{"id":"https://openalex.org/W2807619331","doi":"https://doi.org/10.1016/j.jsbmb.2018.06.006","title":"Novel pregnenolone derivatives modulate apoptosis via Bcl-2 family genes in hepatocellular carcinoma in vitro","display_name":"Novel pregnenolone derivatives modulate apoptosis via Bcl-2 family genes in hepatocellular carcinoma in vitro","publication_year":2018,"publication_date":"2018-06-10","ids":{"openalex":"https://openalex.org/W2807619331","doi":"https://doi.org/10.1016/j.jsbmb.2018.06.006","mag":"2807619331","pmid":"https://pubmed.ncbi.nlm.nih.gov/29898413"},"language":"en","primary_location":{"id":"doi:10.1016/j.jsbmb.2018.06.006","doi":"https://doi.org/10.1016/j.jsbmb.2018.06.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jsbmb.2018.06.006","pdf_url":null,"source":{"id":"https://openalex.org/S168421034","display_name":"The Journal of Steroid Biochemistry and Molecular Biology","issn_l":"0960-0760","issn":["0960-0760","1879-1220"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Steroid Biochemistry and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078478850","display_name":"Manar A. Elhinnawi","orcid":"https://orcid.org/0000-0002-0061-9060","observed_orcids":["https://orcid.org/0000-0002-0061-9060"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Manar A. Elhinnawi","raw_affiliation_strings":["Hormones Department, National Research Centre, Dokki, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hormones Department, National Research Centre, Dokki, Giza, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062612193","display_name":"Rafat M. Mohareb","orcid":"https://orcid.org/0000-0003-3922-803X","observed_orcids":["https://orcid.org/0000-0003-3922-803X"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rafat M. Mohareb","raw_affiliation_strings":["Chemistry Department, Faculty of Science, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Faculty of Science, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005684347","display_name":"Hanaa M. Rady","orcid":"https://orcid.org/0000-0002-6226-8606","observed_orcids":["https://orcid.org/0000-0002-6226-8606"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hanaa M. Rady","raw_affiliation_strings":["Chemistry of Natural Compounds Department, National Research Centre, Dokki, Giza, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-6226-8606","affiliations":[{"raw_affiliation_string":"Chemistry of Natural Compounds Department, National Research Centre, Dokki, Giza, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080399689","display_name":"Wagdy K. B. Khalil","orcid":"https://orcid.org/0000-0002-0598-7217","observed_orcids":["https://orcid.org/0000-0002-0598-7217"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Wagdy K.B. Khalil","raw_affiliation_strings":["Cell Biology Department, National Research Centre, Dokki, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Department, National Research Centre, Dokki, Giza, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064818548","display_name":"Mervat M. Abdelhalim","orcid":"https://orcid.org/0000-0002-6949-0744","observed_orcids":["https://orcid.org/0000-0002-6949-0744"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mervat M. Abd Elhalim","raw_affiliation_strings":["Hormones Department, National Research Centre, Dokki, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hormones Department, National Research Centre, Dokki, Giza, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068272323","display_name":"Gamal A. Elmegeed","orcid":"https://orcid.org/0000-0003-1914-1543","observed_orcids":["https://orcid.org/0000-0003-1914-1543"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Gamal A. Elmegeed","raw_affiliation_strings":["Hormones Department, National Research Centre, Dokki, Giza, Egypt. Electronic address: ga.elmegeed@nrc.sci.eg","Hormones Department, National Research Centre, Dokki, Giza, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-1914-1543","affiliations":[{"raw_affiliation_string":"Hormones Department, National Research Centre, Dokki, Giza, Egypt. Electronic address: ga.elmegeed@nrc.sci.eg","institution_ids":["https://openalex.org/I4210131959"]},{"raw_affiliation_string":"Hormones Department, National Research Centre, Dokki, Giza, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068272323"],"corresponding_institution_ids":["https://openalex.org/I4210131959"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.9209,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.67043752,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"183","issue":null,"first_page":"125","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.7401999831199646,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.7401999831199646,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.10409999638795853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.06340000033378601,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heterocyclic-steroids","display_name":"heterocyclic steroids","score":0.753000020980835},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/bcl-2-family-genes","display_name":"Bcl-2 family genes","score":0.9139999747276306},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.8140000104904175},{"id":"https://openalex.org/keywords/bak","display_name":"Bak","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9259999990463257},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7450000047683716},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8059999942779541},{"id":"https://openalex.org/keywords/compound-6","display_name":"compound 