{"id":"https://openalex.org/W2808033445","doi":"https://doi.org/10.1039/c8an00490k","title":"Multi-functional derivatization of amine, hydroxyl, and carboxylate groups for metabolomic investigations of human tissue by electrospray ionization mass spectrometry","display_name":"Multi-functional derivatization of amine, hydroxyl, and carboxylate groups for metabolomic investigations of human tissue by electrospray ionization mass spectrometry","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2808033445","doi":"https://doi.org/10.1039/c8an00490k","mag":"2808033445","pmid":"https://pubmed.ncbi.nlm.nih.gov/29915825","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6047751"},"language":"en","primary_location":{"id":"doi:10.1039/c8an00490k","doi":"https://doi.org/10.1039/c8an00490k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8an00490k","pdf_url":null,"source":{"id":"https://openalex.org/S105746325","display_name":"The Analyst","issn_l":"0003-2654","issn":["0003-2654","1364-5528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6047751","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033613250","display_name":"Tianjiao Huang","orcid":"https://orcid.org/0009-0003-3775-1940","observed_orcids":["https://orcid.org/0009-0003-3775-1940"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianjiao Huang","raw_affiliation_strings":["Department of Chemistry","Saint Louis University","St louis MO","USA","Department of Chemistry, Saint Louis University, 3501 Laclede Ave, St louis MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Saint Louis University","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"St louis MO","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Saint Louis University, 3501 Laclede Ave, St louis MO, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043299002","display_name":"Maria Toro-Moreno","orcid":"https://orcid.org/0000-0002-0497-2259","observed_orcids":["https://orcid.org/0000-0002-0497-2259"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Toro","raw_affiliation_strings":["Department of Chemistry","Saint Louis University","St louis MO","USA","Department of Chemistry, Duke University, Durham, NC, USA","Department of Chemistry, Saint Louis University, 3501 Laclede Ave, St louis MO, USA"],"raw_orcid":"https://orcid.org/0000-0002-0497-2259","affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Saint Louis University","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"St louis MO","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Department of Chemistry, Saint Louis University, 3501 Laclede Ave, St louis MO, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021641459","display_name":"Richard Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Lee","raw_affiliation_strings":["Cardiovascular Comprehensive Care Center","Saint Louis University","St louis MO","USA","Cardiovascular Comprehensive Care Center, Saint Louis University, 3635 Vista Ave, St louis MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Comprehensive Care Center","institution_ids":[]},{"raw_affiliation_string":"Saint Louis University","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"St louis MO","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Cardiovascular Comprehensive Care Center, Saint Louis University, 3635 Vista Ave, St louis MO, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003822599","display_name":"Dawn S. Hui","orcid":"https://orcid.org/0000-0003-2895-0887","observed_orcids":["https://orcid.org/0000-0003-2895-0887"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn S. Hui","raw_affiliation_strings":["Cardiovascular Comprehensive Care Center","Saint Louis University","St louis MO","USA","Cardiovascular Comprehensive Care Center, Saint Louis University, 3635 Vista Ave, St louis MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Comprehensive Care Center","institution_ids":[]},{"raw_affiliation_string":"Saint Louis University","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"St louis MO","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Cardiovascular Comprehensive Care Center, Saint Louis University, 3635 Vista Ave, St louis MO, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045039849","display_name":"James L. Edwards","orcid":"https://orcid.org/0000-0003-1063-7518","observed_orcids":["https://orcid.org/0000-0003-1063-7518"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James L. Edwards","raw_affiliation_strings":["Department of Chemistry","Saint Louis University","St louis MO","USA","Department of Chemistry, Saint Louis University, 3501 Laclede Ave, St louis MO, USA"],"raw_orcid":"https://orcid.org/0000-0003-1063-7518","affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Saint Louis University","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"St louis MO","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Saint Louis University, 3501 Laclede Ave, St louis MO, USA","institution_ids":["https://openalex.org/I47838141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045039849"],"corresponding_institution_ids":["https://openalex.org/I47838141"],"apc_list":null,"apc_paid":null,"fwci":1.0146,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.7384944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"143","issue":"14","first_page":"3408","last_page":"3414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amine-derivatization","display_name":"amine