{"id":"https://openalex.org/W2807828152","doi":"https://doi.org/10.1038/s41598-018-27599-4","title":"Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure","display_name":"Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure","publication_year":2018,"publication_date":"2018-06-12","ids":{"openalex":"https://openalex.org/W2807828152","doi":"https://doi.org/10.1038/s41598-018-27599-4","mag":"2807828152","pmid":"https://pubmed.ncbi.nlm.nih.gov/29915390"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-27599-4","doi":"https://doi.org/10.1038/s41598-018-27599-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-27599-4","pdf_url":"https://www.nature.com/articles/s41598-018-27599-4.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-27599-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Li Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210092150","display_name":"Chonnam National University Hospital","ror":"https://ror.org/00f200z37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN","KR"],"is_corresponding":false,"raw_author_name":"Li Jin","raw_affiliation_strings":["Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","The Second Affiliated Hospital & Yuying Children's Hospital Wenzhou Medical University, Wenzhou, 325027, China","The Second Affiliated Hospital & Yuying Children\u2019s Hospital Wenzhou Medical University, Wenzhou, 325027, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","institution_ids":["https://openalex.org/I4210092150"]},{"raw_affiliation_string":"The Second Affiliated Hospital & Yuying Children's Hospital Wenzhou Medical University, Wenzhou, 325027, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]},{"raw_affiliation_string":"The Second Affiliated Hospital & Yuying Children\u2019s Hospital Wenzhou Medical University, Wenzhou, 325027, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018836315","display_name":"Simei Sun","orcid":"https://orcid.org/0000-0002-6887-149X","observed_orcids":["https://orcid.org/0000-0002-6887-149X"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]},{"id":"https://openalex.org/I4210092150","display_name":"Chonnam National University Hospital","ror":"https://ror.org/00f200z37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Simei Sun","raw_affiliation_strings":["Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","Molecular Medicine, BK21 plus, Chonnam National University Graduate School, Gwangju, 61469, Republic of Korea","Zhengjiang Rongjun Hospital, 352 Zhongshan road, Jiaxing city, Zhejiang Province, 314000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","institution_ids":["https://openalex.org/I4210092150"]},{"raw_affiliation_string":"Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","institution_ids":["https://openalex.org/I4210092150"]},{"raw_affiliation_string":"Molecular Medicine, BK21 plus, Chonnam National University Graduate School, Gwangju, 61469, Republic of Korea","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"Zhengjiang Rongjun Hospital, 352 Zhongshan road, Jiaxing city, Zhejiang Province, 314000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079888923","display_name":"Yuhee Ryu","orcid":"https://orcid.org/0000-0002-5302-3084","observed_orcids":["https://orcid.org/0000-0002-5302-3084"]},"institutions":[{"id":"https://openalex.org/I4210092150","display_name":"Chonnam National University Hospital","ror":"https://ror.org/00f200z37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yuhee Ryu","raw_affiliation_strings":["Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","institution_ids":["https://openalex.org/I4210092150"]},{"raw_affiliation_string":"Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","institution_ids":["https://openalex.org/I4210092150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112012689","display_name":"Zhe Hao Piao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Hao Piao","raw_affiliation_strings":["The Second Affiliated Hospital & Yuying Children's Hospital Wenzhou Medical University, Wenzhou, 325027, China","The Second Affiliated Hospital & Yuying Children\u2019s Hospital Wenzhou Medical University, Wenzhou, 325027, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital & Yuying Children's Hospital Wenzhou Medical University, Wenzhou, 325027, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]},{"raw_affiliation_string":"The Second Affiliated Hospital & Yuying Children\u2019s Hospital Wenzhou Medical University, Wenzhou, 325027, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395551","display_name":"Bin Liu","orcid":"https://orcid.org/0000-0003-0467-3678","observed_orcids":["https://orcid.org/0000-0003-0467-3678"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Liu","raw_affiliation_strings":["The Second Hospital of Jilin University, Changchun, Jilin, 130041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Jilin University, Changchun, Jilin, 130041, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084288803","display_name":"Sin Young Choi","orcid":"https://orcid.org/0000-0002-8188-9731","observed_orcids":["https://orcid.org/0000-0002-8188-9731"]},"institutions":[{"id":"https://openalex.org/I4210092150","display_name":"Chonnam National University Hospital","ror":"https://ror.org/00f200z37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sin Young Choi","raw_affiliation_strings":["Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","institution_ids":["https://openalex.org/I4210092150"]},{"raw_affiliation_string":"Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","institution_ids":["https://openalex.org/I4210092150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086985845","display_name":"Gwi Ran Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092150","display_name":"Chonnam National University Hospital","ror":"https://ror.org/00f200z37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gwi Ran