{"id":"https://openalex.org/W2807938178","doi":"https://doi.org/10.7717/peerj.4978","title":"Structural insights and characterization of human Npas4 protein","display_name":"Structural insights and characterization of human Npas4 protein","publication_year":2018,"publication_date":"2018-06-14","ids":{"openalex":"https://openalex.org/W2807938178","doi":"https://doi.org/10.7717/peerj.4978","mag":"2807938178","pmid":"https://pubmed.ncbi.nlm.nih.gov/29915698","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6004298"},"language":"en","primary_location":{"id":"doi:10.7717/peerj.4978","doi":"https://doi.org/10.7717/peerj.4978","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.4978","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7717/peerj.4978","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025503608","display_name":"Ammad Fahim","orcid":"https://orcid.org/0000-0003-1378-058X","observed_orcids":["https://orcid.org/0000-0003-1378-058X"]},"institutions":[{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ammad Fahim","raw_affiliation_strings":["Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057019055","display_name":"Zaira Rehman","orcid":"https://orcid.org/0000-0001-9613-4326","observed_orcids":["https://orcid.org/0000-0001-9613-4326"]},"institutions":[{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zaira Rehman","raw_affiliation_strings":["Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001677510","display_name":"Muhammad Faraz Bhatti","orcid":"https://orcid.org/0000-0002-9932-8107","observed_orcids":["https://orcid.org/0000-0002-9932-8107","https://orcid.org/0000-0002-1792-1004"]},"institutions":[{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Muhammad Faraz Bhatti","raw_affiliation_strings":["Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001004081","display_name":"Amjad Ali","orcid":"https://orcid.org/0000-0002-0486-4661","observed_orcids":["https://orcid.org/0000-0002-0486-4661"]},"institutions":[{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Amjad Ali","raw_affiliation_strings":["Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080094687","display_name":"Nasar Virk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Nasar Virk","raw_affiliation_strings":["Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044757404","display_name":"Amir Rashid","orcid":"https://orcid.org/0000-0002-8510-2991","observed_orcids":["https://orcid.org/0000-0002-8510-2991"]},"institutions":[{"id":"https://openalex.org/I4210155929","display_name":"National University of Medical Sciences","ror":"https://ror.org/04tj88f69","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210155929"]},{"id":"https://openalex.org/I58993843","display_name":"Army Medical College","ror":"https://ror.org/03w0kj141","country_code":"PK","type":"education","lineage":["https://openalex.org/I58993843"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Amir Rashid","raw_affiliation_strings":["Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan","institution_ids":["https://openalex.org/I4210155929","https://openalex.org/I58993843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031484265","display_name":"Rehan Zafar Paracha","orcid":"https://orcid.org/0000-0003-4227-1354","observed_orcids":["https://orcid.org/0000-0003-4227-1354"]},"institutions":[{"id":"https://openalex.org/I929597975","display_name":"National University of Sciences and Technology","ror":"https://ror.org/03w2j5y17","country_code":"PK","type":"education","lineage":["https://openalex.org/I929597975"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Rehan Zafar Paracha","raw_affiliation_strings":["Research Center for Modeling and Simulation (RCMS), National University of Sciences & Technology (NUST), Islamabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Modeling and Simulation (RCMS), National University of Sciences & Technology (NUST), Islamabad, Pakistan","institution_ids":["https://openalex.org/I929597975"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001677510","https://openalex.org/A5031484265"],"corresponding_institution_ids":["https://openalex.org/I929597975"],"apc_list":{"value":1395,"currency":"USD","value_usd":1395},"apc_paid":{"value":1395,"currency":"USD","value_usd":1395},"fwci":0.078,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.3499814,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"6","issue":null,"first_page":"e4978","last_page":"e4978"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/npas4","display_name":"Npas4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.6179999709129333},{"id":"https://openalex.org/keywords/protein-tertiary-structure-prediction","display_name":"protein