{"id":"https://openalex.org/W2807518456","doi":null,"title":"Mechanisms Mediating Anti-Inflammatory Effects of Delta-Tocotrienol","display_name":"Mechanisms Mediating Anti-Inflammatory Effects of Delta-Tocotrienol","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2807518456","mag":"2807518456"},"language":"en","primary_location":{"id":"pmh:oai:ttu-ir.tdl.org:2346/73835","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2346/73835","pdf_url":"https://ttu-ir.tdl.org/bitstream/2346/73835/1/MENA-THESIS-2018.pdf","source":{"id":"https://openalex.org/S4306402519","display_name":"ThinkTech (Texas Tech University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12315562","host_organization_name":"Texas Tech University","host_organization_lineage":["https://openalex.org/I12315562"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ttu-ir.tdl.org/bitstream/2346/73835/1/MENA-THESIS-2018.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026008146","display_name":"London T. Mena","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mena, London Tashae'","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026008146"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/delta-tocotrienol","display_name":"delta-tocotrienol","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.6859999895095825},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7739999890327454},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hepatic-triglyceride-accumulation","display_name":"hepatic triglyceride accumulation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.8040000200271606},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.8669999837875366},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.859000027179718},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9369999766349792},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8989999890327454},{"id":"https://openalex.org/keywords/3t3-l1-adipocytes","display_name":"3T3-L1 adipocytes","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C2778310972","wikidata":"https://www.wikidata.org/wiki/Q427419","display_name":"Tocotrienol","level":5,"score":0.5040658712387085},{"id":"https://openalex.org/C5072461","wikidata":"https://www.wikidata.org/wiki/Q49506","display_name":"Delta","level":2,"score":0.4424609839916229},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3508039712905884},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3352428674697876},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26723766326904297},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1654435694217682},{"id":"https://openalex.org/C2781449162","wikidata":"https://www.wikidata.org/wiki/Q910277","display_name":"Tocopherol","level":4,"score":0.12145769596099854},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.08618387579917908},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.07570773363113403},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07568040490150452},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0669923722743988}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ttu-ir.tdl.org:2346/73835","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2346/73835","pdf_url":"https://ttu-ir.tdl.org/bitstream/2346/73835/1/MENA-THESIS-2018.pdf","source":{"id":"https://openalex.org/S4306402519","display_name":"ThinkTech (Texas Tech University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12315562","host_organization_name":"Texas Tech University","host_organization_lineage":["https://openalex.org/I12315562"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:ttu-ir.tdl.org:2346/73835","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2346/73835","pdf_url":"https://ttu-ir.tdl.org/bitstream/2346/73835/1/MENA-THESIS-2018.pdf","source":{"id":"https://openalex.org/S4306402519","display_name":"ThinkTech (Texas Tech University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12315562","host_organization_name":"Texas Tech