{"id":"https://openalex.org/W2807388693","doi":"https://doi.org/10.1155/2018/2052356","title":"Complement C5a Alters the Membrane Potential of Neutrophils during Hemorrhagic Shock","display_name":"Complement C5a Alters the Membrane Potential of Neutrophils during Hemorrhagic Shock","publication_year":2018,"publication_date":"2018-05-29","ids":{"openalex":"https://openalex.org/W2807388693","doi":"https://doi.org/10.1155/2018/2052356","mag":"2807388693","pmid":"https://pubmed.ncbi.nlm.nih.gov/30002598","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5996468"},"language":"en","primary_location":{"id":"doi:10.1155/2018/2052356","doi":"https://doi.org/10.1155/2018/2052356","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/2052356","pdf_url":"http://downloads.hindawi.com/journals/mi/2018/2052356.pdf","source":{"id":"https://openalex.org/S107442880","display_name":"Mediators of Inflammation","issn_l":"0962-9351","issn":["0962-9351","1466-1861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of Inflammation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://downloads.hindawi.com/journals/mi/2018/2052356.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000270741","display_name":"David Alexander Christian Messerer","orcid":"https://orcid.org/0000-0002-0834-038X","observed_orcids":["https://orcid.org/0000-0002-0834-038X"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David A. C. Messerer","raw_affiliation_strings":["Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018750382","display_name":"Stephanie Denk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephanie Denk","raw_affiliation_strings":["Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074620591","display_name":"Karl J. F\u00f6hr","orcid":"https://orcid.org/0000-0003-0116-6750","observed_orcids":["https://orcid.org/0000-0003-0116-6750"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl J. F\u00f6hr","raw_affiliation_strings":["Department of Anesthesiology, University Hospital Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University Hospital Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071109160","display_name":"Rebecca Halbgebauer","orcid":"https://orcid.org/0000-0001-8060-2076","observed_orcids":["https://orcid.org/0000-0001-8060-2076"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rebecca Halbgebauer","raw_affiliation_strings":["Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007427631","display_name":"Christian Braun","orcid":"https://orcid.org/0000-0002-9854-3251","observed_orcids":["https://orcid.org/0000-0002-9854-3251"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian K. Braun","raw_affiliation_strings":["Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9854-3251","affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037449343","display_name":"Felix H\u00f6nes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Felix H\u00f6nes","raw_affiliation_strings":["Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085919410","display_name":"Julia Harant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Harant","raw_affiliation_strings":["Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073957834","display_name":"Michael Fauler","orcid":"https://orcid.org/0000-0002-7371-849X","observed_orcids":["https://orcid.org/0000-0002-7371-849X"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Fauler","raw_affiliation_strings":["Institute of General Physiology, Ulm University, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General Physiology, Ulm University, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027474720","display_name":"Manfred Frick","orcid":"https://orcid.org/0000-0002-4763-1104","observed_orcids":["https://orcid.org/0000-0002-4763-1104"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manfred Frick","raw_affiliation_strings":["Institute of General Physiology, Ulm University, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General Physiology, Ulm University, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113933756","display_name":"Benedikt Lukas Nussbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Benedikt L. Nu\u00dfbaum","raw_affiliation_strings":["Institute of Anesthesiologic Pathophysiology and Method Development, University Hospital Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anesthesiologic Pathophysiology and Method Development, University Hospital Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113488715","display_name":"Peter Radermacher","orcid":"https://orcid.org/0000-0002-5913-3102","observed_orcids":["https://orcid.org/0000-0002-5913-3102"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Radermacher","raw_affiliation_strings":["Institute of Anesthesiologic Pathophysiology and Method Development, University Hospital Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anesthesiologic Pathophysiology and Method Development, University Hospital Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sebastian Hafner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Hafner","raw_affiliation_strings":["Institute of Anesthesiologic Pathophysiology and Method Development, University Hospital Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anesthesiologic Pathophysiology and Method