{"id":"https://openalex.org/W2807841737","doi":"https://doi.org/10.18632/oncotarget.25122","title":"Stability and anti-tumor effect of oncolytic herpes simplex virus type 2","display_name":"Stability and anti-tumor effect of oncolytic herpes simplex virus type 2","publication_year":2018,"publication_date":"2018-05-15","ids":{"openalex":"https://openalex.org/W2807841737","doi":"https://doi.org/10.18632/oncotarget.25122","mag":"2807841737","pmid":"https://pubmed.ncbi.nlm.nih.gov/29872496","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5973869"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.25122","doi":"https://doi.org/10.18632/oncotarget.25122","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.25122","pdf_url":"https://www.oncotarget.com/article/25122/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.oncotarget.com/article/25122/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100619066","display_name":"Yang Wang","orcid":"https://orcid.org/0000-0001-8055-9522","observed_orcids":["https://orcid.org/0000-0001-8055-9522"]},"institutions":[{"id":"https://openalex.org/I74525822","display_name":"Hubei University of Technology","ror":"https://ror.org/02d3fj342","country_code":"CN","type":"education","lineage":["https://openalex.org/I74525822"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Wang","raw_affiliation_strings":["National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, Hubei, China","institution_ids":["https://openalex.org/I74525822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449366","display_name":"Jing Jin","orcid":"https://orcid.org/0000-0001-6300-0364","observed_orcids":["https://orcid.org/0000-0001-6300-0364"]},"institutions":[{"id":"https://openalex.org/I74525822","display_name":"Hubei University of Technology","ror":"https://ror.org/02d3fj342","country_code":"CN","type":"education","lineage":["https://openalex.org/I74525822"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Jin","raw_affiliation_strings":["National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, Hubei, China","institution_ids":["https://openalex.org/I74525822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037687840","display_name":"Zhen Wu","orcid":"https://orcid.org/0009-0002-4600-8115","observed_orcids":["https://orcid.org/0009-0002-4600-8115"]},"institutions":[{"id":"https://openalex.org/I74525822","display_name":"Hubei University of Technology","ror":"https://ror.org/02d3fj342","country_code":"CN","type":"education","lineage":["https://openalex.org/I74525822"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhen Wu","raw_affiliation_strings":["National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, Hubei, China","institution_ids":["https://openalex.org/I74525822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073570261","display_name":"Sheng Hu","orcid":"https://orcid.org/0000-0002-2709-6976","observed_orcids":["https://orcid.org/0000-0002-2709-6976"]},"institutions":[{"id":"https://openalex.org/I4210160841","display_name":"Hubei Cancer Hospital","ror":"https://ror.org/05p38yh32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160841"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Sheng Hu","raw_affiliation_strings":["Department of Medical Oncology, Hubei Cancer Hospital, Wuhan, 430079, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Hubei Cancer Hospital, Wuhan, 430079, Hubei, China","institution_ids":["https://openalex.org/I4210160841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102822449","display_name":"Han Hu","orcid":"https://orcid.org/0000-0002-8188-6143","observed_orcids":["https://orcid.org/0000-0002-8188-6143"]},"institutions":[{"id":"https://openalex.org/I74525822","display_name":"Hubei University of Technology","ror":"https://ror.org/02d3fj342","country_code":"CN","type":"education","lineage":["https://openalex.org/I74525822"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Hu","raw_affiliation_strings":["National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, Hubei, China","institution_ids":["https://openalex.org/I74525822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076394229","display_name":"Zhifeng Ning","orcid":"https://orcid.org/0000-0002-6700-161X","observed_orcids":["https://orcid.org/0000-0002-6700-161X"]},"institutions":[{"id":"https://openalex.org/I4210101555","display_name":"Hubei University of Science and Technology","ror":"https://ror.org/018wg9441","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210101555"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhifeng Ning","raw_affiliation_strings":["Basic Medicine College, Hubei University of Science and Technology, Xianning, 437100, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Medicine College, Hubei University of Science and Technology, Xianning, 437100, Hubei, China","institution_ids":["https://openalex.org/I4210101555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414596","display_name":"Yanfei Li","orcid":"https://orcid.org/0000-0002-8236-6211","observed_orcids":["https://orcid.org/0000-0002-8236-6211"]},"institutions":[{"id":"https://openalex.org/I4210101555","display_name":"Hubei University of Science and