tertiary structure prediction","score":0.7630000114440918},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.953000009059906},{"id":"https://openalex.org/keywords/bhlh-domain","display_name":"bHLH domain","score":0.7099999785423279},{"id":"https://openalex.org/keywords/pas-domain","display_name":"PAS domain","score":0.9860000014305115},{"id":"https://openalex.org/keywords/phosphorylation-sites","display_name":"phosphorylation sites","score":0.9139999747276306},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8169999718666077},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9150000214576721},{"id":"https://openalex.org/keywords/phylogenetic-analysis","display_name":"phylogenetic analysis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.7620000243186951},{"id":"https://openalex.org/keywords/neuronal-survival","display_name":"neuronal survival","score":0.8080000281333923},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.6620000004768372},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.6449999809265137},{"id":"https://openalex.org/keywords/neurotransmission","display_name":"neurotransmission","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C2778875234","wikidata":"https://www.wikidata.org/wiki/Q36626","display_name":"PAS domain","level":4,"score":0.5523607134819031},{"id":"https://openalex.org/C75599170","wikidata":"https://www.wikidata.org/wiki/Q898483","display_name":"Protein tertiary structure","level":2,"score":0.5259640216827393},{"id":"https://openalex.org/C14301744","wikidata":"https://www.wikidata.org/wiki/Q579211","display_name":"Ramachandran plot","level":3,"score":0.4619918167591095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46012070775032043},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.4314742386341095},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.42739391326904297},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41134753823280334},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3909371495246887},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38744473457336426},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3686383068561554},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3289560079574585}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.7717/peerj.4978","doi":"https://doi.org/10.7717/peerj.4978","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.4978","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6004298","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6004298/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6004298/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:4955567","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6004298","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29915698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29915698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d9c8a5b7f1854e919bc0203be1730fba","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d9c8a5b7f1854e919bc0203be1730fba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PeerJ, Vol 6, p e4978 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7717/peerj.4978","doi":"https://doi.org/10.7717/peerj.4978","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.4978","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2807938178.pdf","grobid_xml":"https://content.openalex.org/works/W2807938178.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1491040459","https://openalex.org/W1803102843","https://openalex.org/W1966526845","https://openalex.org/W1974634612","https://openalex.org/W1978304263","https://openalex.org/W1984603208","https://openalex.org/W1992192767","https://openalex.org/W2006192061","https://openalex.org/W2014233647","https://openalex.org/W2014615542","https://openalex.org/W2015115860","https://openalex.org/W2016170088","https://openalex.org/W2037312364","https://openalex.org/W2043308634","https://openalex.org/W2047647552","https://openalex.org/W2053820259","https://openalex.org/W2054157090","https://openalex.org/W2060178110","https://openalex.org/W2063237839","https://openalex.org/W2074986801","https://openalex.org/W2079540311","https://openalex.org/W2080428182","https://openalex.org/W2082023836","https://openalex.org/W2096123613","https://openalex.org/W2096173332","https://openalex.org/W2109807917","https://openalex.org/W2112797448","https://openalex.org/W2120230374","https://openalex.org/W2120744225","https://openalex.org/W2125644182","https://openalex.org/W2139915497","https://openalex.org/W2144020793","https://openalex.org/W2144062280","https://openalex.org/W2146084306","https://openalex.