{"id":"https://openalex.org/W2807535153","doi":"https://doi.org/10.1161/atvbaha.118.311289","title":"Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development","display_name":"Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development","publication_year":2018,"publication_date":"2018-05-31","ids":{"openalex":"https://openalex.org/W2807535153","doi":"https://doi.org/10.1161/atvbaha.118.311289","mag":"2807535153","pmid":"https://pubmed.ncbi.nlm.nih.gov/29853563","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6039426"},"language":"en","primary_location":{"id":"doi:10.1161/atvbaha.118.311289","doi":"https://doi.org/10.1161/atvbaha.118.311289","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvbaha.118.311289","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6039426","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100753780","display_name":"Li He","orcid":"https://orcid.org/0000-0002-7706-9677","observed_orcids":["https://orcid.org/0000-0002-7706-9677"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li He","raw_affiliation_strings":["From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","Li He  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Li He  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037759253","display_name":"Yi Fu","orcid":"https://orcid.org/0000-0002-8832-9331","observed_orcids":["https://orcid.org/0000-0002-8832-9331"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Fu","raw_affiliation_strings":["From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","Yi Fu  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Yi Fu  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011444758","display_name":"Jingna Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingna Deng","raw_affiliation_strings":["Tasly Microcirculation Research Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People\u2019s Republic of China (J.D., J.H.)","Jingna Deng Tasly Microcirculation Research Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of China (J.D., J.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tasly Microcirculation Research Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People\u2019s Republic of China (J.D., J.H.)","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Jingna Deng Tasly Microcirculation Research Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of China (J.D., J.H.)","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064895448","display_name":"Yicong Shen","orcid":"https://orcid.org/0000-0002-8526-2338","observed_orcids":["https://orcid.org/0000-0002-8526-2338"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yicong Shen","raw_affiliation_strings":["From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","Yicong Shen  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Yicong Shen  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015439864","display_name":"Yingbao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingbao Wang","raw_affiliation_strings":["Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing, People\u2019s Republic of China (X.P., Q.L., Ying Wang)","From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","Yingbao Wang  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing, People\u2019s Republic of China (X.P., Q.L., Ying Wang)","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Yingbao Wang  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065076327","display_name":"Fang Hu Ziqiang Yu","orcid":"https://orcid.org/0000-0002-7495-6449","observed_orcids":["https://orcid.org/0000-0002-7495-6449"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Yu","raw_affiliation_strings":["From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","Fang Yu  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Fang Yu  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048954534","display_name":"Nan Xie","orcid":"https://orcid.org/0000-0002-1389-167X","observed_orcids":["https://orcid.org/0000-0002-1389-167X"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Xie","raw_affiliation_strings":["From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","Nan Xie  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Nan Xie  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008287707","display_name":"Zhongjiang Chen","orcid":"https://orcid.org/0000-0001-7794-9204","observed_orcids":["https://orcid.org/0000-0001-7794-9204"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongjiang Chen","raw_affiliation_strings":["From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","Zhongjiang Chen  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Zhongjiang Chen  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006301048","display_name":"Tianpei Hong","orcid":"https://orcid.org/0000-0002-5744-5129","observed_orcids":["https://orcid.org/0000-0002-5744-5129"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianpei Hong","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, People\u2019s Republic of China (T.H.)","Tianpei Hong Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, People's Republic of China (T.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, People\u2019s Republic of China (T.H.)","institution_ids":["https://openalex.org/I4210141942"]},{"raw_affiliation_string":"Tianpei Hong Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, People's Republic of China (T.H.)","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109339990","display_name":"Xinjian Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinjian Peng","raw_affiliation_strings":["Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing, People\u2019s Republic of China (X.P., Q.L., Ying Wang)","Xinjian Peng Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing, People's Republic of China (X.P., Q.L., Ying Wang)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing, People\u2019s Republic of China (X.P., Q.L., Ying Wang)","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Xinjian Peng Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing, People's Republic of China (X.P., Q.L., Ying Wang)","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411166","display_name":"Qingqing