{"id":"https://openalex.org/W2807499669","doi":"https://doi.org/10.1016/j.celrep.2018.04.107","title":"NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury","display_name":"NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2807499669","doi":"https://doi.org/10.1016/j.celrep.2018.04.107","mag":"2807499669","pmid":"https://pubmed.ncbi.nlm.nih.gov/29847798","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6276118"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2018.04.107","doi":"https://doi.org/10.1016/j.celrep.2018.04.107","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2018.04.107","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.celrep.2018.04.107","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028305193","display_name":"Perrine Inquimbert","orcid":"https://orcid.org/0000-0003-2625-1468","observed_orcids":["https://orcid.org/0000-0003-2625-1468"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117903","display_name":"Institut des Neurosciences Cellulaires et Int\u00e9gratives","ror":"https://ror.org/025mhd687","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210117903","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Perrine Inquimbert","raw_affiliation_strings":["Centre National de la Recherche Scientifique, UPR 3212, Institut des Neurosciences Cellulaires et Int\u00e9gratives and Universit\u00e9 de Strasbourg, 67084 Strasbourg, France; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","Centre National de la Recherche Scientifique, UPR 3212, Institut des Neurosciences Cellulaires et Int\u00e9gratives and Universit\u00e9 de Strasbourg, 67084 Strasbourg, France","F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique, UPR 3212, Institut des Neurosciences Cellulaires et Int\u00e9gratives and Universit\u00e9 de Strasbourg, 67084 Strasbourg, France; F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1294671590","https://openalex.org/I136199984","https://openalex.org/I4210117903","https://openalex.org/I68947357"]},{"raw_affiliation_string":"Centre National de la Recherche Scientifique, UPR 3212, Institut des Neurosciences Cellulaires et Int\u00e9gratives and Universit\u00e9 de Strasbourg, 67084 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210117903","https://openalex.org/I68947357"]},{"raw_affiliation_string":"F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080900750","display_name":"Martin Moll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Martin Moll","raw_affiliation_strings":["Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA; Institute of Pharmacology, Heidelberg University, 69120 Heidelberg, Germany","Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA","Institute of Pharmacology, Heidelberg University, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA; Institute of Pharmacology, Heidelberg University, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Institute of Pharmacology, Heidelberg University, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019098800","display_name":"Alban Latr\u00e9moli\u00e8re","orcid":"https://orcid.org/0000-0002-9212-1007","observed_orcids":["https://orcid.org/0000-0002-9212-1007"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alban Latremoliere","raw_affiliation_strings":["F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Department of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA","Department of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA","F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Department of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073326281","display_name":"Chi\u2010Kun Tong","orcid":"https://orcid.org/0000-0003-0188-7638","observed_orcids":["https://orcid.org/0000-0003-0188-7638"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi-Kun Tong","raw_affiliation_strings":["Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029453274","display_name":"John Whang","orcid":"https://orcid.org/0000-0002-2144-9646","observed_orcids":["https://orcid.org/0000-0002-2144-9646"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Whang","raw_affiliation_strings":["Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110562980","display_name":"Gregory F. Sheehan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory F. Sheehan","raw_affiliation_strings":["Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014182745","display_name":"Brendan Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brendan M. Smith","raw_affiliation_strings":["Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020677286","display_name":"Erica Korb","orcid":"https://orcid.org/0000-0002-7064-8123","observed_orcids":["https://orcid.org/0000-0002-7064-8123"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica Korb","raw_affiliation_strings":["Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036423490","display_name":"Maria Carolina Pedro Athi\u00e9","orcid":"https://orcid.org/0000-0002-6649-9065","observed_orcids":["https://orcid.org/0000-0002-6649-9065"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria C.P. Athi\u00e9","raw_affiliation_strings":["Department of Structural and Functional Biology, State University of Campinas, Campinas, SP 13083-865, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural and Functional Biology, State University of Campinas, Campinas, SP 13083-865, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009394965","display_name":"Olusegun Babaniyi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olusegun Babaniyi","raw_affiliation_strings":["F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080521348","display_name":"Nader