org/W2147702777","https://openalex.org/W2149573413","https://openalex.org/W2153187042","https://openalex.org/W2154501851","https://openalex.org/W2158490907","https://openalex.org/W2158590037","https://openalex.org/W2158778721","https://openalex.org/W2165300407","https://openalex.org/W2188430373","https://openalex.org/W2195955429","https://openalex.org/W2284376923","https://openalex.org/W2294967868","https://openalex.org/W2298086467","https://openalex.org/W2311203695","https://openalex.org/W2379244379","https://openalex.org/W2537623931","https://openalex.org/W2544358941","https://openalex.org/W2563026252","https://openalex.org/W2601374267","https://openalex.org/W2615491851","https://openalex.org/W2767649956"],"related_works":["https://openalex.org/W2807801625","https://openalex.org/W2472008876","https://openalex.org/W4308430006","https://openalex.org/W2039516870","https://openalex.org/W7100044842","https://openalex.org/W4404432748","https://openalex.org/W7097903755","https://openalex.org/W4391502965","https://openalex.org/W4396546072","https://openalex.org/W2544358941"],"abstract_inverted_index":{"Npas4":[0,24,33,53,76,88,131,143,161,216,301],"is":[1,8,40,165],"an":[2,166],"activity":[3,256],"dependent":[4],"transcription":[5,259],"factor":[6],"which":[7,245],"responsible":[9],"for":[10],"gearing":[11],"the":[12,21,29,43,49,56,100,106,127,141,228,231,264,268,292,297],"expression":[13],"of":[14,23,32,52,58,75,87,108,130,160,180,215,230,252,300],"target":[15],"genes":[16],"involved":[17,248,273,305],"in":[18,25,195,207,249,274,290,302,306],"neuro-transmission.":[19],"Despite":[20],"importance":[22],"many":[26],"neuronal":[27,276,307],"diseases,":[28],"tertiary":[30,213,225],"structure":[31,214],"protein":[34,67,169,232,284],"along":[35],"with":[36,170,242],"its":[37],"physico-chemical":[38],"properties":[39,159,294],"limited.":[41],"In":[42],"current":[44,287],"study,":[45],"first":[46],"we":[47],"perfomed":[48],"phylogenetic":[50,138],"analysis":[51,139,238,265],"and":[54,61,72,97,99,112,182,191,221,260,279,295,309],"determined":[55],"content":[57],"hydrophobic,":[59],"flexible":[60],"order-disorder":[62],"promoting":[63,275],"amino":[64],"acids.":[65],"The":[66,83,115,137,157,174,211,286],"binding":[68,283],"regions,":[69],"post-translational":[70,175],"modifications":[71],"crystallization":[73],"propensity":[74],"were":[77,132,193],"predicted":[78,90,212],"through":[79,91,134],"different":[80],"in-silico":[81],"methods.":[82],"three":[84],"dimensional":[85],"model":[86,102,117],"was":[89,103,118,205],"LOMET,":[92],"SPARSKS-X,":[93],"I-Tasser,":[94],"RaptorX,":[95],"MUSTER":[96],"Pyhre":[98],"best":[101,116],"selected":[104],"on":[105],"basis":[107],"Ramachandran":[109],"plot,":[110],"PROSA,":[111],"Qmean":[113],"scores.":[114],"then":[119],"subjected":[120],"to":[121,145,149,254,271],"further":[122],"refinement":[123],"though":[124],"MODREFINER.":[125],"Finally":[126],"interacting":[128],"partners":[129],"identified":[133],"STRING":[135],"database.":[136],"showed":[140,162,217],"human":[142],"gene":[144,258],"be":[146],"closely":[147],"related":[148],"other":[150],"primates":[151],"such":[152],"as":[153],"chimpanzees,":[154],"monkey,":[155],"gibbon.":[156],"physiochemical":[158],"that":[163,218],"it":[164],"intrinsically":[167],"disordered":[168],"N-terminal":[171],"ordered":[172],"region.":[173],"modification":[176],"analyses":[177],"indicated":[178],"absence":[179],"acetylation":[181],"mannosylation":[183],"sites.":[184],"Three":[185],"potential":[186],"phosphorylation":[187,202],"sites":[188],"(S108,":[189],"T130":[190],"T136)":[192],"found":[194],"PAS":[196,208,222],"A":[197],"domain":[198,220,223],"whilst":[199],"a":[200],"single":[201],"site":[203],"(S273)":[204],"present":[206],"B":[209],"domain.":[210],"bHLH":[219],"possess":[224],"structures":[226],"while":[227],"rest":[229],"exhibited":[233],"disorder":[234],"property.":[235],"Protein-protein":[236],"interaction":[237,241],"revealed":[239],"NPas4":[240],"various":[243],"proteins":[244,253,272],"are":[246],"mainly":[247],"nuclear":[250],"trafficking":[251],"cytoplasm,":[255],"regulated":[257],"neurodevelopmental":[261],"disorders.":[262],"Moreover":[263],"also":[266],"highlighted":[267],"direct":[269],"relation":[270],"survival,":[277],"plasticity":[278],"cAMP":[280],"responsive":[281],"element":[282],"proteins.":[285],"study":[288],"helps":[289],"understanding":[291],"physicochemical":[293],"reveals":[296],"neuro-modulatory":[298],"role":[299],"crucial":[303],"pathways":[304],"survival":[308],"neural":[310],"signalling":[311],"hemostasis.":[312]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2018-06-21T00:00:00"}