Li","orcid":"https://orcid.org/0000-0002-1217-365X","observed_orcids":["https://orcid.org/0000-0002-1217-365X"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingqing Li","raw_affiliation_strings":["Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing, People\u2019s Republic of China (X.P., Q.L., Ying Wang)","Qingqing Li Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing, People's Republic of China (X.P., Q.L., Ying Wang)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing, People\u2019s Republic of China (X.P., Q.L., Ying Wang)","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Qingqing Li Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing, People's Republic of China (X.P., Q.L., Ying Wang)","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101776384","display_name":"Jing Zhou","orcid":"https://orcid.org/0000-0002-2211-4901","observed_orcids":["https://orcid.org/0000-0002-2211-4901","https://orcid.org/0000-0002-7478-6902"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhou","raw_affiliation_strings":["From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","Jing Zhou  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Jing Zhou  From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102782614","display_name":"Jing\u2010Yan Han","orcid":"https://orcid.org/0000-0002-2286-8076","observed_orcids":["https://orcid.org/0000-0002-2286-8076"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jingyan Han","raw_affiliation_strings":["Tasly Microcirculation Research Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People\u2019s Republic of China (J.D., J.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tasly Microcirculation Research Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People\u2019s Republic of China (J.D., J.H.)","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100347150","display_name":"Ying Wang","orcid":"https://orcid.org/0000-0002-7852-386X","observed_orcids":["https://orcid.org/0000-0002-7852-386X","https://orcid.org/0000-0001-8941-0484"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing, People\u2019s Republic of China (X.P., Q.L., Ying Wang)","From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Basic Medical Sciences, and Key Laboratory of Medical Immunology of Ministry of Health, Peking University Health Science Center, Beijing, People\u2019s Republic of China (X.P., Q.L., Ying Wang)","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043772285","display_name":"Jianzhong Xi","orcid":"https://orcid.org/0000-0003-3015-8418","observed_orcids":["https://orcid.org/0000-0003-3015-8418"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianzhong Xi","raw_affiliation_strings":["Department of Biomedicine, College of Engineering, Peking University, Beijing, People\u2019s Republic of China (J.X.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, College of Engineering, Peking University, Beijing, People\u2019s Republic of China (J.X.)","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032109161","display_name":"Wei Kong","orcid":"https://orcid.org/0000-0001-6720-6810","observed_orcids":["https://orcid.org/0000-0001-6720-6810"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Kong","raw_affiliation_strings":["From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People\u2019s Republic of China (L.H., Y.F., Y.S., Yingbao Wang., F.Y., N.X., Z.C., J.Z., W.K.)","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032109161","https://openalex.org/A5043772285","https://openalex.org/A5100347150","https://openalex.org/A5102782614"],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":null,"apc_paid":null,"fwci":4.5205,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.95598585,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"38","issue":"7","first_page":"1616","last_page":"1631"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.8659999966621399},{"id":"https://openalex.org/keywords/abdominal-aortic-aneurysm","display_name":"abdominal aortic aneurysm","score":0.996999979019165},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mac-1","display_name":"Mac-1","score":0.828000009059906},{"id":"https://openalex.org/keywords/fpr1","display_name":"FPR1","score":0.8769999742507935},{"id":"https://openalex.org/keywords/formyl-peptide-receptor-2","display_name":"formyl peptide receptor 2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gi-protein-signaling","display_name":"Gi protein signaling","score":0.7760000228881836},{"id":"https://openalex.org/keywords/beta-arrestin-signaling","display_name":"\u03b2-arrestin signaling","score":0.9100000262260437},{"id":"https://openalex.org/keywords/elastase-induced-aneurysm","display_name":"elastase-induced aneurysm","score":0.8759999871253967},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6690855026245117},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.6344101428985596},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.5388535857200623},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.5191911458969116},{"id":"https://openalex.org/C2776731609","wikidata":"https://www.wikidata.org/wiki/Q24782993","display_name":"Formyl peptide receptor","level":4,"score":0.4978785514831543},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47987666726112366},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.44368916749954224},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.4143002927303314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39964964985847473},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.38778454065322876},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37735849618911743},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3608850836753845},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34256941080093384},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12284740805625916},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000074085","descriptor_name":"Mice, Knockout, ApoE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016177","descriptor_name":"Macrophage-1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017544","descriptor_name":"Aortic Aneurysm, Abdominal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017544","descriptor_name":"Aortic