{"id":"https://openalex.org/W2807501871","doi":"https://doi.org/10.1186/s12933-018-0708-x","title":"SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice","display_name":"SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice","publication_year":2018,"publication_date":"2018-04-27","ids":{"openalex":"https://openalex.org/W2807501871","doi":"https://doi.org/10.1186/s12933-018-0708-x","mag":"2807501871","pmid":"https://pubmed.ncbi.nlm.nih.gov/29703207","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5921754"},"language":"en","primary_location":{"id":"doi:10.1186/s12933-018-0708-x","doi":"https://doi.org/10.1186/s12933-018-0708-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12933-018-0708-x","pdf_url":"https://cardiab.biomedcentral.com/track/pdf/10.1186/s12933-018-0708-x","source":{"id":"https://openalex.org/S12095120","display_name":"Cardiovascular Diabetology","issn_l":"1475-2840","issn":["1475-2840"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Diabetology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cardiab.biomedcentral.com/track/pdf/10.1186/s12933-018-0708-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023394278","display_name":"Dustin M. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dustin M. Lee","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112824580","display_name":"Micah L. Battson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Micah L. Battson","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069776188","display_name":"Dillon K. Jarrell","orcid":"https://orcid.org/0000-0002-7299-0870","observed_orcids":["https://orcid.org/0000-0002-7299-0870"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dillon K. Jarrell","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075926426","display_name":"Shuofei Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuofei Hou","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033657834","display_name":"Kayl E. Ecton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kayl E. Ecton","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034128223","display_name":"Tiffany L. Weir","orcid":"https://orcid.org/0000-0001-5423-7140","observed_orcids":["https://orcid.org/0000-0001-5423-7140"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiffany L. Weir","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038162906","display_name":"Christopher L. Gentile","orcid":"https://orcid.org/0000-0002-5130-6160","observed_orcids":["https://orcid.org/0000-0002-5130-6160"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher L. Gentile","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA. Christopher.gentile@colostate.edu","Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA"],"raw_orcid":"https://orcid.org/0000-0002-5130-6160","affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA. Christopher.gentile@colostate.edu","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038162906"],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":{"value":4290,"currency":"USD","value_usd":4290},"fwci":16.1014,"has_fulltext":true,"cited_by_count":246,"citation_normalized_percentile":{"value":0.99483241,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"17","issue":"1","first_page":"62","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dapagliflozin","display_name":"dapagliflozin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.9520000219345093},{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":0.9879999756813049},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9850000143051147},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-dysfunction","display_name":"vascular smooth muscle dysfunction","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pulse-wave-velocity","display_name":"pulse wave velocity","score":0.7889999747276306},{"id":"https://openalex.org/keywords/acetylcholine-response","display_name":"acetylcholine response","score":0.6850000023841858},{"id":"https://openalex.org/keywords/sodium-nitroprusside-response","display_name":"sodium nitroprusside response","score":0.777999997138977},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8370000123977661},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/diabetic-mice","display_name":"diabetic mice","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cardiovascular-risk-reduction","display_name":"cardiovascular risk reduction","score":0.7760000228881836},{"id":"https://openalex.org/keywords/drug-microbiota-interactions","display_name":"drug-microbiota interactions","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2777422806","wikidata":"https://www.wikidata.org/wiki/Q409898","display_name":"Dapagliflozin","level":4,"score":0.9527302384376526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8292465209960938},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.8214637041091919},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.7000718116760254},{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.6918426752090454},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5975053310394287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5869943499565125},{"id":"https://openalex.org/C1918360","wikidata":"https://www.wikidata.org/wiki/Q5357720","display_name":"Electrical