{"id":"https://openalex.org/W2807714503","doi":null,"title":"Role of calcitriol in regulating maternal bone and mineral metabolism during pregnancy, lactation, and post-weaning recovery","display_name":"Role of calcitriol in regulating maternal bone and mineral metabolism during pregnancy, lactation, and post-weaning recovery","publication_year":2017,"publication_date":"2017-05-01","ids":{"openalex":"https://openalex.org/W2807714503","mag":"2807714503"},"language":"en","primary_location":{"id":"pmh:oai:research.library.mun.ca:12633","doi":null,"is_oa":true,"landing_page_url":"http://research.library.mun.ca/12633/1/thesis.pdf","pdf_url":"https://memorial.scholaris.ca/bitstreams/90ed7cde-8d15-40a2-92d3-63f8c7354bf7/download","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://memorial.scholaris.ca/bitstreams/90ed7cde-8d15-40a2-92d3-63f8c7354bf7/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072049386","display_name":"Brittany Gillies","orcid":"https://orcid.org/0000-0003-1389-8027","observed_orcids":["https://orcid.org/0000-0003-1389-8027"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Brittany Gillies","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1389-8027","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072049386"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.05530000105500221,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cyp27b1","display_name":"CYP27B1","score":0.8389999866485596},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.746999979019165},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.5690000057220459},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":1.0},{"id":"https://openalex.org/keywords/intestinal-calcium-absorption","display_name":"intestinal calcium absorption","score":0.9459999799728394},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.9169999957084656},{"id":"https://openalex.org/keywords/bone-mineral-content","display_name":"bone mineral content","score":0.875},{"id":"https://openalex.org/keywords/cortical-bone","display_name":"cortical bone","score":0.6069999933242798},{"id":"https://openalex.org/keywords/hypocalcemia","display_name":"hypocalcemia","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2776079296","wikidata":"https://www.wikidata.org/wiki/Q139195","display_name":"Calcitriol","level":3,"score":0.9055317640304565},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7939199209213257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.764258861541748},{"id":"https://openalex.org/C2780655333","wikidata":"https://www.wikidata.org/wiki/Q333203","display_name":"Weaning","level":2,"score":0.7282744646072388},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.7241960763931274},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6435309648513794},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.6398738622665405},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6309918165206909},{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.5319238901138306},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.48846736550331116},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.4587424695491791},{"id":"https://openalex.org/C2781451080","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cortical bone","level":2,"score":0.45442795753479004},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.45001333951950073},{"id":"https://openalex.org/C142590548","wikidata":"https://www.wikidata.org/wiki/Q417801","display_name":"Calcium-sensing receptor","level":4,"score":0.42500758171081543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3841458857059479},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32127201557159424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3054356575012207},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10640895366668701},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:research.library.mun.ca:12633","doi":null,"is_oa":true,"landing_page_url":"http://research.library.mun.ca/12633/1/thesis.pdf","pdf_url":"https://memorial.scholaris.ca/bitstreams/90ed7cde-8d15-40a2-92d3-63f8c7354bf7/download","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:memorial.scholaris.ca:20.500.14783/13730","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14783/13730","pdf_url":null,"source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Master