6","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8028627634048462},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.7781516909599304},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7505561113357544},{"id":"https://openalex.org/C2780193516","wikidata":"https://www.wikidata.org/wiki/Q412158","display_name":"Pregnenolone","level":4,"score":0.6497724056243896},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5730671882629395},{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.5623548626899719},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5372054576873779},{"id":"https://openalex.org/C2776907736","wikidata":"https://www.wikidata.org/wiki/Q408634","display_name":"Ethidium bromide","level":3,"score":0.4977869987487793},{"id":"https://openalex.org/C87439868","wikidata":"https://www.wikidata.org/wiki/Q4780527","display_name":"Apoptotic DNA fragmentation","level":5,"score":0.49369367957115173},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4738505184650421},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4575172960758209},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4411037266254425},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.4348871111869812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4215925335884094},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4110693335533142},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4055558741092682},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2692537307739258},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2661011219024658},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.24299892783164978},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.10164201259613037},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08733522891998291},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011284","descriptor_name":"Pregnenolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011284","descriptor_name":"Pregnenolone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jsbmb.2018.06.006","doi":"https://doi.org/10.1016/j.jsbmb.2018.06.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jsbmb.2018.06.006","pdf_url":null,"source":{"id":"https://openalex.org/S168421034","display_name":"The Journal of Steroid Biochemistry and Molecular Biology","issn_l":"0960-0760","issn":["0960-0760","1879-1220"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Steroid Biochemistry and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:29898413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29898413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of steroid biochemistry and molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310077","display_name":"National Research Centre","ror":"https://ror.org/02n85j827"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W39614084","https://openalex.org/W158070947","https://openalex.org/W588070258","https://openalex.org/W1428073324","https://openalex.org/W1520155613","https://openalex.org/W1529578025","https://openalex.org/W1536085081","https://openalex.org/W1852040970","https://openalex.org/W1968258098","https://openalex.org/W1971518754","https://openalex.org/W1974980413","https://openalex.org/W1979918054","https://openalex.org/W1992986048","https://openalex.org/W1996707930","https://openalex.org/W1996943749","https://openalex.org/W2007698190","https://openalex.org/W2011770773","https://openalex.org/W2014523825","https://openalex.org/W2027045330","https://openalex.org/W2029737836","https://openalex.org/W2029938005","https://openalex.org/W2034269086","https://openalex.org/W2037203845","https://openalex.org/W2040112003","https://openalex.org/W2046848104","https://openalex.org/W2057413031","https://openalex.org/W2059833881","https://openalex.org/W2063148361","https://openalex.org/W2068450443","https://openalex.org/W2068948495","https://openalex.org/W2070263191","https://openalex.org/W2074999513","https://openalex.org/W2076993595","https://openalex.org/W2082002843","https://openalex.org/W2088481746","https://openalex.org/W2104293284","https://openalex.org/W2107277218","https://openalex.org/W2111547058","https://openalex.org/W2114918609","https://openalex.org/W2131640859","https://openalex.org/W2132114977","https://openalex.org/W2140662416","https://openalex.org/W2141330732","https://openalex.org/W2152247516","https://openalex.org/W2152691024","https://openalex.org/W2154391864","https://openalex.org/W2157833022","https://openalex.org/W2162204429","https://openalex.org/W2162851656","https://openalex.org/W2164872597","https://openalex.org/W2172365638","https://openalex.org/W2182484353","https://openalex.org/W2215548764","https://openalex.org/W2298678407","https://openalex.org/W2321826092","https://openalex.org/W2324231806","https://openalex.org/W2410930933","https://openalex.org/W2432069000","https://openalex.org/W2587183199","https://openalex.org/W6642150463","https://openalex.org/W6733105219"],"related_works":["https://openalex.org/W2599408847","https://openalex.org/W2744261995","https://openalex.org/W4411575025","https://openalex.org/W2025945283","https://openalex.org/W1979775379","https://openalex.org/W7114896447","https://openalex.org/W2940894601","https://openalex.org/W2093419827","https://openalex.org/W2289883414","https://openalex.org/W2790385399"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-13T00:00:00"}
