{"id":"https://openalex.org/W2808069363","doi":"https://doi.org/10.1208/s12249-018-1083-3","title":"Levobupivacaine Thermogel for Long-acting Analgesia","display_name":"Levobupivacaine Thermogel for Long-acting Analgesia","publication_year":2018,"publication_date":"2018-06-12","ids":{"openalex":"https://openalex.org/W2808069363","doi":"https://doi.org/10.1208/s12249-018-1083-3","mag":"2808069363","pmid":"https://pubmed.ncbi.nlm.nih.gov/29948983"},"language":"en","primary_location":{"id":"doi:10.1208/s12249-018-1083-3","doi":"https://doi.org/10.1208/s12249-018-1083-3","is_oa":false,"landing_page_url":"https://doi.org/10.1208/s12249-018-1083-3","pdf_url":null,"source":{"id":"https://openalex.org/S1234972","display_name":"AAPS PharmSciTech","issn_l":"1530-9932","issn":["1530-9932"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081924956","display_name":"Ellison Neves de Lima","orcid":"https://orcid.org/0000-0003-1742-8364","observed_orcids":["https://orcid.org/0000-0003-1742-8364"]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ellison Neves de Lima","raw_affiliation_strings":["Center of Cosmetic and Pharmaceutical Development, NUDFAC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, UFPE, Recife, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Cosmetic and Pharmaceutical Development, NUDFAC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, UFPE, Recife, PE, Brazil","institution_ids":["https://openalex.org/I25112270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085777639","display_name":"Ana Rosa Brissant de Andrade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Rosa Brissant de Andrade","raw_affiliation_strings":["Center of Cosmetic and Pharmaceutical Development, NUDFAC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, UFPE, Recife, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Cosmetic and Pharmaceutical Development, NUDFAC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, UFPE, Recife, PE, Brazil","institution_ids":["https://openalex.org/I25112270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091850563","display_name":"Leila Bastos Leal","orcid":"https://orcid.org/0000-0003-3017-9120","observed_orcids":["https://orcid.org/0000-0003-3017-9120"]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Leila Bastos Leal","raw_affiliation_strings":["Center of Cosmetic and Pharmaceutical Development, NUDFAC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, UFPE, Recife, PE, Brazil. leila.leal@nudfac.com.br","Cidade Universit\u00e1ria, Recife, PE, 50740-520, Brazil. leila.leal@nudfac.com.br","Center of Cosmetic and Pharmaceutical Development, NUDFAC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, UFPE, Recife, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Cosmetic and Pharmaceutical Development, NUDFAC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, UFPE, Recife, PE, Brazil. leila.leal@nudfac.com.br","institution_ids":["https://openalex.org/I25112270"]},{"raw_affiliation_string":"Cidade Universit\u00e1ria, Recife, PE, 50740-520, Brazil. leila.leal@nudfac.com.br","institution_ids":[]},{"raw_affiliation_string":"Center of Cosmetic and Pharmaceutical Development, NUDFAC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, UFPE, Recife, PE, Brazil","institution_ids":["https://openalex.org/I25112270"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075933816","display_name":"Davi Pereira de Santana","orcid":"https://orcid.org/0000-0001-5557-4261","observed_orcids":["https://orcid.org/0000-0001-5557-4261"]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Davi Pereira de Santana","raw_affiliation_strings":["Center of Cosmetic and Pharmaceutical Development, NUDFAC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, UFPE, Recife, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Cosmetic and Pharmaceutical Development, NUDFAC, Department of Pharmaceutical Sciences, Federal University of Pernambuco, UFPE, Recife, PE, Brazil","institution_ids":["https://openalex.org/I25112270"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091850563"],"corresponding_institution_ids":["https://openalex.org/I25112270"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":0.495,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.52127955,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"19","issue":"6","first_page":"2533","last_page":"2542"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.3865000009536743,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.03819999843835831,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levobupivacaine","display_name":"levobupivacaine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thermosensitive-hydrogel","display_name":"thermosensitive hydrogel","score":0.9039999842643738},{"id":"https://openalex.org/keywords/poloxamer","display_name":"poloxamer","score":0.8849999904632568},{"id":"https://openalex.org/keywords/local-anesthetics","display_name":"local anesthetics","score":0.8730000257492065},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.8100000023841858},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.6389999985694885},{"id":"https://openalex.org/keywords/excipient-compatibility","display_name":"excipient