Development, University Hospital Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024003678","display_name":"Markus Stefan Huber-Lang","orcid":"https://orcid.org/0000-0003-2359-6516","observed_orcids":["https://orcid.org/0000-0003-2359-6516"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Markus S. Huber-Lang","raw_affiliation_strings":["Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2359-6516","affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024003678"],"corresponding_institution_ids":["https://openalex.org/I4210155144"],"apc_list":{"value":3040,"currency":"USD","value_usd":3040},"apc_paid":{"value":3040,"currency":"USD","value_usd":3040},"fwci":1.2445,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.76059596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"2018","issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.42410001158714294,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c5a","display_name":"C5a","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9710000157356262},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.925000011920929},{"id":"https://openalex.org/keywords/hemorrhagic-shock","display_name":"hemorrhagic shock","score":0.8029999732971191},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.8619999885559082},{"id":"https://openalex.org/keywords/intracellular-ph","display_name":"intracellular pH","score":0.9269999861717224},{"id":"https://openalex.org/keywords/fmlp-chemotaxis","display_name":"fMLP chemotaxis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/neutrophil-dysfunction","display_name":"neutrophil dysfunction","score":0.8840000033378601},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.949999988079071},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2779499704","wikidata":"https://www.wikidata.org/wiki/Q5008266","display_name":"C5a receptor","level":4,"score":0.712011456489563},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.6426424980163574},{"id":"https://openalex.org/C90582226","wikidata":"https://www.wikidata.org/wiki/Q424292","display_name":"Anaphylatoxin","level":4,"score":0.6324931979179382},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.631254255771637},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.6168979406356812},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.6079652905464172},{"id":"https://openalex.org/C71318922","wikidata":"https://www.wikidata.org/wiki/Q426181","display_name":"Complement component 5","level":4,"score":0.561451256275177},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.558452308177948},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5085271596908569},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5076199769973755},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.4752067029476166},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.44106823205947876},{"id":"https://openalex.org/C2780656570","wikidata":"https://www.wikidata.org/wiki/Q5090627","display_name":"N-Formylmethionine leucyl-phenylalanine","level":4,"score":0.43632835149765015},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.4306705892086029},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4278267025947571},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.414762020111084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3897295594215393},{"id":"https://openalex.org/C198677920","wikidata":"https://www.wikidata.org/wiki/Q3299937","display_name":"Neutrophile","level":3,"score":0.38952159881591797},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3788510859012604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37775540351867676},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2655440866947174},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2199939787387848},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19559213519096375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17940738797187805},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15342044830322266},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10527399182319641},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09927251935005188}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015936","descriptor_name":"Complement C5a","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1155/2018/2052356","doi":"https://doi.org/10.1155/2018/2052356","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/2052356","pdf_url":"http://downloads.hindawi.com/journals/mi/2018/2052356.pdf","source":{"id":"https://openalex.org/S107442880","display_name":"Mediators of Inflammation","issn_l":"0962-9351","issn":["0962-9351","1466-1861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of Inflammation","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4993746","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5996468","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30002598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30002598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of inflammation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5996468","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5996468/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators Inflamm","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8748b602bde14a9296c79db7aed0a9e2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8748b602bde14a9296c79db7aed0a9e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mediators of Inflammation, Vol 2018 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2018/2052356","doi":"https://doi.org/10.1155/2018/2052356","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/2052356","pdf_url":"http://downloads.hindawi.com/journals/mi/2018/2052356.pdf","source":{"id":"https://openalex.org/S107442880","display_name":"Mediators of Inflammation","issn_l":"0962-9351","issn":["0962-9351","1466-1861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of Inflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2807388693.pdf","grobid_xml":"https://content.openalex.org/works/W2807388693.