derivatization","score":0.8629999756813049},{"id":"https://openalex.org/keywords/fumarate","display_name":"fumarate","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9210000038146973},{"id":"https://openalex.org/keywords/energy-metabolites","display_name":"energy metabolites","score":0.9639999866485596},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.9670000076293945},{"id":"https://openalex.org/keywords/metabolic-dysfunction","display_name":"metabolic dysfunction","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8008264899253845},{"id":"https://openalex.org/C2776923573","wikidata":"https://www.wikidata.org/wiki/Q2294884","display_name":"Derivatization","level":3,"score":0.7721046805381775},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6670911312103271},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6489742398262024},{"id":"https://openalex.org/C40684141","wikidata":"https://www.wikidata.org/wiki/Q902061","display_name":"Electrospray ionization","level":3,"score":0.618414580821991},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.5901780128479004},{"id":"https://openalex.org/C2778074193","wikidata":"https://www.wikidata.org/wiki/Q3498942","display_name":"Carboxylate","level":2,"score":0.5311868190765381},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4855353832244873},{"id":"https://openalex.org/C194451485","wikidata":"https://www.wikidata.org/wiki/Q1327575","display_name":"Electrospray","level":3,"score":0.439229816198349},{"id":"https://openalex.org/C75233609","wikidata":"https://www.wikidata.org/wiki/Q5422190","display_name":"Extractive electrospray ionization","level":5,"score":0.4245939552783966},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2401151955127716},{"id":"https://openalex.org/C167050937","wikidata":"https://www.wikidata.org/wiki/Q1661644","display_name":"Sample preparation in mass spectrometry","level":4,"score":0.20008409023284912}],"mesh":[{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D017665","descriptor_name":"Hydroxyl Radical","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1039/c8an00490k","doi":"https://doi.org/10.1039/c8an00490k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8an00490k","pdf_url":null,"source":{"id":"https://openalex.org/S105746325","display_name":"The Analyst","issn_l":"0003-2654","issn":["0003-2654","1364-5528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"journal-article"},{"id":"pmid:29915825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29915825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5599805","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6047751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6047751","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6047751/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Analyst","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5599805","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6047751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3829938420","display_name":"BIOMIMETIC PLATFORM FOR METABOLOMIC ANALYSIS","funder_award_id":"R15GM113153","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1983072558","https://openalex.org/W1990665009","https://openalex.org/W1994997661","https://openalex.org/W1995888001","https://openalex.org/W2001468444","https://openalex.org/W2006482650","https://openalex.org/W2026702352","https://openalex.org/W2029936477","https://openalex.org/W2041513075","https://openalex.org/W2061613894","https://openalex.org/W2081221799","https://openalex.org/W2088836337","https://openalex.org/W2096530128","https://openalex.org/W2111489187","https://openalex.org/W2122367003","https://openalex.org/W2128708905","https://openalex.org/W2135977165","https://openalex.org/W2151143607","https://openalex.org/W2169812410","https://openalex.org/W2256540057","https://openalex.org/W2260902962","https://openalex.org/W2295182096","https://openalex.org/W2331594022","https://openalex.org/W2334639196","https://openalex.org/W2335445078","https://openalex.org/W2336829371","https://openalex.org/W2539494034","https://openalex.org/W2583168750","https://openalex.org/W2593540640","https://openalex.org/W2596719579","https://openalex.org/W2725788675","https://openalex.org/W2738177157","https://openalex.org/W2769476641"],"related_works":["https://openalex.org/W2897860205","https://openalex.org/W4315619216","https://openalex.org/W2550621437","https://openalex.org/W2063523286","https://openalex.org/W4292183631","https://openalex.org/W4410788733","https://openalex.org/W2417871446","https://openalex.org/W2765781295","https://openalex.org/W2965861836","https://openalex.org/W2600389906"],"abstract_inverted_index":{"was":[0,4],"0.97.":[1],"This":[2,45],"process":[3],"used":[5],"to":[6,65],"investigate":[7],"metabolite":[8],"changes":[9,22],"from":[10],"human":[11,18,74],"tissue.":[12],"Examination":[13],"of":[14,32,52,70],"diabetic":[15],"and":[16,27],"non-diabetic":[17],"tissue":[19,34],"showed":[20,35],"marked":[21],"in":[23,56,73],"both":[24],"energy":[25],"metabolites":[26,55],"amino":[28],"acids.":[29],"Further":[30],"examination":[31],"the":[33,50],"that":[36],"HbA1C":[37],"value":[38],"is":[39],"inversely":[40],"correlated":[41],"with":[42],"fumarate":[43],"levels.":[44],"technique":[46],"potentially":[47],"allows":[48],"for":[49],"analysis":[51],"virtually":[53],"all":[54],"a":[57,66],"single":[58],"analytical":[59],"run.":[60],"Thus,":[61],"it":[62],"may":[63],"lead":[64],"more":[67],"complete":[68],"picture":[69],"metabolic":[71],"dysfunction":[72],"disease.":[75]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-21T00:00:00"}