalex.org/W2529172713","https://openalex.org/W2541342759"],"related_works":["https://openalex.org/W2541342759","https://openalex.org/W2240856903","https://openalex.org/W2522714512","https://openalex.org/W2811093047","https://openalex.org/W2741652383","https://openalex.org/W2281969699","https://openalex.org/W2513007578","https://openalex.org/W2610986646","https://openalex.org/W1496700758","https://openalex.org/W3107666834"],"abstract_inverted_index":{"Arsenic,":[0],"a":[1],"ubiquitous":[2],"environmental":[3,372],"contaminant,":[4],"is":[5],"known":[6],"to":[7,31,60,69,72,97,129,140,183,200,228,236,255,271,283,335,349],"cause":[8],"immunotoxicity.":[9],"However,":[10],"the":[11,23,83,88,116,142,159,168,175,202,220,238,257,267,272,312,340,353,357],"mechanisms":[12,354],"of":[13,27,127,145,161,206,222,259,269,285,304,326,352,364],"arsenic":[14,146,156,207,365],"induced":[15,359],"immunotoxicity":[16],"are":[17],"still":[18],"not":[19,174],"clear.":[20],"Arsenite":[21],"(As+3),":[22],"trivalent":[24],"inorganic":[25],"form":[26,205],"arsenic,":[28],"was":[29,67,95,180,198,226,296,306],"found":[30,68,96,139,165,182,227,307],"increase":[32,160,237,256],"DNA":[33,162,239,273,314],"damage":[34,163,240,315],"and":[35,49,76,105,150,158,171,195,197,211,241,261,289,299,331,366],"inhibit":[36,242],"PARP":[37,243],"activity":[38,244],"in":[39,45,56,110,124,166,189,191,208,214,245,308,320,343],"thymus":[40,57,136,212,247,293],"cells":[41,58,137,318],"at":[42,62,102,107,233],"50":[43,108],"nM":[44,104,109],"vitro.":[46,111],"Oxidative":[47],"stress":[48],"double":[50,286,290],"strand":[51],"breaks":[52],"(DSBs)":[53],"formation":[54],"occurred":[55],"exposed":[59],"As+3":[61,73,101,188,231,284,305,322,328],"500":[63,103,130],"nM.":[64],"The":[65,112,249,280,324],"genotoxicity":[66,342],"be":[70,98,184,201,336],"related":[71],"exporter":[74],"expressions":[75,325],"reversed":[77],"by":[78,100,360],"zinc":[79],"supplement.":[80],"IL-7":[81],"signaling,":[82],"critical":[84,264],"cytokine":[85],"signal":[86],"for":[87,266],"early":[89],"DN":[90,309,344],"thymic":[91],"T":[92],"cell":[93,117,294],"proliferation,":[94],"suppressed":[99],"MMA+3":[106],"suppressive":[113],"effects":[114,251],"reduced":[115],"cycle":[118],"gene":[119],"expression.":[120],"After":[121],"30":[122],"d":[123],"vivo":[125,215],"exposure":[126],"up":[128],"parts":[131],"per":[132],"billion":[133],"(ppb)":[134],"As+3,":[135],"were":[138,164,252,333],"contain":[141],"higher":[143,313],"levels":[144],"than":[147,187,316],"bone":[148,169,192,209],"marrow":[149,170,210],"spleen":[151,194],"cells.":[152,248,345],"Correlations":[153],"between":[154],"intracellular":[155,302],"concentrations":[157,235,363],"both":[167],"thymus,":[172,196],"but":[173],"spleen.":[176],"Monomethylarsonous":[177],"acid":[178],"(MMA+3)":[179],"also":[181,253,297],"more":[185],"genotoxic":[186],"vitro":[190,321],"marrow,":[193],"demonstrated":[199,254],"most":[203],"prevalent":[204],"after":[213,319],"exposures.":[216],"Benzo(a)":[217],"pyrene-7,8-dihydrodiol":[218],"(BP-diol),":[219],"metabolite":[221],"benzo(a)":[223,277],"pyrene":[224],"(BaP)":[225],"interact":[229],"with":[230,311,339,356,370],"synergistically":[232],"low":[234],"primary":[246],"interactive":[250],"expression":[258],"CYP1A1":[260],"CYP1B1,":[262],"two":[263,327],"enzymes":[265],"metabolism":[268],"BP-diol":[270],"adduct":[274],"forming":[275],"compound,":[276],"pyrene-7,8-dihydrodiol-9,10-epoxide":[278],"(BPDE).":[279],"differential":[281],"sensitivity":[282],"negative":[287],"(DN)":[288],"positive":[291],"(DP)":[292],"subsets":[295],"evaluated":[298],"compared.":[300],"Higher":[301],"accumulation":[303],"cells,":[310],"DP":[317],"treatments.":[323],"exporters,":[329],"Mdr1":[330],"Mrp1,":[332],"shown":[334],"inversely":[337],"correlated":[338],"selective":[341],"These":[346],"studies":[347],"contributed":[348],"our":[350],"understanding":[351],"associated":[355],"toxicity":[358],"environmentally":[361],"relevant":[362],"its":[367],"potential":[368],"interactions":[369],"other":[371],"contaminants.":[373]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-06-21T00:00:00"}