{"id":"https://openalex.org/W2807952267","doi":"https://doi.org/10.12688/f1000research.14421.1","title":"Recent advances in understanding and managing non-alcoholic fatty liver disease","display_name":"Recent advances in understanding and managing non-alcoholic fatty liver disease","publication_year":2018,"publication_date":"2018-06-11","ids":{"openalex":"https://openalex.org/W2807952267","doi":"https://doi.org/10.12688/f1000research.14421.1","mag":"2807952267","pmid":"https://pubmed.ncbi.nlm.nih.gov/29946426","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5998003"},"language":"en","primary_location":{"id":"doi:10.12688/f1000research.14421.1","doi":"https://doi.org/10.12688/f1000research.14421.1","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.14421.1","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.12688/f1000research.14421.1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010897180","display_name":"Somaya A. M. Albhaisi","orcid":"https://orcid.org/0000-0002-7500-4183","observed_orcids":["https://orcid.org/0000-0002-7500-4183"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Somaya Albhaisi","raw_affiliation_strings":["The Division of Internal Medicine, Virginia Commonwealth University, Richmond, USA","The Division of Internal Medicine, Virginia Commonwealth University, Richmond"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Division of Internal Medicine, Virginia Commonwealth University, Richmond, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"The Division of Internal Medicine, Virginia Commonwealth University, Richmond","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070639714","display_name":"Arun Jayant Sanyal","orcid":"https://orcid.org/0000-0001-8682-5748","observed_orcids":["https://orcid.org/0000-0001-8682-5748"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arun Sanyal","raw_affiliation_strings":["The Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, USA","The Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"The Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010897180","https://openalex.org/A5070639714"],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":{"value":1350,"currency":"USD","value_usd":1350},"apc_paid":{"value":1350,"currency":"USD","value_usd":1350},"fwci":1.2503,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.77479893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"7","issue":null,"first_page":"720","last_page":"720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":1.0},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9769999980926514},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":1.0},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/diagnosis","display_name":"diagnosis","score":0.5740000009536743},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.6019999980926514},{"id":"https://openalex.org/keywords/biochemical-markers","display_name":"biochemical markers","score":0.7129999995231628},{"id":"https://openalex.org/keywords/radiological-imaging","display_name":"radiological imaging","score":0.921999990940094},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.9139999747276306},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.972000002861023},{"id":"https://openalex.org/keywords/natural-history-disease","display_name":"natural history (disease)","score":0.6779999732971191},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2983643791","wikidata":"https://www.wikidata.org/wiki/Q1999993","display_name":"Open peer review","level":3,"score":0.8739098310470581},{"id":"https://openalex.org/C2992936677","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Plant biology","level":2,"score":0.7496005892753601},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.7003653049468994},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.6919817328453064},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.5669452548027039},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5266968011856079},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49348509311676025},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4318920969963074},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35891857743263245},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3242051303386688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29615485668182373},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2519867420196533},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18759649991989136},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.054559558629989624},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.12688/f1000research.14421.1","doi":"https://doi.org/10.12688/f1000research.14421.1","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.14421.1","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4965153","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5998003","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5998003","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5998003","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Res","raw_type":"Text"},{"id":"pmid:29946426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29946426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:66f0e084673a49f0b3edc27ddf9a9d0a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/66f0e084673a49f0b3edc27ddf9a9d0a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"F1000Research, Vol 