{"id":"https://openalex.org/W2808018867","doi":"https://doi.org/10.1021/acsinfecdis.8b00081","title":"Virological Basis for the Cure of Chronic Hepatitis B","display_name":"Virological Basis for the Cure of Chronic Hepatitis B","publication_year":2018,"publication_date":"2018-06-12","ids":{"openalex":"https://openalex.org/W2808018867","doi":"https://doi.org/10.1021/acsinfecdis.8b00081","mag":"2808018867","pmid":"https://pubmed.ncbi.nlm.nih.gov/29893548","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8026331"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.8b00081","doi":"https://doi.org/10.1021/acsinfecdis.8b00081","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.8b00081","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8026331","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020341156","display_name":"Jin Hu","orcid":"https://orcid.org/0000-0002-7597-0875","observed_orcids":["https://orcid.org/0000-0002-7597-0875"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jin Hu","raw_affiliation_strings":["Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, 1 Tian-tan Xi-li, Beijing, 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]},{"raw_affiliation_string":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, 1 Tian-tan Xi-li, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103100709","display_name":"Junjun Cheng","orcid":"https://orcid.org/0000-0002-3926-1481","observed_orcids":["https://orcid.org/0000-0002-3926-1481"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junjun Cheng","raw_affiliation_strings":["Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046413696","display_name":"Liudi Tang","orcid":"https://orcid.org/0000-0001-8303-3614","observed_orcids":["https://orcid.org/0000-0001-8303-3614"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liudi Tang","raw_affiliation_strings":["Microbiology and Immunology Graduate Program, Drexel University College of Medicine, 2900 West Queen Lane, Philadelphia, Pennsylvania 19129, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology Graduate Program, Drexel University College of Medicine, 2900 West Queen Lane, Philadelphia, Pennsylvania 19129, United States","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059475763","display_name":"Zhanying Hu","orcid":"https://orcid.org/0000-0002-4169-7778","observed_orcids":["https://orcid.org/0000-0002-4169-7778"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhanying Hu","raw_affiliation_strings":["Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063347622","display_name":"Yue Luo","orcid":"https://orcid.org/0000-0003-3498-4821","observed_orcids":["https://orcid.org/0000-0003-3498-4821"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yue Luo","raw_affiliation_strings":["Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","Institute of Hepatology, Second Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]},{"raw_affiliation_string":"Institute of Hepatology, Second Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036805693","display_name":"Yuhuan Li","orcid":"https://orcid.org/0000-0003-3725-3258","observed_orcids":["https://orcid.org/0000-0003-3725-3258"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhuan Li","raw_affiliation_strings":["Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, 1 Tian-tan Xi-li, Beijing, 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, 1 Tian-tan Xi-li, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027964593","display_name":"Tianlun Zhou","orcid":"https://orcid.org/0000-0001-5864-0578","observed_orcids":["https://orcid.org/0000-0001-5864-0578"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianlun Zhou","raw_affiliation_strings":["Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023737081","display_name":"Jinhong Chang","orcid":"https://orcid.org/0000-0002-6723-494X","observed_orcids":["https://orcid.org/0000-0002-6723-494X"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinhong Chang","raw_affiliation_strings":["Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076597546","display_name":"Ju\u2010Tao Guo","orcid":"https://orcid.org/0000-0001-5335-2788","observed_orcids":["https://orcid.org/0000-0001-5335-2788"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ju-Tao Guo","raw_affiliation_strings":["Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States"],"raw_orcid":"https://orcid.org/0000-0001-5335-2788","affiliations":[{"raw_affiliation_string":"Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5076597546"],"corresponding_institution_ids":["https://openalex.org/I4210157427"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.1077,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.74313156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"5","first_page":"659","last_page":"674"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.9649999737739563},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.984000027179718},{"id":"https://openalex.org/keywords/viral-persistence","display_name":"viral persistence","score":0.6209999918937683},{"id":"https://openalex.org/keywords/hbv-replication","display_name":"HBV replication","score":0.7369999885559082},{"id":"https://openalex.org/keywords/covalently-closed-circular-dna","display_name":"covalently closed circular DNA","score":0.9319999814033508},{"id":"https://openalex.org/keywords/integrated-hbv-dna","display_name":"integrated HBV DNA","score":0.7509999871253967},{"id":"https://openalex.org/keywords/hbsag-loss","display_name":"HBsAg loss","score":0.8169999718666077},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.46700000762939453},{"id":"https://openalex.org/keywords/functional-cure","display_name":"functional