University","host_organization_lineage":["https://openalex.org/I12315562"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2807518456.pdf","grobid_xml":"https://content.openalex.org/works/W2807518456.grobid-xml"},"referenced_works_count":210,"referenced_works":["https://openalex.org/W328561729","https://openalex.org/W788356889","https://openalex.org/W1460913000","https://openalex.org/W1482207773","https://openalex.org/W1505106993","https://openalex.org/W1564215226","https://openalex.org/W1565499480","https://openalex.org/W1587875569","https://openalex.org/W1686797737","https://openalex.org/W1694069654","https://openalex.org/W1763666518","https://openalex.org/W1778009520","https://openalex.org/W1799493824","https://openalex.org/W1827488762","https://openalex.org/W1835622051","https://openalex.org/W1880335557","https://openalex.org/W1892131812","https://openalex.org/W1895810448","https://openalex.org/W1896983858","https://openalex.org/W1897553699","https://openalex.org/W1899552864","https://openalex.org/W1930348682","https://openalex.org/W1950170028","https://openalex.org/W1959770930","https://openalex.org/W1963683487","https://openalex.org/W1963739832","https://openalex.org/W1966507045","https://openalex.org/W1967456880","https://openalex.org/W1968604913","https://openalex.org/W1968699748","https://openalex.org/W1970844785","https://openalex.org/W1973637816","https://openalex.org/W1974186154","https://openalex.org/W1978589050","https://openalex.org/W1981004111","https://openalex.org/W1981261500","https://openalex.org/W1983417944","https://openalex.org/W1984180526","https://openalex.org/W1988109900","https://openalex.org/W1988939283","https://openalex.org/W1989900621","https://openalex.org/W1993000626","https://openalex.org/W1997490378","https://openalex.org/W1999188473","https://openalex.org/W2000054651","https://openalex.org/W2000476522","https://openalex.org/W2001727439","https://openalex.org/W2003506718","https://openalex.org/W2004126648","https://openalex.org/W2007405015","https://openalex.org/W2009478798","https://openalex.org/W2012898950","https://openalex.org/W2015246829","https://openalex.org/W2018083450","https://openalex.org/W2018489015","https://openalex.org/W2020994403","https://openalex.org/W2022801078","https://openalex.org/W2024021877","https://openalex.org/W2026037353","https://openalex.org/W2027102783","https://openalex.org/W2029508720","https://openalex.org/W2031084334","https://openalex.org/W2034810986","https://openalex.org/W2038393880","https://openalex.org/W2038961236","https://openalex.org/W2039169534","https://openalex.org/W2039680101","https://openalex.org/W2040109162","https://openalex.org/W2040854968","https://openalex.org/W2042444876","https://openalex.org/W2043290249","https://openalex.org/W2043367074","https://openalex.org/W2044023498","https://openalex.org/W2047072369","https://openalex.org/W2048678912","https://openalex.org/W2048843416","https://openalex.org/W2049965571","https://openalex.org/W2050063403","https://openalex.org/W2051051060","https://openalex.org/W2051415594","https://openalex.org/W2052045899","https://openalex.org/W2052084403","https://openalex.org/W2052609811","https://openalex.org/W2053584805","https://openalex.org/W2055094070","https://openalex.org/W2057648694","https://openalex.org/W2059462768","https://openalex.org/W2059842910","https://openalex.org/W2060502922","https://openalex.org/W2060978273","https://openalex.org/W2061978941","https://openalex.org/W2063086702","https://openalex.org/W2063236170","https://openalex.org/W2064119981","https://openalex.org/W2065408399","https://openalex.org/W2065788317","https://openalex.org/W2066168649","https://openalex.org/W2066696278","https://openalex.org/W2066839216","https://openalex.org/W2066882494","https://openalex.org/W2067929063","https://openalex.org/W2070023258","https://openalex.org/W2070677419","https://openalex.org/W2071589836","https://openalex.org/W2071633455","https://openalex.org/W2071692398","https://openalex.org/W2072488504","https://openalex.org/W2073404654","https://openalex.org/W2074734623","https://openalex.org/W2075104267","https://openalex.org/W2076485183","https://openalex.org/W2078807483","https://openalex.org/W2079518580","https://openalex.org/W2080818154","https://openalex.org/W2080998956","https://openalex.org/W2081236313","https://openalex.org/W2081841423","https://openalex.org/W2083245140","https://