Technology","ror":"https://ror.org/018wg9441","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210101555"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanfei Li","raw_affiliation_strings":["College of Pharmacology, Hubei University of Science and Technology, Xianning, 437100, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacology, Hubei University of Science and Technology, Xianning, 437100, Hubei, China","institution_ids":["https://openalex.org/I4210101555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028147473","display_name":"Yuting Dong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuting Dong","raw_affiliation_strings":["Wuhan Binhui Biotechnology Co., Ltd., Wuhan, 430075, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Binhui Biotechnology Co., Ltd., Wuhan, 430075, Hubei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianwen Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101555","display_name":"Hubei University of Science and Technology","ror":"https://ror.org/018wg9441","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210101555"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianwen Zou","raw_affiliation_strings":["College of Pharmacology, Hubei University of Science and Technology, Xianning, 437100, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacology, Hubei University of Science and Technology, Xianning, 437100, Hubei, China","institution_ids":["https://openalex.org/I4210101555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040962829","display_name":"Zeyong Mao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeyong Mao","raw_affiliation_strings":["Wuhan Binhui Biotechnology Co., Ltd., Wuhan, 430075, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Binhui Biotechnology Co., Ltd., Wuhan, 430075, Hubei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010905218","display_name":"Xiaotai Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaotai Shi","raw_affiliation_strings":["Wuhan Binhui Biotechnology Co., Ltd., Wuhan, 430075, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Binhui Biotechnology Co., Ltd., Wuhan, 430075, Hubei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052267311","display_name":"Huajun Zheng","orcid":"https://orcid.org/0000-0002-9242-4040","observed_orcids":["https://orcid.org/0000-0002-9242-4040"]},"institutions":[{"id":"https://openalex.org/I4210099308","display_name":"Chinese National Human Genome Center at Shanghai","ror":"https://ror.org/017xz5989","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210099308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huajun Zheng","raw_affiliation_strings":["Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, 201203, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, 201203, Shanghai, China","institution_ids":["https://openalex.org/I4210099308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100645338","display_name":"Shuang Dong","orcid":"https://orcid.org/0000-0002-8992-225X","observed_orcids":["https://orcid.org/0000-0002-8992-225X","https://orcid.org/0009-0008-4954-8065"]},"institutions":[{"id":"https://openalex.org/I4210160841","display_name":"Hubei Cancer Hospital","ror":"https://ror.org/05p38yh32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160841"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Dong","raw_affiliation_strings":["Department of Medical Oncology, Hubei Cancer Hospital, Wuhan, 430079, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Hubei Cancer Hospital, Wuhan, 430079, Hubei, China","institution_ids":["https://openalex.org/I4210160841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022222069","display_name":"Fuxing Liu","orcid":"https://orcid.org/0009-0007-7389-9132","observed_orcids":["https://orcid.org/0009-0007-7389-9132"]},"institutions":[{"id":"https://openalex.org/I4210101555","display_name":"Hubei University of Science and Technology","ror":"https://ror.org/018wg9441","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210101555"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuxing Liu","raw_affiliation_strings":["Basic Medicine College, Hubei University of Science and Technology, Xianning, 437100, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Medicine College, Hubei University of Science and Technology, Xianning, 437100, Hubei, China","institution_ids":["https://openalex.org/I4210101555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082934494","display_name":"Zhizheng Fang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhizheng Fang","raw_affiliation_strings":["Wuhan Binhui Biotechnology Co., Ltd., Wuhan, 430075, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Binhui Biotechnology Co., Ltd., Wuhan, 430075, Hubei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103172659","display_name":"Jiliang Wu","orcid":"https://orcid.org/0000-0002-2879-3888","observed_orcids":["https://orcid.org/0000-0002-2879-3888"]},"institutions":[{"id":"https://openalex.org/I4210101555","display_name":"Hubei University of Science and Technology","ror":"https://ror.org/018wg9441","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210101555"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiliang