{"id":"https://openalex.org/W2807389976","doi":"https://doi.org/10.3389/fneur.2018.00459","title":"Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy","display_name":"Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy","publication_year":2018,"publication_date":"2018-06-20","ids":{"openalex":"https://openalex.org/W2807389976","doi":"https://doi.org/10.3389/fneur.2018.00459","mag":"2807389976","pmid":"https://pubmed.ncbi.nlm.nih.gov/29988316","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6019456"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2018.00459","doi":"https://doi.org/10.3389/fneur.2018.00459","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2018.00459","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2018.00459/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fneur.2018.00459/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016201347","display_name":"Amol M. Mehta","orcid":"https://orcid.org/0000-0002-1343-7389","observed_orcids":["https://orcid.org/0000-0002-1343-7389","https://orcid.org/0009-0003-2967-1086"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amol Mehta","raw_affiliation_strings":["Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002184408","display_name":"Chidiebere U. Awah","orcid":"https://orcid.org/0000-0002-3719-8626","observed_orcids":["https://orcid.org/0000-0002-3719-8626"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chidiebere U. Awah","raw_affiliation_strings":["Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060408739","display_name":"Adam M. Sonabend","orcid":"https://orcid.org/0000-0002-8347-1945","observed_orcids":["https://orcid.org/0000-0002-8347-1945"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adam M. Sonabend","raw_affiliation_strings":["Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060408739"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.4712,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.45675676,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":null,"first_page":"459","last_page":"459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.11490000039339066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/topoisomerase-ii-poisons","display_name":"topoisomerase II poisons","score":0.9810000061988831},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.47099998593330383},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.7490000128746033},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.8700000047683716},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.699999988079071},{"id":"https://openalex.org/keywords/clinical-trial-failure","display_name":"clinical trial failure","score":0.5509999990463257},{"id":"https://openalex.org/keywords/molecular-heterogeneity","display_name":"molecular heterogeneity","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.6329914331436157},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.627303957939148},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5788453221321106},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5443917512893677},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.47682541608810425},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4727635979652405},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4445461630821228},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41615164279937744},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3716081976890564},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34568876028060913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2991026043891907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23600944876670837},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1930515468120575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09096932411193848}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fneur.2018.00459","doi":"https://doi.org/10.3389/fneur.2018.00459","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2018.00459","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2018.00459/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4988096","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6019456","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6019456","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6019456","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurol","raw_type":"Text"},{"id":"pmid:29988316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29988316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neurology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3dee0bb578ed44af90a3ab5dee530c6e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3dee0bb578ed44af90a3ab5dee530c6e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, Vol 9 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2018.00459","doi":"https://doi.org/10.3389/fneur.2018.00459","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2018.00459","pdf_url":"https://www.frontiersin.org/articles/10.3389/fneur.2018.00459/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1164661550","display_name":null,"funder_award_id":"P30CA060553","funder_id":"https://openalex.org/F4320333106","funder_display_name":"Robert H. Lurie Comprehensive Cancer Center"},{"id":"https://openalex.org/G1441721497","display_name":null,"funder_award_id":"1DP5OD021356","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G317886719","display_name":null,"funder_award_id":"P30CA060553","funder_id":"https://openalex.org/F4320309475","funder_display_name":"Northwestern University"},{"id":"https://openalex.org/G420222866","display_name":null,"funder_award_id":"T35 AF044303","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4956023974","display_name":null,"funder_award_id":"P50CA221747","funder_id":"https://openalex.org/F4320309475","funder_display_name":"Northwestern University"},{"id":"https://openalex.org/G8624002065","display_name":"TOP2A effects on transcription in gliomas: implications for personalized therapy","funder_award_id":"DP5OD021356","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000064222","display_name":"SPORE for Translational Approaches to Brain Cancer","funder_award_id":"P50CA221747","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000891045","display_name":"The Robert H. Lurie Comprehensive Cancer Center","funder_award_id":"P30CA060553","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000917834","display_name":"Brief Research In Aging and Interdisciplinary Neurosciences (BRAIN)","funder_award_id":"T35AG044303","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333106","display_name":"Robert H. Lurie Comprehensive Cancer Center","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2807389976.pdf","grobid_xml":"https://content.openalex.org/works/W2807389976.