openalex.org/W2085598380","https://openalex.org/W2085931606","https://openalex.org/W2086260955","https://openalex.org/W2087154687","https://openalex.org/W2088341880","https://openalex.org/W2088986234","https://openalex.org/W2089478514","https://openalex.org/W2089851667","https://openalex.org/W2091759162","https://openalex.org/W2092014129","https://openalex.org/W2092173005","https://openalex.org/W2094863064","https://openalex.org/W2096773810","https://openalex.org/W2097665519","https://openalex.org/W2100017297","https://openalex.org/W2100481760","https://openalex.org/W2100573896","https://openalex.org/W2102313291","https://openalex.org/W2103107392","https://openalex.org/W2104148928","https://openalex.org/W2107277218","https://openalex.org/W2107825795","https://openalex.org/W2108553217","https://openalex.org/W2110713453","https://openalex.org/W2110967191","https://openalex.org/W2112502488","https://openalex.org/W2113318243","https://openalex.org/W2114991545","https://openalex.org/W2115340562","https://openalex.org/W2119514257","https://openalex.org/W2121836743","https://openalex.org/W2123289485","https://openalex.org/W2123371309","https://openalex.org/W2123375980","https://openalex.org/W2123650181","https://openalex.org/W2123684264","https://openalex.org/W2123931921","https://openalex.org/W2124147826","https://openalex.org/W2124456564","https://openalex.org/W2126317966","https://openalex.org/W2126510656","https://openalex.org/W2126619846","https://openalex.org/W2127873334","https://openalex.org/W2127934772","https://openalex.org/W2128846768","https://openalex.org/W2129528814","https://openalex.org/W2129610821","https://openalex.org/W2130064617","https://openalex.org/W2130764919","https://openalex.org/W2130957039","https://openalex.org/W2132256977","https://openalex.org/W2133167638","https://openalex.org/W2135642745","https://openalex.org/W2136348788","https://openalex.org/W2138072361","https://openalex.org/W2139440574","https://openalex.org/W2140937253","https://openalex.org/W2142151435","https://openalex.org/W2142344243","https://openalex.org/W2144773188","https://openalex.org/W2145740221","https://openalex.org/W2148244700","https://openalex.org/W2151181789","https://openalex.org/W2152377123","https://openalex.org/W2153442288","https://openalex.org/W2153852079","https://openalex.org/W2156234074","https://openalex.org/W2157534045","https://openalex.org/W2158079900","https://openalex.org/W2158394935","https://openalex.org/W2163306410","https://openalex.org/W2164213284","https://openalex.org/W2166311080","https://openalex.org/W2166589385","https://openalex.org/W2168536185","https://openalex.org/W2169060502","https://openalex.org/W2169472541","https://openalex.org/W2169517053","https://openalex.org/W2179080580","https://openalex.org/W2197317387","https://openalex.org/W2207929855","https://openalex.org/W2215653021","https://openalex.org/W2219582732","https://openalex.org/W2227126326","https://openalex.org/W2397519467","https://openalex.org/W2416551674","https://openalex.org/W2417423427","https://openalex.org/W2419255724","https://openalex.org/W2564087512","https://openalex.org/W2564524034","https://openalex.org/W2735054066","https://openalex.org/W7098958697"],"related_works":["https://openalex.org/W2735054066","https://openalex.org/W3082780957","https://openalex.org/W3097065687","https://openalex.org/W2742750869","https://openalex.org/W2295505321","https://openalex.org/W2070677419","https://openalex.org/W191026317","https://openalex.org/W4389025173","https://openalex.org/W2898134027","https://openalex.org/W1601589073"],"abstract_inverted_index":{"Inflammation":[0],"is":[1,350,402],"a":[2,24,67,91,197,325,339],"major":[3],"underlying":[4],"cause":[5],"for":[6,82,251,257,303,352],"obesity-associated":[7],"metabolic":[8],"diseases.":[9],"Hence,":[10],"anti-inflammatory":[11,41,211],"dietary":[12],"components":[13],"are":[14],"used":[15,310],"to":[16,88,112,124,151,184,263,279,287],"improve":[17],"obesity-related":[18],"disorders.":[19],"First":[20],"hypothesized":[21],"that":[22,44,319,341,349,412],"\uf064T3,":[23],"member":[25],"of":[26,50,74,115,199,204,210,245,324,332,335,354,356,371,378,429],"the":[27,59,113,