Wu","raw_affiliation_strings":["Hubei Provincial Key Laboratory of Cardiocerebrovascular and Metabolic Diseases, Hubei University of Science and Technology, Xianning, 437100, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Provincial Key Laboratory of Cardiocerebrovascular and Metabolic Diseases, Hubei University of Science and Technology, Xianning, 437100, Hubei, China","institution_ids":["https://openalex.org/I4210101555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085304755","display_name":"Binlei Liu","orcid":"https://orcid.org/0000-0002-2852-600X","observed_orcids":["https://orcid.org/0000-0002-2852-600X","https://orcid.org/0000-0001-6210-1585"]},"institutions":[{"id":"https://openalex.org/I4210101555","display_name":"Hubei University of Science and Technology","ror":"https://ror.org/018wg9441","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210101555"]},{"id":"https://openalex.org/I74525822","display_name":"Hubei University of Technology","ror":"https://ror.org/02d3fj342","country_code":"CN","type":"education","lineage":["https://openalex.org/I74525822"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Binlei Liu","raw_affiliation_strings":["College of Pharmacology, Hubei University of Science and Technology, Xianning, 437100, Hubei, China","National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacology, Hubei University of Science and Technology, Xianning, 437100, Hubei, China","institution_ids":["https://openalex.org/I4210101555"]},{"raw_affiliation_string":"National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, Hubei, China","institution_ids":["https://openalex.org/I74525822"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5037687840","https://openalex.org/A5073570261","https://openalex.org/A5100449366","https://openalex.org/A5100619066"],"corresponding_institution_ids":["https://openalex.org/I4210160841","https://openalex.org/I74525822"],"apc_list":null,"apc_paid":null,"fwci":1.1793,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.77604455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"37","first_page":"24672","last_page":"24683"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/virus-stability","display_name":"virus stability","score":0.6909999847412109},{"id":"https://openalex.org/keywords/anti-tumor-effect","display_name":"anti-tumor effect","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.3370000123977661},{"id":"https://openalex.org/keywords/gene-therapy-vectors","display_name":"gene therapy vectors","score":0.34200000762939453},{"id":"https://openalex.org/keywords/tumor-targeted-gene-delivery","display_name":"tumor-targeted gene delivery","score":0.33899998664855957},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.32499998807907104},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.30300000309944153},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.38499999046325684},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.4189999997615814},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.47999998927116394},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.5580000281333923},{"id":"https://openalex.org/keywords/tumor-cell-adhesion","display_name":"tumor cell adhesion","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.9312940835952759},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.8175008296966553},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6036865711212158},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5924326777458191},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45645850896835327},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.41364091634750366},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.346858412027359}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.18632/oncotarget.25122","doi":"https://doi.org/10.18632/oncotarget.25122","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.25122","pdf_url":"https://www.oncotarget.com/article/25122/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4940109","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5973869","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29872496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29872496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5973869","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5973869/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.25122","doi":"https://doi.org/10.18632/oncotarget.25122","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.25122","pdf_url":"https://www.oncotarget.com/article/25122/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2807841737.pdf","grobid_xml":"https://content.openalex.org/works/W2807841737.