7 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.12688/f1000research.14421.1","doi":"https://doi.org/10.12688/f1000research.14421.1","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.14421.1","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W90736706","https://openalex.org/W986443882","https://openalex.org/W1549627000","https://openalex.org/W1556802048","https://openalex.org/W1868475579","https://openalex.org/W1896344567","https://openalex.org/W1975489439","https://openalex.org/W1979443397","https://openalex.org/W1990168800","https://openalex.org/W1994797654","https://openalex.org/W2000723491","https://openalex.org/W2001837599","https://openalex.org/W2015940498","https://openalex.org/W2019280401","https://openalex.org/W2032129662","https://openalex.org/W2038831349","https://openalex.org/W2042569165","https://openalex.org/W2049384958","https://openalex.org/W2059613020","https://openalex.org/W2062812115","https://openalex.org/W2066841620","https://openalex.org/W2067740038","https://openalex.org/W2068053039","https://openalex.org/W2068572638","https://openalex.org/W2068581556","https://openalex.org/W2073137449","https://openalex.org/W2079332279","https://openalex.org/W2084735116","https://openalex.org/W2090013838","https://openalex.org/W2091106363","https://openalex.org/W2098555833","https://openalex.org/W2105359426","https://openalex.org/W2108347074","https://openalex.org/W2111160264","https://openalex.org/W2129639561","https://openalex.org/W2153997209","https://openalex.org/W2164514101","https://openalex.org/W2202737485","https://openalex.org/W2204688218","https://openalex.org/W2215535790","https://openalex.org/W2254482455","https://openalex.org/W2256856541","https://openalex.org/W2339836793","https://openalex.org/W2346887577","https://openalex.org/W2413015095","https://openalex.org/W2497435666","https://openalex.org/W2508708811","https://openalex.org/W2522782769","https://openalex.org/W2526965202","https://openalex.org/W2560504947","https://openalex.org/W2564467149","https://openalex.org/W2622132351","https://openalex.org/W2623358111","https://openalex.org/W2735896722","https://openalex.org/W2744982526","https://openalex.org/W2746863374","https://openalex.org/W2759997926","https://openalex.org/W2777780841","https://openalex.org/W2790512264","https://openalex.org/W3024785665"],"related_works":["https://openalex.org/W2736924678","https://openalex.org/W2056728315","https://openalex.org/W2114352928","https://openalex.org/W3140414464","https://openalex.org/W1797069455","https://openalex.org/W1980893712","https://openalex.org/W2038773198","https://openalex.org/W3112103684","https://openalex.org/W2622908974","https://openalex.org/W3048587661"],"abstract_inverted_index":{"Non-alcoholic":[0],"fatty":[1,61,91,147],"liver":[2,10,21,62,71,92,148],"disease":[3,11,111],"is":[4,25,41,85,96],"a":[5],"leading":[6],"cause":[7],"of":[8,59,89,118,126,145],"chronic":[9],"that":[12],"can":[13],"lead":[14],"to":[15,27,38,98,115],"cirrhosis,":[16],"hepatocellular":[17],"cancer,":[18],"and":[19,23,30,33,53,66,81,100,122,143],"end-stage":[20],"disease,":[22],"it":[24,95],"linked":[26],"elevated":[28],"cardiovascular-":[29],"cancer-related":[31],"morbidity":[32],"mortality.":[34],"Insulin":[35],"resistance":[36],"related":[37],"metabolic":[39],"syndrome":[40],"the":[42,57,78,86,116,124,137],"main":[43],"pathogenic":[44],"trigger":[45],"that,":[46],"in":[47,73,77,109,135],"association":[48],"with":[49,70],"adverse":[50],"genetic,":[51],"lifestyle,":[52],"other":[54],"factors,":[55],"precipitates":[56],"development":[58,117],"non-alcoholic":[60,90,146],"disease.":[63,149],"Biochemical":[64],"markers":[65],"radiological":[67],"imaging,":[68],"along":[69],"biopsy":[72],"selected":[74],"cases,":[75],"help":[76],"disease's":[79],"diagnosis":[80],"prognostication.":[82],"Weight":[83],"loss":[84],"cornerstone":[87],"treatment":[88],"disease;":[93],"however,":[94],"difficult":[97],"achieve":[99],"maintain,":[101],"so":[102],"pharmacotherapy":[103],"was":[104],"developed.":[105],"The":[106],"remarkable":[107],"evolution":[108],"understanding":[110,136],"pathogenesis":[112],"has":[113],"led":[114],"new":[119],"medical":[120],"therapies":[121],"even":[123],"modification":[125],"currently":[127],"available":[128],"ones.":[129],"This":[130],"review":[131],"summarizes":[132],"recent":[133],"advances":[134],"epidemiology,":[138],"natural":[139],"history,":[140],"pathogenesis,":[141],"diagnosis,":[142],"management":[144]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2018-06-21T00:00:00"}