impedance myography","level":3,"score":0.5559932589530945},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.5370025038719177},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5349883437156677},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5049043297767639},{"id":"https://openalex.org/C2778319312","wikidata":"https://www.wikidata.org/wiki/Q2118022","display_name":"Pulse wave velocity","level":3,"score":0.43282222747802734},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34115666151046753},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.33896762132644653},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1319931447505951},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.1263199746608734}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000077203","descriptor_name":"Sodium-Glucose Transporter 2 Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051297","descriptor_name":"Sodium-Glucose Transporter 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059289","descriptor_name":"Vascular Stiffness","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12933-018-0708-x","doi":"https://doi.org/10.1186/s12933-018-0708-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12933-018-0708-x","pdf_url":"https://cardiab.biomedcentral.com/track/pdf/10.1186/s12933-018-0708-x","source":{"id":"https://openalex.org/S12095120","display_name":"Cardiovascular Diabetology","issn_l":"1475-2840","issn":["1475-2840"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Diabetology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4851200","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5921754","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5921754","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5921754","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovasc Diabetol","raw_type":"Text"},{"id":"pmid:29703207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29703207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular diabetology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:04505a4559bd4d1fb8621f8b2d812b1c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/04505a4559bd4d1fb8621f8b2d812b1c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-14 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12933-018-0708-x","doi":"https://doi.org/10.1186/s12933-018-0708-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12933-018-0708-x","pdf_url":"https://cardiab.biomedcentral.com/track/pdf/10.1186/s12933-018-0708-x","source":{"id":"https://openalex.org/S12095120","display_name":"Cardiovascular Diabetology","issn_l":"1475-2840","issn":["1475-2840"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Diabetology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8799999952316284,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000884917","display_name":"Colorado Nutrition Obesity Research Center","funder_award_id":"P30DK048520","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2807501871.pdf","grobid_xml":"https://content.openalex.org/works/W2807501871.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W312449622","https://openalex.org/W1503352903","https://openalex.org/W1526927233","https://openalex.org/W1969062424","https://openalex.org/W1974180544","https://openalex.org/W1983483428","https://openalex.org/W2012177783","https://openalex.org/W2020398205","https://openalex.org/W2025080264","https://openalex.org/W2032556453","https://openalex.org/W2036897871","https://openalex.org/W2045458218","https://openalex.org/W2057116025","https://openalex.org/W2067804264","https://openalex.org/W2083481797","https://openalex.org/W2088639163","https://openalex.org/W2095574383","https://openalex.org/W2096259240","https://openalex.org/W2124242252","https://openalex.org/W2124658554","https://openalex.org/W2130189158","https://openalex.org/W2133856765","https://openalex.org/W2134304394","https://openalex.org/W2134995526","https://openalex.org/W2139334262","https://openalex.org/W2146264128","https://openalex.org/W2147790901","https://openalex.org/W2160883824","https://openalex.org/W2166171121","https://openalex.org/W2171494858","https://openalex.org/W2175018894","https://openalex.org/W2181092548","https://openalex.org/W2205521320","https://openalex.org/W2335079469","https://openalex.org/W2339765445","https://openalex.org/W2343975335","https://openalex.org/W2344498019","https://openalex.org/W2401404581","https://openalex.org/W2483463543","https://openalex.org/W2492672367","https://openalex.org/W2507316513","https://openalex.org/W2513506562","https://openalex.org/W2529171296","https://openalex.org/W2564078202","https://openalex.org/W2588405995","https://openalex.org/W2592311396","https://openalex.org/W2608515760","https://openalex.org/W2734312801","https://openalex.org/W2735325912","https://openalex.org/W2743031471","https://openalex.org/W2754781643","https://openalex.org/W2756853277","https://openalex.org/W2765097799","https://openalex.org/W2777514005","https://openalex.org/W2780111846","https://openalex.org/W2783768382","https://openalex.org/W2791886727","https://openalex.org/W2792021903"],"related_works":["https://openalex.org/W7037360277","https://openalex.org/W3139496483","https://openalex.org/W2972424965","https://openalex.org/W2794833267","https://openalex.org/W2734312801","https://openalex.org/W3031341062","https://openalex.org/W4410185867","https://openalex.org/W2981970545","https://openalex.org/W4406183662","https://openalex.org/W2765097799"],"abstract_inverted_index":{"BACKGROUND:":[0],"Type":[1],"2":[2,28,95,335],"diabetes":[3],"(T2D)":[4],"is":[5,57,70],"associated":[6,291],"with":[7,202,292],"generalized":[8,90,342],"vascular":[9,21,68,91,178,246,264,313,324,343],"dysfunction":[10,92,181,227,249,322],"characterized":[11],"by":[12,170,184,268],"increases":[13],"in":[14,67,93,225,270,295,300,312,333,341],"large":[15],"artery":[16],"stiffness,":[17,320],"endothelial":[18,175,226,321],"dysfunction,":[19,327],"and":[20,45,52,111,137,177,189,223,245,272,281,287,323,328],"smooth":[22,179,247,325],"muscle":[23,180,248,326],"dysfunction.":[24],"Sodium":[25],"glucose":[26],"cotransporter":[27],"inhibitors":[29],"(SGLT2i)":[30],"represent":[31,346],"the":[32,41,77,112,121,126,230,310,339,351],"most":[33],"recently":[34],"approved":[35],"class":[36],"of":[37,43,76,100,123,275,279,354],"oral":[38],"medications":[39,110],"for":[40,163],"treatment":[42,289,317],"T2D,":[44],"have":[46],"been":[47],"shown":[48],"to":[49,81,119,146,187,195],"reduce":[50],"cardiovascular":[51,63,352],"overall":[53],"mortality.":[54],"Although":[55],"it":[56],"currently":[58],"unclear":[59],"how":[60],"SGLT2i":[61,355],"decrease":[62],"risk,":[64],"an":[65,347],"improvement":[66],"function":[69,176,344],"one":[71],"potential":[72],"mechanism.":[73],"The":[74,277],"aim":[75,117],"current":[78],"study":[79],"was":[80,118,168,290],"examine":[82],"if":[83],"dapagliflozin,":[84],"a":[85,104,115,149,153],"widely":[86],"prescribed":[87],"STLT2i,":[88],"improves":[89,318],"type":[94,334],"diabetic":[96,131,197,199,336],"mice.":[97,337],"In":[98],"light":[99],"several":[101],"studies":[102],"demonstrating":[103],"bi-directional":[105],"relation":[106],"between":[107],"orally":[108],"ingested":[109],"gut":[113,127,296],"microbiota,":[114],"secondary":[116],"determine":[120],"effects":[122,305],"dapagliflozin":[124,157,203,288],"on":[125],"microbiota.":[128],"METHODS:":[129],"Male":[130],"mice":[132,200,283],"(Db,":[133],"n":[134,141],"=":[135,142,210,217,234,240,252,258],"24)":[136],"control":[138],"littermates":[139],"(Con;":[140],"23)":[143],"were":[144,182,266,284],"randomized":[145],"receive":[147],"either":[148],"standard":[150,154],"diet":[151,155],"or":[152],"containing":[156],"(60":[158],"mg":[159],"dapagliflozin/kg":[160],"diet;":[161],"0.006%)":[162],"8":[164],"weeks.":[165],"Arterial":[166],"stiffness":[167,208],"assessed":[169,183],"aortic":[171],"pulse":[172],"wave":[173],"velocity;":[174],"dilatory":[185],"responses":[186],"acetylcholine":[188],"sodium":[190],"nitroprusside,":[191],"respectively.":[192],"RESULTS:":[193],"Compared":[194],"untreated":[196],"mice,":[198,302],"treated":[201],"displayed":[204],"significantly":[205],"lower":[206],"arterial":[207,319],"(Db":[209],"469":[211],"cm/s":[212],"vs.":[213,236,254],"Db":[214,233,237,251,255,280,301],"+":[215,238,256],"dapa":[216,239,257],"435":[218],"cm/s,":[219],"p":[220,242,260],"<":[221,243,261],"0.05),":[222],"improvements":[224,265,311,340],"(area":[228],"under":[229],"curve":[231],"[AUC]":[232],"57.2":[235],"117.0,":[241],"0.05)":[244],"(AUC,":[250],"201.7":[253],"285.5,":[259],"0.05).":[262],"These":[263],"accompanied":[267],"reductions":[269],"hyperglycemia":[271],"circulating":[273],"markers":[274],"inflammation.":[276],"microbiota":[278,297,331],"Con":[282],"distinctly":[285],"different,":[286],"minor":[293],"alterations":[294],"composition,":[298],"particularly":[299],"although":[303],"these":[304],"did":[306],"not":[307],"conclusively":[308],"mediate":[309],"function.":[314],"CONCLUSIONS:":[315],"Dapagliflozin":[316],"subtly":[329],"alters":[330],"composition":[332],"Collectively,":[338],"may":[345],"important":[348],"mechanism":[349],"underlying":[350],"benefits":[353],"treatment.":[356]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":33},{"year":2023,"cited_by_count":46},{"year":2022,"cited_by_count":52},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-13T00:00:00"}