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W78644067","https://openalex.org/W1487685045","https://openalex.org/W1519473807","https://openalex.org/W1533512868","https://openalex.org/W1546078475","https://openalex.org/W1551085198","https://openalex.org/W1590582894","https://openalex.org/W1639029418","https://openalex.org/W1885471961","https://openalex.org/W1890847758","https://openalex.org/W1970432325","https://openalex.org/W1975658051","https://openalex.org/W1977051225","https://openalex.org/W1977695151","https://openalex.org/W1988077852","https://openalex.org/W1990443988","https://openalex.org/W1994583863","https://openalex.org/W2004933597","https://openalex.org/W2012428367","https://openalex.org/W2013296552","https://openalex.org/W2024242455","https://openalex.org/W2032227357","https://openalex.org/W2035706154","https://openalex.org/W2046427435","https://openalex.org/W2048185837","https://openalex.org/W2053168919","https://openalex.org/W2053443014","https://openalex.org/W2062122576","https://openalex.org/W2063340476","https://openalex.org/W2077717093","https://openalex.org/W2090401779","https://openalex.org/W2097575163","https://openalex.org/W2117370254","https://openalex.org/W2119672886","https://openalex.org/W2126878361","https://openalex.org/W2129561523","https://openalex.org/W2131137311","https://openalex.org/W2147142035","https://openalex.org/W2161102001","https://openalex.org/W2254869068","https://openalex.org/W2308695447","https://openalex.org/W2324626880","https://openalex.org/W2346141729","https://openalex.org/W2410716613","https://openalex.org/W2411636689","https://openalex.org/W2508958806","https://openalex.org/W2525327826","https://openalex.org/W2610209479","https://openalex.org/W2612950026","https://openalex.org/W2730693644"],"related_works":["https://openalex.org/W2924426028","https://openalex.org/W3095385028","https://openalex.org/W4394785425","https://openalex.org/W2739677297","https://openalex.org/W4306948239","https://openalex.org/W2012006765","https://openalex.org/W2612950026","https://openalex.org/W2730693644","https://openalex.org/W2130762008","https://openalex.org/W3082195108"],"abstract_inverted_index":{"BACKGROUND:":[0],"Polymorphonuclear":[1],"granulocytes":[2],"(PMN)":[3],"play":[4],"a":[5,23,120,131,143,163],"crucial":[6],"role":[7,57],"in":[8,22,29,65,72,126,146,174,196],"host":[9],"defense.":[10],"Physiologically,":[11],"exposure":[12,93],"of":[13,32,46,58,63,81,150,153,160,167,177],"PMN":[14,47,64,82,97,118,178,194],"to":[15,48,51,67,94,128,183,193],"the":[16,30,44,56,59,147,154,171],"complement":[17],"activation":[18],"product":[19],"C5a":[20,36,129],"results":[21],"protective":[24],"response":[25,66,127,133],"against":[26],"pathogens,":[27],"whereas":[28],"case":[31],"systemic":[33],"inflammation,":[34],"excessive":[35],"substantially":[37],"impairs":[38],"neutrophil":[39],"functions.":[40],"To":[41],"further":[42],"elucidate":[43],"inability":[45],"properly":[49],"respond":[50],"C5a,":[52],"this":[53],"study":[54],"investigates":[55],"cellular":[60,73,155],"membrane":[61,76,148,175,188],"potential":[62,77,149,176,189],"C5a.":[68,95],"METHODS:":[69],"Electrophysiological":[70],"changes":[71,173,190],"and":[74,78,104,123],"mitochondrial":[75],"intracellular":[79],"pH":[80],"from":[83,98],"human":[84],"healthy":[85,184],"volunteers":[86],"were":[87,111,179],"determined":[88],"by":[89],"flow":[90],"cytometry":[91],"after":[92,107,134],"Furthermore,":[96],"male":[99],"Bretoncelles-Meishan-Willebrand":[100],"cross-bred":[101],"pigs":[102],"before":[103],"three":[105],"hours":[106],"severe":[108],"hemorrhagic":[109,169],"shock":[110],"analyzed":[112],"for":[113],"their":[114],"electrophysiological":[115],"response.":[116],"RESULTS:":[117],"showed":[119],"significant":[121,144],"dose-":[122],"time-dependent":[124],"depolarization":[125,159],"with":[130],"strong":[132],"one":[135],"minute.":[136],"The":[137],"chemotactic":[138],"peptide":[139],"fMLP":[140],"also":[141],"evoked":[142],"shift":[145],"PMN.":[151,161],"Acidification":[152],"microenvironment":[156],"significantly":[157],"enhanced":[158],"In":[162],"clinically":[164],"relevant":[165],"model":[166],"porcine":[168],"shock,":[170],"C5a-induced":[172],"markedly":[180],"diminished":[181],"compared":[182],"littermates.":[185],"Overall,":[186],"these":[187],"may":[191],"contribute":[192],"dysfunction":[195],"an":[197],"inflammatory":[198],"environment.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-13T00:00:00"}