Ghasemlou","orcid":"https://orcid.org/0000-0002-1696-7342","observed_orcids":["https://orcid.org/0000-0002-1696-7342"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nader Ghasemlou","raw_affiliation_strings":["F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110338264","display_name":"Yuchio Yanagawa","orcid":"https://orcid.org/0000-0002-7625-8492","observed_orcids":["https://orcid.org/0000-0002-7625-8492","https://orcid.org/0000-0001-8766-7972"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuchio Yanagawa","raw_affiliation_strings":["Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074257216","display_name":"C. David Allis","orcid":"https://orcid.org/0000-0001-7589-713X","observed_orcids":["https://orcid.org/0000-0001-7589-713X"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. David Allis","raw_affiliation_strings":["Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073037534","display_name":"Patrick R. Hof","orcid":"https://orcid.org/0000-0002-3208-1154","observed_orcids":["https://orcid.org/0000-0002-3208-1154"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick R. Hof","raw_affiliation_strings":["Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021866675","display_name":"Joachim Scholz","orcid":"https://orcid.org/0000-0003-4284-8547","observed_orcids":["https://orcid.org/0000-0003-4284-8547"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joachim Scholz","raw_affiliation_strings":["Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: scholz.joachim@gmail.com","Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: scholz.joachim@gmail.com","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5021866675"],"corresponding_institution_ids":["https://openalex.org/I2799503643"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":10.5867,"has_fulltext":false,"cited_by_count":142,"citation_normalized_percentile":{"value":0.99210319,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"23","issue":"9","first_page":"2678","last_page":"2689"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9490000009536743},{"id":"https://openalex.org/keywords/chronic-neuropathic-pain","display_name":"chronic neuropathic pain","score":0.8019999861717224},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.675000011920929},{"id":"https://openalex.org/keywords/sciatic-nerve-injury","display_name":"sciatic nerve injury","score":0.8939999938011169},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.7179999947547913},{"id":"https://openalex.org/keywords/gabaergic-interneurons","display_name":"GABAergic interneurons","score":0.9520000219345093},{"id":"https://openalex.org/keywords/grin1","display_name":"GRIN1","score":0.7200000286102295},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7940000295639038},{"id":"https://openalex.org/keywords/pain-transition","display_name":"pain transition","score":0.46700000762939453},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.7101743221282959},{"id":"https://openalex.org/C2776880756","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Peripheral nerve injury","level":3,"score":0.688399076461792},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.6852684020996094},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.6283786296844482},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6211947202682495},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.620334804058075},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6039799451828003},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.600394070148468},{"id":"https://openalex.org/C2775991916","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Nerve injury","level":2,"score":0.5990946292877197},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.596881628036499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5489020943641663},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.49735239148139954},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.44512343406677246},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32310056686401367},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28687208890914917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22240692377090454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19682830572128296},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000066829","descriptor_name":"Neuroprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020671","descriptor_name":"Posterior Horn Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020671","descriptor_name":"Posterior Horn Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059348","descriptor_name":"Peripheral Nerve Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D059348","descriptor_name":"Peripheral Nerve Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1016/j.celrep.2018.04.107","doi":"https://doi.org/10.1016/j.celrep.2018.04.107","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2018.04.107","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:29847798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29847798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5504299","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6276118","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6276118","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6276118/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Rep","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-03175343v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-03175343","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, 2018, 23 (9), ⟨10.1016/j.celrep.2018.04.107⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:6b0deeb5c0fe4b8aa98ac308e9bf677a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6b0deeb5c0fe4b8aa98ac308e9bf677a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 