thesis"},{"id":"mag:2807714503","doi":null,"is_oa":false,"landing_page_url":"https://research.library.mun.ca/12633/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:research.library.mun.ca:12633","doi":null,"is_oa":true,"landing_page_url":"http://research.library.mun.ca/12633/1/thesis.pdf","pdf_url":"https://memorial.scholaris.ca/bitstreams/90ed7cde-8d15-40a2-92d3-63f8c7354bf7/download","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2807714503.pdf","grobid_xml":"https://content.openalex.org/works/W2807714503.grobid-xml"},"referenced_works_count":153,"referenced_works":["https://openalex.org/W75874857","https://openalex.org/W97227462","https://openalex.org/W164274307","https://openalex.org/W1496891014","https://openalex.org/W1509506308","https://openalex.org/W1518373731","https://openalex.org/W1553449268","https://openalex.org/W1566734997","https://openalex.org/W1827847463","https://openalex.org/W1875731610","https://openalex.org/W1891115592","https://openalex.org/W1900839667","https://openalex.org/W1942834926","https://openalex.org/W1967602328","https://openalex.org/W1968799724","https://openalex.org/W1970131977","https://openalex.org/W1970817442","https://openalex.org/W1971955679","https://openalex.org/W1973334712","https://openalex.org/W1975682914","https://openalex.org/W1977526301","https://openalex.org/W1978346772","https://openalex.org/W1978966296","https://openalex.org/W1979826291","https://openalex.org/W1980025879","https://openalex.org/W1981434750","https://openalex.org/W1981867029","https://openalex.org/W1983660056","https://openalex.org/W1986160116","https://openalex.org/W1986689077","https://openalex.org/W1989061098","https://openalex.org/W1989249998","https://openalex.org/W1989700145","https://openalex.org/W1990935283","https://openalex.org/W1991674531","https://openalex.org/W1994375391","https://openalex.org/W1996011857","https://openalex.org/W1996251556","https://openalex.org/W1997142557","https://openalex.org/W1997377934","https://openalex.org/W1999856310","https://openalex.org/W2004496677","https://openalex.org/W2009441758","https://openalex.org/W2009546961","https://openalex.org/W2009934810","https://openalex.org/W2010617850","https://openalex.org/W2010802348","https://openalex.org/W2014682122","https://openalex.org/W2017290177","https://openalex.org/W2018602999","https://openalex.org/W2018809127","https://openalex.org/W2019582558","https://openalex.org/W2019914536","https://openalex.org/W2021781733","https://openalex.org/W2024089434","https://openalex.org/W2025046506","https://openalex.org/W2027257450","https://openalex.org/W2035167607","https://openalex.org/W2035587062","https://openalex.org/W2035790555","https://openalex.org/W2038783196","https://openalex.org/W2042430322","https://openalex.org/W2046473453","https://openalex.org/W2047133862","https://openalex.org/W2047855561","https://openalex.org/W2051852760","https://openalex.org/W2052887604","https://openalex.org/W2053843272","https://openalex.org/W2055590859","https://openalex.org/W2055658787","https://openalex.org/W2058462628","https://openalex.org/W2060753218","https://openalex.org/W2061769753","https://openalex.org/W2064108065","https://openalex.org/W2064510802","https://openalex.org/W2065893174","https://openalex.org/W2068682682","https://openalex.org/W2070821154","https://openalex.org/W2070928033","https://openalex.org/W2073303754","https://openalex.org/W2075797873","https://openalex.org/W2076974856","https://openalex.org/W2078035241","https://openalex.org/W2080966253","https://openalex.org/W2084093985","https://openalex.org/W2084282123","https://openalex.org/W2087333134","https://openalex.org/W2091704289","https://openalex.org/W2092337942","https://openalex.org/W2093177985","https://openalex.org/W2093719268","https://openalex.org/W2094384585","https://openalex.org/W2095398557","https://openalex.org/W2095982524","https://openalex.org/W2097191932","https://openalex.org/W2098779011","https://openalex.org/W2099795555","https://openalex.org/W2102194944","https://openalex.org/W2102648115","https://openalex.org/W2102911758","https://openalex.org/W2105416620","https://openalex.org/W2109177164","https://openalex.org/W2109430357","https://openalex.org/W2110459072","https://openalex.org/W2111799918","https://openalex.org/W2112450413","https://openalex.org/W2112757808","https://openalex.org/W2114948431","https://openalex.org/W2115454272","https://openalex.org/W2117602643","https://openalex.org/W2118371269","https://openalex.org/W2119018132","https://openalex.org/W2122085108","https://openalex.org/W2122579890","https://openalex.org/W2124668683","https://openalex.org/W2126202517","https://openalex.org/W2128059069","https://openalex.org/W2128840922","https://openalex.org/W2130333682","https://openalex.org/W2131279822","https://openalex.org/W2134345995","https://openalex.org/W2135084283","https://openalex.org/W2135444604","https://openalex.org/W2135