Kim","raw_affiliation_strings":["Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","institution_ids":["https://openalex.org/I4210092150"]},{"raw_affiliation_string":"Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","institution_ids":["https://openalex.org/I4210092150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100642352","display_name":"Hyung-Seok Kim","orcid":"https://orcid.org/0000-0001-7340-0898","observed_orcids":["https://orcid.org/0000-0001-7340-0898"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung-Seok Kim","raw_affiliation_strings":["Department of Forensic Medicine, Chonnam National University Medical School, Gwangju, 61469, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Forensic Medicine, Chonnam National University Medical School, Gwangju, 61469, Republic of Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068223655","display_name":"Hae Jin Kee","orcid":"https://orcid.org/0000-0002-9774-4828","observed_orcids":["https://orcid.org/0000-0002-9774-4828"]},"institutions":[{"id":"https://openalex.org/I4210092150","display_name":"Chonnam National University Hospital","ror":"https://ror.org/00f200z37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hae Jin Kee","raw_affiliation_strings":["Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea. sshjkee@empas.com","Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea. sshjkee@empas.com","Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea. sshjkee@empas.com","institution_ids":["https://openalex.org/I4210092150"]},{"raw_affiliation_string":"Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea. sshjkee@empas.com","institution_ids":["https://openalex.org/I4210092150"]},{"raw_affiliation_string":"Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","institution_ids":["https://openalex.org/I4210092150"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101911180","display_name":"Myung Ho Jeong","orcid":"https://orcid.org/0000-0003-2424-810X","observed_orcids":["https://orcid.org/0000-0003-2424-810X","https://orcid.org/0000-0003-4173-1494"]},"institutions":[{"id":"https://openalex.org/I4210092150","display_name":"Chonnam National University Hospital","ror":"https://ror.org/00f200z37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Myung Ho Jeong","raw_affiliation_strings":["Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea. myungho@chollian.net","Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea. myungho@chollian.net","Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea. myungho@chollian.net","institution_ids":["https://openalex.org/I4210092150"]},{"raw_affiliation_string":"Hypertension Heart Failure Research Center, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea. myungho@chollian.net","institution_ids":["https://openalex.org/I4210092150"]},{"raw_affiliation_string":"Heart Research Center of Chonnam National University Hospital, Gwangju, 61469, Republic of Korea","institution_ids":["https://openalex.org/I4210092150"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5068223655","https://openalex.org/A5101911180"],"corresponding_institution_ids":["https://openalex.org/I4210092150"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":5.3294,"has_fulltext":true,"cited_by_count":84,"citation_normalized_percentile":{"value":0.96674774,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"9302","last_page":"9302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gallic-acid","display_name":"gallic acid","score":1.0},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9139999747276306},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.8069999814033508},{"id":"https://openalex.org/keywords/pressure-overload","display_name":"pressure overload","score":0.968999981880188},{"id":"https://openalex.org/keywords/transverse-aortic-constriction","display_name":"transverse aortic constriction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cardiac-fibroblasts","display_name":"cardiac fibroblasts","score":0.9760000109672546},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9290000200271606},{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.8330000042915344},{"id":"https://openalex.org/keywords/beta-myosin-heavy-chain","display_name":"beta-myosin heavy chain","score":0.8190000057220459},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.7870000004768372},{"id":"https://openalex.org/keywords/carvedilol","display_name":"carvedilol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/furosemide","display_name":"furosemide","score":0.8700000047683716},{"id":"https://openalex.org/keywords/natural-compounds","display_name":"natural compounds","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C2778362808","wikidata":"https://www.wikidata.org/wiki/Q375837","display_name":"Gallic acid","level":3,"score":0.8341587781906128},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.6919006109237671},{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.6211132407188416},{"id":"https://openalex.org/C2778271984","wikidata":"https://www.wikidata.org/wiki/Q17126794","display_name":"Pressure overload","level":4,"score":0.6127082705497742},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6093155145645142},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5944905877113342},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.535637617111206},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5159514546394348},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3953723907470703},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.3756601810455322},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37475717067718506},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33411040902137756},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23906922340393066},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.201683908700943},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.18390744924545288},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003251","descriptor_name":"Constriction, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003251","descriptor_name":"Constriction, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003251","descriptor_name":"Constriction, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005707","descriptor_name":"Gallic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005707","descriptor_name":"Gallic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005707","descriptor_name":"Gallic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-018-27599-4","doi":"https://doi.org/10.1038/s41598-018-27599-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-27599-4","pdf_url":"https://www.nature.com/articles/s41598-018-27599-4.