Aneurysm, Abdominal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017544","descriptor_name":"Aortic Aneurysm, Abdominal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017544","descriptor_name":"Aortic Aneurysm, Abdominal","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020556","descriptor_name":"Neutrophil Infiltration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036904","descriptor_name":"Leukocyte Rolling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044042","descriptor_name":"Receptors, Formyl Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/atvbaha.118.311289","doi":"https://doi.org/10.1161/atvbaha.118.311289","is_oa":false,"landing_page_url":"https://doi.org/10.1161/atvbaha.118.311289","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5007255","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6039426","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6039426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6039426","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arterioscler Thromb Vasc Biol","raw_type":"Text"},{"id":"pmid:29853563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29853563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, thrombosis, and vascular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5007255","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6039426","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1953160336","https://openalex.org/W1971444570","https://openalex.org/W1974702025","https://openalex.org/W1979516727","https://openalex.org/W1984448003","https://openalex.org/W1985018359","https://openalex.org/W1985259009","https://openalex.org/W1988167553","https://openalex.org/W1988822581","https://openalex.org/W1989124918","https://openalex.org/W1994435105","https://openalex.org/W1994606929","https://openalex.org/W1999210891","https://openalex.org/W2017409538","https://openalex.org/W2020245957","https://openalex.org/W2032227357","https://openalex.org/W2035874960","https://openalex.org/W2036359942","https://openalex.org/W2065465687","https://openalex.org/W2069223052","https://openalex.org/W2073020813","https://openalex.org/W2074842903","https://openalex.org/W2078410616","https://openalex.org/W2084900835","https://openalex.org/W2086051107","https://openalex.org/W2094555042","https://openalex.org/W2100320418","https://openalex.org/W2103485196","https://openalex.org/W2116336500","https://openalex.org/W2121913109","https://openalex.org/W2125890170","https://openalex.org/W2131896212","https://openalex.org/W2132076028","https://openalex.org/W2135357968","https://openalex.org/W2137624446","https://openalex.org/W2137665452","https://openalex.org/W2143929149","https://openalex.org/W2166565349","https://openalex.org/W2170330896","https://openalex.org/W2199674886","https://openalex.org/W2287634796","https://openalex.org/W2292977265","https://openalex.org/W2411586275","https://openalex.org/W2415927646","https://openalex.org/W2500457520","https://openalex.org/W2548236558","https://openalex.org/W2606821969","https://openalex.org/W2751634210","https://openalex.org/W2766608682","https://openalex.org/W2780027234","https://openalex.org/W2781838311","https://openalex.org/W2798251956","https://openalex.org/W4286856715"],"related_works":["https://openalex.org/W2551652494","https://openalex.org/W2292977265","https://openalex.org/W2169680285","https://openalex.org/W7095666710","https://openalex.org/W4395039580","https://openalex.org/W4318815742","https://openalex.org/W1986372124","https://openalex.org/W4385284353","https://openalex.org/W2137624446","https://openalex.org/W7117762087"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Chemokine-mediated":[1],"neutrophil":[2,45,56,88,111,195],"recruitment":[3,46,196],"contributes":[4],"to":[5,38,156],"the":[6,40,59,62,140,170],"pathogenesis":[7],"of":[8,42,65,75,125,142,152,172,189],"abdominal":[9],"aortic":[10],"aneurysm":[11],"(AAA)":[12],"and":[13,47,87,99,116,176,191,197,205],"may":[14],"serve":[15],"as":[16,185],"a":[17,30,186],"promising":[18],"therapeutic":[19],"target.":[20],"FAM3D":[21,43,109,114,143,167],"(family":[22],"with":[23,69,95],"sequence":[24],"similarity":[25],"3,":[26],"member":[27],"D)":[28],"is":[29],"recently":[31],"identified":[32],"novel":[33],"chemokine.":[34],"Here,":[35],"we":[36],"aimed":[37],"explore":[39],"role":[41],"in":[44,58,91,100,121,164,179,181],"AAA":[48,66,85,199],"development.":[49],"APPROACH":[50],"AND":[51],"RESULTS:":[52],"mice":[53],"exhibited":[54],"decreased":[55,169],"infiltration":[57],"aorta":[60],"during":[61],"early":[63],"stage":[64],"formation":[67,86],"compared":[68],"their":[70],"wild-type":[71],"littermates.":[72],"Moreover,":[73,149],"application":[74],"FAM3D-neutralizing":[76,96],"antibody":[77,97],"6D7":[78,98],"through":[79,201],"intraperitoneal":[80],"injection":[81],"markedly":[82],"ameliorated":[83],"elastase-induced":[84],"infiltration.":[89],"Further,":[90],"vitro":[92],"coculture":[93],"experiments":[94],"vivo":[101],"intravital":[102],"microscopic":[103],"analysis":[104],"indicated":[105],"that":[106,139],"endothelial":[107],"cell-derived":[108],"induced":[110,193],"recruitment.":[112],"Mechanistically,":[113],"upregulated":[115],"activated":[117],"Mac-1":[118,136,163],"(macrophage-1":[119],"antigen)":[120],"neutrophils,":[122],"whereas":[123,166],"inhibition":[124],"FPR1":[126,190],"(formyl":[127],"peptide":[128],"receptor":[129],"1)":[130],"or":[131,159],"FPR2":[132],"significantly":[133],"blocked":[134],"FAM3D-induced":[135],"activation,":[137],"indicating":[138],"effect":[141],"was":[144],"dependent":[145],"on":[146],"both":[147,173],"FPRs.":[148],"specific":[150],"inhibitors":[151],"FPR":[153],"signaling":[154,178],"related":[155],"Gi":[157,203],"protein":[158,175,204],"\u03b2-arrestin":[160,177,206],"inhibited":[161],"FAM3D-activated":[162],"vitro,":[165],"deficiency":[168],"activation":[171],"FPR-Gi":[174],"neutrophils":[180],"vivo.":[182],"CONCLUSIONS:":[183],"FAM3D,":[184],"dual":[187],"agonist":[188],"FPR2,":[192],"Mac-1-mediated":[194],"aggravated":[198],"development":[200],"FPR-related":[202],"signaling.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-13T00:00:00"}