23, Iss 9, Pp 2678-2689 (2018)","raw_type":"article"},{"id":"doi:10.7916/d8gj11wb","doi":"https://doi.org/10.7916/d8gj11wb","is_oa":true,"landing_page_url":"https://doi.org/10.7916/d8gj11wb","pdf_url":null,"source":{"id":"https://openalex.org/S4306402601","display_name":"Columbia Academic Commons (Columbia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I78577930","host_organization_name":"Columbia University","host_organization_lineage":["https://openalex.org/I78577930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2018.04.107","doi":"https://doi.org/10.1016/j.celrep.2018.04.107","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2018.04.107","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G149246600","display_name":"Transsynaptic Neurodegeneration after Nerve Injury","funder_award_id":"R01NS050408","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3509217898","display_name":"Epigenetic Mechanisms of Depression","funder_award_id":"P50MH096890","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8966433368","display_name":"Molecular Neurobiology of Drug Addiction","funder_award_id":"P01DA008227","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320306257","display_name":"Boehringer Ingelheim","ror":"https://ror.org/05kffp613"},{"id":"https://openalex.org/F4320320868","display_name":"Boehringer Ingelheim Fonds","ror":"https://ror.org/00dkye506"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1582090951","https://openalex.org/W1737174057","https://openalex.org/W1963788090","https://openalex.org/W1965305290","https://openalex.org/W1967450550","https://openalex.org/W1969672804","https://openalex.org/W1969751124","https://openalex.org/W1972794215","https://openalex.org/W1975695406","https://openalex.org/W1977258127","https://openalex.org/W1980369017","https://openalex.org/W1987439527","https://openalex.org/W1993617599","https://openalex.org/W1996627744","https://openalex.org/W2008597649","https://openalex.org/W2010778459","https://openalex.org/W2011831455","https://openalex.org/W2015386261","https://openalex.org/W2018546326","https://openalex.org/W2020341591","https://openalex.org/W2022745333","https://openalex.org/W2045898875","https://openalex.org/W2046296795","https://openalex.org/W2047010161","https://openalex.org/W2047615113","https://openalex.org/W2051520373","https://openalex.org/W2055830898","https://openalex.org/W2056492757","https://openalex.org/W2059635921","https://openalex.org/W2068996358","https://openalex.org/W2069918422","https://openalex.org/W2075784136","https://openalex.org/W2077885131","https://openalex.org/W2081070804","https://openalex.org/W2087999474","https://openalex.org/W2092211307","https://openalex.org/W2092629475","https://openalex.org/W2096083625","https://openalex.org/W2111405228","https://openalex.org/W2115487032","https://openalex.org/W2123728367","https://openalex.org/W2128994172","https://openalex.org/W2132809690","https://openalex.org/W2139845270","https://openalex.org/W2152468922","https://openalex.org/W2155524482","https://openalex.org/W2169382112","https://openalex.org/W2212369426","https://openalex.org/W2271611850","https://openalex.org/W2314655039","https://openalex.org/W2469773095","https://openalex.org/W2511651422","https://openalex.org/W2547373552","https://openalex.org/W2609684457","https://openalex.org/W4211119836","https://openalex.org/W6644450964"],"related_works":["https://openalex.org/W4367042163","https://openalex.org/W2917093803","https://openalex.org/W1737174057","https://openalex.org/W1967450550","https://openalex.org/W2072553414","https://openalex.org/W4404994425","https://openalex.org/W2038193521","https://openalex.org/W2138499080","https://openalex.org/W4241755480","https://openalex.org/W2031285189"],"abstract_inverted_index":{"Peripheral":[0],"nerve":[1,42,103],"lesions":[2],"provoke":[3],"apoptosis":[4],"in":[5,36,54,92,109,123],"the":[6,10,18,23,26,55,60,72,129,141],"dorsal":[7,57,81],"horn":[8,58,82],"of":[9,15,20,28,40,49,70,75,131,143],"spinal":[11],"cord.":[12],"The":[13],"cause":[14],"cell":[16],"death,":[17],"involvement":[19],"neurons,":[21],"and":[22,47,86,99],"relevance":[24],"for":[25],"processing":[27],"somatosensory":[29],"information":[30],"are":[31],"controversial.":[32],"Here,":[33],"we":[34],"demonstrate":[35],"a":[37],"mouse":[38],"model":[39],"sciatic":[41],"injury":[43],"that":[44,135],"glutamate-induced":[45],"neurodegeneration":[46],"loss":[48],"\u03b3-aminobutyric":[50],"acid":[51],"(GABA)ergic":[52],"interneurons":[53],"superficial":[56],"promote":[59],"transition":[61],"from":[62,84],"acute":[63,100],"to":[64,140],"chronic":[65,144],"neuropathic":[66,145],"pain.":[67,146],"Conditional":[68],"deletion":[69],"Grin1,":[71],"essential":[73],"subunit":[74],"N-methyl-d-aspartate-type":[76],"glutamate":[77],"receptors":[78],"(NMDARs),":[79],"protects":[80],"neurons":[83],"excitotoxicity":[85],"preserves":[87],"GABAergic":[88],"inhibition.":[89],"Mice":[90],"deficient":[91],"functional":[93],"NMDARs":[94,115],"exhibit":[95],"normal":[96],"nociceptive":[97],"responses":[98],"pain":[101,110,122],"after":[102],"injury,":[104],"but":[105],"this":[106],"initial":[107],"increase":[108],"sensitivity":[111],"is":[112],"reversible.":[113],"Eliminating":[114],"fully":[116],"prevents":[117],"persistent":[118],"pain-like":[119],"behavior.":[120],"Reduced":[121],"mice":[124],"lacking":[125],"proapoptotic":[126],"Bax":[127],"confirmed":[128],"significance":[130],"neurodegeneration.":[132],"We":[133],"conclude":[134],"NMDAR-mediated":[136],"neuron":[137],"death":[138],"contributes":[139],"development":[142]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-06-13T00:00:00"}