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:29915390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29915390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4967733","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6006337","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6006337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6006337","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5de77ba72801460fbeb665c9c6316f18","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5de77ba72801460fbeb665c9c6316f18","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-27599-4","doi":"https://doi.org/10.1038/s41598-018-27599-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-27599-4","pdf_url":"https://www.nature.com/articles/s41598-018-27599-4.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.800000011920929,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2807828152.pdf","grobid_xml":"https://content.openalex.org/works/W2807828152.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1484767641","https://openalex.org/W1540900252","https://openalex.org/W1927650744","https://openalex.org/W1968550540","https://openalex.org/W1971044506","https://openalex.org/W1974848384","https://openalex.org/W1991373307","https://openalex.org/W2007586155","https://openalex.org/W2008730474","https://openalex.org/W2011813460","https://openalex.org/W2026949120","https://openalex.org/W2027323397","https://openalex.org/W2036252933","https://openalex.org/W2039860107","https://openalex.org/W2052871429","https://openalex.org/W2063242845","https://openalex.org/W2066774498","https://openalex.org/W2073725745","https://openalex.org/W2079746034","https://openalex.org/W2090544953","https://openalex.org/W2120437701","https://openalex.org/W2122808924","https://openalex.org/W2132605891","https://openalex.org/W2143295210","https://openalex.org/W2170299186","https://openalex.org/W2294080015","https://openalex.org/W2299099463","https://openalex.org/W2395642529","https://openalex.org/W2557061717","https://openalex.org/W2580792129","https://openalex.org/W2590599331","https://openalex.org/W2598114468","https://openalex.org/W2600689296","https://openalex.org/W2625594257","https://openalex.org/W2760896698","https://openalex.org/W2761271970","https://openalex.org/W2766306373","https://openalex.org/W2766501949","https://openalex.org/W2767557912","https://openalex.org/W2915698801","https://openalex.org/W2938917295","https://openalex.org/W2940713465","https://openalex.org/W2943912258"],"related_works":["https://openalex.org/W2170369890","https://openalex.org/W1977955927","https://openalex.org/W2158577494","https://openalex.org/W2056149757","https://openalex.org/W2127324952","https://openalex.org/W1970767617","https://openalex.org/W2085377506","https://openalex.org/W2052969372","https://openalex.org/W2330907160","https://openalex.org/W2090921095"],"abstract_inverted_index":{"Gallic":[0,55],"acid":[1,5,20,47,56,118,162,181],"is":[2,182],"a":[3,27,183],"trihydroxybenzoic":[4],"found":[6],"in":[7,26,36,53,70,78,94,156,172,191],"tea":[8],"leaves":[9],"and":[10,24,35,41,61,72,85,88,111,129,137,147,154,166,189],"some":[11],"plants.":[12],"Here,":[13],"we":[14],"report":[15],"the":[16,43,90,100,131],"effect":[17],"of":[18,30,45,50,102,116,133,144,168],"gallic":[19,46,117,161,180],"on":[21],"cardiac":[22,39,58,152,174,187],"dysfunction":[23,153,188],"fibrosis":[25,62,155,190],"mouse":[28],"model":[29],"pressure":[31],"overload-induced":[32],"heart":[33,193],"failure":[34],"primary":[37],"rat":[38],"fibroblasts,":[40],"compare":[42],"effects":[44],"with":[48,160],"those":[49],"drugs":[51],"used":[52],"clinics.":[54],"reduces":[57,130],"hypertrophy,":[59],"dysfunction,":[60],"induced":[63],"by":[64,124],"transverse":[65],"aortic":[66],"constriction":[67],"(TAC)":[68],"stimuli":[69],"vivo":[71],"transforming":[73],"growth":[74,140],"factor":[75],"\u03b21":[76],"(TGF-\u03b21)":[77],"vitro.":[79],"It":[80],"decreases":[81,119],"left":[82],"ventricular":[83],"end-diastolic":[84],"end-systolic":[86],"diameter,":[87],"recovers":[89],"reduced":[91],"fractional":[92],"shortening":[93],"TAC.":[95,157],"In":[96],"addition,":[97],"it":[98],"suppresses":[99],"expression":[101,132],"atrial":[103],"natriuretic":[104,107],"peptide,":[105,108],"brain":[106],"skeletal":[109],"\u03b1-actin,":[110],"\u03b2-myosin":[112],"heavy":[113],"chain.":[114],"Administration":[115],"perivascular":[120],"fibrosis,":[121],"as":[122],"determined":[123],"Trichrome":[125],"II":[126],"Blue":[127],"staining,":[128],"collagen":[134,169],"type":[135,170],"I":[136,171],"connective":[138],"tissue":[139],"factor.":[141],"However,":[142],"administration":[143],"losartan,":[145],"carvedilol,":[146],"furosemide":[148],"does":[149],"not":[150],"reduce":[151],"Moreover,":[158],"treatment":[159],"inhibits":[163],"fibrosis-related":[164],"genes":[165],"deposition":[167],"TGF-\u03b21-treated":[173],"fibroblasts.":[175],"These":[176],"results":[177],"suggest":[178],"that":[179],"therapeutic":[184],"agent":[185],"for":[186],"chronic":[192],"failure.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