733810","https://openalex.org/W2135898296","https://openalex.org/W2137450031","https://openalex.org/W2140168040","https://openalex.org/W2142544310","https://openalex.org/W2142820105","https://openalex.org/W2145199426","https://openalex.org/W2145937652","https://openalex.org/W2146420833","https://openalex.org/W2148772545","https://openalex.org/W2151199141","https://openalex.org/W2158506393","https://openalex.org/W2164952534","https://openalex.org/W2165989629","https://openalex.org/W2169166778","https://openalex.org/W2169864477","https://openalex.org/W2170351820","https://openalex.org/W2174437151","https://openalex.org/W2187435522","https://openalex.org/W2252949782","https://openalex.org/W2275140877","https://openalex.org/W2330768369","https://openalex.org/W2333593745","https://openalex.org/W2335931427","https://openalex.org/W2341849113","https://openalex.org/W2413554891","https://openalex.org/W2416364058","https://openalex.org/W2483876039","https://openalex.org/W2512528376","https://openalex.org/W2616314504"],"related_works":["https://openalex.org/W2739722298","https://openalex.org/W1566734997","https://openalex.org/W7133552855","https://openalex.org/W2771082020","https://openalex.org/W1779645521","https://openalex.org/W4296960242","https://openalex.org/W2064108065","https://openalex.org/W2958056042","https://openalex.org/W2903089634","https://openalex.org/W4403307968"],"abstract_inverted_index":{"Maternal":[0],"physiology":[1],"adapts":[2],"throughout":[3,243],"reproductive":[4],"phases":[5],"to":[6,88,98,115,230,277],"meet":[7],"the":[8,12,29,39,48,68,233,253],"mineral":[9,35,264],"needs":[10],"of":[11,33,71,106,181,208,225,241,274],"fetuses":[13],"and":[14,110,117,136,148,161,195,218,245,265,270],"neonates.":[15],"During":[16,151,176],"pregnancy,":[17],"intestinal":[18,107],"calcium":[19,25,108,154,179,207,248],"absorption":[20,109,249],"doubles;":[21],"conversely,":[22],"during":[23,257,268,282],"lactation,":[24,177],"is":[26,74,80,102,250],"resorbed":[27],"from":[28,174],"skeleton.":[30],"Post-weaning,":[31,205],"restoration":[32],"bone":[34,63,196,219,266,280],"content":[36],"occurs,":[37],"however":[38],"factors":[40],"regulating":[41],"these":[42,90],"adaptations":[43],"are":[44],"unknown.":[45],"Animals":[46],"lacking":[47],"vitamin":[49,57,72],"D":[50,58],"receptor":[51],"(VDR)":[52],"or":[53],"those":[54],"deficient":[55],"in":[56,62,193,252],"achieve":[59],"post-weaning":[60],"increases":[61],"mass,":[64],"suggesting":[65],"that":[66,81,168],"calcitriol,":[67],"active":[69],"form":[70],"D,":[73],"not":[75],"required.":[76],"An":[77],"alternative":[78],"explanation":[79],"calcitriol":[82,101,242,275],"may":[83],"act":[84],"through":[85],"non-genomic":[86],"receptors":[87],"have":[89],"effects.":[91],"We":[92],"used":[93],"calcitriol-deficient":[94],"Cyp27b1":[95,128,182,209,234,254],"null":[96,210,235,255],"mice":[97,256],"test":[99],"whether":[100],"required":[103],"for":[104],"upregulation":[105],"skeletal":[111],"recovery":[112,224],"post-weaning.":[113],"Compared":[114],"WT,":[116,194],"despite":[118],"a":[119],"rescue":[120],"diet":[121],"containing":[122],"2":[123],"%":[124,138],"calcium,":[125],"at":[126],"baseline":[127],"nulls":[129,183],"were":[130,159],"hypocalcemic":[131],"with":[132],"markedly":[133,191],"increased":[134,163],"PTH":[135,157,185,212],"30":[137],"lower":[139],"BMC;":[140],"\u03bcCT":[141,199,222],"displayed":[142],"reduced":[143],"femoral":[144],"length,":[145],"cortical":[146,149,226],"thickness,":[147],"area.":[150],"pregnancy":[152,244,269],"serum":[153,178,206],"levels":[155,158,180,186,213,240],"increased,":[156,187,217],"reduced,":[160],"BMD":[162],"by":[164],"45":[165],"%,":[166],"so":[167],"all":[169],"values":[170],"became":[171],"no":[172],"different":[173],"WT.":[175],"decreased,":[184],"BMC":[188,216],"declined":[189],"more":[190],"than":[192],"strength":[197,220],"decreased;":[198],"analysis":[200],"confirmed":[201,223],"extensive":[202],"endocortical":[203],"resorption.":[204],"normalized,":[211],"remained":[214],"high,":[215],"recovered;":[221],"parameters.":[227],"In":[228,259],"comparison":[229],"WT":[231],"mice,":[232],"females":[236],"display":[237],"very":[238],"low":[239],"lactation.":[246,283],"Intestinal":[247],"upregulated":[251],"pregnancy.":[258],"conclusion,":[260],"calcitriolindependent":[261],"mechanisms":[262],"regulate":[263],"metabolism":[267],"postweaning;":[271],"however,":[272],"absence":[273],"leads":[276],"greater":[278],"transient":[279],"loss":[281]},"counts_by_year":[{"year":2018,"cited_by_count":2}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2018-06-21T00:00:00"}