compatibility","score":0.7580000162124634},{"id":"https://openalex.org/keywords/rheology","display_name":"rheology","score":0.6819999814033508},{"id":"https://openalex.org/keywords/release-kinetics","display_name":"release kinetics","score":0.5979999899864197},{"id":"https://openalex.org/keywords/permeation","display_name":"permeation","score":0.574999988079071},{"id":"https://openalex.org/keywords/cold-method","display_name":"cold method","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C2776572635","wikidata":"https://www.wikidata.org/wiki/Q3272027","display_name":"Levobupivacaine","level":3,"score":0.7134134769439697},{"id":"https://openalex.org/C101335993","wikidata":"https://www.wikidata.org/wiki/Q408943","display_name":"Poloxamer","level":4,"score":0.6826943755149841},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.5519834160804749},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4848855435848236},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45316094160079956},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.41395992040634155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39869335293769836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3666413426399231},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35396692156791687},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.2700737714767456},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.06496894359588623},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.06005436182022095},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05604749917984009},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077554","descriptor_name":"Levobupivacaine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002045","descriptor_name":"Bupivacaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002045","descriptor_name":"Bupivacaine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002045","descriptor_name":"Bupivacaine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020442","descriptor_name":"Poloxamer","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1208/s12249-018-1083-3","doi":"https://doi.org/10.1208/s12249-018-1083-3","is_oa":false,"landing_page_url":"https://doi.org/10.1208/s12249-018-1083-3","pdf_url":null,"source":{"id":"https://openalex.org/S1234972","display_name":"AAPS PharmSciTech","issn_l":"1530-9932","issn":["1530-9932"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"journal-article"},{"id":"pmid:29948983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29948983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W593531940","https://openalex.org/W1487016013","https://openalex.org/W1511667952","https://openalex.org/W1539246738","https://openalex.org/W1965037589","https://openalex.org/W1965611553","https://openalex.org/W1969604041","https://openalex.org/W1985631236","https://openalex.org/W1988359000","https://openalex.org/W2000573359","https://openalex.org/W2001009858","https://openalex.org/W2006313048","https://openalex.org/W2008984449","https://openalex.org/W2009428471","https://openalex.org/W2010132385","https://openalex.org/W2012427136","https://openalex.org/W2034248832","https://openalex.org/W2034541607","https://openalex.org/W2035640123","https://openalex.org/W2036502034","https://openalex.org/W2037907185","https://openalex.org/W2048893610","https://openalex.org/W2049881401","https://openalex.org/W2054016731","https://openalex.org/W2058509094","https://openalex.org/W2060239018","https://openalex.org/W2068292018","https://openalex.org/W2081228751","https://openalex.org/W2084031482","https://openalex.org/W2089878889","https://openalex.org/W2094505929","https://openalex.org/W2115439624","https://openalex.org/W2133347503","https://openalex.org/W2144280209","https://openalex.org/W2149504895","https://openalex.org/W2156689252","https://openalex.org/W2166947595","https://openalex.org/W2168716880","https://openalex.org/W2196132722","https://openalex.org/W2235017840","https://openalex.org/W2238587893","https://openalex.org/W2263434933","https://openalex.org/W2280036172","https://openalex.org/W2309412951","https://openalex.org/W2334767996","https://openalex.org/W2340703191","https://openalex.org/W2346675136","https://openalex.org/W2367297902","https://openalex.org/W2403118666","https://openalex.org/W2407038818","https://openalex.org/W2472501689","https://openalex.org/W2473111248","https://openalex.org/W2473477445","https://openalex.org/W2514508186","https://openalex.org/W2515232231","https://openalex.org/W2516432450","https://openalex.org/W2518969719","https://openalex.org/W2583813861","https://openalex.org/W2589081434","https://openalex.org/W2592589512","https://openalex.org/W2602045418","https://openalex.org/W2683554665","https://openalex.org/W2917835288","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7120293865","https://openalex.org/W4367603001","https://openalex.org/W3136394020","https://openalex.org/W2323026757","https://openalex.org/W2473111248","https://openalex.org/W3213539356","https://openalex.org/W3164205207","https://openalex.org/W4409191699","https://openalex.org/W4401630120","https://openalex.org/W2594276108"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-21T00:00:00"}