cure","score":0.5609999895095825},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.6073659658432007},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5284343361854553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5278601050376892},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5151923298835754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35706013441085815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3215985894203186},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.15472790598869324}],"mesh":[{"descriptor_ui":"D000076662","descriptor_name":"Host Microbial Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004270","descriptor_name":"DNA, Circular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acsinfecdis.8b00081","doi":"https://doi.org/10.1021/acsinfecdis.8b00081","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.8b00081","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:29893548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29893548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8026331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8026331","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8026331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8026331","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Infect Dis","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G36680115","display_name":"Evaluation of therapeutic benefits of HBV nucleocapsid assembly inhibitors","funder_award_id":"R01AI113267","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4430174889","display_name":null,"funder_award_id":"AI113267","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7861222030","display_name":null,"funder_award_id":"W81XWH-17-1-0600","funder_id":"https://openalex.org/F4320332407","funder_display_name":"Office of the Assistant Secretary for Health"}],"funders":[{"id":"https://openalex.org/F4320332407","display_name":"Office of the Assistant Secretary for Health","ror":"https://ror.org/023n3xx64"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":171,"referenced_works":["https://openalex.org/W248460155","https://openalex.org/W956012495","https://openalex.org/W1487129177","https://openalex.org/W1555326244","https://openalex.org/W1611904685","https://openalex.org/W1772419476","https://openalex.org/W1797768250","https://openalex.org/W1799137450","https://openalex.org/W1819459887","https://openalex.org/W1833793913","https://openalex.org/W1858587707","https://openalex.org/W1870441112","https://openalex.org/W1878011119","https://openalex.org/W1906916220","https://openalex.org/W1934998482","https://openalex.org/W1935842334","https://openalex.org/W1965061107","https://openalex.org/W1967159039","https://openalex.org/W1971403557","https://openalex.org/W1972992218","https://openalex.org/W1976222102","https://openalex.org/W1980927876","https://openalex.org/W1986533953","https://openalex.org/W1986926794","https://openalex.org/W1987051472","https://openalex.org/W1987787764","https://openalex.org/W1988032963","https://openalex.org/W1988615815","https://openalex.org/W1990084658","https://openalex.org/W1991592276","https://openalex.org/W1993741152","https://openalex.org/W1997047331","https://openalex.org/W1997270466","https://openalex.org/W1997860146","https://openalex.org/W2002969023","https://openalex.org/W2003440191","https://openalex.org/W2003579761","https://openalex.org/W2006011870","https://openalex.org/W2006422137","https://openalex.org/W2007902841","https://openalex.org/W2015953599","https://openalex.org/W2016775797","https://openalex.org/W2019057425","https://openalex.org/W2020916721","https://openalex.org/W2022853819","https://openalex.org/W2023366700","https://openalex.org/W2031579836","https://openalex.org/W2031689269","https://openalex.org/W2031860444","https://openalex.org/W2035572185","https://openalex.org/W2035920453","https://openalex.org/W2039782374","https://openalex.org/W2041820736","https://openalex.org/W2042153788","https://openalex.org/W2042968167","https://openalex.org/W2043722115","https://openalex.org/W2044715640","https://openalex.org/W2051173965","https://openalex.org/W2053744043","https://openalex.org/W2054524196","https://openalex.org/W2057559708","https://openalex.org/W2059526379","https://openalex.org/W2060528864","https://openalex.org/W2061171442","https://openalex.org/W2061239746","https://openalex.org/W2062190983","https://openalex.org/W2063549241","https://openalex.org/W2065281664","https://openalex.org/W2066410692","https://openalex.org/W2067109440","https://openalex.org/W2073889805","https://openalex.org/W2075466918","https://openalex.org/W2075595885","https://openalex.org/W2077172281","https://openalex.org/W2077533125","https://openalex.org/W2081019716","https://openalex.org/W2088160623","https://openalex.org/W2091841192","https://openalex.org/W2095399200","https://openalex.org/W2098458274","https://openalex.org/W2101452651","https://openalex.org/W2106295967","https://openalex.org/W2113332526","https://openalex.org/W2113985215","https://openalex.org/W2116864678","https://openalex.org/W2117198458","https://openalex.org/W2120426460","https://openalex.org/W2121210720","https://openalex.org/W2121378696","https://openalex.org/W2121562652","https://openalex.org/W2122749974","https://openalex.org/W2127338111","https://openalex.org/W2127856551","https://openalex.org/W2128428550","https://openalex.org/W2129105278","https://openalex.org/W2129135109","https://openalex.org/W2130122169","https://openalex.org/W2134851334","https://openalex.org/W2135