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W158270395","https://openalex.org/W1675411037","https://openalex.org/W1850426716","https://openalex.org/W1851620310","https://openalex.org/W1973919969","https://openalex.org/W1984087886","https://openalex.org/W1987045589","https://openalex.org/W1987194369","https://openalex.org/W1988886443","https://openalex.org/W1994230537","https://openalex.org/W1996487270","https://openalex.org/W1998560601","https://openalex.org/W2000910488","https://openalex.org/W2002987782","https://openalex.org/W2011932334","https://openalex.org/W2012562754","https://openalex.org/W2013149980","https://openalex.org/W2014014132","https://openalex.org/W2017742066","https://openalex.org/W2039482998","https://openalex.org/W2041051519","https://openalex.org/W2042962536","https://openalex.org/W2043510752","https://openalex.org/W2046191257","https://openalex.org/W2050788953","https://openalex.org/W2052000643","https://openalex.org/W2058493148","https://openalex.org/W2059013394","https://openalex.org/W2060608189","https://openalex.org/W2070932895","https://openalex.org/W2079088161","https://openalex.org/W2084875008","https://openalex.org/W2085412165","https://openalex.org/W2086034451","https://openalex.org/W2090709861","https://openalex.org/W2094027340","https://openalex.org/W2096287682","https://openalex.org/W2099350764","https://openalex.org/W2104718696","https://openalex.org/W2106059525","https://openalex.org/W2114800396","https://openalex.org/W2114843025","https://openalex.org/W2114915163","https://openalex.org/W2115494288","https://openalex.org/W2119832888","https://openalex.org/W2125496315","https://openalex.org/W2126824096","https://openalex.org/W2129418158","https://openalex.org/W2129610686","https://openalex.org/W2131487381","https://openalex.org/W2133215155","https://openalex.org/W2133961384","https://openalex.org/W2134767256","https://openalex.org/W2145489645","https://openalex.org/W2148977460","https://openalex.org/W2149441684","https://openalex.org/W2152172559","https://openalex.org/W2152546397","https://openalex.org/W2153715212","https://openalex.org/W2154096369","https://openalex.org/W2155738087","https://openalex.org/W2156900818","https://openalex.org/W2158681922","https://openalex.org/W2161289668","https://openalex.org/W2161446823","https://openalex.org/W2161637607","https://openalex.org/W2163004825","https://openalex.org/W2163967054","https://openalex.org/W2165871546","https://openalex.org/W2166670794","https://openalex.org/W2167803469","https://openalex.org/W2171306265","https://openalex.org/W2264682687","https://openalex.org/W2271507408","https://openalex.org/W2303609953","https://openalex.org/W2324661162","https://openalex.org/W2328259715","https://openalex.org/W2332715237","https://openalex.org/W2335360019","https://openalex.org/W2346831157","https://openalex.org/W2407075689","https://openalex.org/W2413626828","https://openalex.org/W2558715006","https://openalex.org/W2735593947","https://openalex.org/W6606369978","https://openalex.org/W6680004587","https://openalex.org/W6680031806"],"related_works":["https://openalex.org/W2900152064","https://openalex.org/W2941765894","https://openalex.org/W2013108817","https://openalex.org/W3034616810","https://openalex.org/W1988552458","https://openalex.org/W3092351211","https://openalex.org/W2485137032","https://openalex.org/W2052000643","https://openalex.org/W2973818231","https://openalex.org/W2099350764"],"abstract_inverted_index":{"Despite":[0,120],"advances":[1],"in":[2,115,136,173],"surgery,":[3],"radiotherapy,":[4],"and":[5,24,48,111,155,178],"chemotherapy,":[6],"glioblastoma":[7],"(GBM)":[8],"remains":[9],"a":[10,40,80,107],"malignancy":[11],"with":[12,35,39,65,93],"poor":[13],"prognosis.":[14],"The":[15],"molecular":[16,46],"profile":[17],"of":[18,63,74,82,109,118,126,132,200,207,213],"GBM":[19,36],"is":[20,188],"diverse":[21],"across":[22],"patients,":[23],"individual":[25,156],"responses":[26,50],"to":[27,51,57,70,87,96,175,198],"therapy":[28,52],"are":[29,37,103],"highly":[30],"variable.":[31],"Yet,":[32],"patients":[33,64],"diagnosed":[34],"treated":[38],"rather":[41],"uniform":[42],"paradigm.":[43],"Exploiting":[44],"these":[45,127,214],"differences":[47,158],"inter-individual":[49],"may":[53],"present":[54],"an":[55],"opportunity":[56],"improve":[58],"the":[59,116,169,211],"otherwise":[60],"bleak":[61],"prognosis":[62],"GBM.":[66,119,165],"This":[67,187],"review":[68,168],"aims":[69],"examine":[71],"one":[72],"group":[73],"chemotherapeutics:":[75],"Topoisomerase":[76],"2":[77],"(TOP2)":[78],"poisons,":[79],"class":[81],"drugs":[83],"that":[84,202],"enables":[85],"TOP2":[86,176],"induce":[88],"DNA":[89],"damage,":[90],"but":[91],"interferes":[92],"its":[94],"ability":[95],"repair":[97],"it.":[98],"These":[99],"potent":[100],"chemotherapeutic":[101],"agents":[102,128],"currently":[104],"used":[105],"for":[106,139,148,161,164,209],"number":[108],"malignancies":[110],"have":[112,129],"shown":[113],"promise":[114],"treatment":[117],"their":[121],"robust":[122],"efficacy":[123],"in-vitro,":[124],"some":[125],"fallen":[130],"short":[131],"achieving":[133],"similar":[134],"results":[135],"clinical":[137],"trials":[138],"this":[140,143,149,180],"tumor.":[141],"In":[142],"review,":[144],"we":[145],"explore":[146],"reasons":[147],"discrepancy,":[150],"focusing":[151],"on":[152],"drug":[153],"delivery":[154],"susceptibility":[157,174,208],"as":[159,182,190,204],"challenges":[160],"effective":[162],"TOP2-targeting":[163],"We":[166],"critically":[167],"evidence":[170,181,193],"implicating":[171],"genes":[172,201],"poisons":[177],"categorize":[179],"experimental,":[183],"correlative":[184],"or":[185],"both.":[186],"important":[189],"mere":[191],"experimental":[192],"does":[194],"not":[195],"necessarily":[196],"lead":[197],"identification":[199],"serve":[203],"good":[205],"biomarkers":[206],"personalizing":[210],"use":[212],"drugs.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-13T00:00:00"}