152,290,365,372,394,398],"vitamin":[28],"E":[29],"family,":[30],"reduced":[31,142,164,176,224,322,369],"adiposity,":[32],"insulin":[33],"resistance":[34],"and":[35,80,85,119,127,133,141,157,175,201,207,223,231,274,283,289,292,313,317,345,424,434],"hepatic":[36],"triglyceride":[37],"accumulation":[38],"through":[39],"its":[40],"properties.":[42],"Secondly,":[43],"\uf064T3":[45,75,217,246,368,413],"reduces":[46],"inflammation":[47,126,288,426],"via":[48,427],"inhibition":[49,428],"NF-\u03baB":[51],"and/or":[52],"JNK":[53,293,395],"pathway":[54,396],"in":[55,131,138,147,165,179,192,213,228,375,393,431],"adipocytes.":[56],"To":[57,233],"test":[58,234],"first":[60],"hypothesis,":[61,237],"C57BL/6J":[62],"male":[63],"mice":[64,89],"were":[65,86,107,122,145,161,189,240,277,296,359],"fed":[66,90],"HF":[68,96,153],"diet":[69,93],"with":[70,98,242,255,404],"or":[71,95,260],"without":[72],"supplementation":[73],"(HF+\uf064T3)":[76],"at":[77,190,397],"400":[78],"mg/kg":[79],"1600mg/kg":[81],"14":[83],"weeks":[84,110],"compared":[87,150,183],"low-fat":[92],"(LF)":[94],"supplemented":[97],"metformin":[99],"as":[100],"an":[101,347],"anti-diabetic":[102],"control.":[103],"Glucose":[104],"tolerance":[105],"tests":[106],"administered":[108],"two":[109],"prior":[111],"end":[114],"treatments.":[116],"Histology,":[117],"qPCR":[118],"protein":[120,202,383,399],"analyses":[121],"performed":[123,278],"assess":[125,280],"fatty":[128,220,225],"acid":[129,221,226],"metabolism":[130],"adipose":[132,181,229,435],"liver":[134,143,433],"tissues.":[135],"Significant":[136],"improvements":[137],"glucose":[139],"clearance":[140],"triglycerides":[144],"observed":[146,170],"\uf064T3-supplemented":[148],"groups":[149],"group.":[154],"Body":[155],"weight":[156,160],"fat":[158,172,421],"pad":[159],"not":[162,389],"significantly":[163],"HF+\uf064T3":[166,214],"groups,":[167],"however,":[168],"we":[169,387],"smaller":[171],"cell":[173,301,422],"size":[174],"macrophage":[177],"infiltration":[178],"their":[180],"tissues":[182],"other":[185,405],"groups.":[186],"These":[187],"changes":[188],"least":[191],"part":[193],"mechanistically":[194],"explained":[195],"by":[196,361,419],"reduction":[198,392],"mRNA":[200],"expression":[203,209,323,331],"pro-inflammatory":[205,326],"adipokines":[206,212],"increased":[208,219],"mice.":[215],"Moreover,":[216],"dose-dependently":[218],"oxidation":[222],"synthesis":[227],"tissue":[230],"liver.":[232],"our":[235,409],"second":[236],"3T3-L1":[238],"cells":[239],"pretreated":[241],"varying":[243],"doses":[244,304,316,321,380],"(0.0001":[247],"\u2013":[248],"100":[249],"\u00b5M)":[250],"4":[252],"hours":[253,262],"then":[254],"LPS":[256],"1":[258,311,366],"hour":[259],"18":[261],"induce":[264],"inflammation.":[265],"Cell":[266],"viability":[267,302],"was":[268],"tested":[269],"using":[270],"MTT":[271],"assay.":[272],"Q-PCR":[273],"Western":[275],"blots":[276],"specific":[281],"genes":[282],"proteins,":[284],"respectively,":[285],"related":[286],"NF-\uf06bB":[291,430],"pathways.":[294],"There":[295],"no":[297],"significant":[298],"effects":[299],"on":[300],"lower":[305],"than":[306],"25":[307],"\u00b5M.":[308],"We":[309],"\u00b5M":[312,315,367],"5":[314],"found":[318],"these":[320,379],"cytokine":[327],"IL-6.":[328],"Additionally,":[329],"gene":[330],"downstream":[333],"transcripts":[334],"NF-\uf06bB,":[336],"including":[337],"MIP2,":[338],"chemokine":[340],"attracts":[342],"additional":[343],"macrophages,":[344],"COX2,":[346],"enzyme":[348],"responsible":[351],"formation":[353],"mediators":[355],"inflammatory":[357],"reactions,":[358],"downregulated":[360],"\uf064T3.":[362],"In":[363,385,407],"addition,":[364,386],"phosphorylation":[370],"p65":[373],"subunit":[374],"NF-\u03baB.":[376],"None":[377],"affected":[381],"I\uf06bB\uf061":[382],"levels.":[384],"did":[388],"see":[390],"any":[391],"level,":[400],"which":[401],"consistent":[403],"studies.":[406],"conclusion,":[408],"study":[410],"suggests":[411],"may":[414],"promote":[415],"metabolically":[416],"healthy":[417],"obesity":[418],"reducing":[420],"hypertrophy":[423],"decreasing":[425],"both":[432],"tissue.":[436]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