394461","https://openalex.org/W2135991340","https://openalex.org/W2137046095","https://openalex.org/W2137218964","https://openalex.org/W2141460271","https://openalex.org/W2143780877","https://openalex.org/W2146046635","https://openalex.org/W2149133548","https://openalex.org/W2150946670","https://openalex.org/W2151455990","https://openalex.org/W2154110339","https://openalex.org/W2157098396","https://openalex.org/W2166141612","https://openalex.org/W2166374387","https://openalex.org/W2166504564","https://openalex.org/W2168630917","https://openalex.org/W2168803022","https://openalex.org/W2170111772","https://openalex.org/W2170253938","https://openalex.org/W2183248149","https://openalex.org/W2294857314","https://openalex.org/W2298466016","https://openalex.org/W2337051574","https://openalex.org/W2339000844","https://openalex.org/W2341442578","https://openalex.org/W2363366940","https://openalex.org/W2403531472","https://openalex.org/W2408333651","https://openalex.org/W2494120090","https://openalex.org/W2511252329","https://openalex.org/W2516186667","https://openalex.org/W2518924844","https://openalex.org/W2524282402","https://openalex.org/W2541628542","https://openalex.org/W2546292426","https://openalex.org/W2560174408","https://openalex.org/W2577159120","https://openalex.org/W2583077266","https://openalex.org/W2586036588","https://openalex.org/W2589595733","https://openalex.org/W2590636729","https://openalex.org/W2600950260","https://openalex.org/W2605770782","https://openalex.org/W2606204983","https://openalex.org/W2606737810","https://openalex.org/W2608767620","https://openalex.org/W2620405889","https://openalex.org/W2622569284","https://openalex.org/W2670135441","https://openalex.org/W2736609878","https://openalex.org/W2737143554","https://openalex.org/W2741993068","https://openalex.org/W2757654367","https://openalex.org/W2757983152","https://openalex.org/W2759319254","https://openalex.org/W2760560147","https://openalex.org/W2765211655","https://openalex.org/W2766188198","https://openalex.org/W2766192412","https://openalex.org/W2766427799","https://openalex.org/W2766612580","https://openalex.org/W2766658183","https://openalex.org/W2767733689","https://openalex.org/W2774064974","https://openalex.org/W2776983481","https://openalex.org/W2778928474","https://openalex.org/W2785899169","https://openalex.org/W2791855109","https://openalex.org/W2792238529","https://openalex.org/W2797233586","https://openalex.org/W2802639099","https://openalex.org/W4235029171","https://openalex.org/W4300444080"],"related_works":["https://openalex.org/W3164216958","https://openalex.org/W2042445786","https://openalex.org/W3164191180","https://openalex.org/W4366772452","https://openalex.org/W4405545941","https://openalex.org/W3117081014","https://openalex.org/W3201133551","https://openalex.org/W2411477505","https://openalex.org/W2277437902","https://openalex.org/W1877185991"],"abstract_inverted_index":{"Hepatitis":[0],"B":[1,215],"virus":[2,36,216],"(HBV)":[3],"has":[4],"infected":[5,185],"one-third":[6],"of":[7,68,91,101,127,132,135,154,184,194,201],"world":[8],"population,":[9],"and":[10,46,51,58,79,205,221],"240":[11],"million":[12],"people":[13],"are":[14,94],"chronic":[15,81,195],"carriers,":[16],"to":[17,27,37,42,70,96,142,159,189,212],"whom":[18],"a":[19,191],"curative":[20],"therapy":[21],"is":[22,63,187],"still":[23],"not":[24],"available.":[25],"Similar":[26],"other":[28],"viruses,":[29],"persistent":[30],"HBV":[31,56,92,110,172,203],"infection":[32,93],"relies":[33],"on":[34],"the":[35,72,85,118,133,163,169,182],"exploit":[38],"host":[39,49,60,103],"cell":[40,61,88,157],"functions":[41],"support":[43],"its":[44,77],"replication":[45,57,147,173],"efficiently":[47],"evade":[48],"innate":[50],"adaptive":[52],"antiviral":[53],"immunity.":[54],"Understanding":[55],"concomitant":[59],"interactions":[62,74,158],"thus":[64],"instrumental":[65],"for":[66,76,107],"development":[67],"therapeutics":[69],"disrupt":[71],"virus-host":[73],"critical":[75],"persistence":[78],"cure":[80,193],"hepatitis":[82,196,214],"B.":[83,197],"Although":[84],"currently":[86],"available":[87],"culture":[89],"systems":[90],"refractory":[95],"genome-wide":[97],"high":[98],"throughput":[99],"screening":[100],"key":[102,155],"cellular":[104],"factors":[105],"essential":[106,188],"and/or":[108],"regulating":[109],"replication,":[111],"classic":[112],"one-gene":[113],"(or":[114],"pathway)-at-a-time":[115],"studies":[116],"in":[117,140,181],"last":[119],"several":[120],"decades":[121],"have":[122],"already":[123],"revealed":[124],"many":[125],"aspects":[126],"HBV-host":[128],"interactions.":[129],"An":[130],"overview":[131],"landscape":[134],"HBV-hepatocyte":[136],"interaction":[137],"indicates":[138],"that,":[139],"addition":[141],"more":[143],"tightly":[144],"suppressing":[145],"viral":[146,151],"by":[148],"directly":[149],"targeting":[150,200],"proteins,":[152],"disruption":[153],"viral-host":[156],"eliminate":[160],"or":[161],"inactivate":[162],"covalently":[164],"closed":[165],"circular":[166],"(ccc)":[167],"DNA,":[168],"most":[170],"stable":[171],"intermediate":[174],"that":[175],"exists":[176],"as":[177],"an":[178],"episomal":[179],"minichromosome":[180],"nucleus":[183],"hepatocyte,":[186],"achieve":[190],"functional":[192],"Moreover,":[198],"therapeutic":[199],"integrated":[202],"DNA":[204],"their":[206],"transcripts":[207],"may":[208],"also":[209],"be":[210],"required":[211],"induce":[213],"surface":[217],"antigen":[218],"(HBsAg)":[219],"seroclearance":[220],"prevent":[222],"liver":[223],"carcinogenesis.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-21T00:00:00"}