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1980477679","https://openalex.org/W1980717355","https://openalex.org/W1983239966","https://openalex.org/W1988225150","https://openalex.org/W1988337918","https://openalex.org/W2009183592","https://openalex.org/W2011182267","https://openalex.org/W2024327551","https://openalex.org/W2024797655","https://openalex.org/W2025822934","https://openalex.org/W2030976397","https://openalex.org/W2033419482","https://openalex.org/W2034881941","https://openalex.org/W2038709470","https://openalex.org/W2040649916","https://openalex.org/W2041226281","https://openalex.org/W2043133015","https://openalex.org/W2050122913","https://openalex.org/W2062406078","https://openalex.org/W2062504884","https://openalex.org/W2062856806","https://openalex.org/W2081140221","https://openalex.org/W2086938119","https://openalex.org/W2088792337","https://openalex.org/W2093059993","https://openalex.org/W2096615964","https://openalex.org/W2104050479","https://openalex.org/W2105093228","https://openalex.org/W2112326573","https://openalex.org/W2165320653","https://openalex.org/W2293177523","https://openalex.org/W2473956396","https://openalex.org/W2754662247","https://openalex.org/W2912795122","https://openalex.org/W4211189976","https://openalex.org/W4211238487","https://openalex.org/W4234678994"],"related_works":["https://openalex.org/W2902737915","https://openalex.org/W2001949418","https://openalex.org/W2511158572","https://openalex.org/W2998867500","https://openalex.org/W7213460907","https://openalex.org/W3030884457","https://openalex.org/W2587142197","https://openalex.org/W3177001580","https://openalex.org/W1980717355","https://openalex.org/W2372806257"],"abstract_inverted_index":{"//":[0],"Yang":[1],"Wang":[2],"1,":[3,8,13,71],"*":[4,9,14,19,202],",":[5,10,15,20,24,28,32,36,40,44,48,52,56,60,64],"Jing":[6],"Jin":[7],"Zhen":[11],"Wu":[12,66],"Sheng":[16],"Hu":[17,22],"2,":[18],"Han":[21],"1":[23,73],"Zhifeng":[25],"Ning":[26],"3":[27,59,125],"Yanfei":[29],"Li":[30],"4":[31,39,72,139],"Yuting":[33],"Dong":[34,54],"5":[35,43,47,63,153],"Jianwen":[37],"Zou":[38],"Zeyong":[41],"Mao":[42],"Xiaotai":[45],"Shi":[46],"Huajun":[49],"Zheng":[50],"6":[51,163],"Shuang":[53],"2":[55,113,281],"Fuxing":[57],"Liu":[58,70],"Zhizheng":[61],"Fang":[62],"Jiliang":[65,217],"7":[67,182],"and":[68,80,133,147,169,189,196,257,262,296,315,335,341,368],"Binlei":[69,213],"National":[74,173],"\u201c111\u201d":[75],"Center":[76,95,176],"for":[77,353],"Cellular":[78],"Regulation":[79],"Molecular":[81],"Pharmaceutics,":[82],"Key":[83,100,165,185],"Laboratory":[84,101,166,186],"of":[85,89,96,102,107,115,131,141,145,167,187,194,255,275,293,299,350],"Fermentation":[86],"Engineering":[87],"(Ministry":[88],"Education),":[90],"Hubei":[91,99,105,118,129,143,183,192],"Provincial":[92,184],"Cooperative":[93],"Innovation":[94],"Industrial":[97,103],"Fermentation,":[98],"Microbiology,":[104],"University":[106,130,144,193],"Technology,":[108,134,148,197],"Wuhan,":[109,121,159],"430068,":[110],"Hubei,":[111,123,137,151,161,200],"China":[112,124,138,152,162,181,201],"Department":[114],"Medical":[116],"Oncology,":[117],"Cancer":[119],"Hospital,":[120],"430079,":[122],"Basic":[126],"Medicine":[127],"College,":[128],"Science":[132,146,195],"Xianning,":[135,149,198],"437100,":[136,150,199],"College":[140],"Pharmacology,":[142],"Wuhan":[154],"Binhui":[155],"Biotechnology":[156],"Co.,":[157],"Ltd.,":[158],"430075,":[160],"Shanghai-MOST":[164],"Health":[168],"Disease":[170],"Genomics,":[171],"Chinese":[172],"Human":[174],"Genome":[175],"at":[177],"Shanghai,":[178,180],"201203,":[179],"Cardiocerebrovascular":[188],"Metabolic":[190],"Diseases,":[191],"These":[203],"authors":[204],"have":[205],"contributed":[206],"equally":[207],"to":[208,260,285],"this":[209,300,305],"work":[210],"Correspondence":[211],"to:":[212],"Liu,":[214],"email:":[215,219],"1836035949@qq.com":[216],"Wu,":[218],"xywjl@163.com":[220],"Keywords:":[221],"herpes":[222,277],"simplex":[223,278],"virus":[224,279,301,352,363],"type":[225,274,280],"2;":[226],"stability;":[227],"anti-tumor":[228,321,343],"effect":[229],"Received:":[230],"August":[231],"24,":[232],"2017":[233],"Accepted:":[234],"March":[235],"22,":[236],"2018":[237,241],"Published:":[238],"May":[239],"15,":[240],"ABSTRACT":[242],"Oncolytic":[243],"virotherapy":[244],"is":[245,302,361,373],"a":[246,267,272,290,362,374],"new":[247,273],"therapeutic":[248],"strategy":[249],"based":[250],"on":[251],"the":[252,294,342,351],"inherent":[253],"cytotoxicity":[254],"viruses":[256],"their":[258],"ability":[259,298],"replicate":[261],"spread":[263],"in":[264,266,323,337],"tumors":[265],"selective":[268],"manner.":[269],"We":[270],"constructed":[271],"oncolytic":[276,297,376],"(oHSV-2,":[282],"named":[283],"OH2)":[284],"treat":[286],"human":[287],"cancers,":[288],"but":[289],"systematic":[291],"evaluation":[292],"stability":[295,314],"lacking.":[303],"In":[304,358],"study,":[306],"we":[307],"evaluated":[308],"its":[309,320],"physical":[310,328],"stability,":[311,318],"gene":[312],"modification":[313],"biological":[316,369],"characteristics":[317,329],"including":[319],"activity":[322,344],"an":[324],"animal":[325],"model.":[326],"The":[327],"as":[330,332],"well":[331],"genetic":[333],"deletions":[334],"insertions":[336],"OH2":[338,360,372],"were":[339],"stable,":[340],"remained":[345],"stable":[346,366],"even":[347],"after":[348],"passage":[349],"more":[354],"than":[355],"20":[356],"generations.":[357],"conclusion,":[359],"that":[364],"has":[365],"structural":[367],"traits.":[370],"Furthermore,":[371],"potent":[375],"agent":[377],"against":[378],"tumor":[379],"cells.":[380]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-21T00:00:00"}